NBEA_HUMAN
Evidence for PS localization
Functions
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 483 | Ala | Val | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
| 1332 | Pro | Ser | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
| 2801 | Glu | Lys | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
| 946 | His | Tyr | Neurodevelopmentaldisorderwithorwithoutearly-onsetgeneralizedepilepsy(NEDEGE) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NBEA_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 43.0769 | 4 | no |
| GO:0000166 | nucleotide binding | 41.5385 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.9231 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.1538 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.1538 | 5 | no |
| GO:0019900 | kinase binding | 26.1538 | 4 | yes |
| GO:0005524 | ATP binding | 23.0769 | 5 | no |
| GO:0043169 | cation binding | 21.5385 | 4 | no |
| GO:0046872 | metal ion binding | 21.5385 | 5 | no |
| GO:0019901 | protein kinase binding | 21.5385 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NBEA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.3077 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.6923 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.6154 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.6154 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.0769 | 4 | no |
| GO:0008104 | protein localization | 41.5385 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.5385 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.3846 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.3846 | 5 | no |
| GO:0022607 | cellular component assembly | 35.3846 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.8462 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.8462 | 5 | no |
| GO:0051049 | regulation of transport | 33.8462 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.2308 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.2308 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 29.2308 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.2308 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.6923 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.6923 | 6 | no |
| GO:0010468 | regulation of gene expression | 27.6923 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.6923 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.6923 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.1538 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.1538 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.1538 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.1538 | 5 | no |
| GO:0071702 | organic substance transport | 26.1538 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.1538 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.6154 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 24.6154 | 7 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.0769 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.0769 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.5385 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 21.5385 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 21.5385 | 7 | no |
| GO:0030030 | cell projection organization | 21.5385 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.5385 | 8 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.5385 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.5385 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.5385 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.5385 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.5385 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.5385 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.5385 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PFKAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DPP6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EMAL1_HUMAN | [view interactions] | Low throughput | no | no |
| EMAL2_HUMAN | [view interactions] | Low throughput | no | yes |
| EMAL4_HUMAN | [view interactions] | Low throughput | no | yes |
| LRBA_HUMAN | [view interactions] | Low throughput | no | yes |
| NEK9_HUMAN | [view interactions] | Low throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCND2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QKI_HUMAN | [view interactions] | High throughput | no | no |
| GHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCD5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM21_HUMAN | [view interactions] | High throughput | no | no |
| FOSL2_HUMAN | [view interactions] | High throughput | no | yes |
| LOXE3_HUMAN | [view interactions] | High throughput | no | no |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| RBM48_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMPR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| STRAB_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| F124A_HUMAN | [view interactions] | High throughput | no | no |
| AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YJEN3_HUMAN | [view interactions] | High throughput | no | yes |
| IBP5_HUMAN | [view interactions] | High throughput | no | no |
| RDH8_HUMAN | [view interactions] | High throughput | no | no |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |