Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DHB12_HUMAN

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DHB12_HUMAN
GO:0017076 purine nucleotide binding 32.8571 4 no
GO:0032555 purine ribonucleotide binding 32.8571 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.8571 4 no
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DHB12_HUMAN
GO:0048522 positive regulation of cellular process 51.4286 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.2857 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0080090 regulation of primary metabolic process 41.4286 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0006996 organelle organization 38.5714 4 no
GO:0008104 protein localization 38.5714 4 no
GO:0051246 regulation of protein metabolic process 35.7143 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0051128 regulation of cellular component organization 35.7143 4 no
GO:0010646 regulation of cell communication 32.8571 4 no
GO:0071702 organic substance transport 32.8571 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.4286 5 no
GO:0071705 nitrogen compound transport 31.4286 4 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0010468 regulation of gene expression 30.0000 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0015031 protein transport 28.5714 4 no
GO:0009967 positive regulation of signal transduction 27.1429 5 no
GO:0010647 positive regulation of cell communication 27.1429 5 no
GO:0010941 regulation of cell death 27.1429 4 no
GO:0023056 positive regulation of signaling 27.1429 4 no
GO:0048584 positive regulation of response to stimulus 27.1429 4 no
GO:1902531 regulation of intracellular signal transduction 27.1429 5 no
GO:0042127 regulation of cell population proliferation 27.1429 4 no
GO:0051049 regulation of transport 25.7143 4 no
GO:0051174 regulation of phosphorus metabolic process 25.7143 5 no
GO:0071310 cellular response to organic substance 25.7143 4 no
GO:0042981 regulation of apoptotic process 25.7143 6 no
GO:0043067 regulation of programmed cell death 25.7143 5 no
GO:0019220 regulation of phosphate metabolic process 25.7143 6 no
GO:0042325 regulation of phosphorylation 24.2857 7 no
GO:1902533 positive regulation of intracellular signal transduction 24.2857 6 no
GO:0016192 vesicle-mediated transport 24.2857 4 no
GO:0022607 cellular component assembly 24.2857 4 no
GO:0030030 cell projection organization 24.2857 4 no
GO:0031399 regulation of protein modification process 24.2857 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.8571 5 no
GO:0009892 negative regulation of metabolic process 22.8571 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0051240 positive regulation of multicellular organismal process 21.4286 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.4286 6 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043085 positive regulation of catalytic activity 21.4286 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.4286 7 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 yes
GO:0006886 intracellular protein transport 21.4286 4 no
GO:0030155 regulation of cell adhesion 10.0000 4 yes
GO:0008610 lipid biosynthetic process 8.5714 4 yes
GO:0006631 fatty acid metabolic process 7.1429 4 yes
GO:0019752 carboxylic acid metabolic process 7.1429 5 yes
GO:0032787 monocarboxylic acid metabolic process 7.1429 6 yes
GO:0043436 oxoacid metabolic process 7.1429 4 yes
GO:0043603 cellular amide metabolic process 7.1429 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 7.1429 4 yes
GO:0045785 positive regulation of cell adhesion 7.1429 5 yes
GO:0006633 fatty acid biosynthetic process 5.7143 5 yes
GO:0010810 regulation of cell-substrate adhesion 5.7143 5 yes
GO:0016053 organic acid biosynthetic process 5.7143 4 yes
GO:0046394 carboxylic acid biosynthetic process 5.7143 5 yes
GO:0072330 monocarboxylic acid biosynthetic process 5.7143 6 yes
GO:0006163 purine nucleotide metabolic process 4.2857 5 yes
GO:0006753 nucleoside phosphate metabolic process 4.2857 4 yes
GO:0009117 nucleotide metabolic process 4.2857 5 yes
GO:0009150 purine ribonucleotide metabolic process 4.2857 6 yes
GO:0009259 ribonucleotide metabolic process 4.2857 5 yes
GO:0010811 positive regulation of cell-substrate adhesion 4.2857 6 yes
GO:0019693 ribose phosphate metabolic process 4.2857 4 yes
GO:0043604 amide biosynthetic process 4.2857 5 yes
GO:0072521 purine-containing compound metabolic process 4.2857 4 yes
GO:0090407 organophosphate biosynthetic process 4.2857 4 yes
GO:1901566 organonitrogen compound biosynthetic process 4.2857 4 yes
GO:0008202 steroid metabolic process 2.8571 4 yes
GO:0008210 estrogen metabolic process 2.8571 4 yes
GO:0018130 heterocycle biosynthetic process 2.8571 4 yes
GO:0019438 aromatic compound biosynthetic process 2.8571 4 yes
GO:0030198 extracellular matrix organization 2.8571 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 2.8571 4 yes
GO:0043062 extracellular structure organization 2.8571 4 yes
GO:0045229 external encapsulating structure organization 2.8571 4 yes
GO:1901362 organic cyclic compound biosynthetic process 2.8571 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNFL8_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view interactions] High throughput no yes
CATL1_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TM11B_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOF_HUMAN [view interactions] High throughput no no
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
NSDHL_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF5_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ATPG_HUMAN [view interactions] High throughput no yes
COPB_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
SCD_HUMAN [view entry] [view interactions] High throughput yes yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
SSRG_HUMAN [view interactions] High throughput no yes
TECR_HUMAN [view interactions] High throughput no yes
TMCO1_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
SYWC_HUMAN [view interactions] High throughput no yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
CYB5_HUMAN [view interactions] High throughput no no
TRI14_HUMAN [view interactions] High throughput no yes
SYVN1_HUMAN [view interactions] High throughput no yes
CALR3_HUMAN [view interactions] High throughput no no
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
COIL_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LMAN1_HUMAN [view interactions] High throughput no yes
PANX1_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
BROMI_HUMAN [view interactions] High throughput no no
CATB_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
BECN1_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
HDA11_HUMAN [view interactions] High throughput no no
S38A1_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
MK07_HUMAN [view interactions] High throughput no yes
ELK1_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
VAV_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
CNR2_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
MTMRE_HUMAN [view entry] [view interactions] High throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC3_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
M4A4A_HUMAN [view interactions] High throughput no no
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
KS6A5_HUMAN [view entry] [view interactions] High throughput yes yes
JAK3_HUMAN [view interactions] High throughput no no
ADCK2_HUMAN [view interactions] High throughput no yes
TSSK6_HUMAN [view interactions] High throughput no no
SRPK3_HUMAN [view interactions] High throughput no no
SG196_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRB_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL1_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
JMJD4_HUMAN [view interactions] High throughput no no
TECT3_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
MERTK_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
ELOV1_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
RING2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
RN157_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
TPTE_HUMAN [view interactions] High throughput no no
HIF1A_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
CTCF_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
MOT1_HUMAN [view interactions] High throughput no no
S61A1_HUMAN [view interactions] High throughput no no
RN170_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
VIPR1_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
HACD4_HUMAN [view interactions] Computational no no
DHB1_HUMAN [view interactions] Computational no no
ELOV7_HUMAN [view interactions] Computational no no
HACD3_HUMAN [view interactions] Computational no yes
DHB2_HUMAN [view interactions] Computational no no
DHB8_HUMAN [view interactions] Computational no yes
SCD5_HUMAN [view entry] [view interactions] Computational yes yes
ST1E1_HUMAN [view interactions] Computational no no
HACD2_HUMAN [view interactions] Computational no yes
H17B6_HUMAN [view interactions] Computational no yes
ELOV2_HUMAN [view interactions] Computational no no
DHB7_HUMAN [view interactions] Computational no yes
HACD1_HUMAN [view interactions] Computational no no
CP1A1_HUMAN [view interactions] Computational no yes
ELOV3_HUMAN [view interactions] Computational no no
CP19A_HUMAN [view interactions] Computational no no
DHR11_HUMAN [view interactions] Computational no no
ELOV4_HUMAN [view interactions] Computational no no
ELOV6_HUMAN [view interactions] Computational no yes
CP3A5_HUMAN [view interactions] Computational no no
CP1B1_HUMAN [view entry] [view interactions] Computational yes yes