ACTY_HUMAN
Evidence for PS localization
Functions
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACTY_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.4615 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 38.4615 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.4615 | 4 | yes |
| GO:0005524 | ATP binding | 36.5385 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.5385 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.5385 | 5 | yes |
| GO:0003779 | actin binding | 23.0769 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.1538 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.1538 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.1538 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACTY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.3846 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 63.4615 | 4 | no |
| GO:0033043 | regulation of organelle organization | 55.7692 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.0769 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 46.1538 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.2308 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.2308 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.2308 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.3846 | 4 | no |
| GO:0022607 | cellular component assembly | 40.3846 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.3846 | 4 | no |
| GO:0006996 | organelle organization | 38.4615 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 38.4615 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.5385 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.6154 | 4 | no |
| GO:0007010 | cytoskeleton organization | 32.6923 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.6923 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.7692 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.7692 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.7692 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 28.8462 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.8462 | 4 | no |
| GO:0051049 | regulation of transport | 26.9231 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.9231 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.9231 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0032271 | regulation of protein polymerization | 23.0769 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.0769 | 6 | no |
| GO:0010468 | regulation of gene expression | 23.0769 | 5 | no |
| GO:0030030 | cell projection organization | 23.0769 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.0769 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.0769 | 5 | no |
| GO:0033044 | regulation of chromosome organization | 21.1538 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.1538 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 21.1538 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ACTY_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.8462 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | Low throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMAD6_HUMAN | [view interactions] | Low throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN5_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPC2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN6_HUMAN | [view interactions] | High throughput | no | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDCL3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| MERB1_HUMAN | [view interactions] | High throughput | no | yes |
| AROS_HUMAN | [view interactions] | High throughput | no | yes |
| CSPP1_HUMAN | [view interactions] | High throughput | no | no |
| GPS2_HUMAN | [view interactions] | High throughput | no | yes |
| MS18A_HUMAN | [view interactions] | High throughput | no | yes |
| DB127_HUMAN | [view interactions] | High throughput | no | no |
| SCIN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGEF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CC062_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| MTA1_HUMAN | [view interactions] | High throughput | no | yes |
| VEZA_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| OBSCN_HUMAN | [view interactions] | High throughput | no | yes |
| SYNP2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLHL2_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDGFD_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CDCA5_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM2A_HUMAN | [view interactions] | High throughput | no | yes |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DYH5_HUMAN | [view interactions] | Computational | no | no |
| DYH7_HUMAN | [view interactions] | Computational | no | no |
| DYH12_HUMAN | [view interactions] | Computational | no | no |
| DNAL4_HUMAN | [view interactions] | Computational | no | yes |
| DNAL1_HUMAN | [view interactions] | Computational | no | no |
| HAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH1_HUMAN | [view interactions] | Computational | no | yes |
| DYH11_HUMAN | [view interactions] | Computational | no | no |
| DYH2_HUMAN | [view interactions] | Computational | no | no |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYH17_HUMAN | [view interactions] | Computational | no | no |
| MYO1A_HUMAN | [view interactions] | Computational | no | no |
| DYH3_HUMAN | [view interactions] | Computational | no | no |
| DYH6_HUMAN | [view interactions] | Computational | no | no |
| DNAI2_HUMAN | [view interactions] | Computational | no | no |
| DYH14_HUMAN | [view interactions] | Computational | no | no |
| DYH9_HUMAN | [view interactions] | Computational | no | no |