MFF_HUMAN
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MFF_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 28.0000 | 4 | no |
GO:0000166 | nucleotide binding | 26.0000 | 4 | no |
GO:0017076 | purine nucleotide binding | 24.0000 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 24.0000 | 4 | no |
GO:0019001 | guanyl nucleotide binding | 22.0000 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 22.0000 | 5 | no |
GO:0042803 | protein homodimerization activity | 10.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MFF_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 48.0000 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 48.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 42.0000 | 4 | no |
GO:0008104 | protein localization | 42.0000 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 42.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 34.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 32.0000 | 5 | yes |
GO:0061024 | membrane organization | 30.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
GO:0071702 | organic substance transport | 28.0000 | 4 | no |
GO:0051049 | regulation of transport | 28.0000 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | no |
GO:0015031 | protein transport | 26.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 26.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 26.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 26.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 26.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 26.0000 | 5 | no |
GO:0032880 | regulation of protein localization | 26.0000 | 5 | yes |
GO:0060341 | regulation of cellular localization | 26.0000 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 24.0000 | 5 | no |
GO:0043067 | regulation of programmed cell death | 24.0000 | 4 | no |
GO:0033365 | protein localization to organelle | 24.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.0000 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.0000 | 5 | no |
GO:0007005 | mitochondrion organization | 22.0000 | 5 | yes |
GO:0070585 | protein localization to mitochondrion | 22.0000 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 20.0000 | 4 | yes |
GO:0051130 | positive regulation of cellular component organization | 20.0000 | 5 | yes |
GO:0072594 | establishment of protein localization to organelle | 20.0000 | 4 | yes |
GO:0072655 | establishment of protein localization to mitochondrion | 18.0000 | 5 | yes |
GO:0051094 | positive regulation of developmental process | 18.0000 | 4 | yes |
GO:0070201 | regulation of establishment of protein localization | 18.0000 | 6 | yes |
GO:1903829 | positive regulation of protein localization | 16.0000 | 5 | yes |
GO:0010638 | positive regulation of organelle organization | 16.0000 | 6 | yes |
GO:0010821 | regulation of mitochondrion organization | 16.0000 | 6 | yes |
GO:0048284 | organelle fusion | 14.0000 | 5 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 12.0000 | 6 | yes |
GO:0006605 | protein targeting | 12.0000 | 4 | yes |
GO:1905475 | regulation of protein localization to membrane | 10.0000 | 6 | yes |
GO:0000266 | mitochondrial fission | 10.0000 | 6 | yes |
GO:0008637 | apoptotic mitochondrial changes | 10.0000 | 6 | yes |
GO:0048285 | organelle fission | 10.0000 | 5 | yes |
GO:0090140 | regulation of mitochondrial fission | 8.0000 | 5 | yes |
GO:0090141 | positive regulation of mitochondrial fission | 8.0000 | 5 | yes |
GO:1903533 | regulation of protein targeting | 8.0000 | 7 | yes |
GO:1905477 | positive regulation of protein localization to membrane | 8.0000 | 6 | yes |
GO:0001836 | release of cytochrome c from mitochondria | 8.0000 | 7 | yes |
GO:0006626 | protein targeting to mitochondrion | 8.0000 | 5 | yes |
GO:0016559 | peroxisome fission | 8.0000 | 6 | yes |
GO:0043653 | mitochondrial fragmentation involved in apoptotic process | 8.0000 | 7 | yes |
GO:0090199 | regulation of release of cytochrome c from mitochondria | 6.0000 | 7 | yes |
GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 6.0000 | 7 | yes |
GO:0090313 | regulation of protein targeting to membrane | 6.0000 | 7 | yes |
GO:0090314 | positive regulation of protein targeting to membrane | 6.0000 | 7 | yes |
GO:1900063 | regulation of peroxisome organization | 6.0000 | 6 | yes |
GO:0008053 | mitochondrial fusion | 6.0000 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
MFF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PODXL_HUMAN | [view interactions] | Low throughput | no | no |
SAM50_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRAF3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DNM1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
B2CL1_HUMAN | [view interactions] | Low throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ODO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PLCD_HUMAN | [view interactions] | High throughput | no | yes |
TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AQP6_HUMAN | [view interactions] | High throughput | no | no |
LAT2_HUMAN | [view interactions] | High throughput | no | no |
CNIH1_HUMAN | [view interactions] | High throughput | no | yes |
SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLLP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHBL1_HUMAN | [view interactions] | High throughput | no | no |
CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD79A_HUMAN | [view interactions] | High throughput | no | no |
BET1_HUMAN | [view interactions] | High throughput | no | no |
MSPD3_HUMAN | [view interactions] | High throughput | no | no |
MEOX2_HUMAN | [view interactions] | High throughput | no | no |
GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
SGMR2_HUMAN | [view interactions] | High throughput | no | no |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
TM14C_HUMAN | [view interactions] | High throughput | no | no |
OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TSPO2_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
UPK1B_HUMAN | [view interactions] | High throughput | no | no |
UNC50_HUMAN | [view interactions] | High throughput | no | yes |
IBP5_HUMAN | [view interactions] | High throughput | no | no |
VATO_HUMAN | [view interactions] | High throughput | no | no |
VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S35B1_HUMAN | [view interactions] | High throughput | no | no |
SC22A_HUMAN | [view interactions] | High throughput | no | no |
MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F210B_HUMAN | [view interactions] | High throughput | no | yes |
F209A_HUMAN | [view interactions] | High throughput | no | no |
ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
APOL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OPSB_HUMAN | [view interactions] | High throughput | no | no |
TM128_HUMAN | [view interactions] | High throughput | no | yes |
NEUT_HUMAN | [view interactions] | High throughput | no | no |
TM254_HUMAN | [view interactions] | High throughput | no | yes |
TSN2_HUMAN | [view interactions] | High throughput | no | no |
TMM60_HUMAN | [view interactions] | High throughput | no | no |
MIP_HUMAN | [view interactions] | High throughput | no | no |
S41A2_HUMAN | [view interactions] | High throughput | no | yes |
TM6S1_HUMAN | [view interactions] | High throughput | no | no |
NRM_HUMAN | [view interactions] | High throughput | no | no |
FXYD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHSL1_HUMAN | [view interactions] | High throughput | no | yes |
CTR1_HUMAN | [view interactions] | High throughput | no | no |
RETR3_HUMAN | [view interactions] | High throughput | no | yes |
AIG1_HUMAN | [view interactions] | High throughput | no | no |
TM140_HUMAN | [view interactions] | High throughput | no | no |
FATE1_HUMAN | [view interactions] | High throughput | no | no |
TM218_HUMAN | [view interactions] | High throughput | no | no |
TM237_HUMAN | [view interactions] | High throughput | no | no |
ULBP6_HUMAN | [view interactions] | High throughput | no | no |
TSN33_HUMAN | [view interactions] | High throughput | no | no |
FCERG_HUMAN | [view interactions] | High throughput | no | no |
CXL16_HUMAN | [view interactions] | High throughput | no | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
CLD19_HUMAN | [view interactions] | High throughput | no | no |
TX264_HUMAN | [view interactions] | High throughput | no | no |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
SC11C_HUMAN | [view interactions] | High throughput | no | no |
TMM88_HUMAN | [view interactions] | High throughput | no | yes |
SERC2_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
CXB1_HUMAN | [view interactions] | High throughput | no | yes |
GKN1_HUMAN | [view interactions] | High throughput | no | no |
TMM42_HUMAN | [view interactions] | High throughput | no | no |
STX8_HUMAN | [view interactions] | High throughput | no | yes |
JAGN1_HUMAN | [view interactions] | High throughput | no | no |
LPAR3_HUMAN | [view interactions] | High throughput | no | no |
PLK3_HUMAN | [view interactions] | High throughput | no | no |
TR1L1_HUMAN | [view interactions] | High throughput | no | no |
GP152_HUMAN | [view interactions] | High throughput | no | no |
CYBC1_HUMAN | [view interactions] | High throughput | no | yes |
TM86B_HUMAN | [view interactions] | High throughput | no | no |
ADIPO_HUMAN | [view interactions] | High throughput | no | no |
FDSCP_HUMAN | [view interactions] | High throughput | no | no |
CEND_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NRAC_HUMAN | [view interactions] | High throughput | no | no |
TARG1_HUMAN | [view interactions] | High throughput | no | no |
ANR46_HUMAN | [view interactions] | High throughput | no | yes |
C1QL4_HUMAN | [view interactions] | High throughput | no | no |
VACHT_HUMAN | [view interactions] | High throughput | no | no |
CO4A5_HUMAN | [view interactions] | High throughput | no | no |
TM201_HUMAN | [view interactions] | High throughput | no | no |
APOD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
LHPL5_HUMAN | [view interactions] | High throughput | no | no |
MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
T229B_HUMAN | [view interactions] | High throughput | no | yes |
PPLA_HUMAN | [view interactions] | High throughput | no | no |
CTXN3_HUMAN | [view interactions] | High throughput | no | no |
SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMX2_HUMAN | [view interactions] | High throughput | no | yes |
LAT_HUMAN | [view interactions] | High throughput | no | no |
SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS22_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
AQP9_HUMAN | [view interactions] | High throughput | no | no |
TNF14_HUMAN | [view interactions] | High throughput | no | yes |
BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DUS16_HUMAN | [view interactions] | High throughput | no | yes |
ASB14_HUMAN | [view interactions] | High throughput | no | no |
BCL2_HUMAN | [view interactions] | High throughput | no | no |
PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARH5_HUMAN | [view interactions] | High throughput | no | no |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
MEN1_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
ILF3_HUMAN | [view interactions] | High throughput | no | yes |
DDX28_HUMAN | [view interactions] | High throughput | no | yes |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HAX1_HUMAN | [view interactions] | High throughput | no | no |
MAVS_HUMAN | [view interactions] | High throughput | no | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PEX3_HUMAN | [view interactions] | High throughput | no | yes |
PXMP2_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL10_HUMAN | [view interactions] | High throughput | no | yes |
RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
SPT19_HUMAN | [view interactions] | High throughput | no | no |
MGT5A_HUMAN | [view interactions] | High throughput | no | yes |
CC126_HUMAN | [view interactions] | High throughput | no | yes |
ACTBM_HUMAN | [view interactions] | High throughput | no | no |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
COX14_HUMAN | [view interactions] | High throughput | no | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLRKT_HUMAN | [view interactions] | High throughput | no | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
NPAL3_HUMAN | [view interactions] | High throughput | no | yes |
T3JAM_HUMAN | [view interactions] | High throughput | no | no |
S7A14_HUMAN | [view interactions] | High throughput | no | no |