Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHC4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHC4_HUMAN
GO:0019900 kinase binding 71.4286 4 yes
GO:0019901 protein kinase binding 71.4286 5 yes
GO:0030971 receptor tyrosine kinase binding 57.1429 4 yes
GO:1990782 protein tyrosine kinase binding 57.1429 6 yes
GO:0000166 nucleotide binding 42.8571 4 no
GO:0004713 protein tyrosine kinase activity 42.8571 4 no
GO:0004714 transmembrane receptor protein tyrosine kinase activity 42.8571 5 no
GO:0005524 ATP binding 42.8571 5 no
GO:0016301 kinase activity 42.8571 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 42.8571 4 no
GO:0017076 purine nucleotide binding 42.8571 5 no
GO:0019199 transmembrane receptor protein kinase activity 42.8571 4 no
GO:0030554 adenyl nucleotide binding 42.8571 6 no
GO:0032555 purine ribonucleotide binding 42.8571 4 no
GO:0032559 adenyl ribonucleotide binding 42.8571 5 no
GO:0035639 purine ribonucleoside triphosphate binding 42.8571 4 no
GO:0043168 anion binding 42.8571 4 no
GO:0005154 epidermal growth factor receptor binding 28.5714 5 no
GO:0042803 protein homodimerization activity 28.5714 4 no
GO:0070851 growth factor receptor binding 28.5714 4 no
GO:0001784 phosphotyrosine residue binding 28.5714 5 no
GO:0030159 signaling receptor complex adaptor activity 28.5714 4 no
GO:0045309 protein phosphorylated amino acid binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SHC4_HUMAN
GO:0007167 enzyme-linked receptor protein signaling pathway 85.7143 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 85.7143 5 yes
GO:0031323 regulation of cellular metabolic process 85.7143 4 yes
GO:0048522 positive regulation of cellular process 85.7143 4 yes
GO:0009889 regulation of biosynthetic process 71.4286 4 yes
GO:0010468 regulation of gene expression 71.4286 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 71.4286 5 yes
GO:0031326 regulation of cellular biosynthetic process 71.4286 5 yes
GO:0060255 regulation of macromolecule metabolic process 71.4286 4 yes
GO:0009893 positive regulation of metabolic process 71.4286 4 no
GO:0009966 regulation of signal transduction 71.4286 4 no
GO:0010646 regulation of cell communication 71.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 71.4286 5 no
GO:0043408 regulation of MAPK cascade 71.4286 6 no
GO:0048584 positive regulation of response to stimulus 71.4286 4 no
GO:1902531 regulation of intracellular signal transduction 71.4286 5 no
GO:0008284 positive regulation of cell population proliferation 57.1429 5 yes
GO:0042127 regulation of cell population proliferation 57.1429 4 yes
GO:0001932 regulation of protein phosphorylation 57.1429 7 no
GO:0001934 positive regulation of protein phosphorylation 57.1429 8 no
GO:0006796 phosphate-containing compound metabolic process 57.1429 4 no
GO:0009891 positive regulation of biosynthetic process 57.1429 5 no
GO:0009967 positive regulation of signal transduction 57.1429 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 57.1429 6 no
GO:0010562 positive regulation of phosphorus metabolic process 57.1429 6 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0010647 positive regulation of cell communication 57.1429 5 no
GO:0019220 regulation of phosphate metabolic process 57.1429 6 no
GO:0023056 positive regulation of signaling 57.1429 4 no
GO:0031328 positive regulation of cellular biosynthetic process 57.1429 6 no
GO:0031399 regulation of protein modification process 57.1429 6 no
GO:0031401 positive regulation of protein modification process 57.1429 7 no
GO:0036211 protein modification process 57.1429 4 no
GO:0038127 ERBB signaling pathway 57.1429 6 no
GO:0042325 regulation of phosphorylation 57.1429 7 no
GO:0042327 positive regulation of phosphorylation 57.1429 8 no
GO:0043410 positive regulation of MAPK cascade 57.1429 7 no
GO:0043412 macromolecule modification 57.1429 4 no
GO:0045937 positive regulation of phosphate metabolic process 57.1429 7 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051174 regulation of phosphorus metabolic process 57.1429 5 no
GO:0051246 regulation of protein metabolic process 57.1429 5 no
GO:0051247 positive regulation of protein metabolic process 57.1429 6 no
GO:0071363 cellular response to growth factor stimulus 57.1429 4 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:1902533 positive regulation of intracellular signal transduction 57.1429 6 no
GO:2000026 regulation of multicellular organismal development 57.1429 4 no
GO:0051128 regulation of cellular component organization 57.1429 4 no
GO:0006468 protein phosphorylation 42.8571 5 no
GO:0007507 heart development 42.8571 4 no
GO:0008104 protein localization 42.8571 4 no
GO:0016310 phosphorylation 42.8571 5 no
GO:0030182 neuron differentiation 42.8571 4 no
GO:0032880 regulation of protein localization 42.8571 5 no
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043066 negative regulation of apoptotic process 42.8571 6 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0043069 negative regulation of programmed cell death 42.8571 5 no
GO:0051240 positive regulation of multicellular organismal process 42.8571 4 no
GO:0060341 regulation of cellular localization 42.8571 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 42.8571 7 no
GO:0070849 response to epidermal growth factor 42.8571 4 no
GO:0071364 cellular response to epidermal growth factor stimulus 42.8571 5 no
GO:0007173 epidermal growth factor receptor signaling pathway 42.8571 7 no
GO:0042552 myelination 42.8571 4 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0010001 glial cell differentiation 42.8571 4 no
GO:0010628 positive regulation of gene expression 42.8571 7 no
GO:0045595 regulation of cell differentiation 42.8571 4 no
GO:0001667 ameboidal-type cell migration 28.5714 4 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006996 organelle organization 28.5714 4 no
GO:0008285 negative regulation of cell population proliferation 28.5714 5 no
GO:0018108 peptidyl-tyrosine phosphorylation 28.5714 6 no
GO:0018193 peptidyl-amino acid modification 28.5714 5 no
GO:0018212 peptidyl-tyrosine modification 28.5714 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0022008 neurogenesis 28.5714 4 no
GO:0033365 protein localization to organelle 28.5714 5 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0035418 protein localization to synapse 28.5714 6 no
GO:0038128 ERBB2 signaling pathway 28.5714 7 no
GO:0038130 ERBB4 signaling pathway 28.5714 7 no
GO:0038135 ERBB2-ERBB4 signaling pathway 28.5714 8 no
GO:0045893 positive regulation of DNA-templated transcription 28.5714 8 no
GO:0045927 positive regulation of growth 28.5714 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0046777 protein autophosphorylation 28.5714 6 no
GO:0046903 secretion 28.5714 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 28.5714 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 28.5714 9 no
GO:0050808 synapse organization 28.5714 5 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 no
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 28.5714 6 no
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 28.5714 7 no
GO:0062237 protein localization to postsynapse 28.5714 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 28.5714 8 no
GO:0072657 protein localization to membrane 28.5714 4 no
GO:0099633 protein localization to postsynaptic specialization membrane 28.5714 6 no
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 28.5714 4 no
GO:1902414 protein localization to cell junction 28.5714 5 no
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 no
GO:1903539 protein localization to postsynaptic membrane 28.5714 5 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:1990778 protein localization to cell periphery 28.5714 5 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0002684 positive regulation of immune system process 28.5714 4 no
GO:0006974 DNA damage response 28.5714 4 no
GO:0008543 fibroblast growth factor receptor signaling pathway 28.5714 6 no
GO:0014044 Schwann cell development 28.5714 5 no
GO:0021782 glial cell development 28.5714 4 no
GO:0042770 signal transduction in response to DNA damage 28.5714 4 no
GO:0043254 regulation of protein-containing complex assembly 28.5714 5 no
GO:0044089 positive regulation of cellular component biogenesis 28.5714 5 no
GO:0050776 regulation of immune response 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:0002694 regulation of leukocyte activation 28.5714 4 no
GO:0007162 negative regulation of cell adhesion 28.5714 5 no
GO:0022407 regulation of cell-cell adhesion 28.5714 5 no
GO:0022603 regulation of anatomical structure morphogenesis 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0045596 negative regulation of cell differentiation 28.5714 5 no
GO:0045785 positive regulation of cell adhesion 28.5714 5 no
GO:0048709 oligodendrocyte differentiation 28.5714 5 no
GO:0050863 regulation of T cell activation 28.5714 6 no
GO:0050865 regulation of cell activation 28.5714 4 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051249 regulation of lymphocyte activation 28.5714 5 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:1903037 regulation of leukocyte cell-cell adhesion 28.5714 6 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
EGFR_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK1_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
TIE2_HUMAN [view interactions] Low throughput no no
RET_HUMAN [view interactions] Low throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
KIT_HUMAN [view interactions] High throughput no no
MET_HUMAN [view interactions] High throughput no yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
GARE1_HUMAN [view interactions] High throughput no yes
IKKA_HUMAN [view interactions] High throughput no yes
DCAM_HUMAN [view interactions] High throughput no yes
SHC3_HUMAN [view interactions] High throughput no yes
NUAK2_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes