ARF3_HUMAN
Evidence for PS localization
Functions
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARF3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 43.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.3333 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.6667 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 21.6667 | 4 | no |
| GO:0003924 | GTPase activity | 15.0000 | 7 | yes |
| GO:0005525 | GTP binding | 15.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 15.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.0000 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 15.0000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 15.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARF3_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 48.3333 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.6667 | 4 | no |
| GO:0008104 | protein localization | 38.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.3333 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.6667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.0000 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 31.6667 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 31.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.6667 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 30.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 28.3333 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 26.6667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0006412 | translation | 25.0000 | 4 | no |
| GO:0006518 | peptide metabolic process | 25.0000 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 25.0000 | 5 | no |
| GO:0043603 | cellular amide metabolic process | 25.0000 | 4 | no |
| GO:0043604 | amide biosynthetic process | 25.0000 | 5 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 25.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.3333 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 23.3333 | 4 | yes |
| GO:0010941 | regulation of cell death | 23.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.3333 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.3333 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 23.3333 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.3333 | 4 | no |
| GO:0002181 | cytoplasmic translation | 23.3333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.6667 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.6667 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.6667 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.6667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.6667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.6667 | 4 | no |
| GO:0030030 | cell projection organization | 21.6667 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.6667 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 13.3333 | 5 | yes |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 10.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
| ARFP1_HUMAN | [view interactions] | Low throughput | no | no |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| CK068_HUMAN | [view interactions] | High throughput | no | yes |
| PRSR1_HUMAN | [view interactions] | High throughput | no | yes |
| TFDP1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANKH1_HUMAN | [view interactions] | High throughput | no | yes |
| RAI1_HUMAN | [view interactions] | High throughput | no | yes |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| MPI_HUMAN | [view interactions] | High throughput | no | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3B2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COPB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |