DPP6_HUMAN
Promotes cell surface expression of the potassium channel KCND2 (PubMed, PubMed). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed). Has no dipeptidyl aminopeptidase activity (PubMed, PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
385 | Met | Leu | Intellectualdevelopmentaldisorder,autosomaldominant33(MRD33) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DPP6_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 46.1538 | 4 | no |
GO:0005261 | cation channel activity | 46.1538 | 5 | no |
GO:0008324 | cation transmembrane transporter activity | 46.1538 | 4 | no |
GO:0015267 | channel activity | 46.1538 | 4 | no |
GO:0022890 | inorganic cation transmembrane transporter activity | 46.1538 | 4 | no |
GO:0046873 | metal ion transmembrane transporter activity | 46.1538 | 5 | no |
GO:0005244 | voltage-gated ion channel activity | 38.4615 | 4 | no |
GO:0005249 | voltage-gated potassium channel activity | 38.4615 | 6 | no |
GO:0005267 | potassium channel activity | 38.4615 | 6 | no |
GO:0015079 | potassium ion transmembrane transporter activity | 38.4615 | 6 | no |
GO:0022832 | voltage-gated channel activity | 38.4615 | 6 | no |
GO:0022836 | gated channel activity | 38.4615 | 5 | no |
GO:0022843 | voltage-gated cation channel activity | 38.4615 | 5 | no |
GO:0046872 | metal ion binding | 38.4615 | 4 | no |
GO:0015459 | potassium channel regulator activity | 23.0769 | 4 | yes |
GO:0008236 | serine-type peptidase activity | 15.3846 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DPP6_HUMAN |
---|---|---|---|---|
GO:0034762 | regulation of transmembrane transport | 61.5385 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 61.5385 | 5 | yes |
GO:0043269 | regulation of ion transport | 61.5385 | 5 | yes |
GO:0051049 | regulation of transport | 61.5385 | 4 | yes |
GO:0022607 | cellular component assembly | 46.1538 | 4 | no |
GO:0010959 | regulation of metal ion transport | 38.4615 | 6 | yes |
GO:0043266 | regulation of potassium ion transport | 38.4615 | 7 | yes |
GO:1901379 | regulation of potassium ion transmembrane transport | 38.4615 | 7 | yes |
GO:1904062 | regulation of cation transmembrane transport | 38.4615 | 6 | yes |
GO:0048522 | positive regulation of cellular process | 38.4615 | 4 | no |
GO:0043933 | protein-containing complex organization | 38.4615 | 4 | no |
GO:0051259 | protein complex oligomerization | 38.4615 | 6 | no |
GO:0051260 | protein homooligomerization | 38.4615 | 7 | no |
GO:0065003 | protein-containing complex assembly | 38.4615 | 5 | no |
GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
GO:0006811 | ion transport | 30.7692 | 4 | no |
GO:0006812 | cation transport | 30.7692 | 5 | no |
GO:0006813 | potassium ion transport | 30.7692 | 7 | no |
GO:0030001 | metal ion transport | 30.7692 | 6 | no |
GO:0071805 | potassium ion transmembrane transport | 30.7692 | 6 | no |
GO:0098655 | cation transmembrane transport | 30.7692 | 4 | no |
GO:0098660 | inorganic ion transmembrane transport | 30.7692 | 4 | no |
GO:0098662 | inorganic cation transmembrane transport | 30.7692 | 5 | no |
GO:0008104 | protein localization | 23.0769 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 23.0769 | 4 | no |
GO:0030030 | cell projection organization | 23.0769 | 4 | no |
GO:0050807 | regulation of synapse organization | 23.0769 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | no |
GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
GO:0072657 | protein localization to membrane | 15.3846 | 4 | yes |
GO:0072659 | protein localization to plasma membrane | 15.3846 | 5 | yes |
GO:1990778 | protein localization to cell periphery | 15.3846 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in DPP6_HUMAN |
---|---|---|---|---|
DOID:0060038 | specific developmental disorder | 15.3846 | 3 | yes |
DOID:0060307 | autosomal dominant intellectual developmental disorder | 15.3846 | 5 | yes |
DOID:0070063 | autosomal dominant intellectual developmental disorder 33 | 15.3846 | 6 | yes |
DOID:1059 | intellectual disability | 15.3846 | 4 | yes |
DOID:331 | central nervous system disease | 15.3846 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DPP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRND_HUMAN | [view interactions] | Low throughput | no | no |
MYO10_HUMAN | [view interactions] | Low throughput | no | no |
NBEA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCIP1_HUMAN | [view interactions] | Low throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
AT5G1_HUMAN | [view interactions] | High throughput | no | no |
NUDT9_HUMAN | [view interactions] | High throughput | no | yes |
PLMN_HUMAN | [view interactions] | High throughput | no | no |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ITIH2_HUMAN | [view interactions] | High throughput | no | no |
APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCDG7_HUMAN | [view interactions] | High throughput | no | no |
CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
UXS1_HUMAN | [view interactions] | High throughput | no | yes |
PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPP10_HUMAN | [view interactions] | High throughput | no | yes |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
KCNQ3_HUMAN | [view interactions] | High throughput | no | no |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGLO5_HUMAN | [view interactions] | Computational | no | yes |
KCNA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KCIP2_HUMAN | [view interactions] | Computational | no | no |
KCNC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PNMA2_HUMAN | [view interactions] | Computational | no | yes |
KCND3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |