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DYN1_HUMAN

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI002614 DOC_PP2B_PxIxI_1 DOC 843 849 -
ELMI000178 LIG_SH3_2 LIG 833 838 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DYN1_HUMAN
GO:0017076 purine nucleotide binding 28.5714 4 yes
GO:0032555 purine ribonucleotide binding 27.6786 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 27.6786 4 yes
GO:0030554 adenyl nucleotide binding 22.3214 5 no
GO:0019900 kinase binding 21.4286 4 yes
GO:0005524 ATP binding 21.4286 5 no
GO:0032559 adenyl ribonucleotide binding 21.4286 5 no
GO:0046872 metal ion binding 20.5357 4 no
GO:0019901 protein kinase binding 19.6429 5 yes
GO:0003723 RNA binding 16.0714 4 yes
GO:0016462 pyrophosphatase activity 11.6071 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 11.6071 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 11.6071 6 yes
GO:0015631 tubulin binding 9.8214 4 yes
GO:0008017 microtubule binding 8.9286 5 yes
GO:0019001 guanyl nucleotide binding 8.9286 5 yes
GO:0032561 guanyl ribonucleotide binding 8.9286 5 yes
GO:0005525 GTP binding 8.0357 5 yes
GO:0003924 GTPase activity 7.1429 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DYN1_HUMAN
GO:0048522 positive regulation of cellular process 60.7143 4 no
GO:0051128 regulation of cellular component organization 56.2500 4 no
GO:0048523 negative regulation of cellular process 49.1071 4 no
GO:0010646 regulation of cell communication 46.4286 4 yes
GO:0016192 vesicle-mediated transport 45.5357 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.6429 4 no
GO:0022607 cellular component assembly 44.6429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.7500 4 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0006996 organelle organization 41.0714 4 yes
GO:0006897 endocytosis 37.5000 5 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0008104 protein localization 36.6071 4 no
GO:0051130 positive regulation of cellular component organization 34.8214 5 no
GO:0010604 positive regulation of macromolecule metabolic process 33.9286 5 no
GO:0009966 regulation of signal transduction 33.9286 4 no
GO:0051246 regulation of protein metabolic process 33.9286 5 no
GO:0031325 positive regulation of cellular metabolic process 33.0357 5 no
GO:0043933 protein-containing complex organization 33.0357 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.1429 5 no
GO:0010468 regulation of gene expression 31.2500 5 no
GO:0009889 regulation of biosynthetic process 30.3571 4 no
GO:0050804 modulation of chemical synaptic transmission 29.4643 5 yes
GO:0099177 regulation of trans-synaptic signaling 29.4643 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 29.4643 5 no
GO:0010941 regulation of cell death 29.4643 4 no
GO:0030030 cell projection organization 29.4643 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.6786 6 no
GO:0033043 regulation of organelle organization 27.6786 5 no
GO:0060627 regulation of vesicle-mediated transport 26.7857 4 no
GO:0065003 protein-containing complex assembly 26.7857 5 no
GO:0019220 regulation of phosphate metabolic process 26.7857 6 no
GO:0044087 regulation of cellular component biogenesis 26.7857 4 no
GO:0051174 regulation of phosphorus metabolic process 26.7857 5 no
GO:0048584 positive regulation of response to stimulus 25.8929 4 no
GO:0060341 regulation of cellular localization 25.8929 4 no
GO:0071702 organic substance transport 25.8929 4 no
GO:0051247 positive regulation of protein metabolic process 25.8929 6 no
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 24.1071 6 no
GO:0010605 negative regulation of macromolecule metabolic process 24.1071 5 no
GO:0015031 protein transport 24.1071 4 no
GO:0051050 positive regulation of transport 24.1071 4 no
GO:1903506 regulation of nucleic acid-templated transcription 24.1071 7 no
GO:2001141 regulation of RNA biosynthetic process 24.1071 6 no
GO:0001932 regulation of protein phosphorylation 24.1071 7 no
GO:0007010 cytoskeleton organization 24.1071 5 no
GO:0051129 negative regulation of cellular component organization 23.2143 5 no
GO:0120036 plasma membrane bounded cell projection organization 23.2143 5 no
GO:0043085 positive regulation of catalytic activity 23.2143 4 no
GO:0051094 positive regulation of developmental process 22.3214 4 no
GO:0006898 receptor-mediated endocytosis 21.4286 6 yes
GO:0045595 regulation of cell differentiation 21.4286 4 no
GO:0099537 trans-synaptic signaling 21.4286 4 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0009891 positive regulation of biosynthetic process 20.5357 5 no
GO:0022603 regulation of anatomical structure morphogenesis 20.5357 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.5357 6 no
GO:0032880 regulation of protein localization 20.5357 5 no
GO:0036211 protein modification process 20.5357 4 no
GO:0043412 macromolecule modification 20.5357 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.5357 6 no
GO:0051240 positive regulation of multicellular organismal process 20.5357 4 no
GO:0034330 cell junction organization 20.5357 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.5357 6 no
GO:0042327 positive regulation of phosphorylation 20.5357 8 no
GO:0045937 positive regulation of phosphate metabolic process 20.5357 7 no
GO:0061024 membrane organization 15.1786 4 yes
GO:0099003 vesicle-mediated transport in synapse 15.1786 5 yes
GO:0048488 synaptic vesicle endocytosis 13.3929 5 yes
GO:0140238 presynaptic endocytosis 13.3929 4 yes
GO:0031623 receptor internalization 11.6071 7 yes
GO:0016050 vesicle organization 8.9286 5 yes
GO:0006900 vesicle budding from membrane 3.5714 5 yes
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane 2.6786 7 yes
GO:0070142 synaptic vesicle budding 2.6786 6 yes
GO:0007032 endosome organization 1.7857 6 yes
GO:1901998 toxin transport 1.7857 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in DYN1_HUMAN
DOID:331 central nervous system disease 2.6786 3 no
DOID:2476 hereditary spastic paraplegia 1.7857 5 no
DOID:607 paraplegia 1.7857 4 no
DOID:936 brain disease 1.7857 4 no
DOID:0050700 cardiomyopathy 1.7857 4 no
DOID:0060036 intrinsic cardiomyopathy 1.7857 5 no
DOID:114 heart disease 1.7857 3 no
DOID:12930 dilated cardiomyopathy 1.7857 6 no
DOID:0080000 muscular disease 1.7857 3 no
DOID:423 myopathy 1.7857 5 no
DOID:66 muscle tissue disease 1.7857 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
SPTCS_HUMAN [view interactions] Low throughput no yes
SNX9_HUMAN [view entry] [view interactions] Low throughput yes yes
FNBP1_HUMAN [view interactions] Low throughput no yes
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOSTN_HUMAN [view interactions] Low throughput no yes
SNX33_HUMAN [view interactions] Low throughput no yes
NDKA_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] Low throughput yes no
NDKB_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHOCN_HUMAN [view interactions] Low throughput no yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
SPN90_HUMAN [view entry] [view interactions] Low throughput yes no
NCK1_HUMAN [view interactions] Low throughput no yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO1E_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMBP_HUMAN [view interactions] Low throughput no no
P85A_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
NOS3_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
SPD2A_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO1_HUMAN [view interactions] Low throughput no yes
PIAS1_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CLIC4_HUMAN [view interactions] Low throughput no no
CABIN_HUMAN [view interactions] Low throughput no yes
UBS3A_HUMAN [view interactions] Low throughput no no
KIF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYR1A_HUMAN [view interactions] Low throughput no yes
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3B4_HUMAN [view interactions] Low throughput no yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
EH1L1_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
BASP1_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K10_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
LRAD3_HUMAN [view interactions] Low throughput no yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
K1107_HUMAN [view interactions] Low throughput no yes
FER_HUMAN [view interactions] Low throughput no yes
DBNL_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
U2D2L_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
IQCB1_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF1_HUMAN [view interactions] High throughput no no
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
MED31_HUMAN [view interactions] High throughput no yes
ASB13_HUMAN [view interactions] High throughput no yes
PIN4_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
SCN2B_HUMAN [view interactions] High throughput no no
LYPD6_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
TMM9B_HUMAN [view interactions] High throughput no yes
ZBBX_HUMAN [view interactions] High throughput no no
CDKAL_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
ANR22_HUMAN [view interactions] High throughput no no
AMGO1_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
EFNA4_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
NKG2F_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
CD70_HUMAN [view interactions] High throughput no no
ASCL4_HUMAN [view interactions] High throughput no no
DMAP1_HUMAN [view interactions] High throughput no yes
FRIL_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
TYOBP_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
PACN3_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
SHLB1_HUMAN [view interactions] High throughput no yes
I2BPL_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
NPM3_HUMAN [view interactions] High throughput no yes
RU2A_HUMAN [view interactions] High throughput no yes
TBD2A_HUMAN [view interactions] High throughput no yes
RPE_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
JAG1_HUMAN [view interactions] Computational no no
MFN1_HUMAN [view interactions] Computational no yes
EPN1_HUMAN [view entry] [view interactions] Computational yes yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes
CXCR1_HUMAN [view interactions] Computational no yes
CXCR4_HUMAN [view interactions] Computational no no
L1CAM_HUMAN [view entry] [view interactions] Computational yes yes
GBRA1_HUMAN [view entry] [view interactions] Computational yes yes
MFN2_HUMAN [view entry] [view interactions] Computational yes yes
IL8_HUMAN [view interactions] Computational no no
CLH2_HUMAN [view interactions] Computational no no
EFNB1_HUMAN [view interactions] Computational no yes
ARRC_HUMAN [view interactions] Computational no no
GBRA3_HUMAN [view entry] [view interactions] Computational yes yes
RAF1_HUMAN [view entry] [view interactions] Computational yes no
EGFR_HUMAN [view interactions] Computational no no
CLCB_HUMAN [view entry] [view interactions] Computational yes yes
GBRA6_HUMAN [view entry] [view interactions] Computational yes no
GBRA2_HUMAN [view entry] [view interactions] Computational yes no
PICAL_HUMAN [view entry] [view interactions] Computational yes yes
CCL11_HUMAN [view interactions] Computational no no
THRB_HUMAN [view interactions] Computational no no
RGS19_HUMAN [view interactions] Computational no yes
AP2M1_HUMAN [view entry] [view interactions] Computational yes yes
NGF_HUMAN [view interactions] Computational no no
MK01_HUMAN [view entry] [view interactions] Computational yes yes
ITSN2_HUMAN [view entry] [view interactions] Computational yes yes
MP2K2_HUMAN [view entry] [view interactions] Computational yes yes
CCL4_HUMAN [view interactions] Computational no no
MTG1_HUMAN [view interactions] Computational no yes
TA2R_HUMAN [view interactions] Computational no no
DLL1_HUMAN [view interactions] Computational no no
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
SDF1_HUMAN [view interactions] Computational no no
CXCR2_HUMAN [view interactions] Computational no no
HCLS1_HUMAN [view interactions] Computational no no
EDN1_HUMAN [view interactions] Computational no no
TLR4_HUMAN [view interactions] Computational no yes
CD14_HUMAN [view interactions] Computational no no
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
PP2BC_HUMAN [view interactions] Computational no yes
MX1_HUMAN [view interactions] Computational no yes
PP2BB_HUMAN [view entry] [view interactions] Computational yes yes
CLCA_HUMAN [view entry] [view interactions] Computational yes no
FGR_HUMAN [view interactions] Computational no no
GBRA5_HUMAN [view entry] [view interactions] Computational yes no
CXCR3_HUMAN [view interactions] Computational no no
ARRB2_HUMAN [view entry] [view interactions] Computational yes no
EPHB2_HUMAN [view entry] [view interactions] Computational yes yes
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
SYNJ2_HUMAN [view entry] [view interactions] Computational yes yes
LY96_HUMAN [view interactions] Computational no no
GIPC1_HUMAN [view entry] [view interactions] Computational yes yes
CXL10_HUMAN [view interactions] Computational no no
ANGT_HUMAN [view interactions] Computational no no
FIS1_HUMAN [view entry] [view interactions] Computational yes yes
GBRA4_HUMAN [view entry] [view interactions] Computational yes no
EP15R_HUMAN [view entry] [view interactions] Computational yes yes
EGF_HUMAN [view interactions] Computational no no
GAK_HUMAN [view entry] [view interactions] Computational yes yes