GRM2_HUMAN
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GRM2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 34.4828 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 34.4828 | 4 | no |
GO:0046872 | metal ion binding | 34.4828 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 31.0345 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 20.6897 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.6897 | 5 | no |
GO:0001664 | G protein-coupled receptor binding | 20.6897 | 4 | no |
GO:0003924 | GTPase activity | 20.6897 | 7 | no |
GO:0016462 | pyrophosphatase activity | 20.6897 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.6897 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.6897 | 6 | no |
GO:0004930 | G protein-coupled receptor activity | 13.7931 | 4 | yes |
GO:0008066 | glutamate receptor activity | 13.7931 | 4 | yes |
GO:0001640 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | 10.3448 | 6 | yes |
GO:0001641 | group II metabotropic glutamate receptor activity | 10.3448 | 7 | yes |
GO:0005246 | calcium channel regulator activity | 10.3448 | 4 | yes |
GO:0098988 | G protein-coupled glutamate receptor activity | 10.3448 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GRM2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 62.0690 | 4 | no |
GO:0010646 | regulation of cell communication | 55.1724 | 4 | yes |
GO:0051049 | regulation of transport | 48.2759 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 48.2759 | 4 | no |
GO:0009966 | regulation of signal transduction | 44.8276 | 4 | yes |
GO:0008104 | protein localization | 37.9310 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 34.4828 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 34.4828 | 4 | no |
GO:0032880 | regulation of protein localization | 34.4828 | 5 | no |
GO:0051128 | regulation of cellular component organization | 34.4828 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 34.4828 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 34.4828 | 4 | no |
GO:0060341 | regulation of cellular localization | 34.4828 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 34.4828 | 4 | no |
GO:0006996 | organelle organization | 34.4828 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 31.0345 | 5 | yes |
GO:0071702 | organic substance transport | 31.0345 | 4 | yes |
GO:0071705 | nitrogen compound transport | 31.0345 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 31.0345 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 31.0345 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 31.0345 | 5 | no |
GO:0051050 | positive regulation of transport | 31.0345 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 31.0345 | 5 | no |
GO:0051046 | regulation of secretion | 27.5862 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 27.5862 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.5862 | 5 | no |
GO:0031399 | regulation of protein modification process | 27.5862 | 6 | no |
GO:0033043 | regulation of organelle organization | 27.5862 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.5862 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 27.5862 | 6 | no |
GO:0010648 | negative regulation of cell communication | 27.5862 | 5 | no |
GO:0023057 | negative regulation of signaling | 27.5862 | 4 | no |
GO:0043086 | negative regulation of catalytic activity | 24.1379 | 4 | yes |
GO:0043269 | regulation of ion transport | 24.1379 | 5 | yes |
GO:0010941 | regulation of cell death | 24.1379 | 4 | no |
GO:0015031 | protein transport | 24.1379 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.1379 | 6 | no |
GO:0030334 | regulation of cell migration | 24.1379 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 24.1379 | 7 | no |
GO:0042127 | regulation of cell population proliferation | 24.1379 | 4 | no |
GO:0042981 | regulation of apoptotic process | 24.1379 | 6 | no |
GO:0043067 | regulation of programmed cell death | 24.1379 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 24.1379 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.1379 | 5 | no |
GO:0051223 | regulation of protein transport | 24.1379 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 24.1379 | 4 | no |
GO:0070201 | regulation of establishment of protein localization | 24.1379 | 6 | no |
GO:2000145 | regulation of cell motility | 24.1379 | 4 | no |
GO:0007268 | chemical synaptic transmission | 20.6897 | 6 | yes |
GO:0010243 | response to organonitrogen compound | 20.6897 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 20.6897 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 20.6897 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 20.6897 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 20.6897 | 8 | no |
GO:0006796 | phosphate-containing compound metabolic process | 20.6897 | 4 | no |
GO:0006886 | intracellular protein transport | 20.6897 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 20.6897 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 20.6897 | 6 | no |
GO:0036211 | protein modification process | 20.6897 | 4 | no |
GO:0042325 | regulation of phosphorylation | 20.6897 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 20.6897 | 8 | no |
GO:0043066 | negative regulation of apoptotic process | 20.6897 | 7 | no |
GO:0043069 | negative regulation of programmed cell death | 20.6897 | 6 | no |
GO:0043412 | macromolecule modification | 20.6897 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 20.6897 | 7 | no |
GO:0060548 | negative regulation of cell death | 20.6897 | 5 | no |
GO:0061024 | membrane organization | 20.6897 | 4 | no |
GO:0072657 | protein localization to membrane | 20.6897 | 4 | no |
GO:1903829 | positive regulation of protein localization | 20.6897 | 5 | no |
GO:0016192 | vesicle-mediated transport | 20.6897 | 4 | no |
GO:0007194 | negative regulation of adenylate cyclase activity | 17.2414 | 6 | yes |
GO:0014070 | response to organic cyclic compound | 17.2414 | 4 | yes |
GO:0031279 | regulation of cyclase activity | 17.2414 | 4 | yes |
GO:0031280 | negative regulation of cyclase activity | 17.2414 | 5 | yes |
GO:0045761 | regulation of adenylate cyclase activity | 17.2414 | 5 | yes |
GO:0051339 | regulation of lyase activity | 17.2414 | 4 | yes |
GO:0051350 | negative regulation of lyase activity | 17.2414 | 5 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 17.2414 | 6 | yes |
GO:0006811 | ion transport | 13.7931 | 4 | yes |
GO:0046903 | secretion | 13.7931 | 4 | yes |
GO:0007215 | glutamate receptor signaling pathway | 10.3448 | 4 | yes |
GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 10.3448 | 4 | yes |
GO:0010467 | gene expression | 10.3448 | 4 | yes |
GO:0014059 | regulation of dopamine secretion | 10.3448 | 6 | yes |
GO:0032890 | regulation of organic acid transport | 10.3448 | 5 | yes |
GO:0048878 | chemical homeostasis | 10.3448 | 4 | yes |
GO:0050433 | regulation of catecholamine secretion | 10.3448 | 5 | yes |
GO:0050801 | ion homeostasis | 10.3448 | 5 | yes |
GO:0051952 | regulation of amine transport | 10.3448 | 5 | yes |
GO:0006820 | anion transport | 6.8966 | 5 | yes |
GO:0006835 | dicarboxylic acid transport | 6.8966 | 7 | yes |
GO:0006865 | amino acid transport | 6.8966 | 5 | yes |
GO:0014047 | glutamate secretion | 6.8966 | 4 | yes |
GO:0014048 | regulation of glutamate secretion | 6.8966 | 5 | yes |
GO:0015711 | organic anion transport | 6.8966 | 5 | yes |
GO:0015800 | acidic amino acid transport | 6.8966 | 6 | yes |
GO:0015849 | organic acid transport | 6.8966 | 5 | yes |
GO:0035095 | behavioral response to nicotine | 6.8966 | 4 | yes |
GO:0042220 | response to cocaine | 6.8966 | 4 | yes |
GO:0043279 | response to alkaloid | 6.8966 | 5 | yes |
GO:0044070 | regulation of anion transport | 6.8966 | 6 | yes |
GO:0046942 | carboxylic acid transport | 6.8966 | 6 | yes |
GO:0051896 | regulation of protein kinase B signaling | 6.8966 | 6 | yes |
GO:0051955 | regulation of amino acid transport | 6.8966 | 6 | yes |
GO:0055081 | anion homeostasis | 6.8966 | 6 | yes |
GO:0080144 | amino acid homeostasis | 6.8966 | 5 | yes |
GO:0090461 | glutamate homeostasis | 6.8966 | 6 | yes |
GO:2001023 | regulation of response to drug | 6.8966 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RANB9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACE2_HUMAN | [view interactions] | Low throughput | no | no |
DPP4_HUMAN | [view interactions] | Low throughput | no | no |
GRM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NHRF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
NADL2_HUMAN | [view interactions] | High throughput | no | yes |
BIK_HUMAN | [view interactions] | High throughput | no | yes |
S38A1_HUMAN | [view interactions] | High throughput | no | yes |
CLD2_HUMAN | [view interactions] | High throughput | no | no |
PDZ1I_HUMAN | [view interactions] | High throughput | no | no |
CC107_HUMAN | [view interactions] | High throughput | no | no |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
CLD9_HUMAN | [view interactions] | High throughput | no | no |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNT8_HUMAN | [view interactions] | High throughput | no | no |
CPLX4_HUMAN | [view interactions] | High throughput | no | no |
SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM130_HUMAN | [view interactions] | High throughput | no | no |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM248_HUMAN | [view interactions] | High throughput | no | yes |
MF14B_HUMAN | [view interactions] | High throughput | no | no |
AQP6_HUMAN | [view interactions] | High throughput | no | no |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TM237_HUMAN | [view interactions] | High throughput | no | no |
TSN18_HUMAN | [view interactions] | High throughput | no | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PK3CD_HUMAN | [view interactions] | High throughput | no | no |
SYLM_HUMAN | [view interactions] | High throughput | no | yes |
PI2R_HUMAN | [view interactions] | High throughput | no | no |
SSR5_HUMAN | [view interactions] | High throughput | no | no |
PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AMHR2_HUMAN | [view interactions] | High throughput | no | no |
ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRM3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ESR2_HUMAN | [view interactions] | Computational | no | no |
RAI3_HUMAN | [view interactions] | Computational | no | yes |
ESR1_HUMAN | [view interactions] | Computational | no | no |
GPC5C_HUMAN | [view interactions] | Computational | no | no |
GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |