ERLN1_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ERLN1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.0870 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
| GO:0017076 | purine nucleotide binding | 21.7391 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 17.3913 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 15.2174 | 5 | yes |
| GO:0015485 | cholesterol binding | 6.5217 | 4 | yes |
| GO:0032934 | sterol binding | 6.5217 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ERLN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.6522 | 4 | yes |
| GO:0010646 | regulation of cell communication | 45.6522 | 4 | no |
| GO:0008104 | protein localization | 45.6522 | 4 | no |
| GO:0071702 | organic substance transport | 41.3043 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.1304 | 4 | no |
| GO:0071705 | nitrogen compound transport | 39.1304 | 4 | no |
| GO:0022607 | cellular component assembly | 36.9565 | 4 | no |
| GO:0033043 | regulation of organelle organization | 36.9565 | 5 | no |
| GO:0015031 | protein transport | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.6087 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.6087 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 32.6087 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.6087 | 5 | no |
| GO:0010941 | regulation of cell death | 30.4348 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.4348 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2609 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 28.2609 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2609 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.2609 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.2609 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.2609 | 5 | no |
| GO:0051049 | regulation of transport | 28.2609 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 26.0870 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 26.0870 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0006886 | intracellular protein transport | 26.0870 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.0870 | 6 | no |
| GO:0006508 | proteolysis | 23.9130 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 23.9130 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 23.9130 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 23.9130 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 23.9130 | 5 | yes |
| GO:0061024 | membrane organization | 23.9130 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.9130 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.9130 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.9130 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.9130 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.9130 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.9130 | 4 | no |
| GO:0036211 | protein modification process | 23.9130 | 4 | no |
| GO:0043412 | macromolecule modification | 23.9130 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.9130 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.9130 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.9130 | 5 | no |
| GO:0019941 | modification-dependent protein catabolic process | 21.7391 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 21.7391 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 21.7391 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 21.7391 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.7391 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 19.5652 | 7 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 19.5652 | 4 | yes |
| GO:0030163 | protein catabolic process | 17.3913 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 17.3913 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 15.2174 | 5 | yes |
| GO:0010498 | proteasomal protein catabolic process | 15.2174 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 15.2174 | 6 | yes |
| GO:0030433 | ubiquitin-dependent ERAD pathway | 13.0435 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 13.0435 | 6 | yes |
| GO:0036503 | ERAD pathway | 13.0435 | 5 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 10.8696 | 4 | yes |
| GO:0019216 | regulation of lipid metabolic process | 8.6957 | 5 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 6.5217 | 5 | yes |
| GO:0019217 | regulation of fatty acid metabolic process | 6.5217 | 6 | yes |
| GO:0008202 | steroid metabolic process | 4.3478 | 4 | yes |
| GO:0008203 | cholesterol metabolic process | 4.3478 | 5 | yes |
| GO:0010894 | negative regulation of steroid biosynthetic process | 4.3478 | 7 | yes |
| GO:0016125 | sterol metabolic process | 4.3478 | 4 | yes |
| GO:0019218 | regulation of steroid metabolic process | 4.3478 | 6 | yes |
| GO:0032933 | SREBP signaling pathway | 4.3478 | 4 | yes |
| GO:0042304 | regulation of fatty acid biosynthetic process | 4.3478 | 6 | yes |
| GO:0045540 | regulation of cholesterol biosynthetic process | 4.3478 | 6 | yes |
| GO:0045541 | negative regulation of cholesterol biosynthetic process | 4.3478 | 7 | yes |
| GO:0045717 | negative regulation of fatty acid biosynthetic process | 4.3478 | 7 | yes |
| GO:0045833 | negative regulation of lipid metabolic process | 4.3478 | 5 | yes |
| GO:0045922 | negative regulation of fatty acid metabolic process | 4.3478 | 6 | yes |
| GO:0045939 | negative regulation of steroid metabolic process | 4.3478 | 6 | yes |
| GO:0046890 | regulation of lipid biosynthetic process | 4.3478 | 5 | yes |
| GO:0050810 | regulation of steroid biosynthetic process | 4.3478 | 6 | yes |
| GO:0051055 | negative regulation of lipid biosynthetic process | 4.3478 | 6 | yes |
| GO:0062014 | negative regulation of small molecule metabolic process | 4.3478 | 5 | yes |
| GO:0071501 | cellular response to sterol depletion | 4.3478 | 4 | yes |
| GO:0090181 | regulation of cholesterol metabolic process | 4.3478 | 5 | yes |
| GO:0090206 | negative regulation of cholesterol metabolic process | 4.3478 | 6 | yes |
| GO:0106118 | regulation of sterol biosynthetic process | 4.3478 | 7 | yes |
| GO:0106119 | negative regulation of sterol biosynthetic process | 4.3478 | 8 | yes |
| GO:1902652 | secondary alcohol metabolic process | 4.3478 | 4 | yes |
| GO:1902930 | regulation of alcohol biosynthetic process | 4.3478 | 5 | yes |
| GO:1902931 | negative regulation of alcohol biosynthetic process | 4.3478 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ERLN1_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.5217 | 4 | no |
| DOID:331 | central nervous system disease | 6.5217 | 3 | no |
| DOID:12377 | spinal muscular atrophy | 4.3478 | 6 | no |
| DOID:231 | motor neuron disease | 4.3478 | 5 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 4.3478 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 4.3478 | 6 | no |
| DOID:440 | neuromuscular disease | 4.3478 | 5 | no |
| DOID:574 | peripheral nervous system disease | 4.3478 | 3 | no |
| DOID:870 | neuropathy | 4.3478 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RN170_HUMAN | [view interactions] | Low throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INSI1_HUMAN | [view interactions] | Low throughput | no | no |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CF120_HUMAN | [view interactions] | High throughput | no | no |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLN6_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX2_HUMAN | [view interactions] | High throughput | no | no |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| RPKL1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| TM199_HUMAN | [view interactions] | High throughput | no | yes |
| AGR3_HUMAN | [view interactions] | High throughput | no | no |
| SC22A_HUMAN | [view interactions] | High throughput | no | no |
| RBFA_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| FA2H_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA1D_HUMAN | [view interactions] | High throughput | no | no |
| KISSR_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN139_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ASB11_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMUB2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| MBRL_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMUB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| MIC25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RALY_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| PKN2_HUMAN | [view interactions] | High throughput | no | yes |
| MYEF2_HUMAN | [view interactions] | High throughput | no | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| CWC25_HUMAN | [view interactions] | Computational | no | yes |
| ALG11_HUMAN | [view interactions] | Computational | no | yes |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |