KS6A5_HUMAN
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed, PubMed). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed, PubMed). In skeletal myoblasts is required for phosphorylation of RELA at Ser-276 during oxidative stress (PubMed). In erythropoietin-stimulated cells, is necessary for the Ser-727 phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed). Phosphorylates ETV1/ER81 at Ser-191 and Ser-216, and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed). Directly represses transcription via phosphorylation of Ser-1 of histone H2A (PubMed). Phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed). May also phosphorylate Ser-28 of histone H3 (PubMed). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines . Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors . Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury . Phosphorylates TRIM7 at Ser-107 in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI002944 | DOC_MAPK_RevD_3 | DOC | 730 | 744 | - |
ELMI003708 | LIG_SH2_STAP1 | LIG | 423 | 427 | - |
ELMI002944 | DOC_MAPK_RevD_3 | DOC | 730 | 744 | - |
ELMI003708 | LIG_SH2_STAP1 | LIG | 423 | 427 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KS6A5_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 45.4545 | 4 | yes |
GO:0000166 | nucleotide binding | 40.9091 | 4 | yes |
GO:0017076 | purine nucleotide binding | 40.9091 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 40.9091 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 40.9091 | 4 | yes |
GO:0005524 | ATP binding | 31.8182 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 31.8182 | 6 | yes |
GO:0032559 | adenyl ribonucleotide binding | 31.8182 | 5 | yes |
GO:0043169 | cation binding | 27.2727 | 4 | yes |
GO:0046872 | metal ion binding | 25.0000 | 5 | yes |
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
GO:0004674 | protein serine/threonine kinase activity | 20.4545 | 4 | yes |
GO:0016301 | kinase activity | 20.4545 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.4545 | 4 | yes |
GO:0003723 | RNA binding | 20.4545 | 4 | no |
GO:0106310 | protein serine kinase activity | 18.1818 | 4 | yes |
GO:0000287 | magnesium ion binding | 6.8182 | 6 | yes |
GO:0035173 | histone kinase activity | 4.5455 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KS6A5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 75.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 63.6364 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 54.5455 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 52.2727 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.2727 | 4 | yes |
GO:0010646 | regulation of cell communication | 52.2727 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 47.7273 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 47.7273 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 45.4545 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 45.4545 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 43.1818 | 5 | yes |
GO:0009966 | regulation of signal transduction | 43.1818 | 4 | no |
GO:0051049 | regulation of transport | 40.9091 | 4 | no |
GO:0010468 | regulation of gene expression | 40.9091 | 6 | yes |
GO:0006996 | organelle organization | 40.9091 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 38.6364 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 38.6364 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 38.6364 | 6 | yes |
GO:0051246 | regulation of protein metabolic process | 38.6364 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 38.6364 | 4 | no |
GO:0060341 | regulation of cellular localization | 36.3636 | 4 | no |
GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.3636 | 5 | yes |
GO:0071310 | cellular response to organic substance | 36.3636 | 4 | no |
GO:0036211 | protein modification process | 34.0909 | 4 | yes |
GO:0043412 | macromolecule modification | 34.0909 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 34.0909 | 5 | no |
GO:0043067 | regulation of programmed cell death | 34.0909 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 34.0909 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 34.0909 | 5 | no |
GO:0010647 | positive regulation of cell communication | 34.0909 | 5 | no |
GO:0023056 | positive regulation of signaling | 34.0909 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 31.8182 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 31.8182 | 6 | no |
GO:0045595 | regulation of cell differentiation | 31.8182 | 4 | no |
GO:0051094 | positive regulation of developmental process | 31.8182 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 29.5455 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.5455 | 5 | yes |
GO:0080134 | regulation of response to stress | 29.5455 | 4 | no |
GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 7 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 27.2727 | 8 | yes |
GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | yes |
GO:0045597 | positive regulation of cell differentiation | 27.2727 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 27.2727 | 4 | no |
GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0006468 | protein phosphorylation | 25.0000 | 5 | yes |
GO:0016310 | phosphorylation | 25.0000 | 5 | yes |
GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0006915 | apoptotic process | 25.0000 | 4 | no |
GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 22.7273 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
GO:1903829 | positive regulation of protein localization | 22.7273 | 5 | no |
GO:0098657 | import into cell | 22.7273 | 4 | no |
GO:0030030 | cell projection organization | 22.7273 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 22.7273 | 8 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 22.7273 | 9 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 22.7273 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 22.7273 | 7 | yes |
GO:0002684 | positive regulation of immune system process | 22.7273 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 22.7273 | 4 | no |
GO:0010628 | positive regulation of gene expression | 22.7273 | 7 | no |
GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
GO:0051726 | regulation of cell cycle | 20.4545 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 20.4545 | 6 | no |
GO:0009890 | negative regulation of biosynthetic process | 20.4545 | 5 | yes |
GO:0030162 | regulation of proteolysis | 20.4545 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 20.4545 | 6 | no |
GO:0043069 | negative regulation of programmed cell death | 20.4545 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 20.4545 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 20.4545 | 5 | no |
GO:0010648 | negative regulation of cell communication | 20.4545 | 5 | no |
GO:0023057 | negative regulation of signaling | 20.4545 | 4 | no |
GO:0008104 | protein localization | 20.4545 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.4545 | 4 | no |
GO:0032870 | cellular response to hormone stimulus | 20.4545 | 4 | no |
GO:0031399 | regulation of protein modification process | 20.4545 | 6 | no |
GO:0034097 | response to cytokine | 20.4545 | 4 | no |
GO:0060284 | regulation of cell development | 20.4545 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 20.4545 | 6 | no |
GO:2000026 | regulation of multicellular organismal development | 20.4545 | 4 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 18.1818 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 18.1818 | 6 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 18.1818 | 5 | yes |
GO:0031175 | neuron projection development | 15.9091 | 6 | yes |
GO:0050807 | regulation of synapse organization | 15.9091 | 5 | yes |
GO:0019221 | cytokine-mediated signaling pathway | 13.6364 | 4 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 13.6364 | 5 | yes |
GO:0001817 | regulation of cytokine production | 11.3636 | 4 | yes |
GO:0043687 | post-translational protein modification | 11.3636 | 5 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 11.3636 | 8 | yes |
GO:0051091 | positive regulation of DNA-binding transcription factor activity | 11.3636 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 11.3636 | 4 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 11.3636 | 6 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 11.3636 | 7 | yes |
GO:0006954 | inflammatory response | 9.0909 | 4 | yes |
GO:0010629 | negative regulation of gene expression | 9.0909 | 7 | yes |
GO:0007411 | axon guidance | 6.8182 | 8 | yes |
GO:0070498 | interleukin-1-mediated signaling pathway | 6.8182 | 5 | yes |
GO:0097485 | neuron projection guidance | 6.8182 | 7 | yes |
GO:0099175 | regulation of postsynapse organization | 6.8182 | 6 | yes |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 4.5455 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KDM3A_HUMAN | [view interactions] | Low throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SMCA4_HUMAN | [view interactions] | Low throughput | no | yes |
RARA_HUMAN | [view interactions] | Low throughput | no | no |
MK14_HUMAN | [view interactions] | Low throughput | no | yes |
EGF_HUMAN | [view interactions] | Low throughput | no | no |
ATF2_HUMAN | [view interactions] | Low throughput | no | yes |
EP300_HUMAN | [view interactions] | Low throughput | no | yes |
CBP_HUMAN | [view interactions] | Low throughput | no | yes |
NFKB1_HUMAN | [view interactions] | Low throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK11_HUMAN | [view interactions] | Low throughput | no | yes |
BAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CREB1_HUMAN | [view interactions] | Low throughput | no | yes |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
H32_HUMAN | [view interactions] | Low throughput | no | yes |
H2B2E_HUMAN | [view interactions] | Low throughput | no | yes |
H4_HUMAN | [view interactions] | Low throughput | no | yes |
H2B1B_HUMAN | [view interactions] | Low throughput | no | yes |
MBP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
H11_HUMAN | [view interactions] | Low throughput | no | no |
ETV1_HUMAN | [view interactions] | Low throughput | no | no |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATF1_HUMAN | [view interactions] | Low throughput | no | yes |
CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
MDFIC_HUMAN | [view interactions] | High throughput | no | yes |
TXD11_HUMAN | [view interactions] | High throughput | no | yes |
M3K20_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKTS1_HUMAN | [view interactions] | High throughput | no | yes |
DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERH_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDLI1_HUMAN | [view interactions] | High throughput | no | yes |
RAI1_HUMAN | [view interactions] | High throughput | no | yes |
RN19A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ROBO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAD6_HUMAN | [view interactions] | High throughput | no | no |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
U119A_HUMAN | [view interactions] | High throughput | no | no |
ZN775_HUMAN | [view interactions] | High throughput | no | no |
HS904_HUMAN | [view interactions] | High throughput | no | no |
CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
PSD12_HUMAN | [view interactions] | High throughput | no | yes |
PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PFD6_HUMAN | [view interactions] | High throughput | no | yes |
SCO2_HUMAN | [view interactions] | High throughput | no | no |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPAB1_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAD2_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOS2_HUMAN | [view interactions] | High throughput | no | yes |
DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
TEBP_HUMAN | [view interactions] | High throughput | no | yes |
DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GT251_HUMAN | [view interactions] | High throughput | no | no |
COQ8A_HUMAN | [view interactions] | High throughput | no | no |
RM24_HUMAN | [view interactions] | High throughput | no | yes |
SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
CLPB_HUMAN | [view interactions] | High throughput | no | yes |
CPVL_HUMAN | [view interactions] | High throughput | no | no |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
RM27_HUMAN | [view interactions] | High throughput | no | yes |
PSD13_HUMAN | [view interactions] | High throughput | no | yes |
RT17_HUMAN | [view interactions] | High throughput | no | yes |
RT18B_HUMAN | [view interactions] | High throughput | no | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
I17RB_HUMAN | [view interactions] | High throughput | no | no |
ALG8_HUMAN | [view interactions] | High throughput | no | yes |
GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
TLK2_HUMAN | [view interactions] | High throughput | no | no |
CTNA3_HUMAN | [view interactions] | High throughput | no | no |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
MIA40_HUMAN | [view interactions] | High throughput | no | yes |
SPSB4_HUMAN | [view interactions] | High throughput | no | no |
HIDE1_HUMAN | [view interactions] | High throughput | no | no |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
GGH_HUMAN | [view interactions] | High throughput | no | yes |
CLC4A_HUMAN | [view interactions] | High throughput | no | no |
MK04_HUMAN | [view interactions] | High throughput | no | no |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
TMM25_HUMAN | [view interactions] | High throughput | no | yes |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SGK2_HUMAN | [view interactions] | High throughput | no | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
KS6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRYAA_HUMAN | [view interactions] | High throughput | no | no |
STK11_HUMAN | [view interactions] | High throughput | no | yes |
SARG_HUMAN | [view interactions] | High throughput | no | yes |
THOC1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |