Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FIS1_HUMAN

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in FIS1_HUMAN
GO:0043168 anion binding 30.9859 4 no
GO:0000166 nucleotide binding 29.5775 4 no
GO:0017076 purine nucleotide binding 29.5775 5 no
GO:0032555 purine ribonucleotide binding 29.5775 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.3521 4 no
GO:0043169 cation binding 21.1268 4 no
GO:0046872 metal ion binding 21.1268 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in FIS1_HUMAN
GO:0006996 organelle organization 50.7042 4 yes
GO:0008104 protein localization 40.8451 4 yes
GO:0048522 positive regulation of cellular process 38.0282 4 yes
GO:0031323 regulation of cellular metabolic process 35.2113 4 yes
GO:0048523 negative regulation of cellular process 35.2113 4 yes
GO:0060255 regulation of macromolecule metabolic process 35.2113 4 yes
GO:0010646 regulation of cell communication 32.3944 4 yes
GO:0080090 regulation of primary metabolic process 32.3944 4 yes
GO:0009893 positive regulation of metabolic process 30.9859 4 yes
GO:0051128 regulation of cellular component organization 30.9859 4 yes
GO:0071702 organic substance transport 29.5775 4 no
GO:0051246 regulation of protein metabolic process 26.7606 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 25.3521 5 yes
GO:0009966 regulation of signal transduction 23.9437 4 yes
GO:0071705 nitrogen compound transport 23.9437 4 no
GO:0009892 negative regulation of metabolic process 22.5352 4 yes
GO:0033365 protein localization to organelle 22.5352 5 yes
GO:0051049 regulation of transport 22.5352 4 yes
GO:0015031 protein transport 22.5352 4 no
GO:0009894 regulation of catabolic process 22.5352 4 no
GO:0009889 regulation of biosynthetic process 21.1268 4 no
GO:0022607 cellular component assembly 21.1268 4 no
GO:0031324 negative regulation of cellular metabolic process 19.7183 5 yes
GO:0033043 regulation of organelle organization 19.7183 5 yes
GO:0007005 mitochondrion organization 18.3099 5 yes
GO:0019220 regulation of phosphate metabolic process 18.3099 6 yes
GO:0023056 positive regulation of signaling 18.3099 4 yes
GO:0051174 regulation of phosphorus metabolic process 18.3099 5 yes
GO:0051247 positive regulation of protein metabolic process 18.3099 6 yes
GO:1902531 regulation of intracellular signal transduction 18.3099 5 yes
GO:0010647 positive regulation of cell communication 16.9014 5 yes
GO:0051130 positive regulation of cellular component organization 16.9014 5 yes
GO:0060341 regulation of cellular localization 16.9014 4 yes
GO:0032880 regulation of protein localization 15.4930 5 yes
GO:0042981 regulation of apoptotic process 15.4930 5 yes
GO:0043067 regulation of programmed cell death 15.4930 4 yes
GO:0048584 positive regulation of response to stimulus 15.4930 4 yes
GO:0072594 establishment of protein localization to organelle 15.4930 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 14.0845 4 yes
GO:0009967 positive regulation of signal transduction 14.0845 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 14.0845 5 yes
GO:0030003 intracellular monoatomic cation homeostasis 14.0845 5 yes
GO:0055080 monoatomic cation homeostasis 14.0845 4 yes
GO:0070585 protein localization to mitochondrion 14.0845 6 yes
GO:0010563 negative regulation of phosphorus metabolic process 12.6761 6 yes
GO:0010638 positive regulation of organelle organization 12.6761 6 yes
GO:0045936 negative regulation of phosphate metabolic process 12.6761 7 yes
GO:0048284 organelle fusion 12.6761 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 11.2676 4 yes
GO:0043085 positive regulation of catalytic activity 11.2676 4 yes
GO:0048285 organelle fission 11.2676 5 yes
GO:0051094 positive regulation of developmental process 11.2676 4 yes
GO:0070201 regulation of establishment of protein localization 11.2676 6 yes
GO:1902533 positive regulation of intracellular signal transduction 11.2676 6 yes
GO:0000266 mitochondrial fission 9.8592 6 yes
GO:0006874 intracellular calcium ion homeostasis 9.8592 5 yes
GO:0010821 regulation of mitochondrion organization 9.8592 6 yes
GO:0051051 negative regulation of transport 9.8592 4 yes
GO:0055074 calcium ion homeostasis 9.8592 4 yes
GO:0072655 establishment of protein localization to mitochondrion 9.8592 5 yes
GO:1903829 positive regulation of protein localization 9.8592 5 yes
GO:0006605 protein targeting 8.4507 4 yes
GO:0022411 cellular component disassembly 8.4507 4 yes
GO:0030162 regulation of proteolysis 8.4507 6 yes
GO:0051336 regulation of hydrolase activity 8.4507 4 yes
GO:0090140 regulation of mitochondrial fission 8.4507 5 yes
GO:2001233 regulation of apoptotic signaling pathway 8.4507 5 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 8.4507 6 yes
GO:0008053 mitochondrial fusion 7.0423 6 yes
GO:0008637 apoptotic mitochondrial changes 7.0423 6 yes
GO:0016559 peroxisome fission 7.0423 6 yes
GO:0045862 positive regulation of proteolysis 7.0423 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 7.0423 5 yes
GO:0051345 positive regulation of hydrolase activity 7.0423 5 yes
GO:0062012 regulation of small molecule metabolic process 7.0423 4 yes
GO:0090141 positive regulation of mitochondrial fission 7.0423 5 yes
GO:1903008 organelle disassembly 7.0423 5 yes
GO:1903533 regulation of protein targeting 7.0423 7 yes
GO:1904951 positive regulation of establishment of protein localization 7.0423 6 yes
GO:0000422 autophagy of mitochondrion 5.6338 4 yes
GO:0001836 release of cytochrome c from mitochondria 5.6338 7 yes
GO:0006140 regulation of nucleotide metabolic process 5.6338 5 yes
GO:0006626 protein targeting to mitochondrion 5.6338 5 yes
GO:0043653 mitochondrial fragmentation involved in apoptotic process 5.6338 7 yes
GO:0051560 mitochondrial calcium ion homeostasis 5.6338 6 yes
GO:1900542 regulation of purine nucleotide metabolic process 5.6338 6 yes
GO:1903578 regulation of ATP metabolic process 5.6338 7 yes
GO:1905475 regulation of protein localization to membrane 5.6338 6 yes
GO:1905477 positive regulation of protein localization to membrane 5.6338 6 yes
GO:0010952 positive regulation of peptidase activity 4.2254 6 yes
GO:0032368 regulation of lipid transport 4.2254 5 yes
GO:0032890 regulation of organic acid transport 4.2254 5 yes
GO:0043065 positive regulation of apoptotic process 4.2254 6 yes
GO:0043068 positive regulation of programmed cell death 4.2254 5 yes
GO:0045980 negative regulation of nucleotide metabolic process 4.2254 6 yes
GO:0052547 regulation of peptidase activity 4.2254 5 yes
GO:0062014 negative regulation of small molecule metabolic process 4.2254 5 yes
GO:0090313 regulation of protein targeting to membrane 4.2254 7 yes
GO:0090314 positive regulation of protein targeting to membrane 4.2254 7 yes
GO:1900543 negative regulation of purine nucleotide metabolic process 4.2254 7 yes
GO:1903579 negative regulation of ATP metabolic process 4.2254 8 yes
GO:1905952 regulation of lipid localization 4.2254 4 yes
GO:2001235 positive regulation of apoptotic signaling pathway 4.2254 6 yes
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 4.2254 7 yes
GO:0010950 positive regulation of endopeptidase activity 2.8169 7 yes
GO:0032369 negative regulation of lipid transport 2.8169 5 yes
GO:0032469 endoplasmic reticulum calcium ion homeostasis 2.8169 6 yes
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration 2.8169 7 yes
GO:0032891 negative regulation of organic acid transport 2.8169 5 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 2.8169 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 2.8169 8 yes
GO:0051561 positive regulation of mitochondrial calcium ion concentration 2.8169 7 yes
GO:0052548 regulation of endopeptidase activity 2.8169 6 yes
GO:1905953 negative regulation of lipid localization 2.8169 4 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 2.8169 7 yes
GO:2000191 regulation of fatty acid transport 2.8169 6 yes
GO:2000192 negative regulation of fatty acid transport 2.8169 6 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 2.8169 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NOD2_HUMAN [view interactions] Low throughput no yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
MARH5_HUMAN [view interactions] Low throughput no no
BAP31_HUMAN [view interactions] Low throughput no yes
MID51_HUMAN [view interactions] Low throughput no no
LRRK2_HUMAN [view interactions] Low throughput no yes
PX11A_HUMAN [view interactions] Low throughput no no
PX11B_HUMAN [view entry] [view interactions] Low throughput yes yes
PX11C_HUMAN [view interactions] Low throughput no yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP8_HUMAN [view interactions] Low throughput no yes
ATPB_HUMAN [view interactions] Low throughput no yes
GDAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBC15_HUMAN [view interactions] Low throughput no yes
FIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTFR2_HUMAN [view interactions] High throughput no no
MTMR3_HUMAN [view interactions] High throughput no no
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
MTX3_HUMAN [view interactions] High throughput no yes
MYO19_HUMAN [view interactions] High throughput no yes
NBAS_HUMAN [view interactions] High throughput no yes
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PALD_HUMAN [view interactions] High throughput no yes
PHLP_HUMAN [view interactions] High throughput no yes
PDZD8_HUMAN [view interactions] High throughput no yes
PEX1_HUMAN [view interactions] High throughput no no
PEX19_HUMAN [view interactions] High throughput no yes
PEX3_HUMAN [view interactions] High throughput no yes
PEX6_HUMAN [view interactions] High throughput no yes
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
KPCL_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RB3GP_HUMAN [view entry] [view interactions] High throughput yes yes
RBGPR_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RNBP6_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
RN213_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
SENP2_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
SMCR8_HUMAN [view interactions] High throughput no yes
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
SOAT1_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
STBD1_HUMAN [view interactions] High throughput no yes
STIM1_HUMAN [view interactions] High throughput no yes
SYAP1_HUMAN [view entry] [view interactions] High throughput yes yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
TDRKH_HUMAN [view interactions] High throughput no no
TEX2_HUMAN [view interactions] High throughput no yes
TM209_HUMAN [view interactions] High throughput no no
TOM70_HUMAN [view interactions] High throughput no yes
TRABD_HUMAN [view interactions] High throughput no yes
TTC1_HUMAN [view interactions] High throughput no yes
UBXN4_HUMAN [view interactions] High throughput no yes
UBP30_HUMAN [view interactions] High throughput no yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
SPE39_HUMAN [view interactions] High throughput no yes
VMA21_HUMAN [view interactions] High throughput no no
VP13D_HUMAN [view interactions] High throughput no no
VRK2_HUMAN [view interactions] High throughput no no
WDR41_HUMAN [view interactions] High throughput no yes
YKT6_HUMAN [view interactions] High throughput no yes
YMEL1_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
NOS3_HUMAN [view interactions] High throughput no no
CREB3_HUMAN [view interactions] High throughput no no
NMES1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP3_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
KASH5_HUMAN [view interactions] High throughput no yes
F210B_HUMAN [view interactions] High throughput no yes
TM14B_HUMAN [view interactions] High throughput no no
FFAR2_HUMAN [view interactions] High throughput no yes
TMPPE_HUMAN [view interactions] High throughput no yes
ERGI3_HUMAN [view interactions] High throughput no yes
JAGN1_HUMAN [view interactions] High throughput no no
KCNJ6_HUMAN [view entry] [view interactions] High throughput yes no
SOAT_HUMAN [view interactions] High throughput no no
ABHD6_HUMAN [view entry] [view interactions] High throughput yes yes
SCN3B_HUMAN [view interactions] High throughput no no
RNK_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
PIGP_HUMAN [view interactions] High throughput no yes
EBP_HUMAN [view interactions] High throughput no no
APH1A_HUMAN [view interactions] High throughput no yes
F209A_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
VKOR1_HUMAN [view interactions] High throughput no yes
SPCS1_HUMAN [view interactions] High throughput no yes
UT1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
AT12A_HUMAN [view entry] [view interactions] High throughput yes no
VP13A_HUMAN [view interactions] High throughput no yes
NJMU_HUMAN [view interactions] High throughput no yes
BIG3_HUMAN [view interactions] High throughput no yes
UBP24_HUMAN [view interactions] High throughput no yes
QSOX1_HUMAN [view interactions] High throughput no no
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD4_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
CCYL1_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
DCNL5_HUMAN [view interactions] High throughput no yes
F91A1_HUMAN [view interactions] High throughput no yes
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
RAB24_HUMAN [view interactions] High throughput no no
EVI5L_HUMAN [view interactions] High throughput no yes
HEAT6_HUMAN [view interactions] High throughput no no
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
BRF2_HUMAN [view interactions] High throughput no yes
BLT3A_HUMAN [view interactions] High throughput no no
MCAT_HUMAN [view interactions] High throughput no yes
RBGP1_HUMAN [view interactions] High throughput no yes
ZFY26_HUMAN [view interactions] High throughput no yes
TARB1_HUMAN [view interactions] High throughput no no
GBF1_HUMAN [view interactions] High throughput no yes
PLAP_HUMAN [view interactions] High throughput no yes
TBA1C_HUMAN [view interactions] High throughput no yes
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
AQP3_HUMAN [view interactions] High throughput no no
DYLT4_HUMAN [view interactions] High throughput no no
MFD4A_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
FOXA1_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
S22A1_HUMAN [view interactions] High throughput no yes
S22A2_HUMAN [view interactions] High throughput no no
CDV3_HUMAN [view interactions] High throughput no no
TOM40_HUMAN [view interactions] High throughput no yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
COF1_HUMAN [view entry] [view interactions] High throughput yes no
ELAV2_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4A_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
MARH2_HUMAN [view interactions] High throughput no yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
GCP60_HUMAN [view interactions] High throughput no yes
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
ANKL2_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
ARM10_HUMAN [view entry] [view interactions] High throughput yes yes
ARMX2_HUMAN [view interactions] High throughput no yes
ARMX3_HUMAN [view interactions] High throughput no no
ATAD1_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5J_HUMAN [view interactions] High throughput no yes
VAS1_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
ATPF1_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
B2L13_HUMAN [view interactions] High throughput no no
CI072_HUMAN [view entry] [view interactions] High throughput yes no
CCD47_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
CDKAL_HUMAN [view interactions] High throughput no no
CHMP7_HUMAN [view interactions] High throughput no yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCC1_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
EHBP1_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC3_HUMAN [view interactions] High throughput no yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
FBXL4_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
GLPK_HUMAN [view entry] [view interactions] High throughput yes no
GPAT1_HUMAN [view interactions] High throughput no no
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
HXK2_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MAN1_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
LSG1_HUMAN [view interactions] High throughput no yes
MAVS_HUMAN [view interactions] High throughput no yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
MIGA1_HUMAN [view interactions] High throughput no yes
MLX_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
MFR1L_HUMAN [view interactions] High throughput no yes