Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC23A_HUMAN

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SC23A_HUMAN
GO:0043168 anion binding 32.1839 4 no
GO:0000166 nucleotide binding 28.7356 4 no
GO:0017076 purine nucleotide binding 27.5862 5 no
GO:0032555 purine ribonucleotide binding 26.4368 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.4368 4 no
GO:0030554 adenyl nucleotide binding 24.1379 6 no
GO:0005524 ATP binding 22.9885 5 no
GO:0032559 adenyl ribonucleotide binding 22.9885 5 no
GO:0043169 cation binding 21.8391 4 yes
GO:0046872 metal ion binding 21.8391 5 yes
GO:0008270 zinc ion binding 8.0460 7 yes
GO:0046914 transition metal ion binding 8.0460 6 yes
GO:0030695 GTPase regulator activity 4.5977 4 yes
GO:0005096 GTPase activator activity 2.2989 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC23A_HUMAN
GO:0048522 positive regulation of cellular process 52.8736 4 no
GO:0060255 regulation of macromolecule metabolic process 49.4253 4 no
GO:0080090 regulation of primary metabolic process 47.1264 4 no
GO:0031323 regulation of cellular metabolic process 44.8276 4 no
GO:0051128 regulation of cellular component organization 44.8276 4 no
GO:0008104 protein localization 43.6782 4 yes
GO:0048523 negative regulation of cellular process 42.5287 4 no
GO:0010646 regulation of cell communication 39.0805 4 no
GO:0009893 positive regulation of metabolic process 37.9310 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.7816 5 no
GO:0051246 regulation of protein metabolic process 36.7816 5 no
GO:0009889 regulation of biosynthetic process 36.7816 4 no
GO:0031326 regulation of cellular biosynthetic process 36.7816 5 no
GO:0071702 organic substance transport 35.6322 4 yes
GO:0009966 regulation of signal transduction 35.6322 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.4828 5 no
GO:0010468 regulation of gene expression 32.1839 6 no
GO:0071705 nitrogen compound transport 32.1839 4 yes
GO:0006996 organelle organization 31.0345 4 no
GO:0009892 negative regulation of metabolic process 29.8851 4 no
GO:0015031 protein transport 27.5862 4 yes
GO:0031325 positive regulation of cellular metabolic process 27.5862 5 no
GO:0036211 protein modification process 27.5862 4 no
GO:0043412 macromolecule modification 27.5862 4 no
GO:0009894 regulation of catabolic process 26.4368 4 no
GO:0051130 positive regulation of cellular component organization 25.2874 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.2874 5 no
GO:0022607 cellular component assembly 25.2874 4 no
GO:0051247 positive regulation of protein metabolic process 25.2874 6 no
GO:1902531 regulation of intracellular signal transduction 25.2874 5 no
GO:0048584 positive regulation of response to stimulus 24.1379 4 no
GO:0044087 regulation of cellular component biogenesis 22.9885 4 no
GO:0031324 negative regulation of cellular metabolic process 22.9885 5 no
GO:0006796 phosphate-containing compound metabolic process 22.9885 4 no
GO:0010647 positive regulation of cell communication 22.9885 5 no
GO:0023056 positive regulation of signaling 22.9885 4 no
GO:0031399 regulation of protein modification process 22.9885 6 no
GO:0048585 negative regulation of response to stimulus 21.8391 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.8391 5 no
GO:0042127 regulation of cell population proliferation 20.6897 4 no
GO:0009967 positive regulation of signal transduction 20.6897 5 no
GO:0009891 positive regulation of biosynthetic process 20.6897 5 no
GO:0010648 negative regulation of cell communication 20.6897 5 no
GO:0023057 negative regulation of signaling 20.6897 4 no
GO:0031328 positive regulation of cellular biosynthetic process 20.6897 6 no
GO:0006886 intracellular protein transport 19.5402 4 yes
GO:0072657 protein localization to membrane 11.4943 4 yes
GO:0035459 vesicle cargo loading 5.7471 4 yes
GO:0072659 protein localization to plasma membrane 5.7471 5 yes
GO:0090110 COPII-coated vesicle cargo loading 5.7471 4 yes
GO:1990778 protein localization to cell periphery 5.7471 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SC24A_HUMAN [view interactions] Low throughput no no
SC22B_HUMAN [view entry] [view interactions] Low throughput yes no
SC24C_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK18_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK16_HUMAN [view interactions] Low throughput no yes
SC24B_HUMAN [view interactions] Low throughput no yes
STX5_HUMAN [view interactions] Low throughput no yes
GOSR2_HUMAN [view interactions] Low throughput no yes
SAR1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SC31A_HUMAN [view entry] [view interactions] Low throughput yes yes
SC24D_HUMAN [view interactions] Low throughput no yes
TGO1_HUMAN [view interactions] Low throughput no yes
SEC13_HUMAN [view entry] [view interactions] Low throughput yes yes
BET1_HUMAN [view interactions] Low throughput no no
MIA2_HUMAN [view interactions] Low throughput no yes
PDCD6_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA2_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
WIPI2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
INSI2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
PRRC1_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
AP1M1_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
KC1A_HUMAN [view interactions] High throughput no yes
YIPF5_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
ASXL2_HUMAN [view interactions] High throughput no no
ASXL3_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
OTUD1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
PRS7_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TACC3_HUMAN [view entry] [view interactions] High throughput yes yes
TTL12_HUMAN [view interactions] High throughput no yes
UBE2B_HUMAN [view interactions] High throughput no no
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
THADA_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
RCN1_HUMAN [view interactions] High throughput no yes
TTC1_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
SERPH_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
STMN2_HUMAN [view interactions] High throughput no no
SGTA_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
SYCC_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
GARS_HUMAN [view interactions] High throughput no yes
GFPT1_HUMAN [view interactions] High throughput no no
HIRP3_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD2_HUMAN [view interactions] High throughput no yes
ANM3_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
DUS3L_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
MSH2_HUMAN [view interactions] High throughput no yes
SYNC_HUMAN [view interactions] High throughput no yes
OSBP1_HUMAN [view interactions] High throughput no yes
PSMG1_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
RO60_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC1_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] High throughput yes yes
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
COG7_HUMAN [view interactions] High throughput no yes
SP3_HUMAN [view interactions] High throughput no no
ZC21A_HUMAN [view interactions] High throughput no yes
STRBP_HUMAN [view interactions] High throughput no yes
NUF2_HUMAN [view interactions] High throughput no no
UN45A_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
UBP16_HUMAN [view interactions] High throughput no yes
MD1L1_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
RCAS1_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
GBRL1_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
IFM1_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
PRD16_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CLC4E_HUMAN [view interactions] High throughput no no
IFTAP_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CC062_HUMAN [view interactions] High throughput no no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
S18L2_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RFA1_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PGFRB_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
TMEDA_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
TMED9_HUMAN [view interactions] High throughput no yes
TMED7_HUMAN [view interactions] High throughput no yes
TMED3_HUMAN [view entry] [view interactions] High throughput yes yes
ERD21_HUMAN [view interactions] High throughput no yes
GALT1_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
GLRA2_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB2_HUMAN [view interactions] High throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
FATE1_HUMAN [view interactions] High throughput no no
MNAR1_HUMAN [view interactions] High throughput no no
WBP11_HUMAN [view interactions] High throughput no yes
BNIP3_HUMAN [view entry] [view interactions] High throughput yes yes
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
CL17A_HUMAN [view interactions] High throughput no no
SC23B_HUMAN [view interactions] High throughput no yes
S23IP_HUMAN [view interactions] High throughput no yes
DTX2_HUMAN [view interactions] High throughput no yes
TNF14_HUMAN [view interactions] High throughput no yes
ERGI3_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
RN19B_HUMAN [view interactions] High throughput no yes
CTR1_HUMAN [view interactions] High throughput no no
TM45B_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL1_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
DDR2_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA6_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHA8_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MUSK_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view entry] [view interactions] High throughput yes no
STYK1_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
HOMEZ_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
KLH12_HUMAN [view interactions] High throughput no no
PEF1_HUMAN [view interactions] High throughput no no