Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ATAD1_HUMAN

Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane . Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory . Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ATAD1_HUMAN
GO:0017076 purine nucleotide binding 30.7692 4 yes
GO:0032555 purine ribonucleotide binding 30.7692 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.2051 4 yes
GO:0019900 kinase binding 25.6410 4 no
GO:0019901 protein kinase binding 25.6410 5 no
GO:0016462 pyrophosphatase activity 23.0769 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.0769 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.0769 6 yes
GO:0042803 protein homodimerization activity 20.5128 4 no
GO:0030554 adenyl nucleotide binding 17.9487 5 yes
GO:0032559 adenyl ribonucleotide binding 17.9487 5 yes
GO:0005524 ATP binding 15.3846 5 yes
GO:0016887 ATP hydrolysis activity 10.2564 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ATAD1_HUMAN
GO:0048522 positive regulation of cellular process 53.8462 4 yes
GO:0048523 negative regulation of cellular process 41.0256 4 yes
GO:0031323 regulation of cellular metabolic process 41.0256 4 no
GO:0008104 protein localization 38.4615 4 yes
GO:0006996 organelle organization 38.4615 4 no
GO:0009893 positive regulation of metabolic process 38.4615 4 no
GO:0060255 regulation of macromolecule metabolic process 35.8974 4 no
GO:0071702 organic substance transport 35.8974 4 no
GO:0051049 regulation of transport 33.3333 4 yes
GO:0051128 regulation of cellular component organization 33.3333 4 yes
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0010646 regulation of cell communication 30.7692 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 30.7692 5 no
GO:0051171 regulation of nitrogen compound metabolic process 30.7692 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:0031325 positive regulation of cellular metabolic process 30.7692 5 no
GO:0010941 regulation of cell death 28.2051 4 no
GO:0042981 regulation of apoptotic process 28.2051 6 no
GO:0043067 regulation of programmed cell death 28.2051 5 no
GO:0071310 cellular response to organic substance 28.2051 4 no
GO:0009966 regulation of signal transduction 25.6410 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.6410 5 no
GO:0033043 regulation of organelle organization 25.6410 5 no
GO:1902531 regulation of intracellular signal transduction 25.6410 5 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 yes
GO:0009892 negative regulation of metabolic process 23.0769 4 no
GO:0015031 protein transport 23.0769 4 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010468 regulation of gene expression 23.0769 5 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:0051050 positive regulation of transport 20.5128 4 yes
GO:0006886 intracellular protein transport 20.5128 4 no
GO:0009967 positive regulation of signal transduction 20.5128 5 no
GO:0010647 positive regulation of cell communication 20.5128 5 no
GO:0023056 positive regulation of signaling 20.5128 4 no
GO:0033365 protein localization to organelle 20.5128 5 no
GO:0051094 positive regulation of developmental process 20.5128 4 no
GO:1902533 positive regulation of intracellular signal transduction 20.5128 6 no
GO:0009889 regulation of biosynthetic process 20.5128 4 no
GO:0010243 response to organonitrogen compound 20.5128 4 no
GO:0022607 cellular component assembly 20.5128 4 no
GO:0031326 regulation of cellular biosynthetic process 20.5128 5 no
GO:0061024 membrane organization 20.5128 4 no
GO:0016192 vesicle-mediated transport 20.5128 4 no
GO:0010648 negative regulation of cell communication 17.9487 5 yes
GO:0023057 negative regulation of signaling 17.9487 4 yes
GO:0060627 regulation of vesicle-mediated transport 15.3846 4 yes
GO:0050804 modulation of chemical synaptic transmission 10.2564 5 yes
GO:0099177 regulation of trans-synaptic signaling 10.2564 4 yes
GO:0007612 learning 7.6923 4 yes
GO:0030100 regulation of endocytosis 7.6923 5 yes
GO:0050890 cognition 7.6923 4 yes
GO:0007613 memory 5.1282 4 yes
GO:0045807 positive regulation of endocytosis 5.1282 5 yes
GO:0050805 negative regulation of synaptic transmission 5.1282 5 yes
GO:0072657 protein localization to membrane 5.1282 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in ATAD1_HUMAN
DOID:331 central nervous system disease 7.6923 3 no
DOID:10595 Charcot-Marie-Tooth disease 5.1282 6 no
DOID:440 neuromuscular disease 5.1282 5 no
DOID:574 peripheral nervous system disease 5.1282 3 no
DOID:870 neuropathy 5.1282 4 no
DOID:10579 leukodystrophy 5.1282 6 no
DOID:1443 cerebral degeneration 5.1282 5 no
DOID:936 brain disease 5.1282 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GOSR1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
TLC3A_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP2_HUMAN [view interactions] High throughput no yes
NFKB1_HUMAN [view interactions] High throughput no yes
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
SYAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
REV3L_HUMAN [view entry] [view interactions] High throughput yes yes
SRBP2_HUMAN [view interactions] High throughput no yes
PURA2_HUMAN [view interactions] High throughput no yes
PURA1_HUMAN [view interactions] High throughput no no
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
GET3_HUMAN [view interactions] High throughput no yes
KCRM_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
PNPT1_HUMAN [view interactions] High throughput no yes
PRPS2_HUMAN [view interactions] High throughput no no
TPIS_HUMAN [view entry] [view interactions] High throughput yes yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
UBP19_HUMAN [view interactions] High throughput no no
BABA1_HUMAN [view interactions] High throughput no yes
HIF1N_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
MAS_HUMAN [view interactions] High throughput no no
FAF2_HUMAN [view interactions] High throughput no yes
COQ8B_HUMAN [view interactions] High throughput no yes
NMES1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
MAIP1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
ANKS6_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
BSCL2_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN598_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CGRF1_HUMAN [view interactions] High throughput no yes
MARH3_HUMAN [view interactions] High throughput no no
RN170_HUMAN [view interactions] High throughput no yes
RN185_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
ANM8_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
KLK15_HUMAN [view interactions] High throughput no no
GPR45_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
ABCD3_HUMAN [view entry] [view interactions] Computational yes yes
ABCD2_HUMAN [view interactions] Computational no no
PEX16_HUMAN [view interactions] Computational no yes
ABCD1_HUMAN [view entry] [view interactions] Computational yes no
PXMP2_HUMAN [view interactions] Computational no no
GDAP1_HUMAN [view entry] [view interactions] Computational yes yes
PEX26_HUMAN [view interactions] Computational no yes
PEX2_HUMAN [view interactions] Computational no yes
PEX3_HUMAN [view interactions] Computational no yes
ACBD5_HUMAN [view entry] [view interactions] Computational yes yes
PEX13_HUMAN [view interactions] Computational no yes
AL3A2_HUMAN [view entry] [view interactions] Computational yes yes
PM34_HUMAN [view interactions] Computational no yes
PXMP4_HUMAN [view interactions] Computational no yes
PX11B_HUMAN [view entry] [view interactions] Computational yes yes