PALM_HUMAN
Evidence for PS localization
Functions
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PALM_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 42.8571 | 4 | no |
| GO:0043168 | anion binding | 42.8571 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0003924 | GTPase activity | 28.5714 | 7 | no |
| GO:0005525 | GTP binding | 28.5714 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 28.5714 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.5714 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.5714 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 28.5714 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 28.5714 | 5 | no |
| GO:0019900 | kinase binding | 25.7143 | 4 | no |
| GO:0019901 | protein kinase binding | 22.8571 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 5.7143 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PALM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 82.8571 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 62.8571 | 4 | yes |
| GO:0006996 | organelle organization | 48.5714 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.7143 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 37.1429 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 37.1429 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 37.1429 | 6 | yes |
| GO:0022607 | cellular component assembly | 37.1429 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.1429 | 4 | no |
| GO:0051049 | regulation of transport | 37.1429 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.1429 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 37.1429 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.2857 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 34.2857 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 34.2857 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.2857 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.2857 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2857 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 34.2857 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.2857 | 4 | no |
| GO:0030030 | cell projection organization | 34.2857 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.2857 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.2857 | 5 | no |
| GO:0007010 | cytoskeleton organization | 31.4286 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 31.4286 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.4286 | 5 | no |
| GO:0071702 | organic substance transport | 31.4286 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 31.4286 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 31.4286 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.5714 | 4 | yes |
| GO:0007015 | actin filament organization | 28.5714 | 5 | no |
| GO:0030334 | regulation of cell migration | 28.5714 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.5714 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.5714 | 6 | no |
| GO:2000145 | regulation of cell motility | 28.5714 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 25.7143 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.7143 | 5 | yes |
| GO:0030155 | regulation of cell adhesion | 25.7143 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.7143 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 25.7143 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.7143 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.7143 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.7143 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.7143 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.8571 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 22.8571 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 22.8571 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.8571 | 6 | no |
| GO:0031175 | neuron projection development | 22.8571 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.8571 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 22.8571 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.8571 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.8571 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 22.8571 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.8571 | 4 | no |
| GO:0050890 | cognition | 22.8571 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 22.8571 | 4 | no |
| GO:0061024 | membrane organization | 22.8571 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 20.0000 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.0000 | 4 | yes |
| GO:0060491 | regulation of cell projection assembly | 20.0000 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 20.0000 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 17.1429 | 5 | yes |
| GO:0034330 | cell junction organization | 17.1429 | 4 | yes |
| GO:0072657 | protein localization to membrane | 17.1429 | 4 | yes |
| GO:0050808 | synapse organization | 11.4286 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 11.4286 | 5 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 11.4286 | 6 | yes |
| GO:1990778 | protein localization to cell periphery | 11.4286 | 5 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 8.5714 | 4 | yes |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 8.5714 | 5 | yes |
| GO:0060159 | regulation of dopamine receptor signaling pathway | 5.7143 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| RGRF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN624_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| SNX16_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ZPBP2_HUMAN | [view interactions] | High throughput | no | no |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |