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DYN1_HUMAN

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI004808 DOC_PP2B_PxIxIT_1 DOC 844 849 -
ELMI000178 LIG_SH3_2 LIG 833 838 -
ELMI004808 DOC_PP2B_PxIxIT_1 DOC 844 849 -
ELMI000178 LIG_SH3_2 LIG 833 838 -

Molecular function

Term Name % Distance from the top of the tree Annotated in DYN1_HUMAN
GO:0043168 anion binding 35.4839 4 yes
GO:0000166 nucleotide binding 27.9570 4 yes
GO:0017076 purine nucleotide binding 27.9570 5 yes
GO:0032555 purine ribonucleotide binding 26.8817 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 26.8817 4 yes
GO:0019900 kinase binding 24.7312 4 yes
GO:0043169 cation binding 24.7312 4 no
GO:0046872 metal ion binding 22.5806 5 no
GO:0003723 RNA binding 20.4301 4 yes
GO:0019901 protein kinase binding 20.4301 5 yes
GO:0030554 adenyl nucleotide binding 20.4301 6 no
GO:0015631 tubulin binding 13.9785 4 yes
GO:0016462 pyrophosphatase activity 13.9785 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 13.9785 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 13.9785 6 yes
GO:0008017 microtubule binding 12.9032 5 yes
GO:0019001 guanyl nucleotide binding 10.7527 6 yes
GO:0032561 guanyl ribonucleotide binding 10.7527 5 yes
GO:0005525 GTP binding 9.6774 5 yes
GO:0035091 phosphatidylinositol binding 9.6774 4 yes
GO:0003924 GTPase activity 7.5269 7 yes
GO:0042803 protein homodimerization activity 7.5269 4 yes
GO:1901981 phosphatidylinositol phosphate binding 7.5269 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 7.5269 6 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6.4516 5 yes
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3.2258 5 yes
GO:0019003 GDP binding 3.2258 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DYN1_HUMAN
GO:0048522 positive regulation of cellular process 59.1398 4 no
GO:0051128 regulation of cellular component organization 59.1398 4 no
GO:0022607 cellular component assembly 53.7634 4 yes
GO:0048523 negative regulation of cellular process 51.6129 4 no
GO:0006996 organelle organization 47.3118 4 yes
GO:0010646 regulation of cell communication 47.3118 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.3118 4 no
GO:0031323 regulation of cellular metabolic process 46.2366 4 no
GO:0080090 regulation of primary metabolic process 45.1613 4 no
GO:0051049 regulation of transport 44.0860 4 no
GO:0043933 protein-containing complex organization 38.7097 4 yes
GO:0008104 protein localization 38.7097 4 no
GO:0030030 cell projection organization 36.5591 4 no
GO:0009889 regulation of biosynthetic process 35.4839 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.4839 5 no
GO:0031326 regulation of cellular biosynthetic process 35.4839 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0009893 positive regulation of metabolic process 32.2581 4 no
GO:0051246 regulation of protein metabolic process 32.2581 5 no
GO:0098657 import into cell 31.1828 4 yes
GO:0009966 regulation of signal transduction 31.1828 4 no
GO:0031344 regulation of cell projection organization 31.1828 5 no
GO:0044087 regulation of cellular component biogenesis 31.1828 4 no
GO:0065003 protein-containing complex assembly 30.1075 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.1075 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.1075 6 no
GO:0023056 positive regulation of signaling 27.9570 4 no
GO:0031325 positive regulation of cellular metabolic process 27.9570 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.9570 5 no
GO:0010647 positive regulation of cell communication 26.8817 5 no
GO:0007010 cytoskeleton organization 26.8817 5 no
GO:0009892 negative regulation of metabolic process 26.8817 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.8817 5 no
GO:0033043 regulation of organelle organization 26.8817 5 no
GO:0031399 regulation of protein modification process 25.8065 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.8065 5 no
GO:0031324 negative regulation of cellular metabolic process 25.8065 5 no
GO:0042981 regulation of apoptotic process 25.8065 5 no
GO:0043067 regulation of programmed cell death 25.8065 4 no
GO:0051129 negative regulation of cellular component organization 25.8065 5 no
GO:0060627 regulation of vesicle-mediated transport 24.7312 4 no
GO:0048584 positive regulation of response to stimulus 24.7312 4 no
GO:0051094 positive regulation of developmental process 24.7312 4 no
GO:0051252 regulation of RNA metabolic process 24.7312 5 no
GO:0019220 regulation of phosphate metabolic process 23.6559 6 no
GO:0051174 regulation of phosphorus metabolic process 23.6559 5 no
GO:0006355 regulation of DNA-templated transcription 23.6559 7 no
GO:2001141 regulation of RNA biosynthetic process 23.6559 6 no
GO:0051050 positive regulation of transport 22.5806 4 no
GO:0060341 regulation of cellular localization 22.5806 4 no
GO:0009967 positive regulation of signal transduction 22.5806 5 no
GO:0051240 positive regulation of multicellular organismal process 22.5806 4 no
GO:0009890 negative regulation of biosynthetic process 22.5806 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.5806 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.5806 6 no
GO:0010243 response to organonitrogen compound 21.5054 4 no
GO:0071702 organic substance transport 21.5054 4 no
GO:0071705 nitrogen compound transport 21.5054 4 no
GO:0042325 regulation of phosphorylation 21.5054 7 no
GO:0034762 regulation of transmembrane transport 20.4301 4 no
GO:0001932 regulation of protein phosphorylation 20.4301 7 no
GO:0048812 neuron projection morphogenesis 20.4301 5 no
GO:0051247 positive regulation of protein metabolic process 20.4301 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.4301 4 no
GO:1902531 regulation of intracellular signal transduction 20.4301 5 no
GO:0043254 regulation of protein-containing complex assembly 20.4301 5 no
GO:0045595 regulation of cell differentiation 20.4301 4 no
GO:0050890 cognition 20.4301 4 no
GO:0034330 cell junction organization 20.4301 4 no
GO:0061024 membrane organization 17.2043 4 yes
GO:0006898 receptor-mediated endocytosis 16.1290 4 yes
GO:0032535 regulation of cellular component size 16.1290 4 yes
GO:0031623 receptor internalization 13.9785 5 yes
GO:0048488 synaptic vesicle endocytosis 12.9032 5 yes
GO:0140238 presynaptic endocytosis 12.9032 4 yes
GO:0016050 vesicle organization 9.6774 5 yes
GO:0051259 protein complex oligomerization 9.6774 6 yes
GO:0051260 protein homooligomerization 5.3763 7 yes
GO:0051262 protein tetramerization 5.3763 7 yes
GO:0048268 clathrin coat assembly 4.3011 6 yes
GO:0090148 membrane fission 3.2258 5 yes
GO:0006900 vesicle budding from membrane 2.1505 5 yes
GO:0007032 endosome organization 2.1505 6 yes
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane 2.1505 7 yes
GO:0051289 protein homotetramerization 2.1505 8 yes
GO:0070142 synaptic vesicle budding 2.1505 6 yes
GO:0097494 regulation of vesicle size 2.1505 5 yes
GO:0099049 clathrin coat assembly involved in endocytosis 2.1505 7 yes
GO:0099050 vesicle scission 2.1505 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
M3K10_HUMAN [view interactions] Low throughput no yes
EPS15_HUMAN [view entry] [view interactions] Low throughput yes yes
EPN4_HUMAN [view interactions] Low throughput no yes
LRAD3_HUMAN [view interactions] Low throughput no yes
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
BTBD8_HUMAN [view interactions] Low throughput no yes
FER_HUMAN [view interactions] Low throughput no yes
DBNL_HUMAN [view entry] [view interactions] Low throughput yes yes
NMD3A_HUMAN [view entry] [view interactions] Low throughput yes no
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
SPTCS_HUMAN [view interactions] Low throughput no yes
SNX9_HUMAN [view entry] [view interactions] Low throughput yes yes
FNBP1_HUMAN [view interactions] Low throughput no yes
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOSTN_HUMAN [view interactions] Low throughput no yes
SNX33_HUMAN [view interactions] Low throughput no yes
NDKA_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] Low throughput yes no
NDKB_HUMAN [view entry] [view interactions] Low throughput yes yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHOCN_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] Low throughput yes no
SPN90_HUMAN [view entry] [view interactions] Low throughput yes no
NCK1_HUMAN [view interactions] Low throughput no yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO1E_HUMAN [view entry] [view interactions] Low throughput yes yes
DNMBP_HUMAN [view interactions] Low throughput no no
P85A_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
NOS3_HUMAN [view interactions] Low throughput no no
PAXI_HUMAN [view interactions] Low throughput no yes
BSN_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
SPD2A_HUMAN [view entry] [view interactions] Low throughput yes yes
DYR1A_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view entry] [view interactions] Low throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
CLIC4_HUMAN [view interactions] Low throughput no no
CABIN_HUMAN [view interactions] Low throughput no yes
UBS3A_HUMAN [view interactions] Low throughput no no
KIF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
KIF5A_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3B4_HUMAN [view interactions] Low throughput no yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
EH1L1_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
BASP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DMAP1_HUMAN [view interactions] High throughput no yes
FRIL_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
ZNRD2_HUMAN [view interactions] High throughput no yes
MFD4A_HUMAN [view interactions] High throughput no yes
TYOBP_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
UBP53_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
RUNX2_HUMAN [view interactions] High throughput no no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
PACN3_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
SHLB1_HUMAN [view interactions] High throughput no yes
I2BPL_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
NPM3_HUMAN [view interactions] High throughput no yes
RU2A_HUMAN [view interactions] High throughput no yes
TBD2A_HUMAN [view interactions] High throughput no yes
RPE_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SYN2_HUMAN [view entry] [view interactions] High throughput yes no
IST1_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
LSM12_HUMAN [view interactions] High throughput no yes
ZFAN3_HUMAN [view interactions] High throughput no yes
GMPR2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
U2D2L_HUMAN [view interactions] High throughput no no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
IQCB1_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
FCHO2_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
PPT1_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF1_HUMAN [view interactions] High throughput no no
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
MED31_HUMAN [view interactions] High throughput no yes
ASB13_HUMAN [view interactions] High throughput no yes
PIN4_HUMAN [view interactions] High throughput no yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
HSP13_HUMAN [view interactions] High throughput no yes
FTCD_HUMAN [view interactions] High throughput no no
PCNT_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
ASAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAG6_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
SCN2B_HUMAN [view interactions] High throughput no no
LYPD6_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
TBC15_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
TMM9B_HUMAN [view interactions] High throughput no yes
ZBBX_HUMAN [view interactions] High throughput no no
CDKAL_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
ANR22_HUMAN [view interactions] High throughput no no
AMGO1_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
EFNA4_HUMAN [view interactions] High throughput no no
GLPA_HUMAN [view interactions] High throughput no no
NKG2F_HUMAN [view interactions] High throughput no no
TMEM9_HUMAN [view interactions] High throughput no no
CD70_HUMAN [view interactions] High throughput no no
ASCL4_HUMAN [view interactions] High throughput no no