Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SAE1_HUMAN

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SAE1_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0043168 anion binding 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0003723 RNA binding 31.1111 4 no
GO:0005524 ATP binding 28.8889 5 no
GO:0030554 adenyl nucleotide binding 28.8889 6 no
GO:0032559 adenyl ribonucleotide binding 28.8889 5 no
GO:0044389 ubiquitin-like protein ligase binding 24.4444 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044388 small protein activating enzyme binding 6.6667 4 yes
GO:0046982 protein heterodimerization activity 4.4444 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SAE1_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.4444 4 yes
GO:0080090 regulation of primary metabolic process 62.2222 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0051246 regulation of protein metabolic process 51.1111 5 yes
GO:0048523 negative regulation of cellular process 51.1111 4 no
GO:0009893 positive regulation of metabolic process 48.8889 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 yes
GO:0009889 regulation of biosynthetic process 46.6667 4 no
GO:0010468 regulation of gene expression 46.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 46.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 46.6667 5 no
GO:0043412 macromolecule modification 44.4444 4 yes
GO:0036211 protein modification process 42.2222 4 yes
GO:0051247 positive regulation of protein metabolic process 40.0000 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0048584 positive regulation of response to stimulus 40.0000 4 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0010646 regulation of cell communication 37.7778 4 no
GO:0031325 positive regulation of cellular metabolic process 37.7778 5 no
GO:0031399 regulation of protein modification process 35.5556 6 yes
GO:0009966 regulation of signal transduction 35.5556 4 no
GO:0022607 cellular component assembly 35.5556 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0006355 regulation of DNA-templated transcription 31.1111 7 no
GO:2001141 regulation of RNA biosynthetic process 31.1111 6 no
GO:0009894 regulation of catabolic process 31.1111 4 no
GO:0032446 protein modification by small protein conjugation 28.8889 7 yes
GO:0043687 post-translational protein modification 28.8889 5 yes
GO:0070647 protein modification by small protein conjugation or removal 28.8889 6 yes
GO:0009891 positive regulation of biosynthetic process 28.8889 5 no
GO:0009892 negative regulation of metabolic process 28.8889 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.8889 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.8889 5 no
GO:0031328 positive regulation of cellular biosynthetic process 28.8889 6 no
GO:0042981 regulation of apoptotic process 28.8889 5 no
GO:0043067 regulation of programmed cell death 28.8889 4 no
GO:0051049 regulation of transport 28.8889 4 no
GO:0031401 positive regulation of protein modification process 26.6667 7 yes
GO:0019220 regulation of phosphate metabolic process 26.6667 6 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0051174 regulation of phosphorus metabolic process 26.6667 5 no
GO:0045595 regulation of cell differentiation 24.4444 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 24.4444 5 no
GO:1902531 regulation of intracellular signal transduction 24.4444 5 no
GO:0031324 negative regulation of cellular metabolic process 24.4444 5 no
GO:0051094 positive regulation of developmental process 24.4444 4 no
GO:0080134 regulation of response to stress 24.4444 4 no
GO:0032880 regulation of protein localization 22.2222 5 yes
GO:0060341 regulation of cellular localization 22.2222 4 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0030162 regulation of proteolysis 22.2222 6 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0009896 positive regulation of catabolic process 22.2222 5 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0070201 regulation of establishment of protein localization 20.0000 6 yes
GO:1901873 regulation of post-translational protein modification 17.7778 7 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 17.7778 8 yes
GO:0018193 peptidyl-amino acid modification 15.5556 5 yes
GO:1903829 positive regulation of protein localization 15.5556 5 yes
GO:0016925 protein sumoylation 13.3333 7 yes
GO:0018205 peptidyl-lysine modification 13.3333 6 yes
GO:1904951 positive regulation of establishment of protein localization 13.3333 6 yes
GO:1901875 positive regulation of post-translational protein modification 11.1111 8 yes
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 11.1111 9 yes
GO:0033233 regulation of protein sumoylation 4.4444 9 yes
GO:1903214 regulation of protein targeting to mitochondrion 4.4444 8 yes
GO:1903533 regulation of protein targeting 4.4444 7 yes
GO:1903747 regulation of establishment of protein localization to mitochondrion 4.4444 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
P53_HUMAN [view interactions] Low throughput no no
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
SAE2_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view entry] [view interactions] Low throughput yes yes
EHD3_HUMAN [view entry] [view interactions] Low throughput yes no
SUMO2_HUMAN [view entry] [view interactions] Low throughput yes yes
MYC_HUMAN [view interactions] Low throughput no yes
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
UBD_HUMAN [view interactions] Low throughput no no
ETV4_HUMAN [view interactions] Low throughput no yes
UBP2_HUMAN [view interactions] Low throughput no yes
UBP39_HUMAN [view interactions] Low throughput no yes
HS71B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS71A_HUMAN [view entry] [view interactions] Low throughput yes yes
HSP72_HUMAN [view entry] [view interactions] Low throughput yes no
UBP5_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
CACO2_HUMAN [view interactions] High throughput no yes
RM48_HUMAN [view interactions] High throughput no yes
RM46_HUMAN [view interactions] High throughput no yes
NFS1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
FURIN_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
PQBP1_HUMAN [view interactions] High throughput no yes
GDF15_HUMAN [view interactions] High throughput no no
CATC_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
OFD1_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
SODC_HUMAN [view interactions] High throughput no yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
FAF2_HUMAN [view interactions] High throughput no yes
BCL6_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
IKKE_HUMAN [view interactions] High throughput no yes
CP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
IL3RA_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
PAX5_HUMAN [view interactions] High throughput no no
PAX6_HUMAN [view interactions] High throughput no no
CRX_HUMAN [view interactions] High throughput no no
PAX8_HUMAN [view interactions] High throughput no yes
AGTR1_HUMAN [view interactions] High throughput no no
SNF5_HUMAN [view interactions] High throughput no yes
ERR1_HUMAN [view interactions] High throughput no yes
ERR3_HUMAN [view interactions] High throughput no yes
NFYC_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
UNC79_HUMAN [view interactions] High throughput no no
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
ABCE1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
WASP_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
EDEM3_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
DUS28_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ZNRF4_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
DAXX_HUMAN [view interactions] High throughput no yes
CPNE5_HUMAN [view entry] [view interactions] High throughput yes yes
TRI35_HUMAN [view interactions] High throughput no yes
C1QT2_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3D_HUMAN [view interactions] High throughput no yes
IF5_HUMAN [view interactions] High throughput no yes
RBM4_HUMAN [view interactions] High throughput no yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
NMNA1_HUMAN [view interactions] High throughput no yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
IMA4_HUMAN [view interactions] High throughput no yes
E2F4_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HERC5_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ERCC6_HUMAN [view interactions] High throughput no no
SYAC_HUMAN [view interactions] High throughput no yes
PUR8_HUMAN [view interactions] High throughput no yes
DHYS_HUMAN [view interactions] High throughput no no
LPP_HUMAN [view interactions] High throughput no yes
PDE12_HUMAN [view interactions] High throughput no yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CALU_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
DPP9_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
NPL4_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
2A5E_HUMAN [view interactions] High throughput no yes
TM10A_HUMAN [view interactions] High throughput no no
RPR1B_HUMAN [view interactions] High throughput no yes
SRP14_HUMAN [view interactions] High throughput no no
PRPK_HUMAN [view interactions] High throughput no yes
TPD54_HUMAN [view interactions] High throughput no yes
WDR4_HUMAN [view interactions] High throughput no no
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
TYSY_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
LARP7_HUMAN [view interactions] High throughput no yes
RCC2_HUMAN [view interactions] High throughput no no
RUXE_HUMAN [view interactions] High throughput no no
PALM_HUMAN [view entry] [view interactions] High throughput yes yes
KCC1A_HUMAN [view entry] [view interactions] High throughput yes yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
LSM1_HUMAN [view interactions] High throughput no no
IPYR_HUMAN [view interactions] High throughput no yes
PGTB2_HUMAN [view interactions] High throughput no yes
SPS1_HUMAN [view interactions] High throughput no yes
UB2E3_HUMAN [view interactions] High throughput no yes
K1C19_HUMAN [view interactions] High throughput no no
U119B_HUMAN [view interactions] High throughput no yes
TXND9_HUMAN [view interactions] High throughput no yes