KCC1A_HUMAN
Evidence for PS localization
Functions
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on Ser-694, which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on Ser-91, Ser-92, Ser-93 and Ser-294. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of Ser-259 and Ser-498 in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on Ser-276 and Ser-295. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation . Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCC1A_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 53.5714 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0005509 | calcium ion binding | 21.4286 | 5 | no |
| GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 17.8571 | 4 | yes |
| GO:0016301 | kinase activity | 17.8571 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 17.8571 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 14.2857 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 14.2857 | 4 | yes |
| GO:0004683 | calmodulin-dependent protein kinase activity | 10.7143 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCC1A_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 67.8571 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 67.8571 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.7143 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.7143 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.7143 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 57.1429 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 53.5714 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 50.0000 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 50.0000 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 50.0000 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 50.0000 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 46.4286 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 46.4286 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.8571 | 5 | yes |
| GO:0036211 | protein modification process | 42.8571 | 4 | yes |
| GO:0043412 | macromolecule modification | 42.8571 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 42.8571 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 42.8571 | 6 | yes |
| GO:0051049 | regulation of transport | 42.8571 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 42.8571 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 39.2857 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 39.2857 | 7 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.2857 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 39.2857 | 6 | yes |
| GO:0010646 | regulation of cell communication | 39.2857 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 35.7143 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 35.7143 | 6 | yes |
| GO:0042327 | positive regulation of phosphorylation | 35.7143 | 8 | yes |
| GO:0043085 | positive regulation of catalytic activity | 35.7143 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 35.7143 | 7 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.1429 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 32.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.1429 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.1429 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 28.5714 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 28.5714 | 7 | yes |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 28.5714 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 25.0000 | 7 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010564 | regulation of cell cycle process | 25.0000 | 5 | no |
| GO:0019932 | second-messenger-mediated signaling | 25.0000 | 4 | no |
| GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0006468 | protein phosphorylation | 21.4286 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | yes |
| GO:0016310 | phosphorylation | 21.4286 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 21.4286 | 8 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4286 | 6 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 21.4286 | 8 | no |
| GO:0010648 | negative regulation of cell communication | 21.4286 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.4286 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 21.4286 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.4286 | 6 | no |
| GO:0010941 | regulation of cell death | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 21.4286 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 21.4286 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 21.4286 | 5 | no |
| GO:0043269 | regulation of ion transport | 21.4286 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.4286 | 6 | no |
| GO:2001257 | regulation of cation channel activity | 21.4286 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 17.8571 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 17.8571 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 17.8571 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 17.8571 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 17.8571 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 17.8571 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 14.2857 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 14.2857 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 14.2857 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 14.2857 | 6 | yes |
| GO:0032880 | regulation of protein localization | 14.2857 | 5 | yes |
| GO:0043393 | regulation of protein binding | 14.2857 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 14.2857 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 14.2857 | 7 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 14.2857 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 14.2857 | 4 | yes |
| GO:0051223 | regulation of protein transport | 14.2857 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 14.2857 | 6 | yes |
| GO:0070201 | regulation of establishment of protein localization | 14.2857 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 14.2857 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 14.2857 | 8 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 10.7143 | 7 | yes |
| GO:0032386 | regulation of intracellular transport | 10.7143 | 5 | yes |
| GO:0033135 | regulation of peptidyl-serine phosphorylation | 10.7143 | 8 | yes |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 10.7143 | 9 | yes |
| GO:0033157 | regulation of intracellular protein transport | 10.7143 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 10.7143 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 10.7143 | 8 | yes |
| GO:0051222 | positive regulation of protein transport | 10.7143 | 5 | yes |
| GO:1901983 | regulation of protein acetylation | 10.7143 | 7 | yes |
| GO:1901985 | positive regulation of protein acetylation | 10.7143 | 8 | yes |
| GO:1903829 | positive regulation of protein localization | 10.7143 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 10.7143 | 6 | yes |
| GO:0006913 | nucleocytoplasmic transport | 7.1429 | 5 | yes |
| GO:0007399 | nervous system development | 7.1429 | 4 | yes |
| GO:0010975 | regulation of neuron projection development | 7.1429 | 7 | yes |
| GO:0010976 | positive regulation of neuron projection development | 7.1429 | 7 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 7.1429 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 7.1429 | 6 | yes |
| GO:0032388 | positive regulation of intracellular transport | 7.1429 | 5 | yes |
| GO:0046822 | regulation of nucleocytoplasmic transport | 7.1429 | 6 | yes |
| GO:0046825 | regulation of protein export from nucleus | 7.1429 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 7.1429 | 5 | yes |
| GO:0051169 | nuclear transport | 7.1429 | 4 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 7.1429 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCC1A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.1429 | 3 | no |
| DOID:0050700 | cardiomyopathy | 7.1429 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 7.1429 | 5 | no |
| DOID:114 | heart disease | 7.1429 | 3 | no |
| DOID:2843 | long QT syndrome | 7.1429 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KKCC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN6_HUMAN | [view interactions] | Low throughput | no | no |
| PPM1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC9_HUMAN | [view interactions] | Low throughput | no | yes |
| FXL12_HUMAN | [view interactions] | Low throughput | no | yes |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| KKCC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GCM1_HUMAN | [view interactions] | Low throughput | no | no |
| CCND1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK4_HUMAN | [view interactions] | Low throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPME1_HUMAN | [view interactions] | Low throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| PHF19_HUMAN | [view interactions] | High throughput | no | no |
| CGB2_HUMAN | [view interactions] | High throughput | no | no |
| CC106_HUMAN | [view interactions] | High throughput | no | no |
| CDO1_HUMAN | [view interactions] | High throughput | no | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| QPCTL_HUMAN | [view interactions] | High throughput | no | yes |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| NEUL_HUMAN | [view interactions] | High throughput | no | yes |
| KCC1G_HUMAN | [view interactions] | High throughput | no | no |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PO210_HUMAN | [view interactions] | High throughput | no | yes |
| KCC1D_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RU2B_HUMAN | [view interactions] | High throughput | no | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| DKC1_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK14_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| IL16_HUMAN | [view interactions] | High throughput | no | no |
| CER1_HUMAN | [view interactions] | High throughput | no | no |
| SIA7C_HUMAN | [view interactions] | High throughput | no | no |
| PNKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| TAFA3_HUMAN | [view interactions] | High throughput | no | no |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| PA2GD_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| PTH1R_HUMAN | [view interactions] | High throughput | no | no |
| MAP10_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SCF_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX16_HUMAN | [view interactions] | High throughput | no | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| PPM1F_HUMAN | [view interactions] | Computational | no | yes |