ATLA1_HUMAN
Evidence for PS localization
Functions
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed). May also regulate Golgi biogenesis. May regulate axonal development. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ATLA1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | yes |
| GO:0003924 | GTPase activity | 20.0000 | 7 | yes |
| GO:0005525 | GTP binding | 20.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 20.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.0000 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 20.0000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 20.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ATLA1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | no |
| GO:0006996 | organelle organization | 46.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 43.3333 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 36.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.6667 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 36.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | yes |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 30.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0061024 | membrane organization | 26.6667 | 4 | yes |
| GO:0071702 | organic substance transport | 26.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
| GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.3333 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 23.3333 | 5 | no |
| GO:0015031 | protein transport | 23.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.3333 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.3333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.3333 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.3333 | 4 | no |
| GO:0030030 | cell projection organization | 20.0000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 20.0000 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 13.3333 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 13.3333 | 6 | yes |
| GO:0051260 | protein homooligomerization | 13.3333 | 7 | yes |
| GO:0090158 | endoplasmic reticulum membrane organization | 13.3333 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 10.0000 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 10.0000 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 10.0000 | 5 | yes |
| GO:0071786 | endoplasmic reticulum tubular network organization | 10.0000 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 10.0000 | 6 | yes |
| GO:1990809 | endoplasmic reticulum tubular network membrane organization | 10.0000 | 6 | yes |
| GO:0007409 | axonogenesis | 6.6667 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ATLA1_HUMAN |
|---|---|---|---|---|
| DOID:870 | neuropathy | 6.6667 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 6.6667 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 6.6667 | 6 | no |
| DOID:440 | neuromuscular disease | 6.6667 | 5 | no |
| DOID:574 | peripheral nervous system disease | 6.6667 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SPAST_HUMAN | [view interactions] | Low throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | Low throughput | no | yes |
| ATLA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZFY27_HUMAN | [view interactions] | Low throughput | no | yes |
| TMED9_HUMAN | [view interactions] | Low throughput | no | yes |
| RN185_HUMAN | [view interactions] | Low throughput | no | no |
| AMFR_HUMAN | [view interactions] | Low throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PJA1_HUMAN | [view interactions] | Low throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYYC_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T4S5_HUMAN | [view interactions] | High throughput | no | no |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC2_HUMAN | [view interactions] | High throughput | no | no |
| REEP1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |