SYAP1_HUMAN
Evidence for PS localization
Functions
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at Ser-473 after growth factor stimulation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYAP1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.7755 | 4 | no |
| GO:0000166 | nucleotide binding | 36.7347 | 4 | no |
| GO:0017076 | purine nucleotide binding | 36.7347 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 36.7347 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.7347 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 26.5306 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.5306 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.5306 | 6 | no |
| GO:0003924 | GTPase activity | 22.4490 | 7 | no |
| GO:0005525 | GTP binding | 22.4490 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 22.4490 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 22.4490 | 5 | no |
| GO:0003723 | RNA binding | 20.4082 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYAP1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.3878 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.0204 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.9796 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.9796 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.8980 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | yes |
| GO:0006996 | organelle organization | 40.8163 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.8163 | 4 | no |
| GO:0060341 | regulation of cellular localization | 40.8163 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.8163 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.8163 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 38.7755 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.7755 | 4 | no |
| GO:0008104 | protein localization | 36.7347 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 36.7347 | 5 | no |
| GO:0023056 | positive regulation of signaling | 36.7347 | 4 | no |
| GO:0032880 | regulation of protein localization | 36.7347 | 5 | no |
| GO:0051049 | regulation of transport | 36.7347 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.7347 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.7347 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.7347 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 34.6939 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 34.6939 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.6939 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.6939 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 32.6531 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 32.6531 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 32.6531 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.6122 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.5714 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.5306 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.5306 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.5306 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.5306 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 26.5306 | 4 | no |
| GO:2000145 | regulation of cell motility | 26.5306 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.5306 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 24.4898 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 24.4898 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.4898 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 24.4898 | 5 | no |
| GO:0030334 | regulation of cell migration | 24.4898 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.4898 | 6 | no |
| GO:0022607 | cellular component assembly | 24.4898 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.4898 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 22.4490 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 22.4490 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 22.4490 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.4490 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 22.4490 | 5 | no |
| GO:0036211 | protein modification process | 22.4490 | 4 | no |
| GO:0043412 | macromolecule modification | 22.4490 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.4490 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.4490 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.4490 | 4 | no |
| GO:0071702 | organic substance transport | 22.4490 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.4490 | 7 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 20.4082 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 20.4082 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 20.4082 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 20.4082 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.4082 | 4 | no |
| GO:0030030 | cell projection organization | 20.4082 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 20.4082 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 20.4082 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 20.4082 | 6 | no |
| GO:2000147 | positive regulation of cell motility | 20.4082 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.4082 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.4082 | 4 | no |
| GO:0061024 | membrane organization | 20.4082 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.4082 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.4082 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.4082 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.4082 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4082 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 18.3673 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 18.3673 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 18.3673 | 7 | yes |
| GO:0001932 | regulation of protein phosphorylation | 18.3673 | 7 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 18.3673 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 18.3673 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 16.3265 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 16.3265 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 14.2857 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 14.2857 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 12.2449 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 12.2449 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 12.2449 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 12.2449 | 7 | yes |
| GO:0051347 | positive regulation of transferase activity | 12.2449 | 5 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 12.2449 | 7 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 12.2449 | 8 | yes |
| GO:0033674 | positive regulation of kinase activity | 12.2449 | 6 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 10.2041 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 10.2041 | 4 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 8.1633 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 8.1633 | 4 | yes |
| GO:0043434 | response to peptide hormone | 6.1224 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 6.1224 | 4 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 4.0816 | 5 | yes |
| GO:1990314 | cellular response to insulin-like growth factor stimulus | 4.0816 | 6 | yes |
| GO:0031929 | TOR signaling | 4.0816 | 4 | yes |
| GO:0032868 | response to insulin | 4.0816 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NECD_HUMAN | [view interactions] | Low throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| T2R41_HUMAN | [view interactions] | High throughput | no | no |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| S39A1_HUMAN | [view interactions] | High throughput | no | no |
| CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THA_HUMAN | [view interactions] | High throughput | no | yes |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MFN1_HUMAN | [view interactions] | High throughput | no | yes |
| MED25_HUMAN | [view interactions] | High throughput | no | yes |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| TM9S2_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACE1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP16_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |