Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM3_HUMAN
GO:0043169 cation binding 29.4118 4 no
GO:0046872 metal ion binding 29.4118 5 no
GO:0051020 GTPase binding 23.5294 4 no
GO:0001664 G protein-coupled receptor binding 23.5294 4 no
GO:0035254 glutamate receptor binding 23.5294 4 no
GO:0043168 anion binding 23.5294 4 no
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 17.6471 6 yes
GO:0001641 group II metabotropic glutamate receptor activity 17.6471 7 yes
GO:0004930 G protein-coupled receptor activity 17.6471 4 yes
GO:0005246 calcium channel regulator activity 17.6471 5 yes
GO:0008066 glutamate receptor activity 17.6471 4 yes
GO:0098988 G protein-coupled glutamate receptor activity 17.6471 5 yes
GO:0099106 ion channel regulator activity 17.6471 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM3_HUMAN
GO:0010646 regulation of cell communication 70.5882 4 yes
GO:0048522 positive regulation of cellular process 58.8235 4 no
GO:0050804 modulation of chemical synaptic transmission 52.9412 5 yes
GO:0099177 regulation of trans-synaptic signaling 52.9412 4 yes
GO:0051049 regulation of transport 52.9412 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0048523 negative regulation of cellular process 47.0588 4 no
GO:0051128 regulation of cellular component organization 47.0588 4 no
GO:0006996 organelle organization 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0080090 regulation of primary metabolic process 35.2941 4 no
GO:0009967 positive regulation of signal transduction 35.2941 5 no
GO:0010647 positive regulation of cell communication 35.2941 5 no
GO:0023056 positive regulation of signaling 35.2941 4 no
GO:0048584 positive regulation of response to stimulus 35.2941 4 no
GO:0008104 protein localization 35.2941 4 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0033043 regulation of organelle organization 35.2941 5 no
GO:0051130 positive regulation of cellular component organization 35.2941 5 no
GO:0007268 chemical synaptic transmission 29.4118 7 yes
GO:0098916 anterograde trans-synaptic signaling 29.4118 6 yes
GO:0099536 synaptic signaling 29.4118 4 yes
GO:0099537 trans-synaptic signaling 29.4118 5 yes
GO:0022607 cellular component assembly 29.4118 4 no
GO:0010243 response to organonitrogen compound 29.4118 4 no
GO:0030030 cell projection organization 29.4118 4 no
GO:0051094 positive regulation of developmental process 29.4118 4 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 no
GO:0072657 protein localization to membrane 29.4118 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 no
GO:0071310 cellular response to organic substance 29.4118 4 no
GO:0043086 negative regulation of catalytic activity 23.5294 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 23.5294 6 yes
GO:0009893 positive regulation of metabolic process 23.5294 4 no
GO:0051246 regulation of protein metabolic process 23.5294 5 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0014070 response to organic cyclic compound 23.5294 4 no
GO:0051046 regulation of secretion 23.5294 5 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:1903530 regulation of secretion by cell 23.5294 4 no
GO:0009889 regulation of biosynthetic process 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0051050 positive regulation of transport 23.5294 4 no
GO:0051051 negative regulation of transport 23.5294 4 no
GO:0141124 intracellular signaling cassette 23.5294 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.5294 4 no
GO:0031344 regulation of cell projection organization 23.5294 5 no
GO:0051493 regulation of cytoskeleton organization 23.5294 6 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:0007194 negative regulation of adenylate cyclase activity 17.6471 6 yes
GO:0007215 glutamate receptor signaling pathway 17.6471 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 17.6471 4 yes
GO:0009059 macromolecule biosynthetic process 17.6471 4 yes
GO:0010467 gene expression 17.6471 5 yes
GO:0031279 regulation of cyclase activity 17.6471 4 yes
GO:0031280 negative regulation of cyclase activity 17.6471 5 yes
GO:0045761 regulation of adenylate cyclase activity 17.6471 5 yes
GO:0051339 regulation of lyase activity 17.6471 4 yes
GO:0051350 negative regulation of lyase activity 17.6471 5 yes
GO:0099170 postsynaptic modulation of chemical synaptic transmission 17.6471 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRM3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1A_HUMAN [view interactions] Low throughput no yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF2_HUMAN [view interactions] Low throughput no no
NHRF1_HUMAN [view interactions] Low throughput no no
GRM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
FBXW7_HUMAN [view interactions] High throughput no yes
GRM4_HUMAN [view interactions] High throughput no no