DYN3_HUMAN
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DYN3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 22.7273 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 22.7273 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.7273 | 4 | yes |
GO:0001664 | G protein-coupled receptor binding | 18.1818 | 4 | yes |
GO:0015631 | tubulin binding | 18.1818 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 15.9091 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.9091 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.9091 | 6 | yes |
GO:0008017 | microtubule binding | 13.6364 | 5 | yes |
GO:0003924 | GTPase activity | 11.3636 | 7 | yes |
GO:0005525 | GTP binding | 11.3636 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 11.3636 | 5 | yes |
GO:0032561 | guanyl ribonucleotide binding | 11.3636 | 5 | yes |
GO:0031802 | type 5 metabotropic glutamate receptor binding | 9.0909 | 6 | yes |
GO:0035254 | glutamate receptor binding | 9.0909 | 4 | yes |
GO:0035256 | G protein-coupled glutamate receptor binding | 9.0909 | 5 | yes |
GO:0050998 | nitric-oxide synthase binding | 6.8182 | 4 | yes |
GO:0031798 | type 1 metabotropic glutamate receptor binding | 4.5455 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DYN3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 47.7273 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 43.1818 | 4 | no |
GO:0016192 | vesicle-mediated transport | 43.1818 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 43.1818 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 40.9091 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.9091 | 4 | no |
GO:0006897 | endocytosis | 38.6364 | 5 | yes |
GO:0030030 | cell projection organization | 38.6364 | 4 | yes |
GO:0022607 | cellular component assembly | 36.3636 | 4 | yes |
GO:0051049 | regulation of transport | 36.3636 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 36.3636 | 5 | yes |
GO:0008104 | protein localization | 36.3636 | 4 | no |
GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 34.0909 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 34.0909 | 5 | yes |
GO:0009966 | regulation of signal transduction | 34.0909 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | no |
GO:0031344 | regulation of cell projection organization | 31.8182 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.8182 | 6 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 29.5455 | 5 | no |
GO:0010468 | regulation of gene expression | 29.5455 | 5 | no |
GO:0006996 | organelle organization | 27.2727 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | yes |
GO:0044089 | positive regulation of cellular component biogenesis | 27.2727 | 5 | yes |
GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:0006898 | receptor-mediated endocytosis | 25.0000 | 6 | yes |
GO:0010975 | regulation of neuron projection development | 25.0000 | 7 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | yes |
GO:0031346 | positive regulation of cell projection organization | 25.0000 | 6 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
GO:0045597 | positive regulation of cell differentiation | 22.7273 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.7273 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.7273 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | no |
GO:0007010 | cytoskeleton organization | 20.4545 | 5 | no |
GO:0010941 | regulation of cell death | 20.4545 | 4 | no |
GO:0042325 | regulation of phosphorylation | 20.4545 | 7 | no |
GO:1901701 | cellular response to oxygen-containing compound | 20.4545 | 4 | no |
GO:0015031 | protein transport | 20.4545 | 4 | no |
GO:0071702 | organic substance transport | 20.4545 | 4 | no |
GO:0071705 | nitrogen compound transport | 20.4545 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.4545 | 4 | no |
GO:0048488 | synaptic vesicle endocytosis | 20.4545 | 5 | yes |
GO:0050807 | regulation of synapse organization | 20.4545 | 5 | yes |
GO:0051050 | positive regulation of transport | 20.4545 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 20.4545 | 5 | yes |
GO:0099003 | vesicle-mediated transport in synapse | 20.4545 | 5 | yes |
GO:0140238 | presynaptic endocytosis | 20.4545 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 20.4545 | 5 | no |
GO:0010647 | positive regulation of cell communication | 20.4545 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.4545 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 20.4545 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 20.4545 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 20.4545 | 4 | no |
GO:0034330 | cell junction organization | 18.1818 | 4 | yes |
GO:0050808 | synapse organization | 15.9091 | 5 | yes |
GO:0030031 | cell projection assembly | 13.6364 | 5 | yes |
GO:0031345 | negative regulation of cell projection organization | 13.6364 | 6 | yes |
GO:0031623 | receptor internalization | 13.6364 | 7 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 13.6364 | 6 | yes |
GO:0060491 | regulation of cell projection assembly | 11.3636 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 11.3636 | 6 | yes |
GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 11.3636 | 6 | yes |
GO:0007416 | synapse assembly | 9.0909 | 6 | yes |
GO:0010977 | negative regulation of neuron projection development | 9.0909 | 7 | yes |
GO:0034329 | cell junction assembly | 9.0909 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 9.0909 | 4 | yes |
GO:0099175 | regulation of postsynapse organization | 9.0909 | 6 | yes |
GO:0051489 | regulation of filopodium assembly | 6.8182 | 7 | yes |
GO:0051491 | positive regulation of filopodium assembly | 6.8182 | 7 | yes |
GO:0060998 | regulation of dendritic spine development | 6.8182 | 4 | yes |
GO:1903421 | regulation of synaptic vesicle recycling | 6.8182 | 5 | yes |
GO:0046847 | filopodium assembly | 4.5455 | 7 | yes |
GO:0061000 | negative regulation of dendritic spine development | 4.5455 | 5 | yes |
GO:0061001 | regulation of dendritic spine morphogenesis | 4.5455 | 5 | yes |
GO:0061002 | negative regulation of dendritic spine morphogenesis | 4.5455 | 6 | yes |
GO:0098884 | postsynaptic neurotransmitter receptor internalization | 4.5455 | 4 | yes |
GO:0140239 | postsynaptic endocytosis | 4.5455 | 4 | yes |
GO:1903423 | positive regulation of synaptic vesicle recycling | 4.5455 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
FNBP1_HUMAN | [view interactions] | Low throughput | no | yes |
PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FER_HUMAN | [view interactions] | Low throughput | no | yes |
HOME1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
DNMBP_HUMAN | [view interactions] | High throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSF2_HUMAN | [view interactions] | High throughput | no | no |
NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC1_HUMAN | [view interactions] | High throughput | no | yes |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
SACA1_HUMAN | [view interactions] | High throughput | no | no |
DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HAUS8_HUMAN | [view interactions] | High throughput | no | yes |
HERC1_HUMAN | [view interactions] | High throughput | no | no |
P73_HUMAN | [view interactions] | High throughput | no | no |
RAPH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYPD3_HUMAN | [view interactions] | High throughput | no | no |
SCN2B_HUMAN | [view interactions] | High throughput | no | no |
TSP3_HUMAN | [view interactions] | High throughput | no | yes |
LYPD6_HUMAN | [view interactions] | High throughput | no | no |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
ZBBX_HUMAN | [view interactions] | High throughput | no | no |
GLPB_HUMAN | [view interactions] | High throughput | no | no |
IL1R2_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
GTR12_HUMAN | [view interactions] | High throughput | no | yes |
GLPA_HUMAN | [view interactions] | High throughput | no | no |
THB_HUMAN | [view interactions] | High throughput | no | no |
CDKAL_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
S10A6_HUMAN | [view interactions] | High throughput | no | yes |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AMGO1_HUMAN | [view interactions] | High throughput | no | yes |
FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
CML1_HUMAN | [view interactions] | High throughput | no | yes |
EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
NKG2A_HUMAN | [view interactions] | High throughput | no | no |
FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGM1_HUMAN | [view interactions] | High throughput | no | no |
HCST_HUMAN | [view interactions] | High throughput | no | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
TYOBP_HUMAN | [view interactions] | High throughput | no | no |
SNX33_HUMAN | [view interactions] | High throughput | no | yes |
EFNA4_HUMAN | [view interactions] | High throughput | no | no |
S39A7_HUMAN | [view interactions] | High throughput | no | yes |
MND1_HUMAN | [view interactions] | High throughput | no | no |
T22D2_HUMAN | [view interactions] | High throughput | no | yes |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
RT18C_HUMAN | [view interactions] | High throughput | no | yes |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
TBC15_HUMAN | [view interactions] | High throughput | no | yes |
PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GLGB_HUMAN | [view interactions] | High throughput | no | yes |
RPE_HUMAN | [view interactions] | High throughput | no | yes |
AASD1_HUMAN | [view interactions] | High throughput | no | yes |
UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
BABA2_HUMAN | [view interactions] | High throughput | no | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
KRT36_HUMAN | [view interactions] | High throughput | no | no |
GAB1_HUMAN | [view interactions] | High throughput | no | yes |
NGF_HUMAN | [view interactions] | Computational | no | no |
ITSN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
L1CAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GAK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LY96_HUMAN | [view interactions] | Computational | no | no |
NTRK1_HUMAN | [view interactions] | Computational | no | yes |
ITSN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TLR4_HUMAN | [view interactions] | Computational | no | yes |
CD14_HUMAN | [view interactions] | Computational | no | no |
HCLS1_HUMAN | [view interactions] | Computational | no | no |
CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |