Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ROBO2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
945 Ile Thr Vesicoureteralreflux2(VUR2) -
1236 Ala Thr Vesicoureteralreflux2(VUR2) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ROBO2_HUMAN
GO:0000166 nucleotide binding 31.2500 4 no
GO:0015631 tubulin binding 31.2500 4 no
GO:0017076 purine nucleotide binding 31.2500 5 no
GO:0032555 purine ribonucleotide binding 31.2500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.2500 4 no
GO:0043168 anion binding 31.2500 4 no
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0008046 axon guidance receptor activity 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ROBO2_HUMAN
GO:0048522 positive regulation of cellular process 68.7500 4 yes
GO:0048523 negative regulation of cellular process 68.7500 4 yes
GO:0009966 regulation of signal transduction 56.2500 4 yes
GO:0010646 regulation of cell communication 56.2500 4 yes
GO:0030030 cell projection organization 56.2500 4 yes
GO:0051128 regulation of cellular component organization 56.2500 4 yes
GO:0120036 plasma membrane bounded cell projection organization 56.2500 5 yes
GO:0051094 positive regulation of developmental process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009967 positive regulation of signal transduction 43.7500 5 yes
GO:0010647 positive regulation of cell communication 43.7500 5 yes
GO:0023056 positive regulation of signaling 43.7500 4 yes
GO:0031175 neuron projection development 43.7500 6 yes
GO:0048584 positive regulation of response to stimulus 43.7500 4 yes
GO:0009893 positive regulation of metabolic process 43.7500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.7500 5 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0031344 regulation of cell projection organization 37.5000 5 yes
GO:0045595 regulation of cell differentiation 37.5000 4 yes
GO:0045597 positive regulation of cell differentiation 37.5000 5 yes
GO:0050807 regulation of synapse organization 37.5000 5 yes
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 yes
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 yes
GO:0071310 cellular response to organic substance 37.5000 4 yes
GO:2000026 regulation of multicellular organismal development 37.5000 4 yes
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031399 regulation of protein modification process 37.5000 6 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:1902531 regulation of intracellular signal transduction 37.5000 5 no
GO:0006996 organelle organization 37.5000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 yes
GO:0040013 negative regulation of locomotion 31.2500 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.2500 6 yes
GO:0043085 positive regulation of catalytic activity 31.2500 4 no
GO:0051049 regulation of transport 31.2500 4 no
GO:0031401 positive regulation of protein modification process 31.2500 7 no
GO:0051247 positive regulation of protein metabolic process 31.2500 6 no
GO:0019220 regulation of phosphate metabolic process 31.2500 6 no
GO:0030334 regulation of cell migration 31.2500 5 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0051174 regulation of phosphorus metabolic process 31.2500 5 no
GO:0071702 organic substance transport 31.2500 4 no
GO:0071705 nitrogen compound transport 31.2500 4 no
GO:1901701 cellular response to oxygen-containing compound 31.2500 4 no
GO:2000145 regulation of cell motility 31.2500 4 no
GO:0022607 cellular component assembly 31.2500 4 no
GO:0008104 protein localization 31.2500 4 no
GO:0006915 apoptotic process 25.0000 4 yes
GO:0007411 axon guidance 25.0000 8 yes
GO:0010720 positive regulation of cell development 25.0000 6 yes
GO:0010975 regulation of neuron projection development 25.0000 7 yes
GO:0031346 positive regulation of cell projection organization 25.0000 6 yes
GO:0032101 regulation of response to external stimulus 25.0000 4 yes
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0050767 regulation of neurogenesis 25.0000 6 yes
GO:0050769 positive regulation of neurogenesis 25.0000 6 yes
GO:0050920 regulation of chemotaxis 25.0000 4 yes
GO:0051093 negative regulation of developmental process 25.0000 4 yes
GO:0051129 negative regulation of cellular component organization 25.0000 5 yes
GO:0051130 positive regulation of cellular component organization 25.0000 5 yes
GO:0051960 regulation of nervous system development 25.0000 5 yes
GO:0051962 positive regulation of nervous system development 25.0000 5 yes
GO:0060284 regulation of cell development 25.0000 5 yes
GO:0097485 neuron projection guidance 25.0000 7 yes
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0050890 cognition 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0032102 negative regulation of response to external stimulus 18.7500 5 yes
GO:0044087 regulation of cellular component biogenesis 18.7500 4 yes
GO:0051963 regulation of synapse assembly 18.7500 6 yes
GO:1901888 regulation of cell junction assembly 18.7500 5 yes
GO:0001656 metanephros development 12.5000 5 yes
GO:0001657 ureteric bud development 12.5000 5 yes
GO:0001822 kidney development 12.5000 4 yes
GO:0003129 heart induction 12.5000 4 yes
GO:0003148 outflow tract septum morphogenesis 12.5000 4 yes
GO:0003156 regulation of animal organ formation 12.5000 6 yes
GO:0003180 aortic valve morphogenesis 12.5000 4 yes
GO:0003184 pulmonary valve morphogenesis 12.5000 4 yes
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 12.5000 5 yes
GO:0007417 central nervous system development 12.5000 4 yes
GO:0007420 brain development 12.5000 4 yes
GO:0008593 regulation of Notch signaling pathway 12.5000 5 yes
GO:0016198 axon choice point recognition 12.5000 4 yes
GO:0016199 axon midline choice point recognition 12.5000 5 yes
GO:0021891 olfactory bulb interneuron development 12.5000 5 yes
GO:0031290 retinal ganglion cell axon guidance 12.5000 9 yes
GO:0032870 cellular response to hormone stimulus 12.5000 4 yes
GO:0035904 aorta development 12.5000 5 yes
GO:0045747 positive regulation of Notch signaling pathway 12.5000 6 yes
GO:0048666 neuron development 12.5000 4 yes
GO:0050770 regulation of axonogenesis 12.5000 5 yes
GO:0050772 positive regulation of axonogenesis 12.5000 6 yes
GO:0050922 negative regulation of chemotaxis 12.5000 5 yes
GO:0050923 regulation of negative chemotaxis 12.5000 5 yes
GO:0050925 negative regulation of negative chemotaxis 12.5000 6 yes
GO:0051961 negative regulation of nervous system development 12.5000 5 yes
GO:0051964 negative regulation of synapse assembly 12.5000 6 yes
GO:0060412 ventricular septum morphogenesis 12.5000 4 yes
GO:0060429 epithelium development 12.5000 4 yes
GO:0060840 artery development 12.5000 4 yes
GO:0061364 apoptotic process involved in luteolysis 12.5000 6 yes
GO:0072073 kidney epithelium development 12.5000 5 yes
GO:0072163 mesonephric epithelium development 12.5000 6 yes
GO:0072164 mesonephric tubule development 12.5000 4 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 12.5000 4 yes
GO:0110110 positive regulation of animal organ morphogenesis 12.5000 5 yes
GO:1901889 negative regulation of cell junction assembly 12.5000 6 yes
GO:1902742 apoptotic process involved in development 12.5000 5 yes
GO:1905809 negative regulation of synapse organization 12.5000 6 yes
GO:2000027 regulation of animal organ morphogenesis 12.5000 5 yes
GO:2000826 regulation of heart morphogenesis 12.5000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
ROBO2_HUMAN [view entry] [view interactions] Low throughput yes yes
ROBO1_HUMAN [view interactions] Low throughput no yes
MYCB2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL4_HUMAN [view interactions] High throughput no yes
BNI3L_HUMAN [view interactions] High throughput no yes
DPB1_HUMAN [view interactions] High throughput no no
CENPU_HUMAN [view interactions] High throughput no no
NR1H2_HUMAN [view interactions] High throughput no yes
NR4A1_HUMAN [view interactions] High throughput no yes
RDH11_HUMAN [view interactions] High throughput no no
KS6A5_HUMAN [view entry] [view interactions] High throughput yes yes
KCNRG_HUMAN [view interactions] High throughput no no
PAR6B_HUMAN [view interactions] High throughput no no
TM109_HUMAN [view interactions] High throughput no yes
CEP72_HUMAN [view interactions] High throughput no yes
KIF2A_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
TM248_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
KIF1C_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
GP152_HUMAN [view interactions] High throughput no no
CBPE_HUMAN [view interactions] High throughput no yes
NOE2_HUMAN [view entry] [view interactions] High throughput yes yes
PPR1B_HUMAN [view entry] [view interactions] High throughput yes yes
SSRP1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
FADD_HUMAN [view interactions] High throughput no yes
TRI13_HUMAN [view interactions] High throughput no no
TM237_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no