Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYN2_HUMAN
GO:0019900 kinase binding 39.0244 4 no
GO:0019901 protein kinase binding 31.7073 5 no
GO:0043168 anion binding 24.3902 4 yes
GO:0000166 nucleotide binding 21.9512 4 yes
GO:0017076 purine nucleotide binding 21.9512 5 yes
GO:0032555 purine ribonucleotide binding 21.9512 4 yes
GO:0043169 cation binding 21.9512 4 no
GO:0046872 metal ion binding 21.9512 5 no
GO:0030554 adenyl nucleotide binding 19.5122 6 yes
GO:0032559 adenyl ribonucleotide binding 19.5122 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 19.5122 4 yes
GO:0005524 ATP binding 17.0732 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SYN2_HUMAN
GO:0010646 regulation of cell communication 65.8537 4 no
GO:0048522 positive regulation of cellular process 58.5366 4 no
GO:0048523 negative regulation of cellular process 53.6585 4 no
GO:0031323 regulation of cellular metabolic process 53.6585 4 no
GO:0060255 regulation of macromolecule metabolic process 53.6585 4 no
GO:0080090 regulation of primary metabolic process 51.2195 4 no
GO:0051049 regulation of transport 46.3415 4 no
GO:0051246 regulation of protein metabolic process 46.3415 5 no
GO:0050804 modulation of chemical synaptic transmission 41.4634 5 no
GO:0099177 regulation of trans-synaptic signaling 41.4634 4 no
GO:0051128 regulation of cellular component organization 41.4634 4 no
GO:0031399 regulation of protein modification process 41.4634 6 no
GO:0009966 regulation of signal transduction 39.0244 4 no
GO:0019220 regulation of phosphate metabolic process 39.0244 6 no
GO:0051174 regulation of phosphorus metabolic process 39.0244 5 no
GO:0022607 cellular component assembly 36.5854 4 no
GO:0042325 regulation of phosphorylation 34.1463 7 no
GO:0006996 organelle organization 31.7073 4 no
GO:0008104 protein localization 31.7073 4 no
GO:0034762 regulation of transmembrane transport 31.7073 4 no
GO:0001932 regulation of protein phosphorylation 31.7073 7 no
GO:0009892 negative regulation of metabolic process 31.7073 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.7073 5 no
GO:0031324 negative regulation of cellular metabolic process 31.7073 5 no
GO:0009893 positive regulation of metabolic process 31.7073 4 no
GO:0031325 positive regulation of cellular metabolic process 31.7073 5 no
GO:0043549 regulation of kinase activity 29.2683 5 no
GO:0051338 regulation of transferase activity 29.2683 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.2683 5 no
GO:1902531 regulation of intracellular signal transduction 26.8293 5 no
GO:0045859 regulation of protein kinase activity 26.8293 6 no
GO:0009889 regulation of biosynthetic process 26.8293 4 no
GO:0010468 regulation of gene expression 26.8293 6 no
GO:0010556 regulation of macromolecule biosynthetic process 26.8293 5 no
GO:0031326 regulation of cellular biosynthetic process 26.8293 5 no
GO:0010959 regulation of metal ion transport 24.3902 6 no
GO:0022898 regulation of transmembrane transporter activity 24.3902 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 24.3902 5 no
GO:0043269 regulation of monoatomic ion transport 24.3902 5 no
GO:0043933 protein-containing complex organization 24.3902 4 no
GO:0051050 positive regulation of transport 24.3902 4 no
GO:0071310 cellular response to organic substance 24.3902 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 24.3902 6 no
GO:0030030 cell projection organization 24.3902 4 no
GO:0031344 regulation of cell projection organization 24.3902 5 no
GO:0034330 cell junction organization 24.3902 4 no
GO:0044087 regulation of cellular component biogenesis 24.3902 4 no
GO:0010563 negative regulation of phosphorus metabolic process 24.3902 6 no
GO:0031400 negative regulation of protein modification process 24.3902 7 no
GO:0045936 negative regulation of phosphate metabolic process 24.3902 7 no
GO:0051248 negative regulation of protein metabolic process 24.3902 6 no
GO:0051247 positive regulation of protein metabolic process 24.3902 6 no
GO:0048584 positive regulation of response to stimulus 24.3902 4 no
GO:0007268 chemical synaptic transmission 21.9512 7 yes
GO:0098916 anterograde trans-synaptic signaling 21.9512 6 yes
GO:0099536 synaptic signaling 21.9512 4 yes
GO:0099537 trans-synaptic signaling 21.9512 5 yes
GO:0010647 positive regulation of cell communication 21.9512 5 no
GO:0023056 positive regulation of signaling 21.9512 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.9512 5 no
GO:0032880 regulation of protein localization 21.9512 5 no
GO:0060341 regulation of cellular localization 21.9512 4 no
GO:1901701 cellular response to oxygen-containing compound 21.9512 4 no
GO:0010038 response to metal ion 21.9512 4 no
GO:0042981 regulation of apoptotic process 21.9512 5 no
GO:0043067 regulation of programmed cell death 21.9512 4 no
GO:0050890 cognition 21.9512 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.9512 6 no
GO:0141124 intracellular signaling cassette 21.9512 4 no
GO:0033043 regulation of organelle organization 21.9512 5 no
GO:0051130 positive regulation of cellular component organization 21.9512 5 no
GO:0051726 regulation of cell cycle 21.9512 4 no
GO:0051924 regulation of calcium ion transport 21.9512 7 no
GO:1903169 regulation of calcium ion transmembrane transport 21.9512 7 no
GO:0044057 regulation of system process 21.9512 4 no
GO:0023061 signal release 14.6341 4 yes
GO:0046903 secretion 14.6341 4 yes
GO:0099643 signal release from synapse 14.6341 5 yes
GO:0007269 neurotransmitter secretion 9.7561 4 yes
GO:0045055 regulated exocytosis 9.7561 4 yes
GO:0097091 synaptic vesicle clustering 9.7561 5 yes
GO:0097479 synaptic vesicle localization 9.7561 4 yes
GO:0006836 neurotransmitter transport 9.7561 4 yes
GO:0017156 calcium-ion regulated exocytosis 7.3171 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CAPON_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN2_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
SYN3_HUMAN [view entry] [view interactions] Low throughput yes yes
CHD5_HUMAN [view interactions] Low throughput no no
PRS6A_HUMAN [view entry] [view interactions] Low throughput yes yes
RACK1_HUMAN [view interactions] Low throughput no yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
GRID2_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
SPTCS_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ACM4_HUMAN [view entry] [view interactions] High throughput yes yes
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
DPOLL_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
DUS2_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
PDC6I_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
UBP53_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CPLX1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes