ATAD1_HUMAN
Evidence for PS localization
Functions
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane . Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory . Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ATAD1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.9286 | 4 | yes |
| GO:0000166 | nucleotide binding | 32.1429 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | yes |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 5 | no |
| GO:0005524 | ATP binding | 19.6429 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 19.6429 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 19.6429 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 19.6429 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 19.6429 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.6429 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 10.7143 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ATAD1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.2143 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.0714 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.0714 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | no |
| GO:0009966 | regulation of signal transduction | 33.9286 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.1429 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.1429 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 32.1429 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.1429 | 5 | no |
| GO:0008104 | protein localization | 30.3571 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.3571 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.3571 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.3571 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.3571 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3571 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.3571 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | yes |
| GO:0036211 | protein modification process | 28.5714 | 4 | no |
| GO:0043412 | macromolecule modification | 28.5714 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 26.7857 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 26.7857 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.7857 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 26.7857 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.7857 | 5 | no |
| GO:0006508 | proteolysis | 25.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.2143 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.2143 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2143 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.2143 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.2143 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.2143 | 5 | no |
| GO:0043687 | post-translational protein modification | 21.4286 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.4286 | 6 | no |
| GO:0006996 | organelle organization | 21.4286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.4286 | 4 | no |
| GO:0022607 | cellular component assembly | 21.4286 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 7 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
| GO:0071702 | organic substance transport | 21.4286 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.4286 | 4 | no |
| GO:0051050 | positive regulation of transport | 16.0714 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 14.2857 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 14.2857 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 12.5000 | 4 | yes |
| GO:0050890 | cognition | 10.7143 | 4 | yes |
| GO:0007612 | learning | 8.9286 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 8.9286 | 5 | yes |
| GO:0007613 | memory | 7.1429 | 4 | yes |
| GO:0045807 | positive regulation of endocytosis | 7.1429 | 5 | yes |
| GO:0072657 | protein localization to membrane | 5.3571 | 4 | yes |
| GO:0002090 | regulation of receptor internalization | 3.5714 | 7 | yes |
| GO:0002092 | positive regulation of receptor internalization | 3.5714 | 7 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 3.5714 | 6 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 3.5714 | 6 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 3.5714 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 3.5714 | 6 | yes |
| GO:0051967 | negative regulation of synaptic transmission, glutamatergic | 3.5714 | 6 | yes |
| GO:0090150 | establishment of protein localization to membrane | 3.5714 | 4 | yes |
| GO:0140568 | extraction of mislocalized protein from membrane | 3.5714 | 5 | yes |
| GO:0140570 | extraction of mislocalized protein from mitochondrial outer membrane | 3.5714 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ATAD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DESM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| BABA1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAS_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8B_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| MAIP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ANKS6_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH3_HUMAN | [view interactions] | High throughput | no | no |
| RN170_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| KLK15_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| TLC3A_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI72_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| PURA1_HUMAN | [view interactions] | High throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GET3_HUMAN | [view interactions] | High throughput | no | yes |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNPT1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |