KCND3_HUMAN
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
338 | Val | Glu | Spinocerebellarataxia19(SCA19) | - |
345 | Gly | Val | Spinocerebellarataxia19(SCA19) | - |
352 | Thr | Pro | Spinocerebellarataxia19(SCA19) | - |
377 | Thr | Met | Spinocerebellarataxia19(SCA19) | - |
384 | Gly | Ser | Spinocerebellarataxia19(SCA19) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCND3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
GO:0016462 | pyrophosphatase activity | 35.0000 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.0000 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.0000 | 6 | no |
GO:0005216 | ion channel activity | 30.0000 | 4 | yes |
GO:0005244 | voltage-gated ion channel activity | 30.0000 | 4 | yes |
GO:0005261 | cation channel activity | 30.0000 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 30.0000 | 4 | yes |
GO:0015267 | channel activity | 30.0000 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 30.0000 | 6 | yes |
GO:0022836 | gated channel activity | 30.0000 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 30.0000 | 5 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 30.0000 | 4 | yes |
GO:0046872 | metal ion binding | 30.0000 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 30.0000 | 5 | yes |
GO:0005524 | ATP binding | 30.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 30.0000 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | no |
GO:0005249 | voltage-gated potassium channel activity | 25.0000 | 6 | yes |
GO:0005267 | potassium channel activity | 25.0000 | 6 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 25.0000 | 6 | yes |
GO:0016887 | ATP hydrolysis activity | 25.0000 | 7 | no |
GO:0031625 | ubiquitin protein ligase binding | 25.0000 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
GO:0005250 | A-type (transient outward) potassium channel activity | 10.0000 | 8 | yes |
GO:0015271 | outward rectifier potassium channel activity | 10.0000 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCND3_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 55.0000 | 4 | yes |
GO:0022607 | cellular component assembly | 45.0000 | 4 | yes |
GO:0043933 | protein-containing complex organization | 45.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 40.0000 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 40.0000 | 5 | yes |
GO:0043269 | regulation of ion transport | 40.0000 | 5 | yes |
GO:0008104 | protein localization | 40.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 35.0000 | 4 | no |
GO:0065003 | protein-containing complex assembly | 35.0000 | 5 | yes |
GO:0006996 | organelle organization | 35.0000 | 4 | no |
GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
GO:0061024 | membrane organization | 30.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
GO:0033365 | protein localization to organelle | 25.0000 | 5 | no |
GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
GO:0006811 | ion transport | 25.0000 | 4 | yes |
GO:0006812 | cation transport | 25.0000 | 5 | yes |
GO:0030001 | metal ion transport | 25.0000 | 6 | yes |
GO:0044057 | regulation of system process | 25.0000 | 4 | yes |
GO:0098655 | cation transmembrane transport | 25.0000 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 25.0000 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 5 | yes |
GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
GO:0006813 | potassium ion transport | 20.0000 | 7 | yes |
GO:0008016 | regulation of heart contraction | 20.0000 | 6 | yes |
GO:0071805 | potassium ion transmembrane transport | 20.0000 | 6 | yes |
GO:1903522 | regulation of blood circulation | 20.0000 | 5 | yes |
GO:0086091 | regulation of heart rate by cardiac conduction | 15.0000 | 4 | yes |
GO:0051259 | protein complex oligomerization | 10.0000 | 6 | yes |
GO:0051260 | protein homooligomerization | 10.0000 | 7 | yes |
GO:0086009 | membrane repolarization | 10.0000 | 4 | yes |
GO:0086011 | membrane repolarization during action potential | 10.0000 | 5 | yes |
GO:0086013 | membrane repolarization during cardiac muscle cell action potential | 10.0000 | 6 | yes |
GO:0097623 | potassium ion export across plasma membrane | 10.0000 | 4 | yes |
GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential | 10.0000 | 7 | yes |
GO:0099622 | cardiac muscle cell membrane repolarization | 10.0000 | 5 | yes |
GO:0099625 | ventricular cardiac muscle cell membrane repolarization | 10.0000 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCND3_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 15.0000 | 3 | yes |
DOID:0050451 | Brugada syndrome | 10.0000 | 5 | yes |
DOID:0050753 | cerebellar ataxia | 10.0000 | 6 | yes |
DOID:0050951 | hereditary ataxia | 10.0000 | 5 | yes |
DOID:0050970 | spinocerebellar ataxia type 19/22 | 10.0000 | 8 | yes |
DOID:0110226 | Brugada syndrome 9 | 10.0000 | 6 | yes |
DOID:10273 | heart conduction disease | 10.0000 | 4 | yes |
DOID:114 | heart disease | 10.0000 | 3 | yes |
DOID:1289 | neurodegenerative disease | 10.0000 | 4 | yes |
DOID:1441 | autosomal dominant cerebellar ataxia | 10.0000 | 7 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KCIP1_HUMAN | [view interactions] | Low throughput | no | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DPP10_HUMAN | [view interactions] | Low throughput | no | yes |
KCIP2_HUMAN | [view interactions] | Low throughput | no | no |
SEM3A_HUMAN | [view interactions] | Low throughput | no | no |
TLR3_HUMAN | [view interactions] | Low throughput | no | yes |
SCN1B_HUMAN | [view interactions] | Low throughput | no | no |
KCNH2_HUMAN | [view interactions] | Low throughput | no | no |
HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
KCND3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H2A1J_HUMAN | [view interactions] | High throughput | no | yes |
IL16_HUMAN | [view interactions] | High throughput | no | no |
AUP1_HUMAN | [view interactions] | High throughput | no | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
CNBP_HUMAN | [view interactions] | High throughput | no | no |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
LBR_HUMAN | [view interactions] | High throughput | no | yes |
NONO_HUMAN | [view interactions] | High throughput | no | yes |
NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
RCN2_HUMAN | [view interactions] | High throughput | no | yes |
RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPGF3_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCIP4_HUMAN | [view interactions] | Computational | no | no |
KCAB3_HUMAN | [view interactions] | Computational | no | no |
KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CSEN_HUMAN | [view interactions] | Computational | no | no |
DPP6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNE3_HUMAN | [view interactions] | Computational | no | yes |
DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCAB1_HUMAN | [view interactions] | Computational | no | no |