VA0D1_HUMAN
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed, PubMed). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed). May play a role in coupling of proton transport and ATP hydrolysis . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in VA0D1_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 25.7143 | 4 | yes |
GO:0015399 | primary active transmembrane transporter activity | 25.7143 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 25.7143 | 4 | yes |
GO:0022853 | active ion transmembrane transporter activity | 22.8571 | 4 | yes |
GO:0015078 | proton transmembrane transporter activity | 18.5714 | 5 | yes |
GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 12.8571 | 5 | yes |
GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 12.8571 | 4 | yes |
GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 12.8571 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in VA0D1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | yes |
GO:0006996 | organelle organization | 35.7143 | 4 | yes |
GO:0010646 | regulation of cell communication | 35.7143 | 4 | no |
GO:0009894 | regulation of catabolic process | 34.2857 | 4 | yes |
GO:0022607 | cellular component assembly | 34.2857 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 34.2857 | 4 | no |
GO:0051128 | regulation of cellular component organization | 31.4286 | 4 | no |
GO:0008104 | protein localization | 30.0000 | 4 | no |
GO:0006811 | ion transport | 28.5714 | 4 | yes |
GO:0031329 | regulation of cellular catabolic process | 28.5714 | 5 | yes |
GO:0071702 | organic substance transport | 28.5714 | 4 | no |
GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010506 | regulation of autophagy | 27.1429 | 6 | yes |
GO:0043933 | protein-containing complex organization | 27.1429 | 4 | no |
GO:0051049 | regulation of transport | 27.1429 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.7143 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 25.7143 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.7143 | 4 | no |
GO:0016241 | regulation of macroautophagy | 24.2857 | 7 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 24.2857 | 4 | no |
GO:0065003 | protein-containing complex assembly | 24.2857 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.8571 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 22.8571 | 5 | no |
GO:0006812 | cation transport | 21.4286 | 5 | yes |
GO:0048878 | chemical homeostasis | 21.4286 | 4 | yes |
GO:0061024 | membrane organization | 21.4286 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 21.4286 | 5 | no |
GO:0006873 | cellular ion homeostasis | 17.1429 | 4 | yes |
GO:0030003 | cellular cation homeostasis | 17.1429 | 5 | yes |
GO:0050801 | ion homeostasis | 17.1429 | 5 | yes |
GO:0055080 | cation homeostasis | 17.1429 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 17.1429 | 6 | yes |
GO:0098655 | cation transmembrane transport | 15.7143 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 15.7143 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 15.7143 | 5 | yes |
GO:1902600 | proton transmembrane transport | 14.2857 | 6 | yes |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 12.8571 | 6 | yes |
GO:0030030 | cell projection organization | 12.8571 | 4 | yes |
GO:0055067 | monovalent inorganic cation homeostasis | 12.8571 | 7 | yes |
GO:0006875 | cellular metal ion homeostasis | 11.4286 | 6 | yes |
GO:0055065 | metal ion homeostasis | 11.4286 | 7 | yes |
GO:0070925 | organelle assembly | 11.4286 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 11.4286 | 5 | yes |
GO:0006885 | regulation of pH | 7.1429 | 8 | yes |
GO:0007034 | vacuolar transport | 7.1429 | 4 | yes |
GO:0030641 | regulation of cellular pH | 7.1429 | 7 | yes |
GO:0051452 | intracellular pH reduction | 7.1429 | 9 | yes |
GO:0051453 | regulation of intracellular pH | 7.1429 | 8 | yes |
GO:0007035 | vacuolar acidification | 5.7143 | 10 | yes |
GO:0030031 | cell projection assembly | 5.7143 | 5 | yes |
GO:0120031 | plasma membrane bounded cell projection assembly | 5.7143 | 6 | yes |
GO:0006879 | cellular iron ion homeostasis | 4.2857 | 8 | yes |
GO:0036295 | cellular response to increased oxygen levels | 4.2857 | 5 | yes |
GO:0036296 | response to increased oxygen levels | 4.2857 | 4 | yes |
GO:0044782 | cilium organization | 4.2857 | 5 | yes |
GO:0046916 | cellular transition metal ion homeostasis | 4.2857 | 7 | yes |
GO:0055072 | iron ion homeostasis | 4.2857 | 9 | yes |
GO:0055076 | transition metal ion homeostasis | 4.2857 | 8 | yes |
GO:0060271 | cilium assembly | 4.2857 | 6 | yes |
GO:0071453 | cellular response to oxygen levels | 4.2857 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
VATO_HUMAN | [view interactions] | Low throughput | no | no |
VA0E1_HUMAN | [view interactions] | Low throughput | no | no |
VA0E2_HUMAN | [view interactions] | Low throughput | no | no |
RNK_HUMAN | [view interactions] | Low throughput | no | yes |
RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VATF_HUMAN | [view interactions] | Low throughput | no | yes |
VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
VATL_HUMAN | [view interactions] | Low throughput | no | no |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
PPT1_HUMAN | [view interactions] | High throughput | no | yes |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
CD177_HUMAN | [view interactions] | High throughput | no | no |
EGLN_HUMAN | [view interactions] | High throughput | no | no |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
TLX3_HUMAN | [view interactions] | High throughput | no | no |
DMRT3_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
A2MG_HUMAN | [view interactions] | High throughput | no | yes |
SF01_HUMAN | [view interactions] | High throughput | no | yes |
IKZF3_HUMAN | [view interactions] | High throughput | no | no |
IHO1_HUMAN | [view interactions] | High throughput | no | no |
DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
RBPMS_HUMAN | [view interactions] | High throughput | no | no |
GATA1_HUMAN | [view interactions] | High throughput | no | no |
TLE5_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATB1_HUMAN | [view interactions] | High throughput | no | no |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
SERC2_HUMAN | [view interactions] | High throughput | no | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEPR_HUMAN | [view interactions] | High throughput | no | no |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
S22AN_HUMAN | [view interactions] | High throughput | no | yes |
UBP4_HUMAN | [view interactions] | High throughput | no | no |
B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
IKIP_HUMAN | [view interactions] | High throughput | no | no |
K2013_HUMAN | [view interactions] | High throughput | no | yes |
AGRL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACSL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
VPP4_HUMAN | [view interactions] | High throughput | no | no |
T185A_HUMAN | [view interactions] | High throughput | no | no |
UT1_HUMAN | [view interactions] | High throughput | no | no |
TM192_HUMAN | [view interactions] | High throughput | no | yes |
VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
AT1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
ATPD_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YBOX3_HUMAN | [view interactions] | High throughput | no | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR6_HUMAN | [view interactions] | High throughput | no | yes |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM6_HUMAN | [view interactions] | High throughput | no | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
TOM5_HUMAN | [view interactions] | High throughput | no | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LTOR3_HUMAN | [view interactions] | High throughput | no | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
THOC2_HUMAN | [view interactions] | High throughput | no | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
CD2AP_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMC3_HUMAN | [view interactions] | High throughput | no | yes |
WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAST_HUMAN | [view interactions] | High throughput | no | yes |
KI18B_HUMAN | [view interactions] | High throughput | no | no |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
VPP2_HUMAN | [view interactions] | High throughput | no | yes |
S27A6_HUMAN | [view interactions] | High throughput | no | yes |
M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
PGES2_HUMAN | [view interactions] | High throughput | no | yes |
SNX25_HUMAN | [view interactions] | High throughput | no | no |
CC115_HUMAN | [view interactions] | High throughput | no | no |
F210B_HUMAN | [view interactions] | High throughput | no | yes |
SNX19_HUMAN | [view interactions] | High throughput | no | yes |
SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RDH13_HUMAN | [view interactions] | High throughput | no | no |
VA0D2_HUMAN | [view interactions] | High throughput | no | no |
MFS4B_HUMAN | [view interactions] | High throughput | no | yes |
VMA21_HUMAN | [view interactions] | High throughput | no | no |
DHC24_HUMAN | [view interactions] | High throughput | no | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
VPP3_HUMAN | [view interactions] | High throughput | no | no |
MVD1_HUMAN | [view interactions] | High throughput | no | yes |
ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
S27A2_HUMAN | [view interactions] | High throughput | no | no |
TM199_HUMAN | [view interactions] | High throughput | no | yes |
NTCP7_HUMAN | [view interactions] | High throughput | no | no |
S38A9_HUMAN | [view interactions] | High throughput | no | yes |
LTOR2_HUMAN | [view interactions] | High throughput | no | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
ATP5I_HUMAN | [view interactions] | Computational | no | yes |
VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
WDR59_HUMAN | [view interactions] | Computational | no | yes |
KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5G1_HUMAN | [view interactions] | Computational | no | no |
FNIP1_HUMAN | [view interactions] | Computational | no | yes |
XBP1_HUMAN | [view interactions] | Computational | no | no |
ATP5L_HUMAN | [view interactions] | Computational | no | yes |
SESN1_HUMAN | [view interactions] | Computational | no | no |
SZT2_HUMAN | [view interactions] | Computational | no | yes |
ATP5J_HUMAN | [view interactions] | Computational | no | yes |
FNIP2_HUMAN | [view interactions] | Computational | no | yes |
SEH1_HUMAN | [view interactions] | Computational | no | no |
ATP5H_HUMAN | [view interactions] | Computational | no | yes |
SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AT5G2_HUMAN | [view interactions] | Computational | no | yes |
WDR24_HUMAN | [view interactions] | Computational | no | yes |
ATPK_HUMAN | [view interactions] | Computational | no | yes |
CAST1_HUMAN | [view interactions] | Computational | no | yes |
VATG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SESN2_HUMAN | [view interactions] | Computational | no | no |
FLCN_HUMAN | [view interactions] | Computational | no | yes |
ATP6_HUMAN | [view interactions] | Computational | no | no |
MIO_HUMAN | [view interactions] | Computational | no | yes |
NPRL2_HUMAN | [view interactions] | Computational | no | yes |
SAMTR_HUMAN | [view interactions] | Computational | no | yes |
VATG3_HUMAN | [view interactions] | Computational | no | no |
AT5G3_HUMAN | [view interactions] | Computational | no | no |
ITFG2_HUMAN | [view interactions] | Computational | no | yes |
ATP5E_HUMAN | [view interactions] | Computational | no | no |
ATP8_HUMAN | [view interactions] | Computational | no | no |
VATC2_HUMAN | [view interactions] | Computational | no | yes |
SH3B4_HUMAN | [view interactions] | Computational | no | yes |
CAST2_HUMAN | [view interactions] | Computational | no | no |