CLIP1_HUMAN
Evidence for PS localization
Functions
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001058 | LIG_CAP-Gly_1 | LIG | 1434 | 1438 | - |
| ELMI001058 | LIG_CAP-Gly_1 | LIG | 1434 | 1438 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CLIP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.2716 | 4 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.0988 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.6296 | 4 | no |
| GO:0019900 | kinase binding | 25.9259 | 4 | no |
| GO:0019901 | protein kinase binding | 25.9259 | 5 | no |
| GO:0043169 | cation binding | 24.6914 | 4 | yes |
| GO:0046872 | metal ion binding | 24.6914 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 24.6914 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.4568 | 5 | no |
| GO:0005524 | ATP binding | 20.9877 | 5 | no |
| GO:0008017 | microtubule binding | 14.8148 | 5 | yes |
| GO:0015631 | tubulin binding | 14.8148 | 4 | yes |
| GO:0051010 | microtubule plus-end binding | 11.1111 | 6 | yes |
| GO:0008270 | zinc ion binding | 4.9383 | 7 | yes |
| GO:0046914 | transition metal ion binding | 4.9383 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CLIP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.9136 | 4 | yes |
| GO:0006996 | organelle organization | 44.4444 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.9753 | 4 | no |
| GO:0007010 | cytoskeleton organization | 40.7407 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 37.0370 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.5679 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.6296 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.6296 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.6296 | 4 | no |
| GO:0033043 | regulation of organelle organization | 27.1605 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.1605 | 4 | yes |
| GO:0010646 | regulation of cell communication | 27.1605 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.9259 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.6914 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.6914 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4568 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 23.4568 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.4568 | 4 | no |
| GO:0008104 | protein localization | 23.4568 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.2222 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.9877 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.9877 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.9877 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.9877 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.9877 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 19.7531 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 19.7531 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 18.5185 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 18.5185 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 16.0494 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 16.0494 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 16.0494 | 7 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 16.0494 | 5 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 14.8148 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 13.5802 | 6 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 12.3457 | 6 | yes |
| GO:0031113 | regulation of microtubule polymerization | 11.1111 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 11.1111 | 7 | yes |
| GO:0031122 | cytoplasmic microtubule organization | 9.8765 | 4 | yes |
| GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 8.6420 | 7 | yes |
| GO:0031116 | positive regulation of microtubule polymerization | 8.6420 | 7 | yes |
| GO:0001578 | microtubule bundle formation | 4.9383 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DIAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| NDC80_HUMAN | [view interactions] | Low throughput | no | no |
| LIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | Low throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | Low throughput | no | no |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD13L_HUMAN | [view interactions] | High throughput | no | no |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T22D2_HUMAN | [view interactions] | High throughput | no | yes |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCGF1_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| OR2A4_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU107_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| KPYR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD3_HUMAN | [view interactions] | High throughput | no | no |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP93_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NUP37_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF2_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| NU133_HUMAN | [view interactions] | High throughput | no | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| FA50A_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BUB3_HUMAN | [view interactions] | High throughput | no | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| RPB2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| ELP4_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| HMMR_HUMAN | [view interactions] | High throughput | no | yes |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| MAST4_HUMAN | [view interactions] | High throughput | no | no |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| TEX9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| MA7D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MA7D2_HUMAN | [view interactions] | High throughput | no | yes |
| MA7D3_HUMAN | [view interactions] | High throughput | no | no |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |