Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MFF_HUMAN

Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MFF_HUMAN
GO:0043168 anion binding 28.0000 4 no
GO:0000166 nucleotide binding 26.0000 4 no
GO:0017076 purine nucleotide binding 24.0000 5 no
GO:0032555 purine ribonucleotide binding 24.0000 4 no
GO:0019001 guanyl nucleotide binding 22.0000 6 no
GO:0032561 guanyl ribonucleotide binding 22.0000 5 no
GO:0042803 protein homodimerization activity 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MFF_HUMAN
GO:0006996 organelle organization 48.0000 4 yes
GO:0048522 positive regulation of cellular process 48.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.0000 4 no
GO:0008104 protein localization 42.0000 4 yes
GO:0051128 regulation of cellular component organization 42.0000 4 yes
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0031323 regulation of cellular metabolic process 34.0000 4 no
GO:0009893 positive regulation of metabolic process 32.0000 4 no
GO:0010646 regulation of cell communication 32.0000 4 no
GO:0033043 regulation of organelle organization 32.0000 5 yes
GO:0061024 membrane organization 30.0000 4 no
GO:0009966 regulation of signal transduction 30.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.0000 5 no
GO:0048523 negative regulation of cellular process 30.0000 4 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0071702 organic substance transport 28.0000 4 no
GO:0051049 regulation of transport 28.0000 4 no
GO:0051246 regulation of protein metabolic process 28.0000 5 no
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0015031 protein transport 26.0000 4 no
GO:0071705 nitrogen compound transport 26.0000 4 no
GO:0048584 positive regulation of response to stimulus 26.0000 4 no
GO:0010468 regulation of gene expression 26.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 26.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 26.0000 5 no
GO:0032880 regulation of protein localization 26.0000 5 yes
GO:0060341 regulation of cellular localization 26.0000 4 yes
GO:0009892 negative regulation of metabolic process 24.0000 4 no
GO:0042981 regulation of apoptotic process 24.0000 5 no
GO:0043067 regulation of programmed cell death 24.0000 4 no
GO:0033365 protein localization to organelle 24.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.0000 5 no
GO:1902531 regulation of intracellular signal transduction 22.0000 5 no
GO:0007005 mitochondrion organization 22.0000 5 yes
GO:0070585 protein localization to mitochondrion 22.0000 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.0000 4 yes
GO:0051130 positive regulation of cellular component organization 20.0000 5 yes
GO:0072594 establishment of protein localization to organelle 20.0000 4 yes
GO:0072655 establishment of protein localization to mitochondrion 18.0000 5 yes
GO:0051094 positive regulation of developmental process 18.0000 4 yes
GO:0070201 regulation of establishment of protein localization 18.0000 6 yes
GO:1903829 positive regulation of protein localization 16.0000 5 yes
GO:0010638 positive regulation of organelle organization 16.0000 6 yes
GO:0010821 regulation of mitochondrion organization 16.0000 6 yes
GO:0048284 organelle fusion 14.0000 5 yes
GO:1904951 positive regulation of establishment of protein localization 12.0000 6 yes
GO:0006605 protein targeting 12.0000 4 yes
GO:1905475 regulation of protein localization to membrane 10.0000 6 yes
GO:0000266 mitochondrial fission 10.0000 6 yes
GO:0008637 apoptotic mitochondrial changes 10.0000 6 yes
GO:0048285 organelle fission 10.0000 5 yes
GO:0090140 regulation of mitochondrial fission 8.0000 5 yes
GO:0090141 positive regulation of mitochondrial fission 8.0000 5 yes
GO:1903533 regulation of protein targeting 8.0000 7 yes
GO:1905477 positive regulation of protein localization to membrane 8.0000 6 yes
GO:0001836 release of cytochrome c from mitochondria 8.0000 7 yes
GO:0006626 protein targeting to mitochondrion 8.0000 5 yes
GO:0016559 peroxisome fission 8.0000 6 yes
GO:0043653 mitochondrial fragmentation involved in apoptotic process 8.0000 7 yes
GO:0090199 regulation of release of cytochrome c from mitochondria 6.0000 7 yes
GO:0090200 positive regulation of release of cytochrome c from mitochondria 6.0000 7 yes
GO:0090313 regulation of protein targeting to membrane 6.0000 7 yes
GO:0090314 positive regulation of protein targeting to membrane 6.0000 7 yes
GO:1900063 regulation of peroxisome organization 6.0000 6 yes
GO:0008053 mitochondrial fusion 6.0000 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MFF_HUMAN [view entry] [view interactions] Low throughput yes yes
PODXL_HUMAN [view interactions] Low throughput no no
SAM50_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
DNM1L_HUMAN [view entry] [view interactions] Low throughput yes yes
B2CL1_HUMAN [view interactions] Low throughput no yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
ODO2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLCD_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
AQP6_HUMAN [view interactions] High throughput no no
LAT2_HUMAN [view interactions] High throughput no no
CNIH1_HUMAN [view interactions] High throughput no yes
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
PLLP_HUMAN [view entry] [view interactions] High throughput yes no
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RHBL1_HUMAN [view interactions] High throughput no no
CDIPT_HUMAN [view entry] [view interactions] High throughput yes yes
CD79A_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
MSPD3_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
GOSR2_HUMAN [view interactions] High throughput no yes
SGMR2_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
TM14C_HUMAN [view interactions] High throughput no no
OPRM_HUMAN [view entry] [view interactions] High throughput yes no
TSPO2_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
UPK1B_HUMAN [view interactions] High throughput no no
UNC50_HUMAN [view interactions] High throughput no yes
IBP5_HUMAN [view interactions] High throughput no no
VATO_HUMAN [view interactions] High throughput no no
VAMP4_HUMAN [view entry] [view interactions] High throughput yes yes
S35B1_HUMAN [view interactions] High throughput no no
SC22A_HUMAN [view interactions] High throughput no no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
F210B_HUMAN [view interactions] High throughput no yes
F209A_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
APOL2_HUMAN [view entry] [view interactions] High throughput yes yes
OPSB_HUMAN [view interactions] High throughput no no
TM128_HUMAN [view interactions] High throughput no yes
NEUT_HUMAN [view interactions] High throughput no no
TM254_HUMAN [view interactions] High throughput no yes
TSN2_HUMAN [view interactions] High throughput no no
TMM60_HUMAN [view interactions] High throughput no no
MIP_HUMAN [view interactions] High throughput no no
S41A2_HUMAN [view interactions] High throughput no yes
TM6S1_HUMAN [view interactions] High throughput no no
NRM_HUMAN [view interactions] High throughput no no
FXYD6_HUMAN [view entry] [view interactions] High throughput yes yes
SHSL1_HUMAN [view interactions] High throughput no yes
CTR1_HUMAN [view interactions] High throughput no no
RETR3_HUMAN [view interactions] High throughput no yes
AIG1_HUMAN [view interactions] High throughput no no
TM140_HUMAN [view interactions] High throughput no no
FATE1_HUMAN [view interactions] High throughput no no
TM218_HUMAN [view interactions] High throughput no no
TM237_HUMAN [view interactions] High throughput no no
ULBP6_HUMAN [view interactions] High throughput no no
TSN33_HUMAN [view interactions] High throughput no no
FCERG_HUMAN [view interactions] High throughput no no
CXL16_HUMAN [view interactions] High throughput no no
ZFPL1_HUMAN [view interactions] High throughput no yes
CLD19_HUMAN [view interactions] High throughput no no
TX264_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
CKLF5_HUMAN [view interactions] High throughput no yes
SC11C_HUMAN [view interactions] High throughput no no
TMM88_HUMAN [view interactions] High throughput no yes
SERC2_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
CXB1_HUMAN [view interactions] High throughput no yes
GKN1_HUMAN [view interactions] High throughput no no
TMM42_HUMAN [view interactions] High throughput no no
STX8_HUMAN [view interactions] High throughput no yes
JAGN1_HUMAN [view interactions] High throughput no no
LPAR3_HUMAN [view interactions] High throughput no no
PLK3_HUMAN [view interactions] High throughput no no
TR1L1_HUMAN [view interactions] High throughput no no
GP152_HUMAN [view interactions] High throughput no no
CYBC1_HUMAN [view interactions] High throughput no yes
TM86B_HUMAN [view interactions] High throughput no no
ADIPO_HUMAN [view interactions] High throughput no no
FDSCP_HUMAN [view interactions] High throughput no no
CEND_HUMAN [view entry] [view interactions] High throughput yes yes
NRAC_HUMAN [view interactions] High throughput no no
TARG1_HUMAN [view interactions] High throughput no no
ANR46_HUMAN [view interactions] High throughput no yes
C1QL4_HUMAN [view interactions] High throughput no no
VACHT_HUMAN [view interactions] High throughput no no
CO4A5_HUMAN [view interactions] High throughput no no
TM201_HUMAN [view interactions] High throughput no no
APOD_HUMAN [view entry] [view interactions] High throughput yes yes
FAM3C_HUMAN [view interactions] High throughput no yes
LHPL5_HUMAN [view interactions] High throughput no no
MPZL1_HUMAN [view interactions] High throughput no yes
T229B_HUMAN [view interactions] High throughput no yes
PPLA_HUMAN [view interactions] High throughput no no
CTXN3_HUMAN [view interactions] High throughput no no
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TMX2_HUMAN [view interactions] High throughput no yes
LAT_HUMAN [view interactions] High throughput no no
SMIM1_HUMAN [view interactions] High throughput no yes
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DUS22_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
AQP9_HUMAN [view interactions] High throughput no no
TNF14_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
DUS16_HUMAN [view interactions] High throughput no yes
ASB14_HUMAN [view interactions] High throughput no no
BCL2_HUMAN [view interactions] High throughput no no
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MARH5_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ILF3_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
PTH2_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
MAVS_HUMAN [view interactions] High throughput no yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
MTX2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX3_HUMAN [view interactions] High throughput no yes
PXMP2_HUMAN [view interactions] High throughput no no
SQSTM_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
ARL10_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SPT19_HUMAN [view interactions] High throughput no no
MGT5A_HUMAN [view interactions] High throughput no yes
CC126_HUMAN [view interactions] High throughput no yes
ACTBM_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
COX14_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
TOM22_HUMAN [view interactions] High throughput no yes
HTRA2_HUMAN [view interactions] High throughput no yes
NPAL3_HUMAN [view interactions] High throughput no yes
T3JAM_HUMAN [view interactions] High throughput no no
S7A14_HUMAN [view interactions] High throughput no no