SAE1_HUMAN
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SAE1_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
GO:0043168 | anion binding | 33.3333 | 4 | no |
GO:0043169 | cation binding | 33.3333 | 4 | no |
GO:0046872 | metal ion binding | 33.3333 | 5 | no |
GO:0003723 | RNA binding | 31.1111 | 4 | no |
GO:0005524 | ATP binding | 28.8889 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 28.8889 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 28.8889 | 5 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 24.4444 | 4 | no |
GO:0031625 | ubiquitin protein ligase binding | 22.2222 | 5 | no |
GO:0044388 | small protein activating enzyme binding | 6.6667 | 4 | yes |
GO:0046982 | protein heterodimerization activity | 4.4444 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SAE1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 64.4444 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 62.2222 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 51.1111 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 51.1111 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 48.8889 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 46.6667 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 46.6667 | 4 | no |
GO:0010468 | regulation of gene expression | 46.6667 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 46.6667 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 46.6667 | 5 | no |
GO:0043412 | macromolecule modification | 44.4444 | 4 | yes |
GO:0036211 | protein modification process | 42.2222 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 40.0000 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 37.7778 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 37.7778 | 5 | no |
GO:0031399 | regulation of protein modification process | 35.5556 | 6 | yes |
GO:0009966 | regulation of signal transduction | 35.5556 | 4 | no |
GO:0022607 | cellular component assembly | 35.5556 | 4 | no |
GO:0006996 | organelle organization | 33.3333 | 4 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 31.1111 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 31.1111 | 6 | no |
GO:0009894 | regulation of catabolic process | 31.1111 | 4 | no |
GO:0032446 | protein modification by small protein conjugation | 28.8889 | 7 | yes |
GO:0043687 | post-translational protein modification | 28.8889 | 5 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 28.8889 | 6 | yes |
GO:0009891 | positive regulation of biosynthetic process | 28.8889 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 28.8889 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.8889 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.8889 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 28.8889 | 6 | no |
GO:0042981 | regulation of apoptotic process | 28.8889 | 5 | no |
GO:0043067 | regulation of programmed cell death | 28.8889 | 4 | no |
GO:0051049 | regulation of transport | 28.8889 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 26.6667 | 7 | yes |
GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
GO:0045595 | regulation of cell differentiation | 24.4444 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.4444 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.4444 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 24.4444 | 5 | no |
GO:0051094 | positive regulation of developmental process | 24.4444 | 4 | no |
GO:0080134 | regulation of response to stress | 24.4444 | 4 | no |
GO:0032880 | regulation of protein localization | 22.2222 | 5 | yes |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 22.2222 | 8 | no |
GO:0030162 | regulation of proteolysis | 22.2222 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
GO:0032101 | regulation of response to external stimulus | 22.2222 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 22.2222 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 20.0000 | 6 | yes |
GO:1901873 | regulation of post-translational protein modification | 17.7778 | 7 | yes |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 17.7778 | 8 | yes |
GO:0018193 | peptidyl-amino acid modification | 15.5556 | 5 | yes |
GO:1903829 | positive regulation of protein localization | 15.5556 | 5 | yes |
GO:0016925 | protein sumoylation | 13.3333 | 7 | yes |
GO:0018205 | peptidyl-lysine modification | 13.3333 | 6 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 13.3333 | 6 | yes |
GO:1901875 | positive regulation of post-translational protein modification | 11.1111 | 8 | yes |
GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 11.1111 | 9 | yes |
GO:0033233 | regulation of protein sumoylation | 4.4444 | 9 | yes |
GO:1903214 | regulation of protein targeting to mitochondrion | 4.4444 | 8 | yes |
GO:1903533 | regulation of protein targeting | 4.4444 | 7 | yes |
GO:1903747 | regulation of establishment of protein localization to mitochondrion | 4.4444 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
P53_HUMAN | [view interactions] | Low throughput | no | no |
UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SAE2_HUMAN | [view interactions] | Low throughput | no | yes |
SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SUMO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MYC_HUMAN | [view interactions] | Low throughput | no | yes |
TRIM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBD_HUMAN | [view interactions] | Low throughput | no | no |
ETV4_HUMAN | [view interactions] | Low throughput | no | yes |
UBP2_HUMAN | [view interactions] | Low throughput | no | yes |
UBP39_HUMAN | [view interactions] | Low throughput | no | yes |
HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
HSP72_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
RM48_HUMAN | [view interactions] | High throughput | no | yes |
RM46_HUMAN | [view interactions] | High throughput | no | yes |
NFS1_HUMAN | [view interactions] | High throughput | no | yes |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
GDF15_HUMAN | [view interactions] | High throughput | no | no |
CATC_HUMAN | [view interactions] | High throughput | no | yes |
SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
BCL6_HUMAN | [view interactions] | High throughput | no | no |
FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
CP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IL3RA_HUMAN | [view interactions] | High throughput | no | yes |
FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAX5_HUMAN | [view interactions] | High throughput | no | no |
PAX6_HUMAN | [view interactions] | High throughput | no | no |
CRX_HUMAN | [view interactions] | High throughput | no | no |
PAX8_HUMAN | [view interactions] | High throughput | no | yes |
AGTR1_HUMAN | [view interactions] | High throughput | no | no |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
ERR1_HUMAN | [view interactions] | High throughput | no | yes |
ERR3_HUMAN | [view interactions] | High throughput | no | yes |
NFYC_HUMAN | [view interactions] | High throughput | no | no |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
UNC79_HUMAN | [view interactions] | High throughput | no | no |
BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
WASP_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
DUS28_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
RIGI_HUMAN | [view interactions] | High throughput | no | yes |
DAXX_HUMAN | [view interactions] | High throughput | no | yes |
CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI35_HUMAN | [view interactions] | High throughput | no | yes |
C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
IF5_HUMAN | [view interactions] | High throughput | no | yes |
RBM4_HUMAN | [view interactions] | High throughput | no | yes |
IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMNA1_HUMAN | [view interactions] | High throughput | no | yes |
ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IMA4_HUMAN | [view interactions] | High throughput | no | yes |
E2F4_HUMAN | [view interactions] | High throughput | no | no |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HERC5_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
UBP48_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERCC6_HUMAN | [view interactions] | High throughput | no | no |
SYAC_HUMAN | [view interactions] | High throughput | no | yes |
PUR8_HUMAN | [view interactions] | High throughput | no | yes |
DHYS_HUMAN | [view interactions] | High throughput | no | no |
LPP_HUMAN | [view interactions] | High throughput | no | yes |
PDE12_HUMAN | [view interactions] | High throughput | no | yes |
RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALU_HUMAN | [view interactions] | High throughput | no | yes |
CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPP9_HUMAN | [view interactions] | High throughput | no | yes |
MCM3_HUMAN | [view interactions] | High throughput | no | no |
NPL4_HUMAN | [view interactions] | High throughput | no | yes |
OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
PANK4_HUMAN | [view interactions] | High throughput | no | no |
2A5E_HUMAN | [view interactions] | High throughput | no | yes |
TM10A_HUMAN | [view interactions] | High throughput | no | no |
RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
SRP14_HUMAN | [view interactions] | High throughput | no | no |
PRPK_HUMAN | [view interactions] | High throughput | no | yes |
TPD54_HUMAN | [view interactions] | High throughput | no | yes |
WDR4_HUMAN | [view interactions] | High throughput | no | no |
PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TYSY_HUMAN | [view interactions] | High throughput | no | yes |
DCPS_HUMAN | [view interactions] | High throughput | no | yes |
DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
RCC2_HUMAN | [view interactions] | High throughput | no | no |
RUXE_HUMAN | [view interactions] | High throughput | no | no |
PALM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSM1_HUMAN | [view interactions] | High throughput | no | no |
IPYR_HUMAN | [view interactions] | High throughput | no | yes |
PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
SPS1_HUMAN | [view interactions] | High throughput | no | yes |
UB2E3_HUMAN | [view interactions] | High throughput | no | yes |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
U119B_HUMAN | [view interactions] | High throughput | no | yes |
TXND9_HUMAN | [view interactions] | High throughput | no | yes |