ATLA1_HUMAN
Evidence for PS localization
Functions
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed). May also regulate Golgi biogenesis. May regulate axonal development. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
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ATLA1_HUMAN has binary interactions with 35 proteins
Isoforms
Interacting regions
Canonical [ATLA1_HUMAN]
Isoform [Q8WXF7-2] alignment
Isoform [H0YJA7] alignment
Isoform [H0YJ65] alignment
Isoform [G3V5T4] alignment
Isoform [G3V4Y8] alignment
Isoform [G3V321] alignment
Isoform [G3V334] alignment
Isoform [A0A6I8PIS8] alignment
Isoform [A0A6I8PUC8] alignment
Isoform [A0A6I8PRS8] alignment
Isoform [A0A804HLC1] alignment
LOADING 29%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ATLA1_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 27.7778 | 4 | no |
GO:0046872 | metal ion binding | 27.7778 | 5 | no |
GO:0000166 | nucleotide binding | 25.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 25.0000 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
GO:0043168 | anion binding | 25.0000 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 19.4444 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 19.4444 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 19.4444 | 6 | yes |
GO:0003924 | GTPase activity | 16.6667 | 7 | yes |
GO:0005525 | GTP binding | 16.6667 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 16.6667 | 6 | yes |
GO:0032561 | guanyl ribonucleotide binding | 16.6667 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ATLA1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.7778 | 4 | no |
GO:0006996 | organelle organization | 47.2222 | 4 | yes |
GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
GO:0009966 | regulation of signal transduction | 41.6667 | 4 | no |
GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.8889 | 4 | no |
GO:0051128 | regulation of cellular component organization | 38.8889 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.1111 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 36.1111 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
GO:0022607 | cellular component assembly | 30.5556 | 4 | yes |
GO:0061024 | membrane organization | 30.5556 | 4 | yes |
GO:0051049 | regulation of transport | 30.5556 | 4 | no |
GO:0008104 | protein localization | 27.7778 | 4 | no |
GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
GO:0033043 | regulation of organelle organization | 27.7778 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 27.7778 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
3BHS7_HUMAN | [view interactions] | High throughput | no | no |
AMFR_HUMAN | [view interactions] | Low throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATLA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATLA3_HUMAN | [view interactions] | High throughput | no | no |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CISD2_HUMAN | [view interactions] | High throughput | no | yes |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
DHB11_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
JPH3_HUMAN | [view interactions] | High throughput | no | no |
KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LNP_HUMAN | [view interactions] | High throughput | no | yes |