Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VA0D1_HUMAN

Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase) (PubMed, PubMed). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (PubMed). May play a role in coupling of proton transport and ATP hydrolysis . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VA0D1_HUMAN
GO:0008324 cation transmembrane transporter activity 25.7143 4 yes
GO:0015399 primary active transmembrane transporter activity 25.7143 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 25.7143 4 yes
GO:0022853 active ion transmembrane transporter activity 22.8571 4 yes
GO:0015078 proton transmembrane transporter activity 18.5714 5 yes
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 12.8571 5 yes
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 12.8571 4 yes
GO:0046961 proton-transporting ATPase activity, rotational mechanism 12.8571 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VA0D1_HUMAN
GO:0048522 positive regulation of cellular process 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 40.0000 4 yes
GO:0006996 organelle organization 35.7143 4 yes
GO:0010646 regulation of cell communication 35.7143 4 no
GO:0009894 regulation of catabolic process 34.2857 4 yes
GO:0022607 cellular component assembly 34.2857 4 yes
GO:0048523 negative regulation of cellular process 34.2857 4 no
GO:0051128 regulation of cellular component organization 31.4286 4 no
GO:0008104 protein localization 30.0000 4 no
GO:0006811 ion transport 28.5714 4 yes
GO:0031329 regulation of cellular catabolic process 28.5714 5 yes
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010506 regulation of autophagy 27.1429 6 yes
GO:0043933 protein-containing complex organization 27.1429 4 no
GO:0051049 regulation of transport 27.1429 4 no
GO:0016192 vesicle-mediated transport 25.7143 4 no
GO:0080090 regulation of primary metabolic process 25.7143 4 no
GO:0009966 regulation of signal transduction 25.7143 4 no
GO:0016241 regulation of macroautophagy 24.2857 7 yes
GO:0051171 regulation of nitrogen compound metabolic process 24.2857 4 no
GO:0065003 protein-containing complex assembly 24.2857 5 no
GO:0023056 positive regulation of signaling 22.8571 4 no
GO:0010604 positive regulation of macromolecule metabolic process 22.8571 5 no
GO:0006812 cation transport 21.4286 5 yes
GO:0048878 chemical homeostasis 21.4286 4 yes
GO:0061024 membrane organization 21.4286 4 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no
GO:0006873 cellular ion homeostasis 17.1429 4 yes
GO:0030003 cellular cation homeostasis 17.1429 5 yes
GO:0050801 ion homeostasis 17.1429 5 yes
GO:0055080 cation homeostasis 17.1429 6 yes
GO:0098771 inorganic ion homeostasis 17.1429 6 yes
GO:0098655 cation transmembrane transport 15.7143 4 yes
GO:0098660 inorganic ion transmembrane transport 15.7143 4 yes
GO:0098662 inorganic cation transmembrane transport 15.7143 5 yes
GO:1902600 proton transmembrane transport 14.2857 6 yes
GO:0030004 cellular monovalent inorganic cation homeostasis 12.8571 6 yes
GO:0030030 cell projection organization 12.8571 4 yes
GO:0055067 monovalent inorganic cation homeostasis 12.8571 7 yes
GO:0006875 cellular metal ion homeostasis 11.4286 6 yes
GO:0055065 metal ion homeostasis 11.4286 7 yes
GO:0070925 organelle assembly 11.4286 5 yes
GO:0120036 plasma membrane bounded cell projection organization 11.4286 5 yes
GO:0006885 regulation of pH 7.1429 8 yes
GO:0007034 vacuolar transport 7.1429 4 yes
GO:0030641 regulation of cellular pH 7.1429 7 yes
GO:0051452 intracellular pH reduction 7.1429 9 yes
GO:0051453 regulation of intracellular pH 7.1429 8 yes
GO:0007035 vacuolar acidification 5.7143 10 yes
GO:0030031 cell projection assembly 5.7143 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 5.7143 6 yes
GO:0006879 cellular iron ion homeostasis 4.2857 8 yes
GO:0036295 cellular response to increased oxygen levels 4.2857 5 yes
GO:0036296 response to increased oxygen levels 4.2857 4 yes
GO:0044782 cilium organization 4.2857 5 yes
GO:0046916 cellular transition metal ion homeostasis 4.2857 7 yes
GO:0055072 iron ion homeostasis 4.2857 9 yes
GO:0055076 transition metal ion homeostasis 4.2857 8 yes
GO:0060271 cilium assembly 4.2857 6 yes
GO:0071453 cellular response to oxygen levels 4.2857 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VATO_HUMAN [view interactions] Low throughput no no
VA0E1_HUMAN [view interactions] Low throughput no no
VA0E2_HUMAN [view interactions] Low throughput no no
RNK_HUMAN [view interactions] Low throughput no yes
RENR_HUMAN [view entry] [view interactions] Low throughput yes yes
VATD_HUMAN [view entry] [view interactions] Low throughput yes yes
VPP1_HUMAN [view entry] [view interactions] Low throughput yes yes
VATF_HUMAN [view interactions] Low throughput no yes
VAS1_HUMAN [view interactions] Low throughput no yes
VATL_HUMAN [view interactions] Low throughput no no
VMP1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
LITD1_HUMAN [view interactions] High throughput no no
CD177_HUMAN [view interactions] High throughput no no
EGLN_HUMAN [view interactions] High throughput no no
CNDD3_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
TLX3_HUMAN [view interactions] High throughput no no
DMRT3_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
ESR1_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
SF01_HUMAN [view interactions] High throughput no yes
IKZF3_HUMAN [view interactions] High throughput no no
IHO1_HUMAN [view interactions] High throughput no no
DNLI4_HUMAN [view interactions] High throughput no yes
RBPMS_HUMAN [view interactions] High throughput no no
GATA1_HUMAN [view interactions] High throughput no no
TLE5_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VATB1_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SERC2_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
CCDC9_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
LEPR_HUMAN [view interactions] High throughput no no
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
S22AN_HUMAN [view interactions] High throughput no yes
UBP4_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
IKIP_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
AGRL1_HUMAN [view entry] [view interactions] High throughput yes no
ACSL4_HUMAN [view entry] [view interactions] High throughput yes yes
TNIP2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TFE3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
VPP4_HUMAN [view interactions] High throughput no no
T185A_HUMAN [view interactions] High throughput no no
UT1_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
VATE1_HUMAN [view entry] [view interactions] High throughput yes yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
RB6I2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
ATPA_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
AT1A2_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
AT1B3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
ATPD_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
EIF3B_HUMAN [view interactions] High throughput no yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB7_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX3_HUMAN [view interactions] High throughput no yes
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS4_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD3_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6_HUMAN [view interactions] High throughput no yes
NB5R3_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM6_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
TOM5_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR3_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
THOC2_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
KCTD5_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
CBX1_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
EMC3_HUMAN [view interactions] High throughput no yes
WIPI2_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
KI18B_HUMAN [view interactions] High throughput no no
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
TMED2_HUMAN [view interactions] High throughput no yes
VPS4B_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RFWD3_HUMAN [view interactions] High throughput no yes
CSCL2_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
S27A6_HUMAN [view interactions] High throughput no yes
M1IP1_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
SNX25_HUMAN [view interactions] High throughput no no
CC115_HUMAN [view interactions] High throughput no no
F210B_HUMAN [view interactions] High throughput no yes
SNX19_HUMAN [view interactions] High throughput no yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
RDH13_HUMAN [view interactions] High throughput no no
VA0D2_HUMAN [view interactions] High throughput no no
MFS4B_HUMAN [view interactions] High throughput no yes
VMA21_HUMAN [view interactions] High throughput no no
DHC24_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
VPP3_HUMAN [view interactions] High throughput no no
MVD1_HUMAN [view interactions] High throughput no yes
ENPP1_HUMAN [view interactions] High throughput no yes
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
SHIP2_HUMAN [view interactions] High throughput no yes
S27A2_HUMAN [view interactions] High throughput no no
TM199_HUMAN [view interactions] High throughput no yes
NTCP7_HUMAN [view interactions] High throughput no no
S38A9_HUMAN [view interactions] High throughput no yes
LTOR2_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
SDHA_HUMAN [view interactions] High throughput no yes
ATG2A_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
SCRB2_HUMAN [view interactions] High throughput no yes
ATP5I_HUMAN [view interactions] Computational no yes
VATE2_HUMAN [view entry] [view interactions] Computational yes no
WDR59_HUMAN [view interactions] Computational no yes
KPTN_HUMAN [view entry] [view interactions] Computational yes yes
AT5G1_HUMAN [view interactions] Computational no no
FNIP1_HUMAN [view interactions] Computational no yes
XBP1_HUMAN [view interactions] Computational no no
ATP5L_HUMAN [view interactions] Computational no yes
SESN1_HUMAN [view interactions] Computational no no
SZT2_HUMAN [view interactions] Computational no yes
ATP5J_HUMAN [view interactions] Computational no yes
FNIP2_HUMAN [view interactions] Computational no yes
SEH1_HUMAN [view interactions] Computational no no
ATP5H_HUMAN [view interactions] Computational no yes
SEC13_HUMAN [view entry] [view interactions] Computational yes yes
AT5G2_HUMAN [view interactions] Computational no yes
WDR24_HUMAN [view interactions] Computational no yes
ATPK_HUMAN [view interactions] Computational no yes
CAST1_HUMAN [view interactions] Computational no yes
VATG2_HUMAN [view entry] [view interactions] Computational yes yes
SESN2_HUMAN [view interactions] Computational no no
FLCN_HUMAN [view interactions] Computational no yes
ATP6_HUMAN [view interactions] Computational no no
MIO_HUMAN [view interactions] Computational no yes
NPRL2_HUMAN [view interactions] Computational no yes
SAMTR_HUMAN [view interactions] Computational no yes
VATG3_HUMAN [view interactions] Computational no no
AT5G3_HUMAN [view interactions] Computational no no
ITFG2_HUMAN [view interactions] Computational no yes
ATP5E_HUMAN [view interactions] Computational no no
ATP8_HUMAN [view interactions] Computational no no
VATC2_HUMAN [view interactions] Computational no yes
SH3B4_HUMAN [view interactions] Computational no yes
CAST2_HUMAN [view interactions] Computational no no