Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KIF2A_HUMAN

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
317 Ser Asn Corticaldysplasia,complex,withotherbrainmalformations3(CDCBM3) -
321 His Asp Corticaldysplasia,complex,withotherbrainmalformations3(CDCBM3) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KIF2A_HUMAN
GO:0003723 RNA binding 32.0513 4 no
GO:0000166 nucleotide binding 23.0769 4 yes
GO:0017076 purine nucleotide binding 23.0769 5 yes
GO:0043168 anion binding 23.0769 4 yes
GO:0043169 cation binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0032555 purine ribonucleotide binding 21.7949 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 20.5128 4 yes
GO:0030554 adenyl nucleotide binding 19.2308 6 yes
GO:0015631 tubulin binding 17.9487 4 yes
GO:0032559 adenyl ribonucleotide binding 17.9487 5 yes
GO:0005524 ATP binding 16.6667 5 yes
GO:0008017 microtubule binding 15.3846 5 yes
GO:0016462 pyrophosphatase activity 7.6923 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.6923 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 7.6923 6 yes
GO:0016887 ATP hydrolysis activity 5.1282 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KIF2A_HUMAN
GO:0048522 positive regulation of cellular process 48.7179 4 no
GO:0048523 negative regulation of cellular process 48.7179 4 no
GO:0006996 organelle organization 43.5897 4 yes
GO:0051128 regulation of cellular component organization 42.3077 4 no
GO:0060255 regulation of macromolecule metabolic process 42.3077 4 no
GO:0010646 regulation of cell communication 42.3077 4 no
GO:0031323 regulation of cellular metabolic process 41.0256 4 no
GO:0022607 cellular component assembly 41.0256 4 yes
GO:0080090 regulation of primary metabolic process 38.4615 4 no
GO:0008104 protein localization 34.6154 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0009966 regulation of signal transduction 32.0513 4 no
GO:0051246 regulation of protein metabolic process 29.4872 5 no
GO:0044087 regulation of cellular component biogenesis 29.4872 4 no
GO:0009892 negative regulation of metabolic process 26.9231 4 no
GO:0009893 positive regulation of metabolic process 26.9231 4 no
GO:0010604 positive regulation of macromolecule metabolic process 26.9231 5 no
GO:0023056 positive regulation of signaling 25.6410 4 no
GO:0010647 positive regulation of cell communication 25.6410 5 no
GO:0010605 negative regulation of macromolecule metabolic process 24.3590 5 no
GO:0007010 cytoskeleton organization 24.3590 5 yes
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0048585 negative regulation of response to stimulus 21.7949 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.7949 5 no
GO:0051252 regulation of RNA metabolic process 21.7949 5 no
GO:0050804 modulation of chemical synaptic transmission 21.7949 5 no
GO:0099177 regulation of trans-synaptic signaling 21.7949 4 no
GO:0043933 protein-containing complex organization 21.7949 4 yes
GO:0009891 positive regulation of biosynthetic process 20.5128 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.5128 6 no
GO:0033043 regulation of organelle organization 20.5128 5 no
GO:0009967 positive regulation of signal transduction 20.5128 5 no
GO:0097435 supramolecular fiber organization 16.6667 4 yes
GO:0070925 organelle assembly 15.3846 5 yes
GO:0022411 cellular component disassembly 12.8205 4 yes
GO:0030334 regulation of cell migration 8.9744 5 yes
GO:0140694 non-membrane-bounded organelle assembly 8.9744 6 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 8.9744 4 yes
GO:2000145 regulation of cell motility 8.9744 4 yes
GO:0031109 microtubule polymerization or depolymerization 7.6923 4 yes
GO:0007399 nervous system development 6.4103 4 yes
GO:0032984 protein-containing complex disassembly 6.4103 5 yes
GO:0051225 spindle assembly 6.4103 4 yes
GO:0007052 mitotic spindle organization 5.1282 4 yes
GO:0051261 protein depolymerization 5.1282 6 yes
GO:0007019 microtubule depolymerization 3.8462 5 yes
GO:0090307 mitotic spindle assembly 3.8462 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P53_HUMAN [view interactions] Low throughput no no
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
TSNAX_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SNPH_HUMAN [view entry] [view interactions] Low throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SKA3_HUMAN [view interactions] High throughput no no
RS13_HUMAN [view entry] [view interactions] High throughput yes yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
APBA1_HUMAN [view interactions] High throughput no no
PNMA2_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CAN12_HUMAN [view interactions] High throughput no no
HNRC2_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
RL26L_HUMAN [view interactions] High throughput no yes
KGP1_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
BRDT_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CKAP2_HUMAN [view interactions] High throughput no yes
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP4_HUMAN [view entry] [view interactions] High throughput yes no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
RUVB2_HUMAN [view interactions] High throughput no yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
TRI11_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
AATF_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG24_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
DPTOR_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
CL16A_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
KAT6A_HUMAN [view interactions] High throughput no yes
RECQ1_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
H31T_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
BUD23_HUMAN [view interactions] High throughput no yes
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CLU_HUMAN [view interactions] High throughput no yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ERF3A_HUMAN [view interactions] High throughput no yes
PSB8_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
CEBPG_HUMAN [view interactions] High throughput no yes
GFRA1_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR44_HUMAN [view interactions] High throughput no yes
PI42C_HUMAN [view interactions] High throughput no yes
UBP7_HUMAN [view interactions] High throughput no yes
RM48_HUMAN [view interactions] High throughput no yes
TOPK_HUMAN [view interactions] High throughput no no
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
NRBP_HUMAN [view interactions] High throughput no yes
RBGP1_HUMAN [view interactions] High throughput no yes
PLK4_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
CAMP2_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
EMAL4_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
HMMR_HUMAN [view interactions] High throughput no yes
BTBD8_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
MA7D1_HUMAN [view entry] [view interactions] High throughput yes no
MA7D2_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
MAP9_HUMAN [view interactions] High throughput no no
MTUS1_HUMAN [view interactions] High throughput no no
PANX1_HUMAN [view interactions] High throughput no no
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
PRI2_HUMAN [view interactions] High throughput no no
TRI36_HUMAN [view interactions] High throughput no no
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
CSTP1_HUMAN [view interactions] High throughput no yes
CAMP1_HUMAN [view interactions] High throughput no yes
CAMP3_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
LUZP1_HUMAN [view interactions] High throughput no yes
MAP1A_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1S_HUMAN [view interactions] High throughput no no
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
SLAI2_HUMAN [view interactions] High throughput no no
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
NUP43_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
SKA1_HUMAN [view interactions] High throughput no yes
TTK_HUMAN [view interactions] High throughput no yes
ARHGH_HUMAN [view interactions] High throughput no yes
ORML2_HUMAN [view interactions] High throughput no no
KIF2C_HUMAN [view entry] [view interactions] High throughput yes no
LARP4_HUMAN [view interactions] High throughput no yes
GMDS_HUMAN [view interactions] High throughput no yes
ROBO2_HUMAN [view entry] [view interactions] High throughput yes yes
CE192_HUMAN [view interactions] High throughput no yes
GNS_HUMAN [view interactions] High throughput no yes
G45IP_HUMAN [view interactions] High throughput no yes
S35E1_HUMAN [view interactions] High throughput no yes
LTN1_HUMAN [view interactions] High throughput no no
UBR5_HUMAN [view interactions] High throughput no no
ACADV_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
ATP5S_HUMAN [view interactions] High throughput no no
KATIP_HUMAN [view interactions] High throughput no yes
ZMYM1_HUMAN [view interactions] High throughput no no
C170B_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
WDCP_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
GET4_HUMAN [view interactions] High throughput no yes
MTF2_HUMAN [view interactions] High throughput no no
KPCA_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3F_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
TYW3_HUMAN [view interactions] High throughput no yes
RHPN1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
ASPM_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CP110_HUMAN [view interactions] High throughput no yes
LAR1B_HUMAN [view interactions] High throughput no no
FA13C_HUMAN [view interactions] High throughput no yes
RM53_HUMAN [view interactions] High throughput no yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE1_HUMAN [view interactions] High throughput no yes
HDGF_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
MYB_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SPICE_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
FLT3_HUMAN [view interactions] High throughput no no
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
TIE2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
DYLT1_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
LMO3_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
SNR48_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
KS6B2_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
AL7A1_HUMAN [view entry] [view interactions] High throughput yes no
MTRR_HUMAN [view interactions] High throughput no yes
IKBL1_HUMAN [view interactions] High throughput no no
TIAR_HUMAN [view interactions] High throughput no no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
CELF1_HUMAN [view interactions] High throughput no yes
TARA_HUMAN [view interactions] High throughput no yes
WDR35_HUMAN [view interactions] High throughput no yes
TMPS3_HUMAN [view interactions] High throughput no no
FIP1_HUMAN [view interactions] High throughput no yes
C99L2_HUMAN [view interactions] High throughput no yes
ORML1_HUMAN [view interactions] High throughput no no
PESC_HUMAN [view entry] [view interactions] High throughput yes yes
PTN14_HUMAN [view interactions] High throughput no yes
TRIP4_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
HABP4_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
MARK3_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
PLK1_HUMAN [view interactions] High throughput no yes
CLUA1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no