Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PESC_HUMAN

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PESC_HUMAN
GO:0003723 RNA binding 55.5556 4 yes
GO:0000166 nucleotide binding 24.0741 4 no
GO:0017076 purine nucleotide binding 24.0741 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no
GO:0030554 adenyl nucleotide binding 20.3704 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in PESC_HUMAN
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 51.8519 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 48.1481 4 no
GO:0080090 regulation of primary metabolic process 48.1481 4 no
GO:0009889 regulation of biosynthetic process 46.2963 4 no
GO:0010468 regulation of gene expression 46.2963 6 no
GO:0010556 regulation of macromolecule biosynthetic process 46.2963 5 no
GO:0031326 regulation of cellular biosynthetic process 46.2963 5 no
GO:0010646 regulation of cell communication 42.5926 4 no
GO:0009893 positive regulation of metabolic process 40.7407 4 no
GO:0009059 macromolecule biosynthetic process 38.8889 4 no
GO:0006996 organelle organization 38.8889 4 no
GO:0009966 regulation of signal transduction 38.8889 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.8889 5 no
GO:0051128 regulation of cellular component organization 38.8889 4 no
GO:0051246 regulation of protein metabolic process 38.8889 5 no
GO:0009892 negative regulation of metabolic process 37.0370 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.0370 5 no
GO:0022607 cellular component assembly 35.1852 4 no
GO:0090304 nucleic acid metabolic process 35.1852 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.1852 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 31.4815 5 no
GO:0009891 positive regulation of biosynthetic process 31.4815 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 31.4815 6 no
GO:0031328 positive regulation of cellular biosynthetic process 31.4815 6 no
GO:0009890 negative regulation of biosynthetic process 31.4815 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.4815 6 no
GO:0031327 negative regulation of cellular biosynthetic process 31.4815 6 no
GO:0042981 regulation of apoptotic process 31.4815 5 no
GO:0043067 regulation of programmed cell death 31.4815 4 no
GO:0006355 regulation of DNA-templated transcription 29.6296 7 no
GO:2001141 regulation of RNA biosynthetic process 29.6296 6 no
GO:0010647 positive regulation of cell communication 29.6296 5 no
GO:0023056 positive regulation of signaling 29.6296 4 no
GO:0048584 positive regulation of response to stimulus 29.6296 4 no
GO:0006412 translation 27.7778 4 no
GO:1901566 organonitrogen compound biosynthetic process 27.7778 4 no
GO:0008104 protein localization 27.7778 4 no
GO:0043933 protein-containing complex organization 27.7778 4 no
GO:0009967 positive regulation of signal transduction 27.7778 5 no
GO:0009968 negative regulation of signal transduction 27.7778 5 no
GO:0010648 negative regulation of cell communication 27.7778 5 no
GO:0023057 negative regulation of signaling 27.7778 4 no
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0048585 negative regulation of response to stimulus 27.7778 4 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0002181 cytoplasmic translation 25.9259 5 no
GO:0006357 regulation of transcription by RNA polymerase II 25.9259 8 no
GO:0016070 RNA metabolic process 25.9259 5 yes
GO:0051248 negative regulation of protein metabolic process 25.9259 6 no
GO:0031399 regulation of protein modification process 25.9259 6 no
GO:0051130 positive regulation of cellular component organization 24.0741 5 no
GO:0051174 regulation of phosphorus metabolic process 24.0741 5 no
GO:0010629 negative regulation of gene expression 24.0741 7 no
GO:0042127 regulation of cell population proliferation 24.0741 4 no
GO:0019220 regulation of phosphate metabolic process 24.0741 6 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:0051726 regulation of cell cycle 22.2222 4 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0051240 positive regulation of multicellular organismal process 20.3704 4 no
GO:0007010 cytoskeleton organization 20.3704 5 no
GO:0044087 regulation of cellular component biogenesis 20.3704 4 no
GO:0045944 positive regulation of transcription by RNA polymerase II 20.3704 9 no
GO:0065003 protein-containing complex assembly 20.3704 5 no
GO:0010628 positive regulation of gene expression 20.3704 7 no
GO:0008284 positive regulation of cell population proliferation 20.3704 5 no
GO:0009894 regulation of catabolic process 20.3704 4 no
GO:0043066 negative regulation of apoptotic process 20.3704 6 no
GO:0043069 negative regulation of programmed cell death 20.3704 5 no
GO:0006396 RNA processing 16.6667 6 yes
GO:0006364 rRNA processing 12.9630 6 yes
GO:0016072 rRNA metabolic process 12.9630 6 yes
GO:0141188 nucleic acid catabolic process 12.9630 5 yes
GO:0022613 ribonucleoprotein complex biogenesis 11.1111 4 yes
GO:0000470 maturation of LSU-rRNA 7.4074 7 yes
GO:0042273 ribosomal large subunit biogenesis 7.4074 5 yes
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 5.5556 8 yes
GO:0000460 maturation of 5.8S rRNA 3.7037 7 yes
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3.7037 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BOP1_HUMAN [view interactions] Low throughput no yes
WDR12_HUMAN [view interactions] Low throughput no yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
PESC_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI23_HUMAN [view interactions] Low throughput no yes
RBM28_HUMAN [view interactions] High throughput no yes
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
RL4_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
SP16H_HUMAN [view interactions] High throughput no yes
PWP1_HUMAN [view interactions] High throughput no no
RPF2_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
RL27_HUMAN [view entry] [view interactions] High throughput yes yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
NOLC1_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
SIR1_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
ESF1_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC9_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RPA34_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
DDX23_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
ZN330_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
RED1_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
HDA11_HUMAN [view interactions] High throughput no no
AIM2_HUMAN [view interactions] High throughput no no
MNDA_HUMAN [view interactions] High throughput no no
MAGAA_HUMAN [view interactions] High throughput no no
CASQ2_HUMAN [view interactions] High throughput no no
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
SET1A_HUMAN [view interactions] High throughput no yes
NVL_HUMAN [view interactions] High throughput no no
TNC18_HUMAN [view interactions] High throughput no yes
CENPB_HUMAN [view interactions] High throughput no yes
AF9_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
TRI26_HUMAN [view interactions] High throughput no yes
RL7L_HUMAN [view interactions] High throughput no no
KLH23_HUMAN [view interactions] High throughput no no
NOC3L_HUMAN [view interactions] High throughput no no
PPIL4_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
DDX27_HUMAN [view interactions] High throughput no no
NAF1_HUMAN [view interactions] High throughput no yes
PININ_HUMAN [view interactions] High throughput no yes
CWC22_HUMAN [view interactions] High throughput no yes
AFF4_HUMAN [view interactions] High throughput no yes
SRRM2_HUMAN [view interactions] High throughput no yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
WDR55_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
KI67_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
MYLK2_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
BRPF3_HUMAN [view interactions] High throughput no yes
FOXM1_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
MAST1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
FOXL2_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
AKIP_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
CDK7_HUMAN [view interactions] High throughput no yes
CDK8_HUMAN [view interactions] High throughput no no
FBRL_HUMAN [view interactions] High throughput no yes
H31_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
CC14B_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
TLK2_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
MK67I_HUMAN [view interactions] High throughput no yes
PRR11_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MBB1A_HUMAN [view interactions] High throughput no yes
RRP12_HUMAN [view interactions] High throughput no no
MRT4_HUMAN [view interactions] High throughput no yes
BRX1_HUMAN [view interactions] High throughput no no
DKC1_HUMAN [view interactions] High throughput no yes
MMTA2_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no no
NOC2L_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
NOP2_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
ELOA1_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
SNUT1_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
BUB3_HUMAN [view interactions] High throughput no yes
DDX18_HUMAN [view interactions] High throughput no yes
GTPB4_HUMAN [view interactions] High throughput no yes
EBP2_HUMAN [view interactions] High throughput no yes
RRS1_HUMAN [view interactions] High throughput no yes
POP1_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
F263_HUMAN [view interactions] High throughput no yes
UBF1_HUMAN [view interactions] High throughput no yes
CXXC1_HUMAN [view interactions] High throughput no yes
INP5K_HUMAN [view interactions] High throughput no no
RNPS1_HUMAN [view interactions] High throughput no yes
ARK2N_HUMAN [view interactions] High throughput no yes
CCD91_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
NUCL_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
HABP4_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
TLR9_HUMAN [view interactions] High throughput no no
DCA13_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
BRD7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
MAFB_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
MKRN1_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
KRR1_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
DRG1_HUMAN [view interactions] High throughput no yes
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
NPM3_HUMAN [view interactions] High throughput no yes
UT14A_HUMAN [view interactions] High throughput no yes
XPO6_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
AATF_HUMAN [view interactions] High throughput no yes
R113A_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIDN_HUMAN [view interactions] High throughput no no
UBP36_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SRBP2_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
NOC4L_HUMAN [view interactions] High throughput no no
NP1L4_HUMAN [view entry] [view interactions] High throughput yes yes
ARL2_HUMAN [view interactions] High throughput no yes
LZTL1_HUMAN [view interactions] High throughput no no
BLMH_HUMAN [view interactions] High throughput no yes
CEBPZ_HUMAN [view interactions] High throughput no no
SPB1_HUMAN [view interactions] High throughput no yes
GNL1_HUMAN [view entry] [view interactions] High throughput yes yes
GNL3_HUMAN [view interactions] High throughput no yes
NH2L1_HUMAN [view interactions] High throughput no yes
NIP7_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
DDX24_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
GNL3L_HUMAN [view interactions] High throughput no yes
PUM3_HUMAN [view interactions] High throughput no yes
NOP56_HUMAN [view interactions] High throughput no yes
ORC2_HUMAN [view interactions] High throughput no yes