SYN2_HUMAN
Evidence for PS localization
Functions
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYN2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 32.6531 | 4 | no |
| GO:0019901 | protein kinase binding | 26.5306 | 5 | no |
| GO:0046872 | metal ion binding | 22.4490 | 4 | no |
| GO:0017076 | purine nucleotide binding | 18.3673 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 18.3673 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 18.3673 | 4 | yes |
| GO:0005524 | ATP binding | 14.2857 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 14.2857 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 14.2857 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.2245 | 4 | no |
| GO:0010646 | regulation of cell communication | 59.1837 | 4 | no |
| GO:0051049 | regulation of transport | 53.0612 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.9388 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 42.8571 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 42.8571 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 40.8163 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.8163 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.8163 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.8163 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.8163 | 4 | no |
| GO:0008104 | protein localization | 40.8163 | 4 | no |
| GO:0043269 | regulation of ion transport | 38.7755 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 38.7755 | 4 | no |
| GO:0022607 | cellular component assembly | 36.7347 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.7347 | 5 | no |
| GO:0006996 | organelle organization | 34.6939 | 4 | no |
| GO:0023061 | signal release | 32.6531 | 4 | yes |
| GO:0046903 | secretion | 32.6531 | 4 | yes |
| GO:0099643 | signal release from synapse | 32.6531 | 5 | yes |
| GO:0051050 | positive regulation of transport | 32.6531 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.6531 | 6 | no |
| GO:0009966 | regulation of signal transduction | 30.6122 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.6122 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.6122 | 5 | no |
| GO:0006887 | exocytosis | 28.5714 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 28.5714 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 28.5714 | 4 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 26.5306 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 26.5306 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 26.5306 | 4 | yes |
| GO:0051046 | regulation of secretion | 26.5306 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 26.5306 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 26.5306 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.5306 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.5306 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.5306 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.5306 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.5306 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.5306 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.5306 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.5306 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.5306 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 24.4898 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.4898 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.4898 | 5 | no |
| GO:0017157 | regulation of exocytosis | 24.4898 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.4898 | 7 | no |
| GO:0006836 | neurotransmitter transport | 22.4490 | 4 | yes |
| GO:0045055 | regulated exocytosis | 22.4490 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 22.4490 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.4490 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.4490 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.4490 | 5 | no |
| GO:0099003 | vesicle-mediated transport in synapse | 22.4490 | 5 | no |
| GO:0010941 | regulation of cell death | 22.4490 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.4490 | 4 | no |
| GO:0010038 | response to metal ion | 22.4490 | 4 | no |
| GO:0043549 | regulation of kinase activity | 22.4490 | 5 | no |
| GO:0051338 | regulation of transferase activity | 22.4490 | 4 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 22.4490 | 4 | no |
| GO:0007269 | neurotransmitter secretion | 20.4082 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 20.4082 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.4082 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.4082 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 20.4082 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 20.4082 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.4082 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 20.4082 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 20.4082 | 6 | no |
| GO:0030030 | cell projection organization | 20.4082 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 20.4082 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 20.4082 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.4082 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.4082 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.4082 | 6 | no |
| GO:0045859 | regulation of protein kinase activity | 20.4082 | 6 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 20.4082 | 5 | no |
| GO:0044057 | regulation of system process | 20.4082 | 4 | no |
| GO:0017156 | calcium-ion regulated exocytosis | 16.3265 | 6 | yes |
| GO:0097479 | synaptic vesicle localization | 12.2449 | 4 | yes |
| GO:0097091 | synaptic vesicle clustering | 10.2041 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYN2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.0816 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.0816 | 5 | no |
| DOID:114 | heart disease | 4.0816 | 3 | no |
| DOID:2843 | long QT syndrome | 4.0816 | 6 | no |
| DOID:331 | central nervous system disease | 4.0816 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAPON_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHD5_HUMAN | [view interactions] | Low throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| NAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| DPOLL_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CPLX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIMP4_HUMAN | [view interactions] | Computational | no | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |