Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACSL4_HUMAN

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed, PubMed, PubMed). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs . Modulates prostaglandin E2 secretion (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.
Position Amino acid Mutation Disease Overlap with binding region
570 Arg Ser Intellectualdevelopmentaldisorder,X-linked63(XLID63) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ACSL4_HUMAN
GO:0043168 anion binding 40.4762 4 yes
GO:0000166 nucleotide binding 38.0952 4 yes
GO:0017076 purine nucleotide binding 38.0952 5 yes
GO:0032555 purine ribonucleotide binding 38.0952 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 35.7143 4 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0043169 cation binding 23.8095 4 no
GO:0046872 metal ion binding 23.8095 5 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0016462 pyrophosphatase activity 21.4286 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.4286 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.4286 6 no
GO:0030554 adenyl nucleotide binding 19.0476 6 yes
GO:0032559 adenyl ribonucleotide binding 19.0476 5 yes
GO:0005524 ATP binding 16.6667 5 yes
GO:0016405 CoA-ligase activity 4.7619 4 yes
GO:0016878 acid-thiol ligase activity 4.7619 4 yes
GO:0047676 arachidonate-CoA ligase activity 4.7619 4 yes
GO:0090433 palmitoyl-CoA ligase activity 4.7619 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACSL4_HUMAN
GO:0048522 positive regulation of cellular process 59.5238 4 yes
GO:0048523 negative regulation of cellular process 52.3810 4 yes
GO:0031323 regulation of cellular metabolic process 52.3810 4 no
GO:0080090 regulation of primary metabolic process 52.3810 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0010646 regulation of cell communication 47.6190 4 yes
GO:0009893 positive regulation of metabolic process 40.4762 4 no
GO:0009966 regulation of signal transduction 40.4762 4 no
GO:0022607 cellular component assembly 40.4762 4 no
GO:0009889 regulation of biosynthetic process 38.0952 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.0952 5 no
GO:0031326 regulation of cellular biosynthetic process 38.0952 5 no
GO:0051246 regulation of protein metabolic process 38.0952 5 no
GO:0008104 protein localization 35.7143 4 no
GO:0010468 regulation of gene expression 35.7143 6 no
GO:0010556 regulation of macromolecule biosynthetic process 35.7143 5 no
GO:0042981 regulation of apoptotic process 35.7143 5 no
GO:0043067 regulation of programmed cell death 35.7143 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 30.9524 5 yes
GO:0023056 positive regulation of signaling 30.9524 4 yes
GO:0009892 negative regulation of metabolic process 30.9524 4 no
GO:0019220 regulation of phosphate metabolic process 30.9524 6 no
GO:0051174 regulation of phosphorus metabolic process 30.9524 5 no
GO:0051252 regulation of RNA metabolic process 30.9524 5 no
GO:0051049 regulation of transport 28.5714 4 yes
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 26.1905 4 yes
GO:0009967 positive regulation of signal transduction 26.1905 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.1905 6 no
GO:0042127 regulation of cell population proliferation 26.1905 4 no
GO:0044087 regulation of cellular component biogenesis 26.1905 4 no
GO:0048584 positive regulation of response to stimulus 26.1905 4 no
GO:0141124 intracellular signaling cassette 26.1905 4 no
GO:1902533 positive regulation of intracellular signal transduction 26.1905 6 no
GO:0031324 negative regulation of cellular metabolic process 26.1905 5 no
GO:0033043 regulation of organelle organization 26.1905 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0031401 positive regulation of protein modification process 23.8095 7 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0098657 import into cell 23.8095 4 no
GO:0043523 regulation of neuron apoptotic process 23.8095 6 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:0032880 regulation of protein localization 21.4286 5 yes
GO:0060341 regulation of cellular localization 21.4286 4 yes
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0006357 regulation of transcription by RNA polymerase II 21.4286 8 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0042327 positive regulation of phosphorylation 21.4286 8 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0051130 positive regulation of cellular component organization 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0051050 positive regulation of transport 16.6667 4 yes
GO:0070201 regulation of establishment of protein localization 16.6667 6 yes
GO:0001558 regulation of cell growth 16.6667 4 yes
GO:1903829 positive regulation of protein localization 14.2857 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 11.9048 4 yes
GO:0051046 regulation of secretion 11.9048 5 yes
GO:0051223 regulation of protein transport 11.9048 5 yes
GO:1901362 organic cyclic compound biosynthetic process 11.9048 4 yes
GO:0006753 nucleoside phosphate metabolic process 9.5238 4 yes
GO:0009117 nucleotide metabolic process 9.5238 5 yes
GO:0009150 purine ribonucleotide metabolic process 9.5238 6 yes
GO:0009259 ribonucleotide metabolic process 9.5238 5 yes
GO:0019693 ribose phosphate metabolic process 9.5238 4 yes
GO:0030307 positive regulation of cell growth 9.5238 5 yes
GO:0045927 positive regulation of growth 9.5238 4 yes
GO:0051047 positive regulation of secretion 9.5238 5 yes
GO:0051051 negative regulation of transport 9.5238 4 yes
GO:0072521 purine-containing compound metabolic process 9.5238 4 yes
GO:0090407 organophosphate biosynthetic process 9.5238 4 yes
GO:1901566 organonitrogen compound biosynthetic process 9.5238 4 yes
GO:1903530 regulation of secretion by cell 9.5238 4 yes
GO:1904951 positive regulation of establishment of protein localization 9.5238 6 yes
GO:0006163 purine nucleotide metabolic process 9.5238 5 yes
GO:0008610 lipid biosynthetic process 7.1429 4 yes
GO:0009152 purine ribonucleotide biosynthetic process 7.1429 7 yes
GO:0009165 nucleotide biosynthetic process 7.1429 6 yes
GO:0009260 ribonucleotide biosynthetic process 7.1429 6 yes
GO:0019752 carboxylic acid metabolic process 7.1429 5 yes
GO:0043436 oxoacid metabolic process 7.1429 4 yes
GO:0044272 sulfur compound biosynthetic process 7.1429 4 yes
GO:0046390 ribose phosphate biosynthetic process 7.1429 5 yes
GO:0051048 negative regulation of secretion 7.1429 5 yes
GO:0051222 positive regulation of protein transport 7.1429 5 yes
GO:0072522 purine-containing compound biosynthetic process 7.1429 5 yes
GO:1901137 carbohydrate derivative biosynthetic process 7.1429 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 7.1429 5 yes
GO:1903531 negative regulation of secretion by cell 7.1429 5 yes
GO:1903532 positive regulation of secretion by cell 7.1429 5 yes
GO:0006164 purine nucleotide biosynthetic process 7.1429 6 yes
GO:0030182 neuron differentiation 4.7619 4 yes
GO:0032368 regulation of lipid transport 4.7619 5 yes
GO:0032787 monocarboxylic acid metabolic process 4.7619 6 yes
GO:0033865 nucleoside bisphosphate metabolic process 4.7619 5 yes
GO:0033866 nucleoside bisphosphate biosynthetic process 4.7619 6 yes
GO:0033875 ribonucleoside bisphosphate metabolic process 4.7619 6 yes
GO:0034030 ribonucleoside bisphosphate biosynthetic process 4.7619 7 yes
GO:0034032 purine nucleoside bisphosphate metabolic process 4.7619 5 yes
GO:0034033 purine nucleoside bisphosphate biosynthetic process 4.7619 6 yes
GO:0035336 long-chain fatty-acyl-CoA metabolic process 4.7619 5 yes
GO:0035337 fatty-acyl-CoA metabolic process 4.7619 4 yes
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process 4.7619 6 yes
GO:0035384 thioester biosynthetic process 4.7619 4 yes
GO:0046883 regulation of hormone secretion 4.7619 4 yes
GO:0046949 fatty-acyl-CoA biosynthetic process 4.7619 5 yes
GO:0050708 regulation of protein secretion 4.7619 5 yes
GO:0050796 regulation of insulin secretion 4.7619 6 yes
GO:0071616 acyl-CoA biosynthetic process 4.7619 4 yes
GO:0090087 regulation of peptide transport 4.7619 5 yes
GO:0090276 regulation of peptide hormone secretion 4.7619 5 yes
GO:1901568 fatty acid derivative metabolic process 4.7619 4 yes
GO:1901570 fatty acid derivative biosynthetic process 4.7619 5 yes
GO:1905952 regulation of lipid localization 4.7619 4 yes
GO:0001676 long-chain fatty acid metabolic process 4.7619 5 yes
GO:0002791 regulation of peptide secretion 4.7619 6 yes
GO:0006631 fatty acid metabolic process 4.7619 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HTAI2_HUMAN [view interactions] Low throughput no yes
TNAP3_HUMAN [view interactions] Low throughput no yes
STING_HUMAN [view interactions] Low throughput no yes
EED_HUMAN [view interactions] High throughput no yes
EID3_HUMAN [view interactions] High throughput no no
GNAT2_HUMAN [view interactions] High throughput no no
TB22A_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
ABCG1_HUMAN [view interactions] High throughput no yes
TJAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SHLB1_HUMAN [view interactions] High throughput no yes
TOIP2_HUMAN [view interactions] High throughput no no
NEP_HUMAN [view interactions] High throughput no no
S6A15_HUMAN [view interactions] High throughput no yes
S15A1_HUMAN [view interactions] High throughput no no
S39AC_HUMAN [view interactions] High throughput no no
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
RN185_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
CRCM1_HUMAN [view interactions] High throughput no yes
OPRX_HUMAN [view interactions] High throughput no no
NAGAB_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
S22A2_HUMAN [view interactions] High throughput no no
GPR12_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
TNFL8_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
DQA1_HUMAN [view interactions] High throughput no yes
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
ASGR2_HUMAN [view interactions] High throughput no no
RSP14_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
LCN6_HUMAN [view interactions] High throughput no no
T150A_HUMAN [view interactions] High throughput no yes
BRNP2_HUMAN [view interactions] High throughput no no
ACTT2_HUMAN [view interactions] High throughput no no
S22A9_HUMAN [view interactions] High throughput no no
NPRL3_HUMAN [view interactions] High throughput no yes
DHI1_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
KCNK1_HUMAN [view entry] [view interactions] High throughput yes yes
TGT_HUMAN [view interactions] High throughput no no
AT2A3_HUMAN [view interactions] High throughput no yes
DMB_HUMAN [view interactions] High throughput no no
NUBP2_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANTR1_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
NMT1_HUMAN [view interactions] High throughput no yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CNPY3_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
UVRAG_HUMAN [view interactions] High throughput no yes
RT15_HUMAN [view interactions] High throughput no yes
AAAT_HUMAN [view interactions] High throughput no no
TF3B_HUMAN [view interactions] High throughput no yes
EDEM1_HUMAN [view interactions] High throughput no yes
ACSL3_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
PTPM1_HUMAN [view interactions] High throughput no yes
CHC10_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
SPT20_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
MTMRE_HUMAN [view entry] [view interactions] High throughput yes yes
RMC1_HUMAN [view interactions] High throughput no no
H2B1H_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
COQ8A_HUMAN [view interactions] High throughput no no
SG196_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
DSE_HUMAN [view interactions] High throughput no yes
SPART_HUMAN [view interactions] High throughput no yes
FOXA3_HUMAN [view interactions] High throughput no yes
FOXL2_HUMAN [view interactions] High throughput no no
FOXQ1_HUMAN [view interactions] High throughput no no
FOXJ1_HUMAN [view interactions] High throughput no no
FOXI2_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
MIC10_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
FOXP3_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
P53_HUMAN [view interactions] High throughput no no
GCP3_HUMAN [view interactions] High throughput no yes