KIF2A_HUMAN
Evidence for PS localization
Functions
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 317 | Ser | Asn | Corticaldysplasia,complex,withotherbrainmalformations3(CDCBM3) | - |
| 321 | His | Asp | Corticaldysplasia,complex,withotherbrainmalformations3(CDCBM3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF2A_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 33.9286 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | yes |
| GO:0005524 | ATP binding | 21.4286 | 5 | yes |
| GO:0008017 | microtubule binding | 21.4286 | 5 | yes |
| GO:0015631 | tubulin binding | 21.4286 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.4286 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 21.4286 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 16.0714 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 16.0714 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 16.0714 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 8.9286 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF2A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.4286 | 4 | no |
| GO:0006996 | organelle organization | 42.8571 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0714 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.0714 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 32.1429 | 5 | yes |
| GO:0022607 | cellular component assembly | 32.1429 | 4 | yes |
| GO:0008104 | protein localization | 30.3571 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0009966 | regulation of signal transduction | 26.7857 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.2143 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.2143 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.2143 | 4 | no |
| GO:0071702 | organic substance transport | 21.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.4286 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.4286 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 16.0714 | 4 | yes |
| GO:0022411 | cellular component disassembly | 14.2857 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 14.2857 | 4 | yes |
| GO:0070925 | organelle assembly | 12.5000 | 5 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 10.7143 | 4 | yes |
| GO:0007399 | nervous system development | 8.9286 | 4 | yes |
| GO:0030334 | regulation of cell migration | 8.9286 | 5 | yes |
| GO:0031109 | microtubule polymerization or depolymerization | 8.9286 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 8.9286 | 5 | yes |
| GO:0051225 | spindle assembly | 8.9286 | 4 | yes |
| GO:0051261 | protein depolymerization | 8.9286 | 6 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 8.9286 | 6 | yes |
| GO:2000145 | regulation of cell motility | 8.9286 | 4 | yes |
| GO:0007019 | microtubule depolymerization | 7.1429 | 5 | yes |
| GO:0007052 | mitotic spindle organization | 7.1429 | 4 | yes |
| GO:0090307 | mitotic spindle assembly | 5.3571 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KIF2A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.1429 | 3 | yes |
| DOID:0090131 | complex cortical dysplasia with other brain malformations | 3.5714 | 5 | yes |
| DOID:0090134 | complex cortical dysplasia with other brain malformations 3 | 3.5714 | 6 | yes |
| DOID:936 | brain disease | 3.5714 | 4 | yes |
| DOID:1289 | neurodegenerative disease | 3.5714 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TSNAX_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| TTK_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGH_HUMAN | [view interactions] | High throughput | no | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| LARP4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ORML2_HUMAN | [view interactions] | High throughput | no | no |
| S35E1_HUMAN | [view interactions] | High throughput | no | yes |
| G45IP_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| CE192_HUMAN | [view interactions] | High throughput | no | yes |
| ROBO2_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| WDCP_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C170B_HUMAN | [view interactions] | High throughput | no | yes |
| ZMYM1_HUMAN | [view interactions] | High throughput | no | no |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5S_HUMAN | [view interactions] | High throughput | no | no |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACADV_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB7_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPM_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| LAR1B_HUMAN | [view interactions] | High throughput | no | no |
| FA13C_HUMAN | [view interactions] | High throughput | no | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPICE_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| SNR48_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTRR_HUMAN | [view interactions] | High throughput | no | yes |
| IKBL1_HUMAN | [view interactions] | High throughput | no | no |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| WDR35_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS3_HUMAN | [view interactions] | High throughput | no | no |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| C99L2_HUMAN | [view interactions] | High throughput | no | yes |
| ORML1_HUMAN | [view interactions] | High throughput | no | no |
| PESC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| KGP1_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| H31T_HUMAN | [view interactions] | High throughput | no | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| BUD23_HUMAN | [view interactions] | High throughput | no | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| EMAL4_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| K1107_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MA7D2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D3_HUMAN | [view interactions] | High throughput | no | no |
| MAP9_HUMAN | [view interactions] | High throughput | no | no |
| MTUS1_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRI2_HUMAN | [view interactions] | High throughput | no | no |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| TXNL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK049_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP3_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KI18A_HUMAN | [view interactions] | Computational | no | yes |
| NIN_HUMAN | [view interactions] | Computational | no | no |
| CENPE_HUMAN | [view interactions] | Computational | no | no |
| KIF2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |