ATAD1_HUMAN
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane . Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory . Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ATAD1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 30.7692 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.2051 | 4 | yes |
GO:0019900 | kinase binding | 25.6410 | 4 | no |
GO:0019901 | protein kinase binding | 25.6410 | 5 | no |
GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | yes |
GO:0042803 | protein homodimerization activity | 20.5128 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 17.9487 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 17.9487 | 5 | yes |
GO:0005524 | ATP binding | 15.3846 | 5 | yes |
GO:0016887 | ATP hydrolysis activity | 10.2564 | 7 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ATAD1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 41.0256 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 41.0256 | 4 | no |
GO:0008104 | protein localization | 38.4615 | 4 | yes |
GO:0006996 | organelle organization | 38.4615 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.8974 | 4 | no |
GO:0071702 | organic substance transport | 35.8974 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
GO:0010646 | regulation of cell communication | 30.7692 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 30.7692 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.7692 | 5 | no |
GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
GO:0010941 | regulation of cell death | 28.2051 | 4 | no |
GO:0042981 | regulation of apoptotic process | 28.2051 | 6 | no |
GO:0043067 | regulation of programmed cell death | 28.2051 | 5 | no |
GO:0071310 | cellular response to organic substance | 28.2051 | 4 | no |
GO:0009966 | regulation of signal transduction | 25.6410 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.6410 | 5 | no |
GO:0033043 | regulation of organelle organization | 25.6410 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.6410 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
GO:0015031 | protein transport | 23.0769 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 23.0769 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | no |
GO:0010468 | regulation of gene expression | 23.0769 | 5 | no |
GO:0014070 | response to organic cyclic compound | 23.0769 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
GO:0051050 | positive regulation of transport | 20.5128 | 4 | yes |
GO:0006886 | intracellular protein transport | 20.5128 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 20.5128 | 5 | no |
GO:0010647 | positive regulation of cell communication | 20.5128 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.5128 | 4 | no |
GO:0033365 | protein localization to organelle | 20.5128 | 5 | no |
GO:0051094 | positive regulation of developmental process | 20.5128 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 20.5128 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 20.5128 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.5128 | 4 | no |
GO:0022607 | cellular component assembly | 20.5128 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 20.5128 | 5 | no |
GO:0061024 | membrane organization | 20.5128 | 4 | no |
GO:0016192 | vesicle-mediated transport | 20.5128 | 4 | no |
GO:0010648 | negative regulation of cell communication | 17.9487 | 5 | yes |
GO:0023057 | negative regulation of signaling | 17.9487 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 15.3846 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 10.2564 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 10.2564 | 4 | yes |
GO:0007612 | learning | 7.6923 | 4 | yes |
GO:0030100 | regulation of endocytosis | 7.6923 | 5 | yes |
GO:0050890 | cognition | 7.6923 | 4 | yes |
GO:0007613 | memory | 5.1282 | 4 | yes |
GO:0045807 | positive regulation of endocytosis | 5.1282 | 5 | yes |
GO:0050805 | negative regulation of synaptic transmission | 5.1282 | 5 | yes |
GO:0072657 | protein localization to membrane | 5.1282 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ATAD1_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 7.6923 | 3 | no |
DOID:10595 | Charcot-Marie-Tooth disease | 5.1282 | 6 | no |
DOID:440 | neuromuscular disease | 5.1282 | 5 | no |
DOID:574 | peripheral nervous system disease | 5.1282 | 3 | no |
DOID:870 | neuropathy | 5.1282 | 4 | no |
DOID:10579 | leukodystrophy | 5.1282 | 6 | no |
DOID:1443 | cerebral degeneration | 5.1282 | 5 | no |
DOID:936 | brain disease | 5.1282 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GOSR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TLC3A_HUMAN | [view interactions] | High throughput | no | no |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAP2_HUMAN | [view interactions] | High throughput | no | yes |
NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
PURA2_HUMAN | [view interactions] | High throughput | no | yes |
PURA1_HUMAN | [view interactions] | High throughput | no | no |
ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GET3_HUMAN | [view interactions] | High throughput | no | yes |
KCRM_HUMAN | [view interactions] | High throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
PRPS2_HUMAN | [view interactions] | High throughput | no | no |
TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
UBP19_HUMAN | [view interactions] | High throughput | no | no |
BABA1_HUMAN | [view interactions] | High throughput | no | yes |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view interactions] | High throughput | no | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAS_HUMAN | [view interactions] | High throughput | no | no |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
NMES1_HUMAN | [view interactions] | High throughput | no | no |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
ANKS6_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN598_HUMAN | [view interactions] | High throughput | no | no |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
MARH3_HUMAN | [view interactions] | High throughput | no | no |
RN170_HUMAN | [view interactions] | High throughput | no | yes |
RN185_HUMAN | [view interactions] | High throughput | no | no |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
ANM8_HUMAN | [view interactions] | High throughput | no | yes |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
KLK15_HUMAN | [view interactions] | High throughput | no | no |
GPR45_HUMAN | [view interactions] | High throughput | no | no |
GP182_HUMAN | [view interactions] | High throughput | no | no |
FFAR1_HUMAN | [view interactions] | High throughput | no | no |
ABCD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ABCD2_HUMAN | [view interactions] | Computational | no | no |
PEX16_HUMAN | [view interactions] | Computational | no | yes |
ABCD1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PXMP2_HUMAN | [view interactions] | Computational | no | no |
GDAP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PEX26_HUMAN | [view interactions] | Computational | no | yes |
PEX2_HUMAN | [view interactions] | Computational | no | yes |
PEX3_HUMAN | [view interactions] | Computational | no | yes |
ACBD5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PEX13_HUMAN | [view interactions] | Computational | no | yes |
AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PM34_HUMAN | [view interactions] | Computational | no | yes |
PXMP4_HUMAN | [view interactions] | Computational | no | yes |
PX11B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |