ARFG2_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARFG2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 47.1698 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 43.3962 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 43.3962 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 32.0755 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.0755 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.0755 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 26.4151 | 5 | no |
| GO:0005525 | GTP binding | 22.6415 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.6415 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.6415 | 5 | no |
| GO:0005524 | ATP binding | 22.6415 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.6415 | 5 | no |
| GO:0003723 | RNA binding | 20.7547 | 4 | no |
| GO:0003924 | GTPase activity | 20.7547 | 7 | no |
| GO:0046872 | metal ion binding | 13.2075 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 5.6604 | 4 | yes |
| GO:0005096 | GTPase activator activity | 3.7736 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARFG2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6038 | 4 | no |
| GO:0008104 | protein localization | 54.7170 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.7170 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 52.8302 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.9434 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.9434 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.9434 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.0566 | 4 | no |
| GO:0006996 | organelle organization | 47.1698 | 4 | yes |
| GO:0071702 | organic substance transport | 47.1698 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 47.1698 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.2830 | 4 | no |
| GO:0015031 | protein transport | 43.3962 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.3962 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 43.3962 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.6226 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.6226 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 37.7358 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.8491 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8491 | 5 | no |
| GO:0006886 | intracellular protein transport | 33.9623 | 4 | no |
| GO:0022607 | cellular component assembly | 33.9623 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.0755 | 5 | no |
| GO:0051049 | regulation of transport | 32.0755 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.1887 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.1887 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.3019 | 5 | no |
| GO:0010646 | regulation of cell communication | 26.4151 | 4 | no |
| GO:0033043 | regulation of organelle organization | 26.4151 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.4151 | 6 | no |
| GO:0060341 | regulation of cellular localization | 26.4151 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.5283 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.5283 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.5283 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.5283 | 5 | no |
| GO:0043412 | macromolecule modification | 22.6415 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 22.6415 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.6415 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.6415 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.7547 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.7547 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.7547 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.7547 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.7547 | 6 | no |
| GO:0036211 | protein modification process | 20.7547 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.7547 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.7547 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.7547 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.7547 | 5 | no |
| GO:0016050 | vesicle organization | 11.3208 | 5 | yes |
| GO:0006901 | vesicle coating | 3.7736 | 6 | yes |
| GO:0048200 | Golgi transport vesicle coating | 3.7736 | 7 | yes |
| GO:0048205 | COPI coating of Golgi vesicle | 3.7736 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEGN_HUMAN | [view interactions] | Low throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACRBP_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| TSSK6_HUMAN | [view interactions] | High throughput | no | no |
| OCM2_HUMAN | [view interactions] | High throughput | no | no |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VRK2_HUMAN | [view interactions] | High throughput | no | no |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| KPB2_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| HMDH_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM3A_HUMAN | [view interactions] | High throughput | no | no |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC9_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO8_HUMAN | [view interactions] | High throughput | no | no |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEX3B_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| IC1_HUMAN | [view interactions] | High throughput | no | no |
| CEPT1_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| JAZF1_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| ARF4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MLF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COPG2_HUMAN | [view interactions] | Computational | no | yes |
| COPZ1_HUMAN | [view interactions] | Computational | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| COPG1_HUMAN | [view interactions] | Computational | no | yes |
| ARL1_HUMAN | [view interactions] | Computational | no | yes |