SHC4_HUMAN
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SHC4_HUMAN |
---|---|---|---|---|
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 71.4286 | 4 | no |
GO:0004713 | protein tyrosine kinase activity | 71.4286 | 4 | no |
GO:0005524 | ATP binding | 71.4286 | 5 | no |
GO:0016301 | kinase activity | 71.4286 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 71.4286 | 4 | no |
GO:0017076 | purine nucleotide binding | 71.4286 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 71.4286 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 71.4286 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 71.4286 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 71.4286 | 4 | no |
GO:0019900 | kinase binding | 57.1429 | 4 | yes |
GO:0019901 | protein kinase binding | 57.1429 | 5 | yes |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 35.7143 | 5 | no |
GO:0070851 | growth factor receptor binding | 35.7143 | 4 | no |
GO:0042169 | SH2 domain binding | 28.5714 | 4 | no |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 28.5714 | 5 | no |
GO:0019199 | transmembrane receptor protein kinase activity | 28.5714 | 4 | no |
GO:0046875 | ephrin receptor binding | 28.5714 | 4 | no |
GO:0019902 | phosphatase binding | 21.4286 | 4 | no |
GO:0019903 | protein phosphatase binding | 21.4286 | 5 | no |
GO:0046872 | metal ion binding | 21.4286 | 4 | no |
GO:0001784 | phosphotyrosine residue binding | 21.4286 | 5 | no |
GO:0045309 | protein phosphorylated amino acid binding | 21.4286 | 4 | no |
GO:0030971 | receptor tyrosine kinase binding | 14.2857 | 4 | yes |
GO:1990782 | protein tyrosine kinase binding | 14.2857 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SHC4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 85.7143 | 4 | yes |
GO:0009966 | regulation of signal transduction | 85.7143 | 4 | no |
GO:0010646 | regulation of cell communication | 85.7143 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 85.7143 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 85.7143 | 5 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 85.7143 | 4 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 85.7143 | 5 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 78.5714 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 78.5714 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 78.5714 | 5 | no |
GO:0048523 | negative regulation of cellular process | 78.5714 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 78.5714 | 4 | no |
GO:0010468 | regulation of gene expression | 71.4286 | 5 | yes |
GO:0001932 | regulation of protein phosphorylation | 71.4286 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 71.4286 | 8 | no |
GO:0006796 | phosphate-containing compound metabolic process | 71.4286 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 71.4286 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 71.4286 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 71.4286 | 5 | no |
GO:0010647 | positive regulation of cell communication | 71.4286 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 71.4286 | 6 | no |
GO:0023056 | positive regulation of signaling | 71.4286 | 4 | no |
GO:0031399 | regulation of protein modification process | 71.4286 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 71.4286 | 7 | no |
GO:0036211 | protein modification process | 71.4286 | 4 | no |
GO:0042325 | regulation of phosphorylation | 71.4286 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 71.4286 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 71.4286 | 4 | no |
GO:0043412 | macromolecule modification | 71.4286 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 71.4286 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 71.4286 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 71.4286 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 71.4286 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 71.4286 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 71.4286 | 6 | no |
GO:0080090 | regulation of primary metabolic process | 71.4286 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 71.4286 | 6 | no |
GO:0071310 | cellular response to organic substance | 71.4286 | 4 | no |
GO:0006468 | protein phosphorylation | 64.2857 | 5 | no |
GO:0016310 | phosphorylation | 64.2857 | 5 | no |
GO:0051128 | regulation of cellular component organization | 64.2857 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 64.2857 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 64.2857 | 6 | no |
GO:0008284 | positive regulation of cell population proliferation | 57.1429 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 57.1429 | 4 | yes |
GO:0010941 | regulation of cell death | 57.1429 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 57.1429 | 6 | no |
GO:0043549 | regulation of kinase activity | 57.1429 | 5 | no |
GO:0046777 | protein autophosphorylation | 57.1429 | 6 | no |
GO:0051338 | regulation of transferase activity | 57.1429 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 57.1429 | 5 | no |
GO:0060548 | negative regulation of cell death | 57.1429 | 5 | no |
GO:0043410 | positive regulation of MAPK cascade | 57.1429 | 7 | no |
GO:0070848 | response to growth factor | 57.1429 | 4 | no |
GO:0071363 | cellular response to growth factor stimulus | 57.1429 | 5 | no |
GO:0018108 | peptidyl-tyrosine phosphorylation | 50.0000 | 6 | no |
GO:0018193 | peptidyl-amino acid modification | 50.0000 | 5 | no |
GO:0018212 | peptidyl-tyrosine modification | 50.0000 | 6 | no |
GO:0022407 | regulation of cell-cell adhesion | 50.0000 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | no |
GO:0030155 | regulation of cell adhesion | 50.0000 | 4 | no |
GO:0030334 | regulation of cell migration | 50.0000 | 5 | no |
GO:0032101 | regulation of response to external stimulus | 50.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 50.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | no |
GO:0080134 | regulation of response to stress | 50.0000 | 4 | no |
GO:2000145 | regulation of cell motility | 50.0000 | 4 | no |
GO:0002694 | regulation of leukocyte activation | 50.0000 | 4 | no |
GO:0010628 | positive regulation of gene expression | 50.0000 | 6 | no |
GO:0050865 | regulation of cell activation | 50.0000 | 4 | no |
GO:0051049 | regulation of transport | 50.0000 | 4 | no |
GO:0051050 | positive regulation of transport | 50.0000 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 50.0000 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 42.8571 | 5 | no |
GO:0002684 | positive regulation of immune system process | 42.8571 | 4 | no |
GO:0007162 | negative regulation of cell adhesion | 42.8571 | 5 | no |
GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 42.8571 | 6 | no |
GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 42.8571 | 7 | no |
GO:0022607 | cellular component assembly | 42.8571 | 4 | no |
GO:0030030 | cell projection organization | 42.8571 | 4 | no |
GO:0042981 | regulation of apoptotic process | 42.8571 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 42.8571 | 7 | no |
GO:0043067 | regulation of programmed cell death | 42.8571 | 5 | no |
GO:0043069 | negative regulation of programmed cell death | 42.8571 | 6 | no |
GO:0045859 | regulation of protein kinase activity | 42.8571 | 6 | no |
GO:0045860 | positive regulation of protein kinase activity | 42.8571 | 7 | no |
GO:0050776 | regulation of immune response | 42.8571 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 42.8571 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | no |
GO:0032880 | regulation of protein localization | 42.8571 | 5 | no |
GO:0045785 | positive regulation of cell adhesion | 42.8571 | 5 | no |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 42.8571 | 8 | no |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 42.8571 | 9 | no |
GO:0050804 | modulation of chemical synaptic transmission | 42.8571 | 5 | no |
GO:0050863 | regulation of T cell activation | 42.8571 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 42.8571 | 4 | no |
GO:0051249 | regulation of lymphocyte activation | 42.8571 | 5 | no |
GO:0060341 | regulation of cellular localization | 42.8571 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 42.8571 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 42.8571 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 42.8571 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 35.7143 | 6 | no |
GO:0007173 | epidermal growth factor receptor signaling pathway | 35.7143 | 7 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.7143 | 6 | no |
GO:0030335 | positive regulation of cell migration | 35.7143 | 6 | no |
GO:0032103 | positive regulation of response to external stimulus | 35.7143 | 5 | no |
GO:0033043 | regulation of organelle organization | 35.7143 | 5 | no |
GO:0038127 | ERBB signaling pathway | 35.7143 | 6 | no |
GO:0040017 | positive regulation of locomotion | 35.7143 | 4 | no |
GO:0043087 | regulation of GTPase activity | 35.7143 | 5 | no |
GO:1901888 | regulation of cell junction assembly | 35.7143 | 5 | no |
GO:2000147 | positive regulation of cell motility | 35.7143 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 35.7143 | 6 | no |
GO:0009891 | positive regulation of biosynthetic process | 35.7143 | 5 | no |
GO:0010243 | response to organonitrogen compound | 35.7143 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.7143 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 35.7143 | 6 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 35.7143 | 6 | no |
GO:0031347 | regulation of defense response | 35.7143 | 5 | no |
GO:0032386 | regulation of intracellular transport | 35.7143 | 5 | no |
GO:0033993 | response to lipid | 35.7143 | 4 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 35.7143 | 7 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 35.7143 | 6 | no |
GO:0051094 | positive regulation of developmental process | 35.7143 | 4 | no |
GO:0051223 | regulation of protein transport | 35.7143 | 5 | no |
GO:0051241 | negative regulation of multicellular organismal process | 35.7143 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 35.7143 | 5 | no |
GO:0051254 | positive regulation of RNA metabolic process | 35.7143 | 6 | no |
GO:0051345 | positive regulation of hydrolase activity | 35.7143 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 35.7143 | 6 | no |
GO:0071396 | cellular response to lipid | 35.7143 | 5 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 35.7143 | 7 | no |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 35.7143 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 35.7143 | 7 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 35.7143 | 8 | no |
GO:1903829 | positive regulation of protein localization | 35.7143 | 5 | no |
GO:2001141 | regulation of RNA biosynthetic process | 35.7143 | 6 | no |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 35.7143 | 7 | no |
GO:0006996 | organelle organization | 35.7143 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 35.7143 | 5 | no |
GO:0031344 | regulation of cell projection organization | 35.7143 | 5 | no |
GO:0031346 | positive regulation of cell projection organization | 35.7143 | 6 | no |
GO:0043254 | regulation of protein-containing complex assembly | 28.5714 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 28.5714 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
GO:0050807 | regulation of synapse organization | 28.5714 | 5 | no |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 28.5714 | 4 | no |
GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 28.5714 | 5 | no |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 28.5714 | 4 | no |
GO:0051726 | regulation of cell cycle | 28.5714 | 4 | no |
GO:0007229 | integrin-mediated signaling pathway | 28.5714 | 4 | no |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 28.5714 | 8 | no |
GO:0071417 | cellular response to organonitrogen compound | 28.5714 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 28.5714 | 4 | no |
GO:0010810 | regulation of cell-substrate adhesion | 28.5714 | 5 | no |
GO:0022408 | negative regulation of cell-cell adhesion | 28.5714 | 6 | no |
GO:0022604 | regulation of cell morphogenesis | 28.5714 | 5 | no |
GO:0030162 | regulation of proteolysis | 28.5714 | 6 | no |
GO:0031175 | neuron projection development | 28.5714 | 6 | no |
GO:0038093 | Fc receptor signaling pathway | 28.5714 | 5 | no |
GO:0038094 | Fc-gamma receptor signaling pathway | 28.5714 | 6 | no |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 28.5714 | 4 | no |
GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
GO:0045862 | positive regulation of proteolysis | 28.5714 | 7 | no |
GO:0048013 | ephrin receptor signaling pathway | 28.5714 | 6 | no |
GO:0050778 | positive regulation of immune response | 28.5714 | 5 | no |
GO:0051493 | regulation of cytoskeleton organization | 28.5714 | 6 | no |
GO:0051896 | regulation of protein kinase B signaling | 28.5714 | 6 | no |
GO:0065003 | protein-containing complex assembly | 28.5714 | 5 | no |
GO:0001817 | regulation of cytokine production | 28.5714 | 4 | no |
GO:0001819 | positive regulation of cytokine production | 28.5714 | 5 | no |
GO:0002237 | response to molecule of bacterial origin | 28.5714 | 4 | no |
GO:0002696 | positive regulation of leukocyte activation | 28.5714 | 5 | no |
GO:0010942 | positive regulation of cell death | 28.5714 | 5 | no |
GO:0014070 | response to organic cyclic compound | 28.5714 | 4 | no |
GO:0022409 | positive regulation of cell-cell adhesion | 28.5714 | 6 | no |
GO:0032147 | activation of protein kinase activity | 28.5714 | 8 | no |
GO:0032496 | response to lipopolysaccharide | 28.5714 | 4 | no |
GO:0033157 | regulation of intracellular protein transport | 28.5714 | 6 | no |
GO:0044057 | regulation of system process | 28.5714 | 4 | no |
GO:0050727 | regulation of inflammatory response | 28.5714 | 5 | no |
GO:0050867 | positive regulation of cell activation | 28.5714 | 5 | no |
GO:0050870 | positive regulation of T cell activation | 28.5714 | 7 | no |
GO:0051222 | positive regulation of protein transport | 28.5714 | 5 | no |
GO:0051251 | positive regulation of lymphocyte activation | 28.5714 | 6 | no |
GO:0071219 | cellular response to molecule of bacterial origin | 28.5714 | 4 | no |
GO:0071222 | cellular response to lipopolysaccharide | 28.5714 | 5 | no |
GO:1901214 | regulation of neuron death | 28.5714 | 5 | no |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 28.5714 | 7 | no |
GO:1904951 | positive regulation of establishment of protein localization | 28.5714 | 6 | no |
GO:0002683 | negative regulation of immune system process | 28.5714 | 4 | no |
GO:0007507 | heart development | 28.5714 | 4 | no |
GO:0010001 | glial cell differentiation | 28.5714 | 4 | no |
GO:0034330 | cell junction organization | 28.5714 | 4 | no |
GO:0051093 | negative regulation of developmental process | 28.5714 | 4 | no |
GO:0071900 | regulation of protein serine/threonine kinase activity | 28.5714 | 7 | no |
GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
GO:0010638 | positive regulation of organelle organization | 28.5714 | 6 | no |
GO:0010975 | regulation of neuron projection development | 28.5714 | 7 | no |
GO:0010976 | positive regulation of neuron projection development | 28.5714 | 7 | no |
GO:0042542 | response to hydrogen peroxide | 21.4286 | 4 | no |
GO:0042770 | signal transduction in response to DNA damage | 21.4286 | 4 | no |
GO:0045787 | positive regulation of cell cycle | 21.4286 | 5 | no |
GO:0048872 | homeostasis of number of cells | 21.4286 | 4 | no |
GO:0001952 | regulation of cell-matrix adhesion | 21.4286 | 6 | no |
GO:0050890 | cognition | 21.4286 | 4 | no |
GO:0051056 | regulation of small GTPase mediated signal transduction | 21.4286 | 6 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 21.4286 | 7 | no |
GO:0060284 | regulation of cell development | 21.4286 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | no |
GO:0007411 | axon guidance | 21.4286 | 8 | no |
GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
GO:0001764 | neuron migration | 21.4286 | 4 | no |
GO:2000377 | regulation of reactive oxygen species metabolic process | 21.4286 | 5 | no |
GO:0034329 | cell junction assembly | 21.4286 | 5 | no |
GO:0002831 | regulation of response to biotic stimulus | 21.4286 | 4 | no |
GO:0010632 | regulation of epithelial cell migration | 21.4286 | 4 | no |
GO:0031348 | negative regulation of defense response | 21.4286 | 5 | no |
GO:0032102 | negative regulation of response to external stimulus | 21.4286 | 5 | no |
GO:0045088 | regulation of innate immune response | 21.4286 | 5 | no |
GO:0050728 | negative regulation of inflammatory response | 21.4286 | 6 | no |
GO:0050777 | negative regulation of immune response | 21.4286 | 5 | no |
GO:0019216 | regulation of lipid metabolic process | 21.4286 | 5 | no |
GO:0043550 | regulation of lipid kinase activity | 21.4286 | 6 | no |
GO:0043551 | regulation of phosphatidylinositol 3-kinase activity | 21.4286 | 7 | no |
GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 21.4286 | 7 | no |
GO:0045834 | positive regulation of lipid metabolic process | 21.4286 | 5 | no |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 21.4286 | 6 | no |
GO:0051893 | regulation of focal adhesion assembly | 21.4286 | 7 | no |
GO:0070663 | regulation of leukocyte proliferation | 21.4286 | 5 | no |
GO:0090109 | regulation of cell-substrate junction assembly | 21.4286 | 6 | no |
GO:0090218 | positive regulation of lipid kinase activity | 21.4286 | 6 | no |
GO:0097485 | neuron projection guidance | 21.4286 | 7 | no |
GO:0150116 | regulation of cell-substrate junction organization | 21.4286 | 5 | no |
GO:2000209 | regulation of anoikis | 21.4286 | 7 | no |
GO:2000811 | negative regulation of anoikis | 21.4286 | 8 | no |
GO:0007015 | actin filament organization | 21.4286 | 5 | no |
GO:0008285 | negative regulation of cell population proliferation | 21.4286 | 5 | no |
GO:0019221 | cytokine-mediated signaling pathway | 21.4286 | 4 | no |
GO:0031349 | positive regulation of defense response | 21.4286 | 5 | no |
GO:0031960 | response to corticosteroid | 21.4286 | 5 | no |
GO:0032388 | positive regulation of intracellular transport | 21.4286 | 5 | no |
GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | 21.4286 | 9 | no |
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 21.4286 | 10 | no |
GO:0043065 | positive regulation of apoptotic process | 21.4286 | 7 | no |
GO:0043068 | positive regulation of programmed cell death | 21.4286 | 6 | no |
GO:0043523 | regulation of neuron apoptotic process | 21.4286 | 6 | no |
GO:0045597 | positive regulation of cell differentiation | 21.4286 | 5 | no |
GO:0048008 | platelet-derived growth factor receptor signaling pathway | 21.4286 | 6 | no |
GO:0048534 | hematopoietic or lymphoid organ development | 21.4286 | 4 | no |
GO:0048545 | response to steroid hormone | 21.4286 | 4 | no |
GO:0051046 | regulation of secretion | 21.4286 | 5 | no |
GO:0052547 | regulation of peptidase activity | 21.4286 | 5 | no |
GO:0052548 | regulation of endopeptidase activity | 21.4286 | 6 | no |
GO:0071407 | cellular response to organic cyclic compound | 21.4286 | 5 | no |
GO:0090316 | positive regulation of intracellular protein transport | 21.4286 | 6 | no |
GO:0097435 | supramolecular fiber organization | 21.4286 | 4 | no |
GO:1900180 | regulation of protein localization to nucleus | 21.4286 | 6 | no |
GO:1900182 | positive regulation of protein localization to nucleus | 21.4286 | 6 | no |
GO:1901654 | response to ketone | 21.4286 | 4 | no |
GO:1903530 | regulation of secretion by cell | 21.4286 | 4 | no |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 21.4286 | 7 | no |
GO:0030182 | neuron differentiation | 21.4286 | 4 | no |
GO:0043405 | regulation of MAP kinase activity | 21.4286 | 8 | no |
GO:0043406 | positive regulation of MAP kinase activity | 21.4286 | 8 | no |
GO:0043547 | positive regulation of GTPase activity | 21.4286 | 6 | no |
GO:0045596 | negative regulation of cell differentiation | 21.4286 | 5 | no |
GO:0071364 | cellular response to epidermal growth factor stimulus | 21.4286 | 4 | no |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 21.4286 | 8 | no |
GO:0000302 | response to reactive oxygen species | 21.4286 | 4 | no |
GO:0001667 | ameboidal-type cell migration | 21.4286 | 4 | no |
GO:0003018 | vascular process in circulatory system | 21.4286 | 4 | no |
GO:0006974 | cellular response to DNA damage stimulus | 21.4286 | 4 | no |
GO:0007612 | learning | 21.4286 | 4 | no |
GO:0008104 | protein localization | 21.4286 | 4 | no |
GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
GO:0016192 | vesicle-mediated transport | 21.4286 | 4 | no |
GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
GO:0030855 | epithelial cell differentiation | 21.4286 | 4 | no |
GO:0031400 | negative regulation of protein modification process | 21.4286 | 7 | no |
GO:0006915 | apoptotic process | 21.4286 | 4 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 21.4286 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 21.4286 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SHC4_HUMAN |
---|---|---|---|---|
DOID:0050686 | organ system cancer | 14.2857 | 3 | no |
DOID:331 | central nervous system disease | 14.2857 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TIE2_HUMAN | [view interactions] | Low throughput | no | no |
RET_HUMAN | [view interactions] | Low throughput | no | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
KIT_HUMAN | [view interactions] | High throughput | no | no |
MET_HUMAN | [view interactions] | High throughput | no | yes |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GARE1_HUMAN | [view interactions] | High throughput | no | yes |
IKKA_HUMAN | [view interactions] | High throughput | no | yes |
DCAM_HUMAN | [view interactions] | High throughput | no | yes |
SHC3_HUMAN | [view interactions] | High throughput | no | yes |
NUAK2_HUMAN | [view interactions] | High throughput | no | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INSR_HUMAN | [view interactions] | Computational | no | yes |
BCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SOS2_HUMAN | [view interactions] | Computational | no | yes |
FAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PGFRA_HUMAN | [view interactions] | Computational | no | no |
PGFRB_HUMAN | [view interactions] | Computational | no | yes |
JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FGFR3_HUMAN | [view interactions] | Computational | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FGFR2_HUMAN | [view interactions] | Computational | no | yes |
ZAP70_HUMAN | [view interactions] | Computational | no | no |
IL6RA_HUMAN | [view interactions] | Computational | no | no |
GAB1_HUMAN | [view interactions] | Computational | no | yes |
KSYK_HUMAN | [view interactions] | Computational | no | no |
NTRK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UFO_HUMAN | [view interactions] | Computational | no | no |
SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VGFR2_HUMAN | [view interactions] | Computational | no | no |