Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC23A_HUMAN

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SC23A_HUMAN
GO:0017076 purine nucleotide binding 27.0270 4 no
GO:0032555 purine ribonucleotide binding 27.0270 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.0270 4 no
GO:0005524 ATP binding 20.2703 5 no
GO:0030554 adenyl nucleotide binding 20.2703 5 no
GO:0032559 adenyl ribonucleotide binding 20.2703 5 no
GO:0046872 metal ion binding 17.5676 4 yes
GO:0008270 zinc ion binding 5.4054 6 yes
GO:0046914 transition metal ion binding 5.4054 5 yes
GO:0030695 GTPase regulator activity 2.7027 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC23A_HUMAN
GO:0048522 positive regulation of cellular process 52.7027 4 no
GO:0060255 regulation of macromolecule metabolic process 48.6486 4 no
GO:0080090 regulation of primary metabolic process 47.2973 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.9459 4 no
GO:0008104 protein localization 44.5946 4 yes
GO:0071702 organic substance transport 43.2432 4 yes
GO:0071705 nitrogen compound transport 43.2432 4 yes
GO:0051128 regulation of cellular component organization 43.2432 4 no
GO:0031323 regulation of cellular metabolic process 41.8919 4 no
GO:0009893 positive regulation of metabolic process 40.5405 4 no
GO:0015031 protein transport 37.8378 4 yes
GO:0048523 negative regulation of cellular process 37.8378 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.4865 5 no
GO:0051246 regulation of protein metabolic process 35.1351 5 no
GO:0016192 vesicle-mediated transport 33.7838 4 no
GO:0006996 organelle organization 31.0811 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 31.0811 5 no
GO:0010646 regulation of cell communication 31.0811 4 no
GO:0006886 intracellular protein transport 29.7297 4 yes
GO:0010468 regulation of gene expression 28.3784 5 no
GO:0009966 regulation of signal transduction 28.3784 4 no
GO:0031325 positive regulation of cellular metabolic process 28.3784 5 no
GO:0022607 cellular component assembly 25.6757 4 no
GO:0009892 negative regulation of metabolic process 25.6757 4 no
GO:0051130 positive regulation of cellular component organization 25.6757 5 no
GO:0044087 regulation of cellular component biogenesis 25.6757 4 no
GO:0051247 positive regulation of protein metabolic process 24.3243 6 no
GO:0009889 regulation of biosynthetic process 24.3243 4 no
GO:0009894 regulation of catabolic process 22.9730 4 no
GO:0033043 regulation of organelle organization 22.9730 5 no
GO:0036211 protein modification process 22.9730 4 no
GO:0043412 macromolecule modification 22.9730 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.6216 5 no
GO:0031326 regulation of cellular biosynthetic process 21.6216 5 no
GO:0048193 Golgi vesicle transport 21.6216 5 no
GO:0031344 regulation of cell projection organization 20.2703 5 no
GO:0031399 regulation of protein modification process 20.2703 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.2703 6 no
GO:0010648 negative regulation of cell communication 20.2703 5 no
GO:0023057 negative regulation of signaling 20.2703 4 no
GO:0042127 regulation of cell population proliferation 20.2703 4 no
GO:0072657 protein localization to membrane 9.4595 4 yes
GO:0035459 vesicle cargo loading 8.1081 4 yes
GO:0090110 COPII-coated vesicle cargo loading 8.1081 4 yes
GO:0072659 protein localization to plasma membrane 4.0541 5 yes
GO:1990778 protein localization to cell periphery 4.0541 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in SC23A_HUMAN
DOID:0050700 cardiomyopathy 4.0541 4 no
DOID:0060036 intrinsic cardiomyopathy 4.0541 5 no
DOID:114 heart disease 4.0541 3 no
DOID:0050686 organ system cancer 2.7027 3 no
DOID:440 neuromuscular disease 2.7027 5 no
DOID:574 peripheral nervous system disease 2.7027 3 no
DOID:870 neuropathy 2.7027 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MIA2_HUMAN [view interactions] Low throughput no yes
SC24A_HUMAN [view interactions] Low throughput no no
SC22B_HUMAN [view entry] [view interactions] Low throughput yes no
GOSR2_HUMAN [view interactions] Low throughput no yes
SC24C_HUMAN [view entry] [view interactions] Low throughput yes yes
STX5_HUMAN [view interactions] Low throughput no yes
CDK18_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK16_HUMAN [view interactions] Low throughput no yes
SC24B_HUMAN [view interactions] Low throughput no yes
SAR1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SC31A_HUMAN [view entry] [view interactions] Low throughput yes yes
SC24D_HUMAN [view interactions] Low throughput no yes
TGO1_HUMAN [view interactions] Low throughput no yes
SEC13_HUMAN [view entry] [view interactions] Low throughput yes yes
BET1_HUMAN [view interactions] Low throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
DDR2_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA5_HUMAN [view interactions] High throughput no no
EPHA6_HUMAN [view interactions] High throughput no no
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
EPHA8_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MUSK_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
RYK_HUMAN [view interactions] High throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
CAPS1_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
HOMEZ_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
SHIP1_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
SC16A_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
MCM2_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
ATOH1_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KLH12_HUMAN [view interactions] High throughput no no
PEF1_HUMAN [view interactions] High throughput no no
PDCD6_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PKHA2_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
WIPI2_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
INSI2_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
P53_HUMAN [view interactions] High throughput no no
UBQL2_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
PRRC1_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
AP1M1_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
KC1A_HUMAN [view interactions] High throughput no yes
YIPF5_HUMAN [view interactions] High throughput no yes
ITA2B_HUMAN [view interactions] High throughput no no
PRS7_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
TACC3_HUMAN [view entry] [view interactions] High throughput yes yes
TTL12_HUMAN [view interactions] High throughput no yes
UBE2B_HUMAN [view interactions] High throughput no no
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
THADA_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
RCN1_HUMAN [view interactions] High throughput no yes
TTC1_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
SERPH_HUMAN [view interactions] High throughput no no
S10A6_HUMAN [view interactions] High throughput no yes
PSB2_HUMAN [view interactions] High throughput no yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
STMN2_HUMAN [view interactions] High throughput no no
SGTA_HUMAN [view interactions] High throughput no yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
SYCC_HUMAN [view interactions] High throughput no yes
IF4B_HUMAN [view entry] [view interactions] High throughput yes yes
GARS_HUMAN [view interactions] High throughput no yes
GFPT1_HUMAN [view interactions] High throughput no no
HIRP3_HUMAN [view interactions] High throughput no no
H4_HUMAN [view interactions] High throughput no yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
DPYL3_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD2_HUMAN [view interactions] High throughput no yes
ANM3_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
DUS3L_HUMAN [view interactions] High throughput no yes
FAF1_HUMAN [view interactions] High throughput no yes
MSH2_HUMAN [view interactions] High throughput no yes
SYNC_HUMAN [view interactions] High throughput no yes
OSBP1_HUMAN [view interactions] High throughput no yes
PSMG1_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
RO60_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
ARMC1_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
RL7_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6C_HUMAN [view interactions] High throughput no no
PTN1_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
IFTAP_HUMAN [view interactions] High throughput no no
CC062_HUMAN [view interactions] High throughput no no
S18L2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PGFRB_HUMAN [view interactions] High throughput no yes
TENS3_HUMAN [view interactions] High throughput no no
TMEDA_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
TMED9_HUMAN [view interactions] High throughput no yes
TMED7_HUMAN [view interactions] High throughput no yes
TMED3_HUMAN [view entry] [view interactions] High throughput yes yes
ERD21_HUMAN [view interactions] High throughput no yes
GALT1_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
GLRA2_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB2_HUMAN [view interactions] High throughput no yes
TNFL6_HUMAN [view interactions] High throughput no yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
FATE1_HUMAN [view interactions] High throughput no no
MNAR1_HUMAN [view interactions] High throughput no no
WBP11_HUMAN [view interactions] High throughput no yes
BNIP3_HUMAN [view entry] [view interactions] High throughput yes yes
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
CL17A_HUMAN [view interactions] High throughput no no
SC23B_HUMAN [view interactions] High throughput no yes
S23IP_HUMAN [view interactions] High throughput no yes
DTX2_HUMAN [view interactions] High throughput no yes
TNF14_HUMAN [view interactions] High throughput no yes
ERGI3_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
RN19B_HUMAN [view interactions] High throughput no yes
SL7A1_HUMAN [view interactions] High throughput no no
TM45B_HUMAN [view interactions] High throughput no yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL1_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TMM17_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
PREB_HUMAN [view interactions] Computational no yes
ANR40_HUMAN [view interactions] Computational no yes
CO7A1_HUMAN [view interactions] Computational no no
COPB_HUMAN [view interactions] Computational no yes
SCFD1_HUMAN [view entry] [view interactions] Computational yes yes
SAR1B_HUMAN [view interactions] Computational no yes
GORS1_HUMAN [view interactions] Computational no yes
STX17_HUMAN [view interactions] Computational no yes
TPC6B_HUMAN [view interactions] Computational no yes
USO1_HUMAN [view entry] [view interactions] Computational yes yes
RAB1B_HUMAN [view entry] [view interactions] Computational yes yes
SC31B_HUMAN [view interactions] Computational no yes
RAB1A_HUMAN [view entry] [view interactions] Computational yes yes
SC16B_HUMAN [view interactions] Computational no no
LMAN1_HUMAN [view interactions] Computational no yes
COPD_HUMAN [view entry] [view interactions] Computational yes yes