SYN2_HUMAN
Evidence for PS localization
Functions
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons . [View more on UniProt]
Protein features
Transmembrane
ELM
Phosphorylation
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 37%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Close ✖
SYN2_HUMAN has binary interactions with 40 proteins
Isoforms
Interacting regions
Canonical [SYN2_HUMAN]
Isoform [Q92777-2] alignment
Isoform [A0A087WW91] alignment
LOADING 58%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SYN2_HUMAN |
---|---|---|---|---|
GO:0019900 | kinase binding | 39.0244 | 4 | no |
GO:0019901 | protein kinase binding | 31.7073 | 5 | no |
GO:0043168 | anion binding | 24.3902 | 4 | yes |
GO:0000166 | nucleotide binding | 21.9512 | 4 | yes |
GO:0017076 | purine nucleotide binding | 21.9512 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 21.9512 | 4 | yes |
GO:0043169 | cation binding | 21.9512 | 4 | no |
GO:0046872 | metal ion binding | 21.9512 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 19.5122 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 19.5122 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 19.5122 | 4 | yes |
GO:0005524 | ATP binding | 17.0732 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SYN2_HUMAN |
---|---|---|---|---|
GO:0010646 | regulation of cell communication | 65.8537 | 4 | no |
GO:0048522 | positive regulation of cellular process | 58.5366 | 4 | no |
GO:0048523 | negative regulation of cellular process | 53.6585 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 53.6585 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.6585 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 51.2195 | 4 | no |
GO:0051049 | regulation of transport | 46.3415 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 46.3415 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 41.4634 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 41.4634 | 4 | no |
GO:0051128 | regulation of cellular component organization | 41.4634 | 4 | no |
GO:0031399 | regulation of protein modification process | 41.4634 | 6 | no |
GO:0009966 | regulation of signal transduction | 39.0244 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 39.0244 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 39.0244 | 5 | no |
GO:0022607 | cellular component assembly | 36.5854 | 4 | no |
GO:0042325 | regulation of phosphorylation | 34.1463 | 7 | no |
GO:0006996 | organelle organization | 31.7073 | 4 | no |
GO:0008104 | protein localization | 31.7073 | 4 | no |
GO:0034762 | regulation of transmembrane transport | 31.7073 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 31.7073 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 31.7073 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 31.7073 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 31.7073 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 31.7073 | 4 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPON_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHD5_HUMAN | [view interactions] | Low throughput | no | no |
CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPOLL_HUMAN | [view interactions] | High throughput | no | no |
DUS2_HUMAN | [view interactions] | High throughput | no | no |
DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |