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KS6A5_HUMAN

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed, PubMed). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed, PubMed). In skeletal myoblasts is required for phosphorylation of RELA at Ser-276 during oxidative stress (PubMed). In erythropoietin-stimulated cells, is necessary for the Ser-727 phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed). Phosphorylates ETV1/ER81 at Ser-191 and Ser-216, and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed). Directly represses transcription via phosphorylation of Ser-1 of histone H2A (PubMed). Phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed). May also phosphorylate Ser-28 of histone H3 (PubMed). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines . Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors . Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury . Phosphorylates TRIM7 at Ser-107 in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed). [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI002944 DOC_MAPK_RevD_3 DOC 730 744 -
ELMI003708 LIG_SH2_STAP1 LIG 423 427 -
ELMI002944 DOC_MAPK_RevD_3 DOC 730 744 -
ELMI003708 LIG_SH2_STAP1 LIG 423 427 -

Molecular function

Term Name % Distance from the top of the tree Annotated in KS6A5_HUMAN
GO:0043168 anion binding 45.4545 4 yes
GO:0000166 nucleotide binding 40.9091 4 yes
GO:0017076 purine nucleotide binding 40.9091 5 yes
GO:0032555 purine ribonucleotide binding 40.9091 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.9091 4 yes
GO:0005524 ATP binding 31.8182 5 yes
GO:0030554 adenyl nucleotide binding 31.8182 6 yes
GO:0032559 adenyl ribonucleotide binding 31.8182 5 yes
GO:0043169 cation binding 27.2727 4 yes
GO:0046872 metal ion binding 25.0000 5 yes
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0004674 protein serine/threonine kinase activity 20.4545 4 yes
GO:0016301 kinase activity 20.4545 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.4545 4 yes
GO:0003723 RNA binding 20.4545 4 no
GO:0106310 protein serine kinase activity 18.1818 4 yes
GO:0000287 magnesium ion binding 6.8182 6 yes
GO:0035173 histone kinase activity 4.5455 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KS6A5_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 63.6364 4 yes
GO:0031323 regulation of cellular metabolic process 54.5455 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 52.2727 4 yes
GO:0080090 regulation of primary metabolic process 52.2727 4 yes
GO:0010646 regulation of cell communication 52.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0009889 regulation of biosynthetic process 47.7273 4 yes
GO:0051128 regulation of cellular component organization 47.7273 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 45.4545 5 yes
GO:0031326 regulation of cellular biosynthetic process 45.4545 5 yes
GO:0031325 positive regulation of cellular metabolic process 43.1818 5 yes
GO:0009966 regulation of signal transduction 43.1818 4 no
GO:0051049 regulation of transport 40.9091 4 no
GO:0010468 regulation of gene expression 40.9091 6 yes
GO:0006996 organelle organization 40.9091 4 no
GO:0009891 positive regulation of biosynthetic process 38.6364 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 38.6364 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 38.6364 6 yes
GO:0051246 regulation of protein metabolic process 38.6364 5 no
GO:0048584 positive regulation of response to stimulus 38.6364 4 no
GO:0060341 regulation of cellular localization 36.3636 4 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 yes
GO:0071310 cellular response to organic substance 36.3636 4 no
GO:0036211 protein modification process 34.0909 4 yes
GO:0043412 macromolecule modification 34.0909 4 yes
GO:0042981 regulation of apoptotic process 34.0909 5 no
GO:0043067 regulation of programmed cell death 34.0909 4 no
GO:0051240 positive regulation of multicellular organismal process 34.0909 4 no
GO:1902531 regulation of intracellular signal transduction 34.0909 5 no
GO:0010647 positive regulation of cell communication 34.0909 5 no
GO:0023056 positive regulation of signaling 34.0909 4 no
GO:0009892 negative regulation of metabolic process 31.8182 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 31.8182 5 yes
GO:0051247 positive regulation of protein metabolic process 31.8182 6 no
GO:0045595 regulation of cell differentiation 31.8182 4 no
GO:0051094 positive regulation of developmental process 31.8182 4 no
GO:0006796 phosphate-containing compound metabolic process 29.5455 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.5455 5 yes
GO:0080134 regulation of response to stress 29.5455 4 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0006355 regulation of DNA-templated transcription 27.2727 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 27.2727 8 yes
GO:0051252 regulation of RNA metabolic process 27.2727 5 yes
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 yes
GO:0045597 positive regulation of cell differentiation 27.2727 5 no
GO:1901701 cellular response to oxygen-containing compound 27.2727 4 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0006468 protein phosphorylation 25.0000 5 yes
GO:0016310 phosphorylation 25.0000 5 yes
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0042325 regulation of phosphorylation 22.7273 7 no
GO:0043085 positive regulation of catalytic activity 22.7273 4 no
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 no
GO:1903829 positive regulation of protein localization 22.7273 5 no
GO:0098657 import into cell 22.7273 4 no
GO:0030030 cell projection organization 22.7273 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.7273 5 yes
GO:0045893 positive regulation of DNA-templated transcription 22.7273 8 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 22.7273 9 yes
GO:0051254 positive regulation of RNA metabolic process 22.7273 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 22.7273 7 yes
GO:0002684 positive regulation of immune system process 22.7273 4 no
GO:0032101 regulation of response to external stimulus 22.7273 4 no
GO:0010628 positive regulation of gene expression 22.7273 7 no
GO:0043933 protein-containing complex organization 22.7273 4 no
GO:0019220 regulation of phosphate metabolic process 22.7273 6 no
GO:0051726 regulation of cell cycle 20.4545 4 no
GO:0010638 positive regulation of organelle organization 20.4545 6 no
GO:0009890 negative regulation of biosynthetic process 20.4545 5 yes
GO:0030162 regulation of proteolysis 20.4545 6 no
GO:0043066 negative regulation of apoptotic process 20.4545 6 no
GO:0043069 negative regulation of programmed cell death 20.4545 5 no
GO:0051336 regulation of hydrolase activity 20.4545 4 no
GO:0009968 negative regulation of signal transduction 20.4545 5 no
GO:0010648 negative regulation of cell communication 20.4545 5 no
GO:0023057 negative regulation of signaling 20.4545 4 no
GO:0008104 protein localization 20.4545 4 no
GO:0010243 response to organonitrogen compound 20.4545 4 no
GO:0032870 cellular response to hormone stimulus 20.4545 4 no
GO:0031399 regulation of protein modification process 20.4545 6 no
GO:0034097 response to cytokine 20.4545 4 no
GO:0060284 regulation of cell development 20.4545 5 no
GO:1902533 positive regulation of intracellular signal transduction 20.4545 6 no
GO:2000026 regulation of multicellular organismal development 20.4545 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 18.1818 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 18.1818 6 yes
GO:0120036 plasma membrane bounded cell projection organization 18.1818 5 yes
GO:0031175 neuron projection development 15.9091 6 yes
GO:0050807 regulation of synapse organization 15.9091 5 yes
GO:0019221 cytokine-mediated signaling pathway 13.6364 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 13.6364 5 yes
GO:0001817 regulation of cytokine production 11.3636 4 yes
GO:0043687 post-translational protein modification 11.3636 5 yes
GO:0045892 negative regulation of DNA-templated transcription 11.3636 8 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 11.3636 4 yes
GO:0051241 negative regulation of multicellular organismal process 11.3636 4 yes
GO:0051253 negative regulation of RNA metabolic process 11.3636 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 11.3636 7 yes
GO:0006954 inflammatory response 9.0909 4 yes
GO:0010629 negative regulation of gene expression 9.0909 7 yes
GO:0007411 axon guidance 6.8182 8 yes
GO:0070498 interleukin-1-mediated signaling pathway 6.8182 5 yes
GO:0097485 neuron projection guidance 6.8182 7 yes
GO:0099175 regulation of postsynapse organization 6.8182 6 yes
GO:0051092 positive regulation of NF-kappaB transcription factor activity 4.5455 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
KDM3A_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
SMCA4_HUMAN [view interactions] Low throughput no yes
RARA_HUMAN [view interactions] Low throughput no no
MK14_HUMAN [view interactions] Low throughput no yes
EGF_HUMAN [view interactions] Low throughput no no
ATF2_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
CBP_HUMAN [view interactions] Low throughput no yes
NFKB1_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
MK11_HUMAN [view interactions] Low throughput no yes
BAD_HUMAN [view entry] [view interactions] Low throughput yes yes
CREB1_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
H32_HUMAN [view interactions] Low throughput no yes
H2B2E_HUMAN [view interactions] Low throughput no yes
H4_HUMAN [view interactions] Low throughput no yes
H2B1B_HUMAN [view interactions] Low throughput no yes
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
H11_HUMAN [view interactions] Low throughput no no
ETV1_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
ATF1_HUMAN [view interactions] Low throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
MDFIC_HUMAN [view interactions] High throughput no yes
TXD11_HUMAN [view interactions] High throughput no yes
M3K20_HUMAN [view interactions] High throughput no yes
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
AKTS1_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
DDAH2_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
ERH_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
ITSN1_HUMAN [view entry] [view interactions] High throughput yes yes
PDLI1_HUMAN [view interactions] High throughput no yes
RAI1_HUMAN [view interactions] High throughput no yes
RN19A_HUMAN [view entry] [view interactions] High throughput yes yes
ROBO2_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD6_HUMAN [view interactions] High throughput no no
SNF5_HUMAN [view interactions] High throughput no yes
U119A_HUMAN [view interactions] High throughput no no
ZN775_HUMAN [view interactions] High throughput no no
HS904_HUMAN [view interactions] High throughput no no
CNOT1_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
PFD6_HUMAN [view interactions] High throughput no yes
SCO2_HUMAN [view interactions] High throughput no no
ATP5H_HUMAN [view interactions] High throughput no yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
RPAB1_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ATPO_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
BAP31_HUMAN [view interactions] High throughput no yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
KAD2_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
DCAF7_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD1_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS2_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD6_HUMAN [view interactions] High throughput no yes
TEBP_HUMAN [view interactions] High throughput no yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
GT251_HUMAN [view interactions] High throughput no no
COQ8A_HUMAN [view interactions] High throughput no no
RM24_HUMAN [view interactions] High throughput no yes
SIN3A_HUMAN [view interactions] High throughput no yes
CLPB_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
RM27_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
RT17_HUMAN [view interactions] High throughput no yes
RT18B_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
I17RB_HUMAN [view interactions] High throughput no no
ALG8_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
NR4A1_HUMAN [view interactions] High throughput no yes
TLK2_HUMAN [view interactions] High throughput no no
CTNA3_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MIA40_HUMAN [view interactions] High throughput no yes
SPSB4_HUMAN [view interactions] High throughput no no
HIDE1_HUMAN [view interactions] High throughput no no
LAMP3_HUMAN [view interactions] High throughput no no
CIA2A_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
MK04_HUMAN [view interactions] High throughput no no
F174A_HUMAN [view interactions] High throughput no yes
TMM25_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A1_HUMAN [view entry] [view interactions] High throughput yes yes
SGK2_HUMAN [view interactions] High throughput no yes
AKT3_HUMAN [view interactions] High throughput no yes
KS6B1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAA_HUMAN [view interactions] High throughput no no
STK11_HUMAN [view interactions] High throughput no yes
SARG_HUMAN [view interactions] High throughput no yes
THOC1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes