ARF3_HUMAN
Evidence for PS localization
Functions
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARF3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 40.2597 | 4 | no |
| GO:0043168 | anion binding | 23.3766 | 4 | yes |
| GO:0000166 | nucleotide binding | 20.7792 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 20.7792 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.7792 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.7792 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 14.2857 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 14.2857 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 14.2857 | 6 | yes |
| GO:0003924 | GTPase activity | 11.6883 | 7 | yes |
| GO:0005525 | GTP binding | 11.6883 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 11.6883 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 11.6883 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARF3_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 49.3506 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.7532 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.5584 | 4 | no |
| GO:0008104 | protein localization | 40.2597 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 38.9610 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.9610 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.9610 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.9610 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 38.9610 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.6623 | 4 | no |
| GO:0006996 | organelle organization | 37.6623 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0649 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 32.4675 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.1688 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.1688 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.8701 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.8701 | 4 | no |
| GO:0022607 | cellular component assembly | 29.8701 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 24.6753 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.6753 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.6753 | 6 | no |
| GO:0009059 | macromolecule biosynthetic process | 24.6753 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.6753 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.6753 | 5 | no |
| GO:0015031 | protein transport | 23.3766 | 4 | yes |
| GO:0051049 | regulation of transport | 22.0779 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.0779 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 22.0779 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.0779 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.7792 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 20.7792 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.7792 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.7792 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 20.7792 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.7792 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.7792 | 5 | no |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 7.7922 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
| ARFP1_HUMAN | [view interactions] | Low throughput | no | no |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| PRSR1_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
| RAI1_HUMAN | [view interactions] | High throughput | no | yes |
| BCL6_HUMAN | [view interactions] | High throughput | no | no |
| FOXC1_HUMAN | [view interactions] | High throughput | no | no |
| FOLR1_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| CTDS2_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| AP4E1_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| ZO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI3_HUMAN | [view interactions] | High throughput | no | yes |
| F135A_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |