VA0D1_HUMAN
Evidence for PS localization
Functions
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed, PubMed). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed). May play a role in coupling of proton transport and ATP hydrolysis . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VA0D1_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 28.9474 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 28.9474 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 23.6842 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 22.3684 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 22.3684 | 4 | yes |
| GO:0000166 | nucleotide binding | 22.3684 | 4 | no |
| GO:0043169 | cation binding | 21.0526 | 4 | no |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 11.8421 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 11.8421 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VA0D1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 44.7368 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.7368 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 43.4211 | 4 | no |
| GO:0022607 | cellular component assembly | 40.7895 | 4 | yes |
| GO:0010646 | regulation of cell communication | 39.4737 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.4737 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.8421 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.8421 | 4 | no |
| GO:0009894 | regulation of catabolic process | 35.5263 | 4 | yes |
| GO:0008104 | protein localization | 35.5263 | 4 | no |
| GO:0051049 | regulation of transport | 35.5263 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.8947 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.5789 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.9474 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.9474 | 4 | no |
| GO:0071702 | organic substance transport | 28.9474 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.9474 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 27.6316 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.6316 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.3158 | 4 | no |
| GO:0006811 | monoatomic ion transport | 25.0000 | 4 | yes |
| GO:0010506 | regulation of autophagy | 25.0000 | 6 | yes |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.6842 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.6842 | 5 | no |
| GO:0006812 | monoatomic cation transport | 22.3684 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 22.3684 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 22.3684 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 22.3684 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 22.3684 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.3684 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.3684 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.3684 | 4 | no |
| GO:0033043 | regulation of organelle organization | 22.3684 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.0526 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
| GO:0016241 | regulation of macroautophagy | 19.7368 | 7 | yes |
| GO:0098655 | monoatomic cation transmembrane transport | 19.7368 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 19.7368 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 17.1053 | 5 | yes |
| GO:0030030 | cell projection organization | 15.7895 | 4 | yes |
| GO:0070925 | organelle assembly | 14.4737 | 5 | yes |
| GO:0097401 | synaptic vesicle lumen acidification | 13.1579 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 13.1579 | 5 | yes |
| GO:0007034 | vacuolar transport | 11.8421 | 4 | yes |
| GO:0051452 | intracellular pH reduction | 11.8421 | 4 | yes |
| GO:0007035 | vacuolar acidification | 10.5263 | 5 | yes |
| GO:0030031 | cell projection assembly | 5.2632 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 5.2632 | 6 | yes |
| GO:0006879 | intracellular iron ion homeostasis | 3.9474 | 4 | yes |
| GO:0036295 | cellular response to increased oxygen levels | 3.9474 | 5 | yes |
| GO:0036296 | response to increased oxygen levels | 3.9474 | 4 | yes |
| GO:0044782 | cilium organization | 3.9474 | 5 | yes |
| GO:0060271 | cilium assembly | 3.9474 | 6 | yes |
| GO:0071453 | cellular response to oxygen levels | 3.9474 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| VA0E1_HUMAN | [view interactions] | Low throughput | no | no |
| VATO_HUMAN | [view interactions] | Low throughput | no | no |
| RNK_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| KI18B_HUMAN | [view interactions] | High throughput | no | no |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| MFS4B_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| RDH13_HUMAN | [view interactions] | High throughput | no | no |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX19_HUMAN | [view interactions] | High throughput | no | yes |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| CC115_HUMAN | [view interactions] | High throughput | no | no |
| SNX25_HUMAN | [view interactions] | High throughput | no | no |
| PGES2_HUMAN | [view interactions] | High throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| S27A6_HUMAN | [view interactions] | High throughput | no | yes |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM199_HUMAN | [view interactions] | High throughput | no | yes |
| NTCP7_HUMAN | [view interactions] | High throughput | no | no |
| S38A9_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TLX3_HUMAN | [view interactions] | High throughput | no | no |
| DMRT3_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| IKZF3_HUMAN | [view interactions] | High throughput | no | no |
| IHO1_HUMAN | [view interactions] | High throughput | no | no |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| GATA1_HUMAN | [view interactions] | High throughput | no | no |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| S22AN_HUMAN | [view interactions] | High throughput | no | yes |
| UBP4_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| AGRL1_HUMAN | [view interactions] | High throughput | no | no |
| ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| UT1_HUMAN | [view interactions] | High throughput | no | no |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S38A7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUL_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |