PERI_HUMAN
Evidence for PS localization
Functions
Class-III neuronal intermediate filament protein . May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed, PubMed). Assembly of the neuronal intermediate filaments may be regulated by RAB7A . Plays a role in the development of unmyelinated sensory neurons . May be involved in axon elongation and axon regeneration after injury . Inhibits neurite extension in type II spiral ganglion neurons in the cochlea . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PERI_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.3030 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.7879 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.7879 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.2727 | 5 | no |
| GO:0046872 | metal ion binding | 27.2727 | 4 | no |
| GO:0005524 | ATP binding | 25.7576 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.7576 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PERI_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 51.5152 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 39.3939 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.8788 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.8788 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.8788 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.8485 | 4 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.3030 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.7879 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.7879 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.7879 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.7879 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.2727 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0043412 | macromolecule modification | 25.7576 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.7576 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 24.2424 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2424 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.2424 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.2424 | 5 | no |
| GO:0036211 | protein modification process | 24.2424 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.2424 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.7273 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.7273 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0008104 | protein localization | 21.2121 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.2121 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.2121 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.2121 | 5 | no |
| GO:0051049 | regulation of transport | 21.2121 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PERI_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.0606 | 3 | no |
| DOID:1289 | neurodegenerative disease | 4.5455 | 4 | no |
| DOID:936 | brain disease | 3.0303 | 4 | no |
| DOID:0080000 | muscular disease | 3.0303 | 3 | no |
| DOID:423 | myopathy | 3.0303 | 5 | no |
| DOID:66 | muscle tissue disease | 3.0303 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DYST_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNCI_HUMAN | [view interactions] | Low throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS7_HUMAN | [view interactions] | High throughput | no | no |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| RN112_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | High throughput | no | no |
| SMRD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDF1_HUMAN | [view interactions] | High throughput | no | yes |
| KT33B_HUMAN | [view interactions] | High throughput | no | no |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| TEN1L_HUMAN | [view interactions] | High throughput | no | no |
| PHX2A_HUMAN | [view interactions] | High throughput | no | no |
| LUR1L_HUMAN | [view interactions] | High throughput | no | no |
| ENKUR_HUMAN | [view interactions] | High throughput | no | no |
| CENPV_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC23_HUMAN | [view interactions] | High throughput | no | yes |
| FCHO1_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| C1D_HUMAN | [view interactions] | High throughput | no | yes |
| SMOX_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1A2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CS044_HUMAN | [view interactions] | High throughput | no | no |
| CA198_HUMAN | [view interactions] | High throughput | no | yes |
| CF132_HUMAN | [view interactions] | High throughput | no | no |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| CEP41_HUMAN | [view interactions] | High throughput | no | yes |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKS2_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAP20_HUMAN | [view interactions] | High throughput | no | no |
| FA83B_HUMAN | [view interactions] | High throughput | no | no |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFFO1_HUMAN | [view interactions] | High throughput | no | yes |
| IFFO2_HUMAN | [view interactions] | High throughput | no | yes |
| IFT74_HUMAN | [view interactions] | High throughput | no | yes |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPMK_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHG1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| RASF8_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| SACS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L3_HUMAN | [view interactions] | High throughput | no | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| SYTM_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBKB1_HUMAN | [view interactions] | High throughput | no | no |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| VP13C_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM6_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF7_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| MPP9_HUMAN | [view interactions] | High throughput | no | yes |
| PDD2L_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI3_HUMAN | [view interactions] | High throughput | no | no |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C20_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN572_HUMAN | [view interactions] | High throughput | no | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MGN2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| CT55_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| LCA5L_HUMAN | [view interactions] | High throughput | no | no |
| K1C24_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| ZC4H2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCP1L_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| PIHD2_HUMAN | [view interactions] | High throughput | no | no |
| TMM54_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| USH1G_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM11_HUMAN | [view interactions] | High throughput | no | no |
| ATLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP16B_HUMAN | [view interactions] | High throughput | no | yes |
| NFH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |