MTMRE_HUMAN
Evidence for PS localization
Functions
Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MTMRE_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 35.8974 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.8974 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.8974 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.8974 | 4 | no |
| GO:0043168 | anion binding | 35.8974 | 4 | no |
| GO:0005524 | ATP binding | 28.2051 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.2051 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.2051 | 5 | no |
| GO:0043169 | cation binding | 20.5128 | 4 | no |
| GO:0046872 | metal ion binding | 20.5128 | 5 | no |
| GO:0004722 | protein serine/threonine phosphatase activity | 7.6923 | 4 | yes |
| GO:0016791 | phosphatase activity | 7.6923 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 7.6923 | 4 | yes |
| GO:0004438 | phosphatidylinositol-3-phosphate phosphatase activity | 5.1282 | 8 | yes |
| GO:0034593 | phosphatidylinositol bisphosphate phosphatase activity | 5.1282 | 7 | yes |
| GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | 5.1282 | 9 | yes |
| GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 5.1282 | 7 | yes |
| GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 5.1282 | 6 | yes |
| GO:0106018 | phosphatidylinositol-3,5-bisphosphate phosphatase activity | 5.1282 | 8 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MTMRE_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.2821 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 46.1538 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.1538 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.1538 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.8974 | 4 | no |
| GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 30.7692 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.7692 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0008104 | protein localization | 28.2051 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.2051 | 6 | no |
| GO:0043933 | protein-containing complex organization | 28.2051 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.2051 | 5 | no |
| GO:0032880 | regulation of protein localization | 28.2051 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.6410 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.6410 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.6410 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.6410 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.6410 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.6410 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.6410 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.6410 | 6 | no |
| GO:0036211 | protein modification process | 25.6410 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 25.6410 | 4 | no |
| GO:0043412 | macromolecule modification | 25.6410 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.6410 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.6410 | 4 | no |
| GO:0051049 | regulation of transport | 25.6410 | 4 | no |
| GO:0008610 | lipid biosynthetic process | 23.0769 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.0769 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 23.0769 | 6 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 23.0769 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 23.0769 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0030030 | cell projection organization | 20.5128 | 4 | no |
| GO:0071702 | organic substance transport | 20.5128 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5128 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.5128 | 7 | no |
| GO:0033043 | regulation of organelle organization | 20.5128 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.5128 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 20.5128 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5128 | 6 | no |
| GO:0090407 | organophosphate biosynthetic process | 17.9487 | 4 | yes |
| GO:0016236 | macroautophagy | 15.3846 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 10.2564 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 7.6923 | 5 | yes |
| GO:0016311 | dephosphorylation | 7.6923 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 7.6923 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 5.1282 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 5.1282 | 6 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 5.1282 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 5.1282 | 5 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 5.1282 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATG12_HUMAN | [view interactions] | Low throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | Low throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| MTA2_HUMAN | [view interactions] | High throughput | no | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELK4_HUMAN | [view interactions] | High throughput | no | yes |
| CAV2_HUMAN | [view interactions] | High throughput | no | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRR_HUMAN | [view interactions] | High throughput | no | yes |
| RHG20_HUMAN | [view interactions] | High throughput | no | no |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| POSTN_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TIE1_HUMAN | [view interactions] | High throughput | no | no |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| AFAM_HUMAN | [view interactions] | High throughput | no | no |
| BPIB1_HUMAN | [view interactions] | High throughput | no | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| GNB1L_HUMAN | [view interactions] | High throughput | no | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| GMPPA_HUMAN | [view interactions] | High throughput | no | no |
| MISSL_HUMAN | [view interactions] | High throughput | no | yes |
| ANFC_HUMAN | [view interactions] | High throughput | no | no |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| SCO2_HUMAN | [view interactions] | High throughput | no | no |
| SFXN4_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD8_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR3_HUMAN | [view interactions] | High throughput | no | no |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| WDR54_HUMAN | [view interactions] | High throughput | no | no |
| PLSI_HUMAN | [view interactions] | High throughput | no | no |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| BSPRY_HUMAN | [view interactions] | High throughput | no | no |
| CDN2C_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAD1_HUMAN | [view interactions] | High throughput | no | yes |
| FN3K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KT3K_HUMAN | [view interactions] | High throughput | no | yes |
| GPX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| PADI2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |