Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PERI_HUMAN

GO
G2C
SynGO

Class-III neuronal intermediate filament protein . May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed, PubMed). Assembly of the neuronal intermediate filaments may be regulated by RAB7A . Plays a role in the development of unmyelinated sensory neurons . May be involved in axon elongation and axon regeneration after injury . Inhibits neurite extension in type II spiral ganglion neurons in the cochlea . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PERI_HUMAN
GO:0043169 cation binding 32.3944 4 no
GO:0000166 nucleotide binding 30.9859 4 no
GO:0017076 purine nucleotide binding 30.9859 5 no
GO:0043168 anion binding 30.9859 4 no
GO:0046872 metal ion binding 30.9859 5 no
GO:0030554 adenyl nucleotide binding 28.1690 6 no
GO:0032555 purine ribonucleotide binding 28.1690 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.1690 4 no
GO:0005524 ATP binding 25.3521 5 no
GO:0032559 adenyl ribonucleotide binding 25.3521 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in PERI_HUMAN
GO:0006996 organelle organization 45.0704 4 no
GO:0048522 positive regulation of cellular process 45.0704 4 no
GO:0031323 regulation of cellular metabolic process 42.2535 4 no
GO:0048523 negative regulation of cellular process 39.4366 4 no
GO:0022607 cellular component assembly 38.0282 4 no
GO:0010646 regulation of cell communication 38.0282 4 no
GO:0060255 regulation of macromolecule metabolic process 38.0282 4 no
GO:0080090 regulation of primary metabolic process 36.6197 4 no
GO:0009966 regulation of signal transduction 32.3944 4 no
GO:0051128 regulation of cellular component organization 32.3944 4 no
GO:0009889 regulation of biosynthetic process 30.9859 4 no
GO:0010556 regulation of macromolecule biosynthetic process 30.9859 5 no
GO:0031326 regulation of cellular biosynthetic process 30.9859 5 no
GO:0009893 positive regulation of metabolic process 29.5775 4 no
GO:0009894 regulation of catabolic process 29.5775 4 no
GO:0007010 cytoskeleton organization 26.7606 5 no
GO:0031325 positive regulation of cellular metabolic process 26.7606 5 no
GO:0051246 regulation of protein metabolic process 26.7606 5 no
GO:0010468 regulation of gene expression 26.7606 6 no
GO:0010604 positive regulation of macromolecule metabolic process 25.3521 5 no
GO:0006796 phosphate-containing compound metabolic process 25.3521 4 no
GO:0008104 protein localization 23.9437 4 no
GO:0009892 negative regulation of metabolic process 23.9437 4 no
GO:0043412 macromolecule modification 23.9437 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.9437 5 no
GO:0043933 protein-containing complex organization 22.5352 4 no
GO:1902531 regulation of intracellular signal transduction 22.5352 5 no
GO:0009891 positive regulation of biosynthetic process 22.5352 5 no
GO:0031324 negative regulation of cellular metabolic process 22.5352 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.5352 6 no
GO:0036211 protein modification process 22.5352 4 no
GO:0051252 regulation of RNA metabolic process 22.5352 5 no
GO:0065003 protein-containing complex assembly 21.1268 5 no
GO:0033043 regulation of organelle organization 21.1268 5 no
GO:0048584 positive regulation of response to stimulus 21.1268 4 no
GO:0048585 negative regulation of response to stimulus 21.1268 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.1268 6 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DYST_HUMAN [view entry] [view interactions] Low throughput yes yes
SYNCI_HUMAN [view interactions] Low throughput no no
PDD2L_HUMAN [view interactions] High throughput no yes
PDLI3_HUMAN [view interactions] High throughput no no
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL2_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SH319_HUMAN [view interactions] High throughput no no
SMG7_HUMAN [view interactions] High throughput no no
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
STK38_HUMAN [view entry] [view interactions] High throughput yes yes
ASPP2_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
MD13L_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
K1C20_HUMAN [view interactions] High throughput no no
K1C16_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
ZN572_HUMAN [view interactions] High throughput no yes
PPR18_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
MGN2_HUMAN [view interactions] High throughput no yes
AAPK2_HUMAN [view interactions] High throughput no yes
ASPP1_HUMAN [view interactions] High throughput no yes
K1C19_HUMAN [view interactions] High throughput no no
PSA1_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
K2C75_HUMAN [view interactions] High throughput no no
LENG1_HUMAN [view interactions] High throughput no no
CT55_HUMAN [view interactions] High throughput no no
K1C27_HUMAN [view interactions] High throughput no no
ZMAT2_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
TCEA2_HUMAN [view interactions] High throughput no yes
LCA5L_HUMAN [view interactions] High throughput no no
K1C24_HUMAN [view entry] [view interactions] High throughput yes no
K1C14_HUMAN [view interactions] High throughput no no
ZC4H2_HUMAN [view entry] [view interactions] High throughput yes yes
TCP1L_HUMAN [view interactions] High throughput no no
INCA1_HUMAN [view interactions] High throughput no no
PHX2A_HUMAN [view interactions] High throughput no no
TEN1L_HUMAN [view interactions] High throughput no no
CRYAA_HUMAN [view interactions] High throughput no no
KT33B_HUMAN [view interactions] High throughput no no
NDF1_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
RN112_HUMAN [view entry] [view interactions] High throughput yes yes
ZN232_HUMAN [view interactions] High throughput no no
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
K0408_HUMAN [view entry] [view interactions] High throughput yes no
HAUS7_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
PP16B_HUMAN [view interactions] High throughput no yes
ATLA1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM11_HUMAN [view interactions] High throughput no no
RUSF1_HUMAN [view interactions] High throughput no yes
KCD17_HUMAN [view interactions] High throughput no yes
F167A_HUMAN [view interactions] High throughput no yes
CC120_HUMAN [view interactions] High throughput no no
TMM54_HUMAN [view interactions] High throughput no no
PIHD2_HUMAN [view interactions] High throughput no no
USH1G_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
KLC3_HUMAN [view interactions] High throughput no no
CENPV_HUMAN [view interactions] High throughput no yes
ENKUR_HUMAN [view interactions] High throughput no no
LUR1L_HUMAN [view interactions] High throughput no no
K1C15_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
TTC23_HUMAN [view interactions] High throughput no yes
FCHO1_HUMAN [view entry] [view interactions] High throughput yes yes
KIFC3_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
GAN_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
REQU_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
K2C8_HUMAN [view interactions] High throughput no no
C1D_HUMAN [view interactions] High throughput no yes
SMOX_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
NENF_HUMAN [view interactions] High throughput no yes
C1TC_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
AL1A2_HUMAN [view interactions] High throughput no yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
CS044_HUMAN [view interactions] High throughput no no
CA198_HUMAN [view interactions] High throughput no yes
CF132_HUMAN [view interactions] High throughput no no
CAMP3_HUMAN [view interactions] High throughput no no
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
CEP41_HUMAN [view interactions] High throughput no yes
CFA97_HUMAN [view interactions] High throughput no yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
CKS2_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DD19B_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
IF4H_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ETFA_HUMAN [view interactions] High throughput no yes
EXOC4_HUMAN [view entry] [view interactions] High throughput yes yes
FAP20_HUMAN [view interactions] High throughput no no
FA83B_HUMAN [view interactions] High throughput no no
SYFA_HUMAN [view entry] [view interactions] High throughput yes yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
HINT1_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
IFFO1_HUMAN [view interactions] High throughput no yes
IFFO2_HUMAN [view interactions] High throughput no yes
IFT74_HUMAN [view interactions] High throughput no yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
IPMK_HUMAN [view interactions] High throughput no yes
K1671_HUMAN [view interactions] High throughput no yes
K1C18_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LIMD1_HUMAN [view interactions] High throughput no yes
NEST_HUMAN [view interactions] High throughput no no
NUD19_HUMAN [view interactions] High throughput no no
OCRL_HUMAN [view interactions] High throughput no yes
PDLI7_HUMAN [view entry] [view interactions] High throughput yes no
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG1_HUMAN [view interactions] High throughput no yes
PRS7_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
RASF8_HUMAN [view interactions] High throughput no yes
RIPK2_HUMAN [view interactions] High throughput no yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
RTCB_HUMAN [view interactions] High throughput no yes
SACS_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L3_HUMAN [view entry] [view interactions] High throughput yes yes
SIR2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
SYNJ1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNEM_HUMAN [view entry] [view interactions] High throughput yes no
TAB2_HUMAN [view interactions] High throughput no yes
SYTM_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TBKB1_HUMAN [view interactions] High throughput no no
TCHP_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
UBP54_HUMAN [view interactions] High throughput no yes
VP13C_HUMAN [view interactions] High throughput no yes
ZMYM6_HUMAN [view interactions] High throughput no yes
ARFG2_HUMAN [view entry] [view interactions] High throughput yes yes
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ASNS_HUMAN [view interactions] High throughput no yes
CC85C_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
CSTFT_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
IRAK1_HUMAN [view interactions] High throughput no yes
SKT_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF7_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
LPP_HUMAN [view interactions] High throughput no yes
MPP9_HUMAN [view interactions] High throughput no yes