MFF_HUMAN
Evidence for PS localization
Functions
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MFF_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.0870 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 23.9130 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.9130 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.9130 | 5 | no |
| GO:0003924 | GTPase activity | 21.7391 | 7 | no |
| GO:0005525 | GTP binding | 21.7391 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 21.7391 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.7391 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.7391 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0042803 | protein homodimerization activity | 8.6957 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MFF_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.8261 | 4 | yes |
| GO:0006996 | organelle organization | 43.4783 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.3043 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3043 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.3043 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0008104 | protein localization | 39.1304 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 36.9565 | 4 | no |
| GO:0033043 | regulation of organelle organization | 36.9565 | 5 | yes |
| GO:0071702 | organic substance transport | 34.7826 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 32.6087 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.6087 | 4 | no |
| GO:0061024 | membrane organization | 32.6087 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.6087 | 4 | no |
| GO:0015031 | protein transport | 32.6087 | 4 | yes |
| GO:0051049 | regulation of transport | 32.6087 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
| GO:0006886 | intracellular protein transport | 28.2609 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0010941 | regulation of cell death | 26.0870 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.0870 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 23.9130 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.9130 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 23.9130 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.9130 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | yes |
| GO:0033365 | protein localization to organelle | 21.7391 | 5 | yes |
| GO:0070585 | protein localization to mitochondrion | 19.5652 | 6 | yes |
| GO:0006839 | mitochondrial transport | 19.5652 | 4 | yes |
| GO:0007005 | mitochondrion organization | 19.5652 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 19.5652 | 6 | yes |
| GO:0051050 | positive regulation of transport | 19.5652 | 4 | yes |
| GO:0051223 | regulation of protein transport | 17.3913 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 17.3913 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 17.3913 | 4 | yes |
| GO:0006605 | protein targeting | 17.3913 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 17.3913 | 6 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 15.2174 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 15.2174 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 15.2174 | 4 | yes |
| GO:0048284 | organelle fusion | 15.2174 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 13.0435 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 13.0435 | 6 | yes |
| GO:0032386 | regulation of intracellular transport | 13.0435 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 13.0435 | 6 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 10.8696 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 10.8696 | 6 | yes |
| GO:0000266 | mitochondrial fission | 10.8696 | 6 | yes |
| GO:0006626 | protein targeting to mitochondrion | 10.8696 | 5 | yes |
| GO:0008637 | apoptotic mitochondrial changes | 10.8696 | 6 | yes |
| GO:0010822 | positive regulation of mitochondrion organization | 10.8696 | 7 | yes |
| GO:0032388 | positive regulation of intracellular transport | 10.8696 | 5 | yes |
| GO:0048285 | organelle fission | 10.8696 | 5 | yes |
| GO:0070584 | mitochondrion morphogenesis | 8.6957 | 5 | yes |
| GO:0090140 | regulation of mitochondrial fission | 8.6957 | 5 | yes |
| GO:0090141 | positive regulation of mitochondrial fission | 8.6957 | 5 | yes |
| GO:1903533 | regulation of protein targeting | 8.6957 | 7 | yes |
| GO:1905477 | positive regulation of protein localization to membrane | 8.6957 | 6 | yes |
| GO:0001836 | release of cytochrome c from mitochondria | 8.6957 | 7 | yes |
| GO:0008053 | mitochondrial fusion | 8.6957 | 6 | yes |
| GO:0016559 | peroxisome fission | 8.6957 | 6 | yes |
| GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 8.6957 | 7 | yes |
| GO:0090199 | regulation of release of cytochrome c from mitochondria | 6.5217 | 7 | yes |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 6.5217 | 8 | yes |
| GO:0090313 | regulation of protein targeting to membrane | 6.5217 | 7 | yes |
| GO:0090314 | positive regulation of protein targeting to membrane | 6.5217 | 7 | yes |
| GO:1900063 | regulation of peroxisome organization | 6.5217 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MFF_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 8.6957 | 3 | no |
| DOID:870 | neuropathy | 8.6957 | 4 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 6.5217 | 6 | no |
| DOID:440 | neuromuscular disease | 6.5217 | 5 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 4.3478 | 7 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PODXL_HUMAN | [view interactions] | Low throughput | no | no |
| SAM50_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MFF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
| TM86B_HUMAN | [view interactions] | High throughput | no | no |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| FDSCP_HUMAN | [view interactions] | High throughput | no | no |
| CEND_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRAC_HUMAN | [view interactions] | High throughput | no | no |
| TARG1_HUMAN | [view interactions] | High throughput | no | no |
| ANR46_HUMAN | [view interactions] | High throughput | no | yes |
| C1QL4_HUMAN | [view interactions] | High throughput | no | no |
| VACHT_HUMAN | [view interactions] | High throughput | no | no |
| CO4A5_HUMAN | [view interactions] | High throughput | no | no |
| TM201_HUMAN | [view interactions] | High throughput | no | no |
| APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
| T229B_HUMAN | [view interactions] | High throughput | no | yes |
| PPLA_HUMAN | [view interactions] | High throughput | no | no |
| CTXN3_HUMAN | [view interactions] | High throughput | no | no |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| LAT_HUMAN | [view interactions] | High throughput | no | no |
| SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| AQP9_HUMAN | [view interactions] | High throughput | no | no |
| TNF14_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| BCL2_HUMAN | [view interactions] | High throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPT19_HUMAN | [view interactions] | High throughput | no | no |
| CC126_HUMAN | [view interactions] | High throughput | no | yes |
| ACTBM_HUMAN | [view interactions] | High throughput | no | no |
| MGT5A_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| COX14_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| NPAL3_HUMAN | [view interactions] | High throughput | no | yes |
| T3JAM_HUMAN | [view interactions] | High throughput | no | no |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| PLCD_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| LAT2_HUMAN | [view interactions] | High throughput | no | no |
| CNIH1_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLLP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBL1_HUMAN | [view interactions] | High throughput | no | no |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| MSPD3_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| TM14C_HUMAN | [view interactions] | High throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSPO2_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| UPK1B_HUMAN | [view interactions] | High throughput | no | no |
| UNC50_HUMAN | [view interactions] | High throughput | no | yes |
| IBP5_HUMAN | [view interactions] | High throughput | no | no |
| VATO_HUMAN | [view interactions] | High throughput | no | no |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| S35B1_HUMAN | [view interactions] | High throughput | no | no |
| SC22A_HUMAN | [view interactions] | High throughput | no | no |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F210B_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPSB_HUMAN | [view interactions] | High throughput | no | no |
| TM128_HUMAN | [view interactions] | High throughput | no | yes |
| NEUT_HUMAN | [view interactions] | High throughput | no | no |
| TM254_HUMAN | [view interactions] | High throughput | no | yes |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| TMM60_HUMAN | [view interactions] | High throughput | no | no |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| S41A2_HUMAN | [view interactions] | High throughput | no | yes |
| TM6S1_HUMAN | [view interactions] | High throughput | no | no |
| NRM_HUMAN | [view interactions] | High throughput | no | no |
| FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| SL7A1_HUMAN | [view interactions] | High throughput | no | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| AIG1_HUMAN | [view interactions] | High throughput | no | no |
| TM140_HUMAN | [view interactions] | High throughput | no | no |
| FATE1_HUMAN | [view interactions] | High throughput | no | no |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| TM237_HUMAN | [view interactions] | High throughput | no | no |
| ULBP6_HUMAN | [view interactions] | High throughput | no | no |
| TSN33_HUMAN | [view interactions] | High throughput | no | no |
| FCERG_HUMAN | [view interactions] | High throughput | no | no |
| CXL16_HUMAN | [view interactions] | High throughput | no | no |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| CLD19_HUMAN | [view interactions] | High throughput | no | no |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| TMM88_HUMAN | [view interactions] | High throughput | no | yes |
| SERC2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CXB1_HUMAN | [view interactions] | High throughput | no | yes |
| GKN1_HUMAN | [view interactions] | High throughput | no | no |
| TMM42_HUMAN | [view interactions] | High throughput | no | no |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| LPAR3_HUMAN | [view interactions] | High throughput | no | no |
| PLK3_HUMAN | [view interactions] | High throughput | no | no |
| TR1L1_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DENR_HUMAN | [view interactions] | Computational | no | yes |
| MID49_HUMAN | [view interactions] | Computational | no | yes |
| MID51_HUMAN | [view interactions] | Computational | no | no |
| MFN1_HUMAN | [view interactions] | Computational | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |