DYN3_HUMAN
Evidence for PS localization
Functions
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis . [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
Isoforms
Interacting regions
Canonical [DYN3_HUMAN]
Isoform [H0YBC6] alignment
Isoform [Q9UQ16-4] alignment
Isoform [Q9UQ16-5] alignment
Isoform [Q9UQ16-2] alignment
Isoform [Q9UQ16-3] alignment
Isoform [A0A8I5KXV5] alignment
Isoform [E5RIK2] alignment
Isoform [E5RHK8] alignment
LOADING 95%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DYN3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 23.8095 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | yes |
GO:0043168 | anion binding | 23.8095 | 4 | yes |
GO:0000166 | nucleotide binding | 23.8095 | 4 | yes |
GO:0015631 | tubulin binding | 21.4286 | 4 | yes |
GO:0019900 | kinase binding | 21.4286 | 4 | yes |
GO:0042803 | protein homodimerization activity | 21.4286 | 4 | no |
GO:0019901 | protein kinase binding | 19.0476 | 5 | yes |
GO:0001664 | G protein-coupled receptor binding | 16.6667 | 4 | yes |
GO:0016462 | pyrophosphatase activity | 16.6667 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.6667 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.6667 | 6 | yes |
GO:0008017 | microtubule binding | 14.2857 | 5 | yes |
GO:0003924 | GTPase activity | 11.9048 | 7 | yes |
GO:0005525 | GTP binding | 11.9048 | 5 | yes |
GO:0019001 | guanyl nucleotide binding | 11.9048 | 6 | yes |
GO:0032561 | guanyl ribonucleotide binding | 11.9048 | 5 | yes |
GO:0031802 | type 5 metabotropic glutamate receptor binding | 9.5238 | 6 | yes |
GO:0035254 | glutamate receptor binding | 9.5238 | 4 | yes |
GO:0035256 | G protein-coupled glutamate receptor binding | 9.5238 | 5 | yes |
GO:0031798 | type 1 metabotropic glutamate receptor binding | 4.7619 | 6 | yes |
GO:0050998 | nitric-oxide synthase binding | 4.7619 | 4 | yes |
GO:0120283 | protein serine/threonine kinase binding | 4.7619 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DYN3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 47.6190 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 47.6190 | 4 | no |
GO:0048523 | negative regulation of cellular process | 45.2381 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 45.2381 | 4 | no |
GO:0051049 | regulation of transport | 42.8571 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 40.4762 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 40.4762 | 4 | no |
GO:0010646 | regulation of cell communication | 40.4762 | 4 | no |
GO:0022607 | cellular component assembly | 38.0952 | 4 | yes |
GO:0030030 | cell projection organization | 38.0952 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | no |
GO:0008104 | protein localization | 35.7143 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
GO:0009966 | regulation of signal transduction | 35.7143 | 4 | no |
GO:0010468 | regulation of gene expression | 35.7143 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.7143 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 35.7143 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0031344 | regulation of cell projection organization | 30.9524 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 30.9524 | 4 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.9524 | 6 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AASD1_HUMAN | [view interactions] | High throughput | no | yes |
ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALMS1_HUMAN | [view interactions] | High throughput | no | no |
AMGO1_HUMAN | [view interactions] | High throughput | no | yes |
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BABA2_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
CDKAL_HUMAN | [view interactions] | High throughput | no | no |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CML1_HUMAN | [view interactions] | High throughput | no | yes |
CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DNMBP_HUMAN | [view interactions] | High throughput | no | no |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
EFNA4_HUMAN | [view interactions] | High throughput | no | no |
EFNB1_HUMAN | [view interactions] | High throughput | no | yes |