Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNQ2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed, PubMed, PubMed, PubMed, PubMed). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
214 Arg Trp Seizures,benignfamilialneonatal1(BFNS1) -
284 Tyr Cys Seizures,benignfamilialneonatal1(BFNS1) -
306 Ala Thr Developmentalandepilepticencephalopathy7(DEE7) -
306 Ala Thr Seizures,benignfamilialneonatal1(BFNS1) -
207 Arg Trp Seizures,benignfamilialneonatal1(BFNS1) -
208 Met Val Seizures,benignfamilialneonatal1(BFNS1) -
228 His Gln Seizures,benignfamilialneonatal1(BFNS1) -
243 Leu Phe Seizures,benignfamilialneonatal1(BFNS1) -
247 Ser Trp Developmentalandepilepticencephalopathy7(DEE7) -
333 Arg Gln Seizures,benignfamilialneonatal1(BFNS1) -
554 Lys Asn Developmentalandepilepticencephalopathy7(DEE7) -
554 Lys Asn Seizures,benignfamilialneonatal1(BFNS1) -
266 Asp Glu Developmentalandepilepticencephalopathy7(DEE7) -
268 Leu Phe Developmentalandepilepticencephalopathy7(DEE7) -
291 Arg Ser Developmentalandepilepticencephalopathy7(DEE7) -
294 Ala Val Developmentalandepilepticencephalopathy7(DEE7) -
301 Gly Ser Developmentalandepilepticencephalopathy7(DEE7) -
581 Arg Gln Developmentalandepilepticencephalopathy7(DEE7) -
114 Thr Ala Seizures,benignfamilialneonatal1(BFNS1) -
154 Tyr Asp Seizures,benignfamilialneonatal1(BFNS1) -
159 Gly Glu Seizures,benignfamilialneonatal1(BFNS1) -
159 Gly Arg Seizures,benignfamilialneonatal1(BFNS1) -
196 Ala Val Seizures,benignfamilialneonatal1(BFNS1) -
201 Arg Cys Developmentalandepilepticencephalopathy7(DEE7) -
210 Arg Cys Developmentalandepilepticencephalopathy7(DEE7) -
213 Arg Gln Developmentalandepilepticencephalopathy7(DEE7) -
213 Arg Gln Seizures,benignfamilialneonatal1(BFNS1) -
217 Thr Ala Seizures,benignfamilialneonatal1(BFNS1) -
234 Thr Pro Developmentalandepilepticencephalopathy7(DEE7) -
276 Thr Ile Developmentalandepilepticencephalopathy7(DEE7) -
353 Arg Gly Seizures,benignfamilialneonatal1(BFNS1) -
358 Ser Phe Seizures,benignfamilialneonatal1(BFNS1) -
547 Arg Trp Seizures,benignfamilialneonatal1(BFNS1) -
561 Pro Ser Developmentalandepilepticencephalopathy7(DEE7) -
578 Met Val Seizures,benignfamilialneonatal1(BFNS1) -
588 Arg Ser Seizures,benignfamilialneonatal1(BFNS1) -
637 Leu Arg Seizures,benignfamilialneonatal1(BFNS1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNQ2_HUMAN
GO:0045296 cadherin binding 21.1538 4 no
GO:0005216 monoatomic ion channel activity 19.2308 4 yes
GO:0005261 monoatomic cation channel activity 19.2308 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 19.2308 4 yes
GO:0015267 channel activity 19.2308 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 19.2308 4 yes
GO:0046873 metal ion transmembrane transporter activity 19.2308 5 yes
GO:0022836 gated channel activity 17.3077 5 yes
GO:0005267 potassium channel activity 15.3846 6 yes
GO:0015079 potassium ion transmembrane transporter activity 15.3846 6 yes
GO:0005244 voltage-gated monoatomic ion channel activity 13.4615 5 yes
GO:0005249 voltage-gated potassium channel activity 13.4615 7 yes
GO:0022832 voltage-gated channel activity 13.4615 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 13.4615 6 yes
GO:0030506 ankyrin binding 5.7692 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCNQ2_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0008104 protein localization 46.1538 4 no
GO:0010646 regulation of cell communication 44.2308 4 no
GO:0031323 regulation of cellular metabolic process 44.2308 4 no
GO:0048523 negative regulation of cellular process 44.2308 4 no
GO:0060255 regulation of macromolecule metabolic process 40.3846 4 no
GO:0051128 regulation of cellular component organization 36.5385 4 no
GO:0022607 cellular component assembly 34.6154 4 no
GO:0051049 regulation of transport 34.6154 4 no
GO:0006996 organelle organization 32.6923 4 no
GO:0009893 positive regulation of metabolic process 30.7692 4 no
GO:0080090 regulation of primary metabolic process 30.7692 4 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.8462 5 no
GO:0031325 positive regulation of cellular metabolic process 28.8462 5 no
GO:0010556 regulation of macromolecule biosynthetic process 28.8462 5 no
GO:0030030 cell projection organization 26.9231 4 no
GO:0009966 regulation of signal transduction 26.9231 4 no
GO:0010468 regulation of gene expression 26.9231 6 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0007010 cytoskeleton organization 21.1538 5 no
GO:0010647 positive regulation of cell communication 21.1538 5 no
GO:0033043 regulation of organelle organization 21.1538 5 no
GO:0034330 cell junction organization 21.1538 4 no
GO:0009891 positive regulation of biosynthetic process 21.1538 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.1538 6 no
GO:0009892 negative regulation of metabolic process 21.1538 4 no
GO:0044057 regulation of system process 21.1538 4 no
GO:0006811 monoatomic ion transport 19.2308 4 yes
GO:0006812 monoatomic cation transport 17.3077 5 yes
GO:0030001 metal ion transport 17.3077 6 yes
GO:0098655 monoatomic cation transmembrane transport 15.3846 4 yes
GO:0098662 inorganic cation transmembrane transport 15.3846 4 yes
GO:0006813 potassium ion transport 13.4615 7 yes
GO:0071805 potassium ion transmembrane transport 13.4615 5 yes
GO:0007268 chemical synaptic transmission 9.6154 7 yes
GO:0098916 anterograde trans-synaptic signaling 9.6154 6 yes
GO:0099536 synaptic signaling 9.6154 4 yes
GO:0099537 trans-synaptic signaling 9.6154 5 yes
GO:0007399 nervous system development 5.7692 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNQ2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNQ3_HUMAN [view entry] [view interactions] Low throughput yes no
KCNQ1_HUMAN [view interactions] Low throughput no yes
NEDD4_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
ODB2_HUMAN [view entry] [view interactions] High throughput yes yes
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
DVL2_HUMAN [view interactions] High throughput no yes
DVL3_HUMAN [view interactions] High throughput no yes
EDC4_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
WAC2C_HUMAN [view interactions] High throughput no yes
WAC2A_HUMAN [view interactions] High throughput no yes
HACD3_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
KCNB2_HUMAN [view interactions] High throughput no no
KCNQ5_HUMAN [view entry] [view interactions] High throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYEF2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RB3GP_HUMAN [view entry] [view interactions] High throughput yes yes
RBP2_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
RS26_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
S39A7_HUMAN [view interactions] High throughput no yes
SYUB_HUMAN [view interactions] High throughput no yes
MTCL3_HUMAN [view interactions] High throughput no no
SPKAP_HUMAN [view interactions] High throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SYT1_HUMAN [view entry] [view interactions] High throughput yes no
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
GRN_HUMAN [view interactions] High throughput no no
GGYF1_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
GRIK1_HUMAN [view entry] [view interactions] High throughput yes yes
BTG3_HUMAN [view interactions] High throughput no yes
GOLM1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TOP3B_HUMAN [view interactions] High throughput no no
OTU7A_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
AMGO1_HUMAN [view interactions] High throughput no yes
AT2A3_HUMAN [view interactions] High throughput no yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNB1_HUMAN [view entry] [view interactions] High throughput yes yes
KCND3_HUMAN [view entry] [view interactions] High throughput yes yes
KCIP2_HUMAN [view interactions] High throughput no no
KCNS1_HUMAN [view interactions] High throughput no no
KCNS2_HUMAN [view interactions] High throughput no no
KCNV1_HUMAN [view interactions] High throughput no no
PDIA1_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
ATLA1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
DAAM1_HUMAN [view entry] [view interactions] High throughput yes yes