KCNQ2_HUMAN
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed, PubMed, PubMed, PubMed, PubMed). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCNQ2_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 43.7500 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 43.7500 | 4 | yes |
GO:0005216 | ion channel activity | 40.6250 | 4 | yes |
GO:0005261 | cation channel activity | 40.6250 | 5 | yes |
GO:0015267 | channel activity | 40.6250 | 4 | yes |
GO:0022836 | gated channel activity | 40.6250 | 5 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 40.6250 | 5 | yes |
GO:0005244 | voltage-gated ion channel activity | 34.3750 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 34.3750 | 6 | yes |
GO:0005249 | voltage-gated potassium channel activity | 28.1250 | 6 | yes |
GO:0005267 | potassium channel activity | 28.1250 | 6 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 28.1250 | 6 | yes |
GO:0022843 | voltage-gated cation channel activity | 28.1250 | 5 | yes |
GO:0003779 | actin binding | 21.8750 | 4 | no |
GO:0046872 | metal ion binding | 21.8750 | 4 | no |
GO:0005251 | delayed rectifier potassium channel activity | 15.6250 | 7 | yes |
GO:0030506 | ankyrin binding | 12.5000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCNQ2_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 75.0000 | 4 | yes |
GO:0043269 | regulation of ion transport | 68.7500 | 5 | yes |
GO:0034762 | regulation of transmembrane transport | 59.3750 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 59.3750 | 5 | yes |
GO:0006811 | ion transport | 46.8750 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 46.8750 | 4 | no |
GO:0006812 | cation transport | 43.7500 | 5 | yes |
GO:0030001 | metal ion transport | 43.7500 | 6 | yes |
GO:0008104 | protein localization | 43.7500 | 4 | no |
GO:0098655 | cation transmembrane transport | 37.5000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 37.5000 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 37.5000 | 5 | yes |
GO:0010959 | regulation of metal ion transport | 37.5000 | 6 | no |
GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 34.3750 | 4 | no |
GO:0001508 | action potential | 34.3750 | 4 | no |
GO:0022607 | cellular component assembly | 34.3750 | 4 | no |
GO:0051050 | positive regulation of transport | 34.3750 | 4 | no |
GO:1904062 | regulation of cation transmembrane transport | 34.3750 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | no |
GO:0043270 | positive regulation of ion transport | 31.2500 | 5 | no |
GO:0006813 | potassium ion transport | 28.1250 | 7 | yes |
GO:0071805 | potassium ion transmembrane transport | 28.1250 | 6 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 28.1250 | 4 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 28.1250 | 5 | no |
GO:0034330 | cell junction organization | 28.1250 | 4 | no |
GO:0044057 | regulation of system process | 28.1250 | 4 | no |
GO:0051128 | regulation of cellular component organization | 28.1250 | 4 | no |
GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
GO:0034764 | positive regulation of transmembrane transport | 25.0000 | 5 | no |
GO:0034767 | positive regulation of ion transmembrane transport | 25.0000 | 6 | no |
GO:1904064 | positive regulation of cation transmembrane transport | 25.0000 | 7 | no |
GO:0010038 | response to metal ion | 25.0000 | 4 | no |
GO:0030030 | cell projection organization | 25.0000 | 4 | no |
GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
GO:0016192 | vesicle-mediated transport | 21.8750 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 21.8750 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 21.8750 | 4 | no |
GO:0006937 | regulation of muscle contraction | 21.8750 | 6 | no |
GO:0008016 | regulation of heart contraction | 21.8750 | 6 | no |
GO:0032411 | positive regulation of transporter activity | 21.8750 | 4 | no |
GO:0032414 | positive regulation of ion transmembrane transporter activity | 21.8750 | 5 | no |
GO:0043266 | regulation of potassium ion transport | 21.8750 | 7 | no |
GO:0061024 | membrane organization | 21.8750 | 4 | no |
GO:0072657 | protein localization to membrane | 21.8750 | 4 | no |
GO:0090257 | regulation of muscle system process | 21.8750 | 5 | no |
GO:1901379 | regulation of potassium ion transmembrane transport | 21.8750 | 7 | no |
GO:1903522 | regulation of blood circulation | 21.8750 | 5 | no |
GO:2001257 | regulation of cation channel activity | 21.8750 | 6 | no |
GO:2001259 | positive regulation of cation channel activity | 21.8750 | 6 | no |
GO:0032410 | negative regulation of transporter activity | 21.8750 | 4 | no |
GO:0032413 | negative regulation of ion transmembrane transporter activity | 21.8750 | 5 | no |
GO:0034763 | negative regulation of transmembrane transport | 21.8750 | 5 | no |
GO:0034766 | negative regulation of ion transmembrane transport | 21.8750 | 6 | no |
GO:0043271 | negative regulation of ion transport | 21.8750 | 5 | no |
GO:1904063 | negative regulation of cation transmembrane transport | 21.8750 | 7 | no |
GO:0006996 | organelle organization | 21.8750 | 4 | no |
GO:0007268 | chemical synaptic transmission | 12.5000 | 6 | yes |
GO:0007399 | nervous system development | 12.5000 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 12.5000 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 12.5000 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCNQ2_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 21.8750 | 3 | yes |
DOID:114 | heart disease | 18.7500 | 3 | no |
DOID:0050701 | electroclinical syndrome | 15.6250 | 6 | yes |
DOID:0112202 | developmental and epileptic encephalopathy | 15.6250 | 7 | yes |
DOID:1826 | epilepsy | 15.6250 | 5 | yes |
DOID:936 | brain disease | 15.6250 | 4 | yes |
DOID:0050700 | cardiomyopathy | 12.5000 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 12.5000 | 5 | no |
DOID:2843 | long QT syndrome | 9.3750 | 6 | no |
DOID:10273 | heart conduction disease | 9.3750 | 4 | no |
DOID:0050702 | neonatal period electroclinical syndrome | 6.2500 | 7 | yes |
DOID:0080462 | developmental and epileptic encephalopathy 7 | 6.2500 | 8 | yes |
DOID:14264 | benign neonatal seizures | 6.2500 | 8 | yes |
DOID:0050155 | sensory system disease | 6.2500 | 3 | no |
DOID:0050563 | nonsyndromic deafness | 6.2500 | 5 | no |
DOID:0050564 | autosomal dominant nonsyndromic deafness | 6.2500 | 6 | no |
DOID:2742 | auditory system disease | 6.2500 | 4 | no |
DOID:0050951 | hereditary ataxia | 6.2500 | 5 | no |
DOID:1289 | neurodegenerative disease | 6.2500 | 4 | no |
DOID:0050703 | infancy electroclinical syndrome | 6.2500 | 7 | no |
DOID:0060169 | benign familial infantile epilepsy | 6.2500 | 8 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ANXA6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNQ3_HUMAN | [view interactions] | Low throughput | no | no |
KCNQ1_HUMAN | [view interactions] | Low throughput | no | yes |
NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNQ2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRN_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARI2_HUMAN | [view interactions] | High throughput | no | no |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
AMGO1_HUMAN | [view interactions] | High throughput | no | yes |
AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCND3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCIP2_HUMAN | [view interactions] | High throughput | no | no |
KCNS1_HUMAN | [view interactions] | High throughput | no | no |
KCNS2_HUMAN | [view interactions] | High throughput | no | no |
KCNV1_HUMAN | [view interactions] | High throughput | no | no |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCJ18_HUMAN | [view interactions] | Computational | no | no |
NFASC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNJ4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNQ4_HUMAN | [view interactions] | Computational | no | yes |
KCAB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ANK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB1_HUMAN | [view interactions] | Computational | no | no |
SCN8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCJ14_HUMAN | [view interactions] | Computational | no | no |
SCN1A_HUMAN | [view interactions] | Computational | no | no |
SCN1B_HUMAN | [view interactions] | Computational | no | no |
KCNH2_HUMAN | [view interactions] | Computational | no | no |
NRCAM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNH5_HUMAN | [view interactions] | Computational | no | no |
ANK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNQ5_HUMAN | [view interactions] | Computational | no | yes |
KCJ12_HUMAN | [view interactions] | Computational | no | no |
SCN2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACHA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNE1_HUMAN | [view interactions] | Computational | no | no |
SPTN4_HUMAN | [view entry] [view interactions] | Computational | yes | no |