NBEA_HUMAN
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins . [View more on UniProt]
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To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
483 | Ala | Val | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
1332 | Pro | Ser | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
2801 | Glu | Lys | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
946 | His | Tyr | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NBEA_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 43.0769 | 4 | no |
GO:0000166 | nucleotide binding | 41.5385 | 4 | no |
GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 36.9231 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 26.1538 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 26.1538 | 5 | no |
GO:0019900 | kinase binding | 26.1538 | 4 | yes |
GO:0005524 | ATP binding | 23.0769 | 5 | no |
GO:0043169 | cation binding | 21.5385 | 4 | no |
GO:0046872 | metal ion binding | 21.5385 | 5 | no |
GO:0019901 | protein kinase binding | 21.5385 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NBEA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.3077 | 4 | no |
GO:0010646 | regulation of cell communication | 47.6923 | 4 | no |
GO:0051128 | regulation of cellular component organization | 44.6154 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.6154 | 4 | no |
GO:0048523 | negative regulation of cellular process | 43.0769 | 4 | no |
GO:0008104 | protein localization | 41.5385 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 41.5385 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0006996 | organelle organization | 38.4615 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.3846 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.3846 | 5 | no |
GO:0022607 | cellular component assembly | 35.3846 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.8462 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.8462 | 5 | no |
GO:0051049 | regulation of transport | 33.8462 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
GO:0010647 | positive regulation of cell communication | 29.2308 | 5 | no |
GO:0023056 | positive regulation of signaling | 29.2308 | 4 | no |
GO:0031344 | regulation of cell projection organization | 29.2308 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 29.2308 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 27.6923 | 6 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.6923 | 6 | no |
GO:0010468 | regulation of gene expression | 27.6923 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 27.6923 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 27.6923 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 26.1538 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 26.1538 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 26.1538 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 26.1538 | 5 | no |
GO:0071702 | organic substance transport | 26.1538 | 4 | no |
GO:0071705 | nitrogen compound transport | 26.1538 | 4 | no |
GO:0031399 | regulation of protein modification process | 24.6154 | 6 | no |
GO:0042325 | regulation of phosphorylation | 24.6154 | 7 | no |
GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.0769 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 23.0769 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 21.5385 | 8 | no |
GO:0009967 | positive regulation of signal transduction | 21.5385 | 5 | no |
GO:0010975 | regulation of neuron projection development | 21.5385 | 7 | no |
GO:0030030 | cell projection organization | 21.5385 | 4 | no |
GO:0042327 | positive regulation of phosphorylation | 21.5385 | 8 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.5385 | 5 | no |
GO:0009891 | positive regulation of biosynthetic process | 21.5385 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 21.5385 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5385 | 5 | no |
GO:0042981 | regulation of apoptotic process | 21.5385 | 5 | no |
GO:0043067 | regulation of programmed cell death | 21.5385 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 21.5385 | 5 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PFKAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DPP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EMAL1_HUMAN | [view interactions] | Low throughput | no | no |
EMAL2_HUMAN | [view interactions] | Low throughput | no | yes |
EMAL4_HUMAN | [view interactions] | Low throughput | no | yes |
LRBA_HUMAN | [view interactions] | Low throughput | no | yes |
NEK9_HUMAN | [view interactions] | Low throughput | no | yes |
NBEA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCND2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QKI_HUMAN | [view interactions] | High throughput | no | no |
GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RM21_HUMAN | [view interactions] | High throughput | no | no |
FOSL2_HUMAN | [view interactions] | High throughput | no | yes |
LOXE3_HUMAN | [view interactions] | High throughput | no | no |
RD3_HUMAN | [view interactions] | High throughput | no | no |
RBM48_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP135_HUMAN | [view interactions] | High throughput | no | no |
STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DSCR9_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
BET1_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTPRH_HUMAN | [view interactions] | High throughput | no | no |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
LTK_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STYK1_HUMAN | [view interactions] | High throughput | no | yes |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NAB2_HUMAN | [view interactions] | High throughput | no | yes |
STRAB_HUMAN | [view interactions] | High throughput | no | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
F124A_HUMAN | [view interactions] | High throughput | no | no |
AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGS12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
YJEN3_HUMAN | [view interactions] | High throughput | no | yes |
IBP5_HUMAN | [view interactions] | High throughput | no | no |
RDH8_HUMAN | [view interactions] | High throughput | no | no |
PIGR_HUMAN | [view interactions] | High throughput | no | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
AMPN_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARL14_HUMAN | [view interactions] | High throughput | no | no |