Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRM3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRM3_HUMAN
GO:0046872 metal ion binding 47.6190 4 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0017076 purine nucleotide binding 28.5714 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0008066 glutamate receptor activity 23.8095 4 yes
GO:0004930 G protein-coupled receptor activity 19.0476 4 yes
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity 14.2857 6 yes
GO:0001641 group II metabotropic glutamate receptor activity 14.2857 7 yes
GO:0005246 calcium channel regulator activity 14.2857 4 yes
GO:0098988 G protein-coupled glutamate receptor activity 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRM3_HUMAN
GO:0010646 regulation of cell communication 80.9524 4 yes
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0050804 modulation of chemical synaptic transmission 61.9048 5 yes
GO:0099177 regulation of trans-synaptic signaling 61.9048 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.3810 4 no
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 no
GO:0080090 regulation of primary metabolic process 52.3810 4 no
GO:0051049 regulation of transport 52.3810 4 no
GO:0009966 regulation of signal transduction 52.3810 4 no
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0048523 negative regulation of cellular process 47.6190 4 no
GO:0051246 regulation of protein metabolic process 47.6190 5 no
GO:0008104 protein localization 47.6190 4 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0007268 chemical synaptic transmission 38.0952 6 yes
GO:0098916 anterograde trans-synaptic signaling 38.0952 5 yes
GO:0099537 trans-synaptic signaling 38.0952 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.0952 5 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0043085 positive regulation of catalytic activity 38.0952 4 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.0952 5 no
GO:0051247 positive regulation of protein metabolic process 38.0952 6 no
GO:0050890 cognition 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0072657 protein localization to membrane 33.3333 4 no
GO:0051046 regulation of secretion 33.3333 5 no
GO:1903530 regulation of secretion by cell 33.3333 4 no
GO:0043086 negative regulation of catalytic activity 28.5714 4 yes
GO:0010941 regulation of cell death 28.5714 4 no
GO:0060627 regulation of vesicle-mediated transport 28.5714 4 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0043269 regulation of ion transport 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051050 positive regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0007194 negative regulation of adenylate cyclase activity 23.8095 6 yes
GO:0007215 glutamate receptor signaling pathway 23.8095 4 yes
GO:0031279 regulation of cyclase activity 23.8095 4 yes
GO:0031280 negative regulation of cyclase activity 23.8095 5 yes
GO:0045761 regulation of adenylate cyclase activity 23.8095 5 yes
GO:0051339 regulation of lyase activity 23.8095 4 yes
GO:0051350 negative regulation of lyase activity 23.8095 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 23.8095 6 yes
GO:0006811 ion transport 23.8095 4 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0043933 protein-containing complex organization 23.8095 4 no
GO:0050806 positive regulation of synaptic transmission 23.8095 5 no
GO:0051129 negative regulation of cellular component organization 23.8095 5 no
GO:0051336 regulation of hydrolase activity 23.8095 4 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0032880 regulation of protein localization 23.8095 5 no
GO:0060341 regulation of cellular localization 23.8095 4 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0042981 regulation of apoptotic process 23.8095 6 no
GO:0043067 regulation of programmed cell death 23.8095 5 no
GO:0033043 regulation of organelle organization 23.8095 5 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0051051 negative regulation of transport 23.8095 4 no
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0001934 positive regulation of protein phosphorylation 23.8095 8 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0071702 organic substance transport 23.8095 4 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 14.2857 4 yes
GO:0010467 gene expression 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRM3_HUMAN [view entry] [view interactions] Low throughput yes no
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1A_HUMAN [view interactions] Low throughput no yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
GRASP_HUMAN [view entry] [view interactions] Low throughput yes yes
NHRF2_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF1_HUMAN [view interactions] Low throughput no no
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SMC1A_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
GRM4_HUMAN [view interactions] High throughput no no
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
5HT2A_HUMAN [view entry] [view interactions] Computational yes yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
GRM2_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
KAPCG_HUMAN [view interactions] Computational no no
ESR2_HUMAN [view interactions] Computational no no
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes