Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RN112_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RN112_HUMAN
GO:0046872 metal ion binding 66.6667 4 yes
GO:0046914 transition metal ion binding 55.5556 5 yes
GO:0008270 zinc ion binding 33.3333 6 yes
GO:0003924 GTPase activity 22.2222 7 yes
GO:0004842 ubiquitin-protein transferase activity 22.2222 4 yes
GO:0005525 GTP binding 22.2222 5 yes
GO:0016462 pyrophosphatase activity 22.2222 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 yes
GO:0017076 purine nucleotide binding 22.2222 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 yes
GO:0019001 guanyl nucleotide binding 22.2222 5 yes
GO:0032555 purine ribonucleotide binding 22.2222 4 yes
GO:0032561 guanyl ribonucleotide binding 22.2222 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 yes
GO:0061630 ubiquitin protein ligase activity 22.2222 5 yes
GO:0061659 ubiquitin-like protein ligase activity 22.2222 4 yes
GO:0001664 G protein-coupled receptor binding 22.2222 4 no
GO:0015631 tubulin binding 22.2222 4 no
GO:0019900 kinase binding 22.2222 4 no
GO:0000976 transcription cis-regulatory region binding 22.2222 5 no
GO:0001067 transcription regulatory region nucleic acid binding 22.2222 4 no
GO:0003677 DNA binding 22.2222 4 no
GO:0003690 double-stranded DNA binding 22.2222 5 no
GO:0004866 endopeptidase inhibitor activity 22.2222 5 no
GO:0030414 peptidase inhibitor activity 22.2222 4 no
GO:0042803 protein homodimerization activity 22.2222 4 no
GO:0043565 sequence-specific DNA binding 22.2222 5 no
GO:0061135 endopeptidase regulator activity 22.2222 4 no
GO:1990837 sequence-specific double-stranded DNA binding 22.2222 6 no
GO:0005507 copper ion binding 22.2222 6 no
GO:1903136 cuprous ion binding 22.2222 7 no

Biological process

Term Name % Distance from top the of the tree Annotated in RN112_HUMAN
GO:0006996 organelle organization 66.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0036211 protein modification process 55.5556 4 yes
GO:0043412 macromolecule modification 55.5556 4 yes
GO:0001932 regulation of protein phosphorylation 55.5556 7 no
GO:0009894 regulation of catabolic process 55.5556 4 no
GO:0009966 regulation of signal transduction 55.5556 4 no
GO:0009968 negative regulation of signal transduction 55.5556 5 no
GO:0010646 regulation of cell communication 55.5556 4 no
GO:0010648 negative regulation of cell communication 55.5556 5 no
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0023057 negative regulation of signaling 55.5556 4 no
GO:0031323 regulation of cellular metabolic process 55.5556 4 no
GO:0031329 regulation of cellular catabolic process 55.5556 5 no
GO:0031399 regulation of protein modification process 55.5556 6 no
GO:0042325 regulation of phosphorylation 55.5556 7 no
GO:0043549 regulation of kinase activity 55.5556 5 no
GO:0045859 regulation of protein kinase activity 55.5556 6 no
GO:0048523 negative regulation of cellular process 55.5556 4 no
GO:0048585 negative regulation of response to stimulus 55.5556 4 no
GO:0051171 regulation of nitrogen compound metabolic process 55.5556 4 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0051246 regulation of protein metabolic process 55.5556 5 no
GO:0051338 regulation of transferase activity 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 55.5556 4 no
GO:0080090 regulation of primary metabolic process 55.5556 4 no
GO:0022607 cellular component assembly 44.4444 4 yes
GO:0043933 protein-containing complex organization 44.4444 4 yes
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 yes
GO:0051259 protein complex oligomerization 44.4444 6 yes
GO:0065003 protein-containing complex assembly 44.4444 5 yes
GO:0008344 adult locomotory behavior 44.4444 4 no
GO:0009892 negative regulation of metabolic process 44.4444 4 no
GO:0010506 regulation of autophagy 44.4444 6 no
GO:0010605 negative regulation of macromolecule metabolic process 44.4444 5 no
GO:0031324 negative regulation of cellular metabolic process 44.4444 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 44.4444 7 no
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0009896 positive regulation of catabolic process 44.4444 5 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0010941 regulation of cell death 44.4444 4 no
GO:0010942 positive regulation of cell death 44.4444 5 no
GO:0022898 regulation of transmembrane transporter activity 44.4444 4 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031331 positive regulation of cellular catabolic process 44.4444 6 no
GO:0033043 regulation of organelle organization 44.4444 5 no
GO:0034762 regulation of transmembrane transport 44.4444 4 no
GO:0034765 regulation of ion transmembrane transport 44.4444 5 no
GO:0042981 regulation of apoptotic process 44.4444 6 no
GO:0043065 positive regulation of apoptotic process 44.4444 7 no
GO:0043067 regulation of programmed cell death 44.4444 5 no
GO:0043068 positive regulation of programmed cell death 44.4444 6 no
GO:0043269 regulation of ion transport 44.4444 5 no
GO:0044087 regulation of cellular component biogenesis 44.4444 4 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0051050 positive regulation of transport 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0051336 regulation of hydrolase activity 44.4444 4 no
GO:0060548 negative regulation of cell death 44.4444 5 no
GO:1904062 regulation of cation transmembrane transport 44.4444 6 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0050727 regulation of inflammatory response 33.3333 5 no
GO:0050729 positive regulation of inflammatory response 33.3333 6 no
GO:0051129 negative regulation of cellular component organization 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0051347 positive regulation of transferase activity 33.3333 5 no
GO:0052547 regulation of peptidase activity 33.3333 5 no
GO:0052548 regulation of endopeptidase activity 33.3333 6 no
GO:0062012 regulation of small molecule metabolic process 33.3333 4 no
GO:0062013 positive regulation of small molecule metabolic process 33.3333 5 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 yes
GO:0045597 positive regulation of cell differentiation 33.3333 5 yes
GO:0045664 regulation of neuron differentiation 33.3333 5 yes
GO:0045666 positive regulation of neuron differentiation 33.3333 6 yes
GO:1901214 regulation of neuron death 33.3333 5 no
GO:1901215 negative regulation of neuron death 33.3333 6 no
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0051260 protein homooligomerization 33.3333 7 yes
GO:1901983 regulation of protein acetylation 33.3333 7 no
GO:0051726 regulation of cell cycle 33.3333 4 yes
GO:1902903 regulation of supramolecular fiber organization 33.3333 5 no
GO:0070647 protein modification by small protein conjugation or removal 33.3333 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0006469 negative regulation of protein kinase activity 33.3333 7 no
GO:2000116 regulation of cysteine-type endopeptidase activity 33.3333 7 no
GO:2000377 regulation of reactive oxygen species metabolic process 33.3333 5 no
GO:2000379 positive regulation of reactive oxygen species metabolic process 33.3333 6 no
GO:2000756 regulation of peptidyl-lysine acetylation 33.3333 8 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0010970 transport along microtubule 33.3333 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 33.3333 4 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0033673 negative regulation of kinase activity 33.3333 6 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0043086 negative regulation of catalytic activity 33.3333 4 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0051348 negative regulation of transferase activity 33.3333 5 no
GO:0099111 microtubule-based transport 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010638 positive regulation of organelle organization 33.3333 6 no
GO:0010821 regulation of mitochondrion organization 33.3333 6 no
GO:0016192 vesicle-mediated transport 33.3333 4 no
GO:0043066 negative regulation of apoptotic process 33.3333 7 no
GO:0043069 negative regulation of programmed cell death 33.3333 6 no
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 7 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031056 regulation of histone modification 33.3333 7 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0031347 regulation of defense response 33.3333 5 no
GO:0031349 positive regulation of defense response 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0032101 regulation of response to external stimulus 33.3333 4 no
GO:0032103 positive regulation of response to external stimulus 33.3333 5 no
GO:0033135 regulation of peptidyl-serine phosphorylation 33.3333 8 no
GO:0033138 positive regulation of peptidyl-serine phosphorylation 33.3333 9 no
GO:0033674 positive regulation of kinase activity 33.3333 6 no
GO:0035065 regulation of histone acetylation 33.3333 8 no
GO:0042176 regulation of protein catabolic process 33.3333 5 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 33.3333 8 no
GO:0043467 regulation of generation of precursor metabolites and energy 33.3333 5 no
GO:0043523 regulation of neuron apoptotic process 33.3333 6 no
GO:0045860 positive regulation of protein kinase activity 33.3333 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0046688 response to copper ion 22.2222 5 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 22.2222 5 no
GO:0048878 chemical homeostasis 22.2222 4 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0050808 synapse organization 22.2222 5 no
GO:0050865 regulation of cell activation 22.2222 4 no
GO:0051091 positive regulation of DNA-binding transcription factor activity 22.2222 4 no
GO:0051099 positive regulation of binding 22.2222 4 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051253 negative regulation of RNA metabolic process 22.2222 6 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0051262 protein tetramerization 22.2222 7 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0051896 regulation of protein kinase B signaling 22.2222 6 no
GO:0051897 positive regulation of protein kinase B signaling 22.2222 7 no
GO:0051963 regulation of synapse assembly 22.2222 6 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0070555 response to interleukin-1 22.2222 5 no
GO:0007029 endoplasmic reticulum organization 22.2222 5 yes
GO:0071241 cellular response to inorganic substance 22.2222 4 no
GO:0010720 positive regulation of cell development 22.2222 6 yes
GO:0071248 cellular response to metal ion 22.2222 5 no
GO:0014013 regulation of gliogenesis 22.2222 7 yes
GO:0071280 cellular response to copper ion 22.2222 6 no
GO:0014015 positive regulation of gliogenesis 22.2222 7 yes
GO:0016567 protein ubiquitination 22.2222 7 yes
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0030182 neuron differentiation 22.2222 4 yes
GO:0071867 response to monoamine 22.2222 5 no
GO:0032446 protein modification by small protein conjugation 22.2222 6 yes
GO:0071868 cellular response to monoamine stimulus 22.2222 5 no
GO:0033194 response to hydroperoxide 22.2222 4 yes
GO:0071869 response to catecholamine 22.2222 4 no
GO:0071870 cellular response to catecholamine stimulus 22.2222 5 no
GO:0036474 cell death in response to hydrogen peroxide 22.2222 4 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 22.2222 8 no
GO:0080135 regulation of cellular response to stress 22.2222 4 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0097435 supramolecular fiber organization 22.2222 4 no
GO:0099174 regulation of presynapse organization 22.2222 6 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0045685 regulation of glial cell differentiation 22.2222 5 yes
GO:1900180 regulation of protein localization to nucleus 22.2222 6 no
GO:0045687 positive regulation of glial cell differentiation 22.2222 6 yes
GO:1900407 regulation of cellular response to oxidative stress 22.2222 5 no
GO:1900542 regulation of purine nucleotide metabolic process 22.2222 6 no
GO:0048568 embryonic organ development 22.2222 4 yes
GO:0050767 regulation of neurogenesis 22.2222 6 yes
GO:0050769 positive regulation of neurogenesis 22.2222 6 yes
GO:1901216 positive regulation of neuron death 22.2222 6 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901888 regulation of cell junction assembly 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0051865 protein autoubiquitination 22.2222 8 yes
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 no
GO:0051960 regulation of nervous system development 22.2222 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:0051962 positive regulation of nervous system development 22.2222 5 yes
GO:1902882 regulation of response to oxidative stress 22.2222 5 no
GO:0060284 regulation of cell development 22.2222 5 yes
GO:1903201 regulation of oxidative stress-induced cell death 22.2222 5 no
GO:0070315 G1 to G0 transition involved in cell differentiation 22.2222 4 yes
GO:1903203 regulation of oxidative stress-induced neuron death 22.2222 6 no
GO:1903209 positive regulation of oxidative stress-induced cell death 22.2222 6 no
GO:1990403 embryonic brain development 22.2222 5 yes
GO:2000026 regulation of multicellular organismal development 22.2222 4 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 22.2222 8 no
GO:1903508 positive regulation of nucleic acid-templated transcription 22.2222 8 no
GO:1903828 negative regulation of protein localization 22.2222 5 no
GO:1903829 positive regulation of protein localization 22.2222 5 no
GO:0008088 axo-dendritic transport 22.2222 5 no
GO:1905606 regulation of presynapse assembly 22.2222 7 no
GO:1905897 regulation of response to endoplasmic reticulum stress 22.2222 5 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 22.2222 8 no
GO:0022900 electron transport chain 22.2222 4 no
GO:0022904 respiratory electron transport chain 22.2222 5 no
GO:0001504 neurotransmitter uptake 22.2222 4 no
GO:0006811 ion transport 22.2222 4 no
GO:0016241 regulation of macroautophagy 22.2222 7 no
GO:0006812 cation transport 22.2222 5 no
GO:0006836 neurotransmitter transport 22.2222 4 no
GO:0007005 mitochondrion organization 22.2222 5 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0010466 negative regulation of peptidase activity 22.2222 6 no
GO:0010565 regulation of cellular ketone metabolic process 22.2222 5 no
GO:0010951 negative regulation of endopeptidase activity 22.2222 7 no
GO:0015844 monoamine transport 22.2222 5 no
GO:0015850 organic hydroxy compound transport 22.2222 5 no
GO:0015872 dopamine transport 22.2222 6 no
GO:0019752 carboxylic acid metabolic process 22.2222 5 no
GO:0023061 signal release 22.2222 4 no
GO:0031330 negative regulation of cellular catabolic process 22.2222 6 no
GO:0043405 regulation of MAP kinase activity 22.2222 8 no
GO:0031333 negative regulation of protein-containing complex assembly 22.2222 6 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0031334 positive regulation of protein-containing complex assembly 22.2222 6 no
GO:0032768 regulation of monooxygenase activity 22.2222 5 no
GO:0032787 monocarboxylic acid metabolic process 22.2222 6 no
GO:0034599 cellular response to oxidative stress 22.2222 4 no
GO:0042177 negative regulation of protein catabolic process 22.2222 6 no
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 8 no
GO:0050905 neuromuscular process 22.2222 4 no
GO:0043254 regulation of protein-containing complex assembly 22.2222 5 no
GO:0043436 oxoacid metabolic process 22.2222 4 no
GO:0043457 regulation of cellular respiration 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0045861 negative regulation of proteolysis 22.2222 7 no
GO:0046903 secretion 22.2222 4 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0051341 regulation of oxidoreductase activity 22.2222 4 no
GO:0051346 negative regulation of hydrolase activity 22.2222 5 no
GO:0051353 positive regulation of oxidoreductase activity 22.2222 5 no
GO:0072384 organelle transport along microtubule 22.2222 4 no
GO:0051583 dopamine uptake involved in synaptic transmission 22.2222 6 no
GO:0051934 catecholamine uptake involved in synaptic transmission 22.2222 5 no
GO:0051937 catecholamine transport 22.2222 6 no
GO:0062197 cellular response to chemical stress 22.2222 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0006915 apoptotic process 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0090493 catecholamine uptake 22.2222 5 no
GO:0007612 learning 22.2222 4 no
GO:0090494 dopamine uptake 22.2222 6 no
GO:0098657 import into cell 22.2222 4 no
GO:0098810 neurotransmitter reuptake 22.2222 4 no
GO:1901617 organic hydroxy compound biosynthetic process 22.2222 4 no
GO:0010508 positive regulation of autophagy 22.2222 7 no
GO:1901984 negative regulation of protein acetylation 22.2222 8 no
GO:1902956 regulation of mitochondrial electron transport, NADH to ubiquinone 22.2222 8 no
GO:1903426 regulation of reactive oxygen species biosynthetic process 22.2222 5 no
GO:1903715 regulation of aerobic respiration 22.2222 7 no
GO:0010822 positive regulation of mitochondrion organization 22.2222 7 no
GO:2000117 negative regulation of cysteine-type endopeptidase activity 22.2222 8 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031648 protein destabilization 22.2222 4 no
GO:0032411 positive regulation of transporter activity 22.2222 4 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0034764 positive regulation of transmembrane transport 22.2222 5 no
GO:0034767 positive regulation of ion transmembrane transport 22.2222 6 no
GO:0043270 positive regulation of ion transport 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0051279 regulation of release of sequestered calcium ion into cytosol 22.2222 5 no
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 22.2222 6 no
GO:0051282 regulation of sequestering of calcium ion 22.2222 4 no
GO:0051650 establishment of vesicle localization 22.2222 4 no
GO:0051924 regulation of calcium ion transport 22.2222 7 no
GO:0051928 positive regulation of calcium ion transport 22.2222 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:1903146 regulation of autophagy of mitochondrion 22.2222 7 no
GO:1903169 regulation of calcium ion transmembrane transport 22.2222 7 no
GO:1903599 positive regulation of autophagy of mitochondrion 22.2222 8 no
GO:1904064 positive regulation of cation transmembrane transport 22.2222 7 no
GO:1904427 positive regulation of calcium ion transmembrane transport 22.2222 7 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:2001234 negative regulation of apoptotic signaling pathway 22.2222 6 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 22.2222 6 no
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 22.2222 7 no
GO:2001257 regulation of cation channel activity 22.2222 6 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0001774 microglial cell activation 22.2222 4 no
GO:0001817 regulation of cytokine production 22.2222 4 no
GO:0001819 positive regulation of cytokine production 22.2222 5 no
GO:0002684 positive regulation of immune system process 22.2222 4 no
GO:0006109 regulation of carbohydrate metabolic process 22.2222 5 no
GO:0006140 regulation of nucleotide metabolic process 22.2222 5 no
GO:0006897 endocytosis 22.2222 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 6 no
GO:0010629 negative regulation of gene expression 22.2222 6 no
GO:0010639 negative regulation of organelle organization 22.2222 6 no
GO:0010950 positive regulation of endopeptidase activity 22.2222 7 no
GO:0010952 positive regulation of peptidase activity 22.2222 6 no
GO:0014070 response to organic cyclic compound 22.2222 4 no
GO:0019216 regulation of lipid metabolic process 22.2222 5 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0034097 response to cytokine 22.2222 4 no
GO:0034248 regulation of cellular amide metabolic process 22.2222 5 no
GO:0034330 cell junction organization 22.2222 4 no
GO:0042116 macrophage activation 22.2222 4 no
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 22.2222 9 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0045807 positive regulation of endocytosis 22.2222 5 no
GO:0045862 positive regulation of proteolysis 22.2222 7 no
GO:0045892 negative regulation of DNA-templated transcription 22.2222 7 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 7 no
GO:0045913 positive regulation of carbohydrate metabolic process 22.2222 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 6 no

Disease

Term Name % Distance from top the of the tree Annotated in RN112_HUMAN
DOID:331 central nervous system disease 22.2222 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TADBP_HUMAN [view interactions] Low throughput no yes
ZBT16_HUMAN [view interactions] Low throughput no yes
UB2D1_HUMAN [view interactions] Low throughput no yes
UB2D2_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
UB2E1_HUMAN [view interactions] Low throughput no yes
RN112_HUMAN [view entry] [view interactions] Low throughput yes yes
A2MG_HUMAN [view interactions] High throughput no yes
DOPO_HUMAN [view interactions] High throughput no no
GRN_HUMAN [view interactions] High throughput no no
MECP2_HUMAN [view interactions] High throughput no yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
PAHX_HUMAN [view interactions] High throughput no yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
RNF11_HUMAN [view interactions] High throughput no yes
PEX26_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no