Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LETM1_HUMAN

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed). Required for the maintenance of the tubular shape and cristae organization (PubMed). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LETM1_HUMAN
GO:0003723 RNA binding 31.6667 4 no
GO:0017076 purine nucleotide binding 26.6667 4 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0046872 metal ion binding 20.0000 4 yes
GO:0008324 cation transmembrane transporter activity 11.6667 4 yes
GO:0015078 proton transmembrane transporter activity 10.0000 5 yes
GO:0022853 active ion transmembrane transporter activity 10.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 10.0000 4 yes
GO:0005509 calcium ion binding 3.3333 5 yes
GO:0043022 ribosome binding 3.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LETM1_HUMAN
GO:0048523 negative regulation of cellular process 41.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 41.6667 4 no
GO:0006996 organelle organization 40.0000 4 yes
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.3333 4 no
GO:0010468 regulation of gene expression 35.0000 5 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 31.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.6667 5 no
GO:0051246 regulation of protein metabolic process 31.6667 5 no
GO:0009966 regulation of signal transduction 28.3333 4 no
GO:0010646 regulation of cell communication 28.3333 4 no
GO:0008104 protein localization 26.6667 4 no
GO:0071702 organic substance transport 26.6667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 26.6667 5 no
GO:0009892 negative regulation of metabolic process 26.6667 4 no
GO:0010941 regulation of cell death 26.6667 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0071705 nitrogen compound transport 23.3333 4 no
GO:0051128 regulation of cellular component organization 23.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 23.3333 5 no
GO:0042981 regulation of apoptotic process 23.3333 6 no
GO:1902531 regulation of intracellular signal transduction 23.3333 5 no
GO:0051247 positive regulation of protein metabolic process 21.6667 6 no
GO:0051252 regulation of RNA metabolic process 21.6667 5 no
GO:0043933 protein-containing complex organization 18.3333 4 yes
GO:0065003 protein-containing complex assembly 18.3333 5 yes
GO:0080134 regulation of response to stress 16.6667 4 yes
GO:0007005 mitochondrion organization 13.3333 5 yes
GO:0061024 membrane organization 13.3333 4 yes
GO:0006811 ion transport 10.0000 4 yes
GO:0048878 chemical homeostasis 10.0000 4 yes
GO:0006873 cellular ion homeostasis 8.3333 4 yes
GO:0030003 cellular cation homeostasis 8.3333 5 yes
GO:0050801 ion homeostasis 8.3333 5 yes
GO:0055080 cation homeostasis 8.3333 6 yes
GO:0080135 regulation of cellular response to stress 8.3333 4 yes
GO:0098771 inorganic ion homeostasis 8.3333 6 yes
GO:0006812 cation transport 6.6667 5 yes
GO:0006875 cellular metal ion homeostasis 6.6667 6 yes
GO:0055065 metal ion homeostasis 6.6667 7 yes
GO:0098655 cation transmembrane transport 6.6667 4 yes
GO:0007006 mitochondrial membrane organization 5.0000 5 yes
GO:0007007 inner mitochondrial membrane organization 5.0000 6 yes
GO:0051259 protein complex oligomerization 5.0000 6 yes
GO:0051260 protein homooligomerization 5.0000 7 yes
GO:0098660 inorganic ion transmembrane transport 5.0000 4 yes
GO:0098662 inorganic cation transmembrane transport 5.0000 5 yes
GO:0006874 cellular calcium ion homeostasis 3.3333 7 yes
GO:0030001 metal ion transport 3.3333 6 yes
GO:0042407 cristae formation 3.3333 7 yes
GO:0055074 calcium ion homeostasis 3.3333 8 yes
GO:0072503 cellular divalent inorganic cation homeostasis 3.3333 6 yes
GO:0072507 divalent inorganic cation homeostasis 3.3333 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in LETM1_HUMAN
DOID:700 mitochondrial metabolism disease 5.0000 3 no
DOID:1289 neurodegenerative disease 5.0000 4 no
DOID:331 central nervous system disease 5.0000 3 no
DOID:10595 Charcot-Marie-Tooth disease 5.0000 6 no
DOID:440 neuromuscular disease 5.0000 5 no
DOID:574 peripheral nervous system disease 5.0000 3 no
DOID:870 neuropathy 5.0000 4 no
DOID:0060286 combined oxidative phosphorylation deficiency 3.3333 4 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 3.3333 7 no
DOID:231 motor neuron disease 3.3333 5 no
DOID:0050155 sensory system disease 3.3333 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BCS1_HUMAN [view interactions] Low throughput no yes
ACOT9_HUMAN [view interactions] High throughput no yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
ADAS_HUMAN [view interactions] High throughput no yes
NB5R3_HUMAN [view interactions] High throughput no yes
MCAT_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
PREB_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ASPH_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
MRM1_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
GRSF1_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
MTRFR_HUMAN [view interactions] High throughput no yes
CQ080_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
CH082_HUMAN [view interactions] High throughput no yes
MCUR1_HUMAN [view interactions] High throughput no no
CC90B_HUMAN [view interactions] High throughput no yes
CHCH1_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
DDX28_HUMAN [view interactions] High throughput no yes
FAKD2_HUMAN [view interactions] High throughput no no
FAKD3_HUMAN [view interactions] High throughput no yes
FAKD5_HUMAN [view interactions] High throughput no yes
EFGM_HUMAN [view interactions] High throughput no yes
RRF2M_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
MCU_HUMAN [view interactions] High throughput no yes
MCUB_HUMAN [view interactions] High throughput no no
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
MET15_HUMAN [view interactions] High throughput no no
MET17_HUMAN [view interactions] High throughput no yes
MIC26_HUMAN [view entry] [view interactions] High throughput yes yes
RM11_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
FMT_HUMAN [view interactions] High throughput no yes
MTG1_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
RF1M_HUMAN [view interactions] High throughput no yes
RF1ML_HUMAN [view interactions] High throughput no yes
NGRN_HUMAN [view interactions] High throughput no yes
OTC_HUMAN [view interactions] High throughput no no
MPPA_HUMAN [view interactions] High throughput no yes
MPPB_HUMAN [view interactions] High throughput no yes
RMND1_HUMAN [view interactions] High throughput no yes
RUSD3_HUMAN [view interactions] High throughput no yes
RUSD4_HUMAN [view interactions] High throughput no yes
S2551_HUMAN [view interactions] High throughput no no
SLIRP_HUMAN [view interactions] High throughput no yes
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
SURF1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
FAKD4_HUMAN [view interactions] High throughput no yes
TEFM_HUMAN [view interactions] High throughput no no
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
TIM29_HUMAN [view interactions] High throughput no no
TMM70_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
CLPP_HUMAN [view interactions] High throughput no yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
DJC15_HUMAN [view interactions] High throughput no no
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
DJC28_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
SYAM_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
COX8A_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
PEX3_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ICT1_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
LATS2_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
SNR27_HUMAN [view interactions] High throughput no yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
RN19B_HUMAN [view interactions] High throughput no yes
UBP47_HUMAN [view interactions] High throughput no yes
3BHS2_HUMAN [view interactions] High throughput no no
CP1A1_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
NMES1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
PTPM1_HUMAN [view interactions] High throughput no yes
MAIP1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
PPM1A_HUMAN [view interactions] High throughput no yes
PEPL_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
CRCM_HUMAN [view interactions] High throughput no no
SGK1_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
PSA3_HUMAN [view interactions] High throughput no no
ZNF76_HUMAN [view interactions] High throughput no no
KRA62_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKIP_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PDK1_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
TR61B_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
LACTB_HUMAN [view interactions] High throughput no yes
OMA1_HUMAN [view interactions] High throughput no no
PARL_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PCDGG_HUMAN [view interactions] High throughput no no
RT11_HUMAN [view interactions] High throughput no yes
LYPD4_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CLC14_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
F234A_HUMAN [view interactions] High throughput no yes
RCL1_HUMAN [view interactions] High throughput no no
HYPM_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
CART_HUMAN [view interactions] High throughput no yes
GSX1_HUMAN [view interactions] High throughput no no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
MSS4_HUMAN [view interactions] High throughput no yes
LR14B_HUMAN [view interactions] High throughput no no
FSD2_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
MLC1_HUMAN [view interactions] High throughput no no
O2T10_HUMAN [view interactions] High throughput no no
CRYAA_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
PAIRB_HUMAN [view interactions] High throughput no yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SNP29_HUMAN [view interactions] High throughput no yes
MYLK4_HUMAN [view interactions] High throughput no no
UB2Q2_HUMAN [view interactions] High throughput no no
ICE2_HUMAN [view interactions] High throughput no no
TIDC1_HUMAN [view interactions] High throughput no yes
TRML2_HUMAN [view interactions] High throughput no no
T183A_HUMAN [view interactions] High throughput no no
MND1_HUMAN [view interactions] High throughput no no
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
OSGEP_HUMAN [view interactions] High throughput no yes
CDKAL_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
NTNG1_HUMAN [view interactions] High throughput no no
CBCO1_HUMAN [view interactions] High throughput no no
DNAL4_HUMAN [view interactions] High throughput no yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
CEP43_HUMAN [view interactions] High throughput no no
PEX19_HUMAN [view interactions] High throughput no yes
DNJB1_HUMAN [view entry] [view interactions] High throughput yes yes
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
EP300_HUMAN [view interactions] High throughput no yes
CLU_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
ASSY_HUMAN [view interactions] High throughput no yes
CLIP1_HUMAN [view entry] [view interactions] High throughput yes yes
DDB1_HUMAN [view interactions] High throughput no yes
HEAT3_HUMAN [view interactions] High throughput no yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
RER1_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
FITM2_HUMAN [view interactions] High throughput no no
ATG7_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
C10_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
ATPG_HUMAN [view interactions] High throughput no yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
THEM4_HUMAN [view interactions] Computational no no
NELFA_HUMAN [view interactions] Computational no yes
MICU1_HUMAN [view interactions] Computational no yes
NCLX_HUMAN [view interactions] Computational no yes
TPC10_HUMAN [view interactions] Computational no no