CYFP1_HUMAN
Evidence for PS localization
Functions
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA . Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . May act as an invasion suppressor in cancers. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CYFP1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.4198 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.8025 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.1852 | 4 | no |
| GO:0019900 | kinase binding | 26.5432 | 4 | no |
| GO:0019901 | protein kinase binding | 24.6914 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.8395 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 21.6049 | 5 | no |
| GO:0003779 | actin binding | 20.9877 | 4 | yes |
| GO:0003723 | RNA binding | 15.4321 | 4 | yes |
| GO:0051020 | GTPase binding | 6.1728 | 4 | yes |
| GO:0031267 | small GTPase binding | 4.9383 | 5 | yes |
| GO:0000339 | RNA cap binding | 1.2346 | 5 | yes |
| GO:0000340 | RNA 7-methylguanosine cap binding | 1.2346 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CYFP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.8148 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.6420 | 4 | yes |
| GO:0010646 | regulation of cell communication | 48.1481 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 47.5309 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.2963 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.8272 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.8272 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.9753 | 4 | yes |
| GO:0006996 | organelle organization | 41.9753 | 4 | no |
| GO:0022607 | cellular component assembly | 40.7407 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.6543 | 4 | no |
| GO:0033043 | regulation of organelle organization | 36.4198 | 5 | yes |
| GO:0051049 | regulation of transport | 36.4198 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.4198 | 4 | yes |
| GO:0030030 | cell projection organization | 35.8025 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 33.9506 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 33.9506 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9506 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.7160 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.4815 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.8642 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.2469 | 6 | yes |
| GO:0010468 | regulation of gene expression | 29.6296 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 29.6296 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 29.6296 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.0123 | 6 | yes |
| GO:0016192 | vesicle-mediated transport | 27.7778 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 25.9259 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.9259 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 25.3086 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.3086 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 25.3086 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.3086 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 25.3086 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 24.6914 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 24.6914 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 24.6914 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 24.6914 | 4 | yes |
| GO:0010941 | regulation of cell death | 24.6914 | 4 | no |
| GO:0071702 | organic substance transport | 24.6914 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.0741 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.0741 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 24.0741 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 24.0741 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 24.0741 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0741 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0741 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.4568 | 5 | no |
| GO:0036211 | protein modification process | 23.4568 | 4 | no |
| GO:0043412 | macromolecule modification | 23.4568 | 4 | no |
| GO:0071310 | cellular response to organic substance | 22.8395 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 22.8395 | 4 | no |
| GO:0110053 | regulation of actin filament organization | 22.2222 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 22.2222 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.6049 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 21.6049 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.6049 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 20.9877 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 20.9877 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.3704 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.3704 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.3704 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.3704 | 4 | no |
| GO:0034330 | cell junction organization | 19.7531 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 19.1358 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 18.5185 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 18.5185 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 18.5185 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 17.9012 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 17.9012 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 16.6667 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 16.6667 | 5 | yes |
| GO:0060284 | regulation of cell development | 16.6667 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.6667 | 4 | yes |
| GO:0031175 | neuron projection development | 16.0494 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 16.0494 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 16.0494 | 7 | yes |
| GO:0060491 | regulation of cell projection assembly | 14.8148 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 14.8148 | 6 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 14.8148 | 6 | yes |
| GO:0030031 | cell projection assembly | 14.1975 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 14.1975 | 6 | yes |
| GO:0050808 | synapse organization | 14.1975 | 5 | yes |
| GO:1901699 | cellular response to nitrogen compound | 14.1975 | 4 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 13.5802 | 4 | yes |
| GO:0010720 | positive regulation of cell development | 12.9630 | 6 | yes |
| GO:0022604 | regulation of cell morphogenesis | 12.9630 | 5 | yes |
| GO:0030832 | regulation of actin filament length | 12.9630 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 12.9630 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 12.9630 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 12.9630 | 6 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 12.3457 | 4 | yes |
| GO:0030833 | regulation of actin filament polymerization | 11.7284 | 7 | yes |
| GO:0050767 | regulation of neurogenesis | 11.7284 | 6 | yes |
| GO:0050890 | cognition | 11.1111 | 4 | yes |
| GO:0007265 | Ras protein signal transduction | 11.1111 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 10.4938 | 6 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 10.4938 | 6 | yes |
| GO:0051051 | negative regulation of transport | 9.8765 | 4 | yes |
| GO:0050769 | positive regulation of neurogenesis | 9.2593 | 6 | yes |
| GO:0051962 | positive regulation of nervous system development | 9.2593 | 5 | yes |
| GO:0034248 | regulation of cellular amide metabolic process | 8.6420 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 8.6420 | 4 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 8.6420 | 6 | yes |
| GO:0001558 | regulation of cell growth | 8.0247 | 4 | yes |
| GO:1901652 | response to peptide | 7.4074 | 4 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 6.7901 | 7 | yes |
| GO:0010592 | positive regulation of lamellipodium assembly | 6.7901 | 7 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 6.7901 | 6 | yes |
| GO:0010976 | positive regulation of neuron projection development | 6.7901 | 7 | yes |
| GO:0048638 | regulation of developmental growth | 6.7901 | 4 | yes |
| GO:1902743 | regulation of lamellipodium organization | 6.7901 | 7 | yes |
| GO:1902745 | positive regulation of lamellipodium organization | 6.7901 | 7 | yes |
| GO:0006417 | regulation of translation | 6.7901 | 6 | yes |
| GO:0008360 | regulation of cell shape | 6.7901 | 6 | yes |
| GO:0032870 | cellular response to hormone stimulus | 6.1728 | 4 | yes |
| GO:0050770 | regulation of axonogenesis | 6.1728 | 5 | yes |
| GO:0045927 | positive regulation of growth | 5.5556 | 4 | yes |
| GO:0097485 | neuron projection guidance | 5.5556 | 7 | yes |
| GO:0099563 | modification of synaptic structure | 5.5556 | 6 | yes |
| GO:1901653 | cellular response to peptide | 5.5556 | 5 | yes |
| GO:0016601 | Rac protein signal transduction | 4.9383 | 6 | yes |
| GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation | 4.9383 | 8 | yes |
| GO:0043434 | response to peptide hormone | 4.9383 | 4 | yes |
| GO:0051125 | regulation of actin nucleation | 4.9383 | 7 | yes |
| GO:0061387 | regulation of extent of cell growth | 4.9383 | 5 | yes |
| GO:0007411 | axon guidance | 4.9383 | 8 | yes |
| GO:0030516 | regulation of axon extension | 4.3210 | 5 | yes |
| GO:0032868 | response to insulin | 4.3210 | 5 | yes |
| GO:0051127 | positive regulation of actin nucleation | 4.3210 | 7 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 4.3210 | 4 | yes |
| GO:0097581 | lamellipodium organization | 4.3210 | 6 | yes |
| GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 4.3210 | 8 | yes |
| GO:0030307 | positive regulation of cell growth | 3.7037 | 5 | yes |
| GO:0048639 | positive regulation of developmental growth | 3.7037 | 5 | yes |
| GO:1905244 | regulation of modification of synaptic structure | 3.7037 | 6 | yes |
| GO:0030032 | lamellipodium assembly | 3.0864 | 7 | yes |
| GO:0032869 | cellular response to insulin stimulus | 3.0864 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 3.0864 | 6 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 3.0864 | 5 | yes |
| GO:0099159 | regulation of modification of postsynaptic structure | 3.0864 | 7 | yes |
| GO:1900027 | regulation of ruffle assembly | 3.0864 | 7 | yes |
| GO:1990138 | neuron projection extension | 3.0864 | 4 | yes |
| GO:0031529 | ruffle organization | 2.4691 | 6 | yes |
| GO:0031641 | regulation of myelination | 2.4691 | 4 | yes |
| GO:0045773 | positive regulation of axon extension | 1.8519 | 6 | yes |
| GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway | 1.8519 | 5 | yes |
| GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway | 1.8519 | 6 | yes |
| GO:0097484 | dendrite extension | 1.8519 | 5 | yes |
| GO:1900029 | positive regulation of ruffle assembly | 1.8519 | 7 | yes |
| GO:1903421 | regulation of synaptic vesicle recycling | 1.8519 | 5 | yes |
| GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton | 1.8519 | 8 | yes |
| GO:0048675 | axon extension | 1.2346 | 5 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 1.2346 | 6 | yes |
| GO:0099547 | regulation of translation at synapse, modulating synaptic transmission | 1.2346 | 6 | yes |
| GO:0099578 | regulation of translation at postsynapse, modulating synaptic transmission | 1.2346 | 7 | yes |
| GO:0140243 | regulation of translation at synapse | 1.2346 | 7 | yes |
| GO:0140245 | regulation of translation at postsynapse | 1.2346 | 8 | yes |
| GO:1900006 | positive regulation of dendrite development | 1.2346 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CYFP1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.0864 | 3 | no |
| DOID:114 | heart disease | 1.8519 | 3 | no |
| DOID:574 | peripheral nervous system disease | 1.8519 | 3 | no |
| DOID:870 | neuropathy | 1.8519 | 4 | no |
| DOID:936 | brain disease | 1.8519 | 4 | no |
| DOID:0050700 | cardiomyopathy | 1.2346 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.2346 | 5 | no |
| DOID:2843 | long QT syndrome | 1.2346 | 6 | no |
| DOID:1891 | optic nerve disease | 1.2346 | 6 | no |
| DOID:5656 | cranial nerve disease | 1.2346 | 5 | no |
| DOID:5723 | optic atrophy | 1.2346 | 7 | no |
| DOID:0050686 | organ system cancer | 1.2346 | 3 | no |
| DOID:0050701 | electroclinical syndrome | 1.2346 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 1.2346 | 7 | no |
| DOID:1826 | epilepsy | 1.2346 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IF6_HUMAN | [view interactions] | Low throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | Low throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NYAP1_HUMAN | [view interactions] | Low throughput | no | no |
| MYO16_HUMAN | [view interactions] | Low throughput | no | no |
| WASF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IF4E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRK1_HUMAN | [view interactions] | Low throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WASF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NYAP2_HUMAN | [view interactions] | Low throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD23_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ZN511_HUMAN | [view interactions] | High throughput | no | yes |
| UBX11_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| PTN7_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RHG12_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| INSI2_HUMAN | [view interactions] | High throughput | no | yes |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| K1522_HUMAN | [view interactions] | High throughput | no | yes |
| ES8L1_HUMAN | [view interactions] | High throughput | no | no |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1G3_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5MP1_HUMAN | [view interactions] | High throughput | no | no |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| NCKPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AB1IP_HUMAN | [view interactions] | High throughput | no | no |
| KIF19_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| NHSL2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CGB2_HUMAN | [view interactions] | High throughput | no | no |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| GAS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| PCD10_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| TRPC4_HUMAN | [view interactions] | High throughput | no | no |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| NPS3B_HUMAN | [view interactions] | High throughput | no | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPGF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| PROX1_HUMAN | [view interactions] | High throughput | no | no |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| YLPM1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TM240_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S4A8_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDE4A_HUMAN | [view interactions] | High throughput | no | no |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RX7_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMBL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCDN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC24_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| ERC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1S1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCTR_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| RFX6_HUMAN | [view interactions] | High throughput | no | no |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FHR3_HUMAN | [view interactions] | Computational | no | no |
| NIPA1_HUMAN | [view interactions] | Computational | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASP_HUMAN | [view interactions] | Computational | no | yes |
| NIPA2_HUMAN | [view interactions] | Computational | no | no |
| I4E1B_HUMAN | [view interactions] | Computational | no | no |
| ARPC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GCP5_HUMAN | [view interactions] | Computational | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FHR1_HUMAN | [view interactions] | Computational | no | no |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IF4E2_HUMAN | [view interactions] | Computational | no | no |