SYAP1_HUMAN
Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at Ser-473 after growth factor stimulation (PubMed). [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SYAP1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 37.2093 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 34.8837 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 34.8837 | 4 | no |
GO:0016462 | pyrophosphatase activity | 25.5814 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.5814 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.5814 | 6 | no |
GO:0003924 | GTPase activity | 23.2558 | 7 | no |
GO:0005525 | GTP binding | 23.2558 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 23.2558 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 23.2558 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SYAP1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 69.7674 | 4 | yes |
GO:0010646 | regulation of cell communication | 51.1628 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 46.5116 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 44.1860 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 44.1860 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 44.1860 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 41.8605 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.8605 | 4 | yes |
GO:0009966 | regulation of signal transduction | 41.8605 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 41.8605 | 4 | no |
GO:0051049 | regulation of transport | 41.8605 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 39.5349 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.2093 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 37.2093 | 5 | no |
GO:0023056 | positive regulation of signaling | 37.2093 | 4 | no |
GO:0060341 | regulation of cellular localization | 37.2093 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 37.2093 | 5 | no |
GO:0008104 | protein localization | 34.8837 | 4 | no |
GO:0006996 | organelle organization | 34.8837 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 34.8837 | 5 | no |
GO:0048523 | negative regulation of cellular process | 34.8837 | 4 | no |
GO:0010468 | regulation of gene expression | 32.5581 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 32.5581 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 32.5581 | 5 | yes |
GO:0032880 | regulation of protein localization | 32.5581 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 30.2326 | 6 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 30.2326 | 5 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 30.2326 | 6 | no |
GO:0022607 | cellular component assembly | 27.9070 | 4 | no |
GO:0031344 | regulation of cell projection organization | 27.9070 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.9070 | 6 | no |
GO:0042325 | regulation of phosphorylation | 27.9070 | 7 | yes |
GO:0051247 | positive regulation of protein metabolic process | 27.9070 | 6 | yes |
GO:0042127 | regulation of cell population proliferation | 27.9070 | 4 | no |
GO:0010941 | regulation of cell death | 27.9070 | 4 | no |
GO:0033043 | regulation of organelle organization | 27.9070 | 5 | no |
GO:0051050 | positive regulation of transport | 27.9070 | 4 | no |
GO:0030030 | cell projection organization | 25.5814 | 4 | no |
GO:2000145 | regulation of cell motility | 25.5814 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 25.5814 | 6 | yes |
GO:0042327 | positive regulation of phosphorylation | 25.5814 | 8 | yes |
GO:0043085 | positive regulation of catalytic activity | 25.5814 | 4 | yes |
GO:0045595 | regulation of cell differentiation | 25.5814 | 4 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 25.5814 | 7 | yes |
GO:0051094 | positive regulation of developmental process | 25.5814 | 4 | yes |
GO:0071310 | cellular response to organic substance | 25.5814 | 4 | yes |
GO:0071702 | organic substance transport | 25.5814 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.5814 | 5 | no |
GO:0043067 | regulation of programmed cell death | 25.5814 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 25.5814 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 23.2558 | 4 | no |
GO:0030334 | regulation of cell migration | 23.2558 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.2558 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.2558 | 4 | no |
GO:0043408 | regulation of MAPK cascade | 23.2558 | 6 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 23.2558 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.2558 | 6 | yes |
GO:0008284 | positive regulation of cell population proliferation | 23.2558 | 5 | no |
GO:0071705 | nitrogen compound transport | 23.2558 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 23.2558 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.2558 | 4 | no |
GO:0032386 | regulation of intracellular transport | 23.2558 | 5 | no |
GO:0042981 | regulation of apoptotic process | 23.2558 | 6 | no |
GO:0051223 | regulation of protein transport | 23.2558 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 23.2558 | 6 | no |
GO:1903829 | positive regulation of protein localization | 23.2558 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 20.9302 | 4 | no |
GO:0061024 | membrane organization | 20.9302 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 20.9302 | 4 | no |
GO:0016192 | vesicle-mediated transport | 20.9302 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.9302 | 4 | yes |
GO:0031401 | positive regulation of protein modification process | 20.9302 | 7 | yes |
GO:0051338 | regulation of transferase activity | 20.9302 | 4 | yes |
GO:0015031 | protein transport | 20.9302 | 4 | no |
GO:0036211 | protein modification process | 20.9302 | 4 | no |
GO:0043412 | macromolecule modification | 20.9302 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 18.6047 | 7 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 18.6047 | 8 | yes |
GO:0051347 | positive regulation of transferase activity | 18.6047 | 5 | yes |
GO:0033674 | positive regulation of kinase activity | 16.2791 | 6 | yes |
GO:0043549 | regulation of kinase activity | 16.2791 | 5 | yes |
GO:0045597 | positive regulation of cell differentiation | 16.2791 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 16.2791 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 16.2791 | 4 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 16.2791 | 4 | yes |
GO:0071417 | cellular response to organonitrogen compound | 11.6279 | 4 | yes |
GO:1901699 | cellular response to nitrogen compound | 11.6279 | 4 | yes |
GO:0045859 | regulation of protein kinase activity | 9.3023 | 6 | yes |
GO:0045860 | positive regulation of protein kinase activity | 9.3023 | 7 | yes |
GO:0048168 | regulation of neuronal synaptic plasticity | 9.3023 | 4 | yes |
GO:0070848 | response to growth factor | 9.3023 | 4 | yes |
GO:0071363 | cellular response to growth factor stimulus | 9.3023 | 5 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 9.3023 | 7 | yes |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | 9.3023 | 8 | yes |
GO:0032870 | cellular response to hormone stimulus | 6.9767 | 4 | yes |
GO:0043434 | response to peptide hormone | 6.9767 | 4 | yes |
GO:1901652 | response to peptide | 6.9767 | 4 | yes |
GO:0032868 | response to insulin | 4.6512 | 5 | yes |
GO:0071364 | cellular response to epidermal growth factor stimulus | 4.6512 | 4 | yes |
GO:0071375 | cellular response to peptide hormone stimulus | 4.6512 | 5 | yes |
GO:1901653 | cellular response to peptide | 4.6512 | 5 | yes |
GO:1990314 | cellular response to insulin-like growth factor stimulus | 4.6512 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NECD_HUMAN | [view interactions] | Low throughput | no | no |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC61B_HUMAN | [view interactions] | High throughput | no | yes |
RN183_HUMAN | [view interactions] | High throughput | no | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
BAP31_HUMAN | [view interactions] | High throughput | no | yes |
CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
DHB11_HUMAN | [view interactions] | High throughput | no | yes |
3BHS7_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LNP_HUMAN | [view interactions] | High throughput | no | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET7A_HUMAN | [view interactions] | High throughput | no | no |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3B_HUMAN | [view interactions] | High throughput | no | no |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEC62_HUMAN | [view interactions] | High throughput | no | yes |
SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STIM1_HUMAN | [view interactions] | High throughput | no | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
AMPN_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
ECD_HUMAN | [view interactions] | High throughput | no | yes |
SNR27_HUMAN | [view interactions] | High throughput | no | yes |
FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAI2_HUMAN | [view interactions] | High throughput | no | no |
T2R41_HUMAN | [view interactions] | High throughput | no | no |
UBP47_HUMAN | [view interactions] | High throughput | no | yes |
S39A1_HUMAN | [view interactions] | High throughput | no | no |
CP1A1_HUMAN | [view interactions] | High throughput | no | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THA_HUMAN | [view interactions] | High throughput | no | yes |
TR10C_HUMAN | [view interactions] | High throughput | no | no |
MIP_HUMAN | [view interactions] | High throughput | no | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ADIPO_HUMAN | [view interactions] | High throughput | no | no |
TM216_HUMAN | [view interactions] | High throughput | no | no |
BET1_HUMAN | [view interactions] | High throughput | no | no |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX14_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA8_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RET_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
PRPS2_HUMAN | [view interactions] | High throughput | no | no |
CERS2_HUMAN | [view interactions] | High throughput | no | no |
RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MFN1_HUMAN | [view interactions] | High throughput | no | yes |
MED25_HUMAN | [view interactions] | High throughput | no | yes |
GP107_HUMAN | [view interactions] | High throughput | no | yes |
TM9S2_HUMAN | [view interactions] | High throughput | no | yes |
ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PACE1_HUMAN | [view interactions] | High throughput | no | yes |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSB7_HUMAN | [view interactions] | High throughput | no | yes |
PSB4_HUMAN | [view interactions] | High throughput | no | yes |
PSA5_HUMAN | [view interactions] | High throughput | no | yes |
CBX3_HUMAN | [view interactions] | High throughput | no | yes |
ERF1_HUMAN | [view interactions] | High throughput | no | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
PYRG2_HUMAN | [view interactions] | Computational | no | yes |