SAE1_HUMAN
Evidence for PS localization
Functions
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAE1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.2353 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.2941 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.2941 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 32.3529 | 5 | no |
| GO:0046872 | metal ion binding | 29.4118 | 4 | no |
| GO:0003723 | RNA binding | 29.4118 | 4 | no |
| GO:0005524 | ATP binding | 29.4118 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.4118 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.5882 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5882 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5882 | 6 | no |
| GO:0031625 | ubiquitin protein ligase binding | 20.5882 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.5882 | 4 | no |
| GO:0045296 | cadherin binding | 20.5882 | 4 | no |
| GO:0046982 | protein heterodimerization activity | 8.8235 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAE1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.7647 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 61.7647 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 58.8235 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.8235 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.9412 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.1176 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 44.1176 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.1765 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2353 | 5 | no |
| GO:0031399 | regulation of protein modification process | 38.2353 | 6 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.2353 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 35.2941 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.2941 | 5 | no |
| GO:0006996 | organelle organization | 35.2941 | 4 | no |
| GO:0043412 | macromolecule modification | 35.2941 | 4 | yes |
| GO:0051049 | regulation of transport | 35.2941 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.3529 | 5 | no |
| GO:0022607 | cellular component assembly | 32.3529 | 4 | no |
| GO:0008104 | protein localization | 32.3529 | 4 | no |
| GO:0036211 | protein modification process | 32.3529 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.3529 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 29.4118 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.4118 | 4 | no |
| GO:0010941 | regulation of cell death | 29.4118 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.4118 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.4118 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 26.4706 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.4706 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 23.5294 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.5294 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.5294 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.5294 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 23.5294 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 23.5294 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 23.5294 | 7 | yes |
| GO:0032880 | regulation of protein localization | 23.5294 | 5 | yes |
| GO:0051223 | regulation of protein transport | 23.5294 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 23.5294 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 20.5882 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 20.5882 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 20.5882 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 20.5882 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.5882 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.5882 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0060548 | negative regulation of cell death | 20.5882 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5882 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.5882 | 6 | no |
| GO:0071702 | organic substance transport | 20.5882 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 20.5882 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0032446 | protein modification by small protein conjugation | 20.5882 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 20.5882 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 20.5882 | 5 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 14.7059 | 7 | yes |
| GO:0018193 | peptidyl-amino acid modification | 14.7059 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 14.7059 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 14.7059 | 6 | yes |
| GO:0032388 | positive regulation of intracellular transport | 11.7647 | 5 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 11.7647 | 6 | yes |
| GO:1903214 | regulation of protein targeting to mitochondrion | 5.8824 | 8 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 5.8824 | 8 | yes |
| GO:1903533 | regulation of protein targeting | 5.8824 | 7 | yes |
| GO:1903747 | regulation of establishment of protein localization to mitochondrion | 5.8824 | 7 | yes |
| GO:0016925 | protein sumoylation | 5.8824 | 7 | yes |
| GO:0018205 | peptidyl-lysine modification | 5.8824 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| SAE2_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SUMO2_HUMAN | [view interactions] | Low throughput | no | yes |
| MYC_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBD_HUMAN | [view interactions] | Low throughput | no | no |
| ETV4_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| SNUT2_HUMAN | [view interactions] | Low throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP72_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PDE12_HUMAN | [view interactions] | High throughput | no | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP9_HUMAN | [view interactions] | High throughput | no | yes |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| NPL4_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| PRPK_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RCC2_HUMAN | [view interactions] | High throughput | no | no |
| RUXE_HUMAN | [view interactions] | High throughput | no | no |
| PALM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| SPS1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2E3_HUMAN | [view interactions] | High throughput | no | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CATC_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| PQBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| BCL6_HUMAN | [view interactions] | High throughput | no | no |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| CP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| IL3RA_HUMAN | [view interactions] | High throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX5_HUMAN | [view interactions] | High throughput | no | no |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| CRX_HUMAN | [view interactions] | High throughput | no | no |
| PAX8_HUMAN | [view interactions] | High throughput | no | yes |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ERR1_HUMAN | [view interactions] | High throughput | no | yes |
| ERR3_HUMAN | [view interactions] | High throughput | no | yes |
| NFYC_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| UNC79_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WASP_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI35_HUMAN | [view interactions] | High throughput | no | yes |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMNA1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA4_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| SYAC_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PIAS1_HUMAN | [view interactions] | Computational | no | yes |
| BUB3_HUMAN | [view interactions] | Computational | no | yes |
| SUMO4_HUMAN | [view interactions] | Computational | no | no |
| ENY2_HUMAN | [view interactions] | Computational | no | yes |
| NSE2_HUMAN | [view interactions] | Computational | no | yes |
| SKP1_HUMAN | [view interactions] | Computational | no | yes |
| PCNA_HUMAN | [view interactions] | Computational | no | no |
| RWDD3_HUMAN | [view interactions] | Computational | no | no |
| SENP6_HUMAN | [view interactions] | Computational | no | yes |
| SENP1_HUMAN | [view interactions] | Computational | no | no |
| DUT_HUMAN | [view interactions] | Computational | no | yes |
| CUL1_HUMAN | [view interactions] | Computational | no | yes |