Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ERLN2_HUMAN

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed, PubMed). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ERLN2_HUMAN
GO:0000166 nucleotide binding 29.4872 4 no
GO:0043168 anion binding 29.4872 4 no
GO:0017076 purine nucleotide binding 28.2051 5 no
GO:0032555 purine ribonucleotide binding 26.9231 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.9231 4 no
GO:0043169 cation binding 25.6410 4 no
GO:0003723 RNA binding 25.6410 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0019900 kinase binding 21.7949 4 no
GO:0019901 protein kinase binding 21.7949 5 no
GO:0016462 pyrophosphatase activity 20.5128 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.5128 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.5128 6 no
GO:0044389 ubiquitin-like protein ligase binding 15.3846 4 yes
GO:0031625 ubiquitin protein ligase binding 14.1026 5 yes
GO:0015485 cholesterol binding 3.8462 4 yes
GO:0032934 sterol binding 3.8462 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ERLN2_HUMAN
GO:0048522 positive regulation of cellular process 55.1282 4 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.8718 4 no
GO:0048523 negative regulation of cellular process 43.5897 4 yes
GO:0080090 regulation of primary metabolic process 43.5897 4 yes
GO:0008104 protein localization 43.5897 4 no
GO:0010646 regulation of cell communication 39.7436 4 no
GO:0051128 regulation of cellular component organization 37.1795 4 no
GO:0009889 regulation of biosynthetic process 35.8974 4 yes
GO:0031326 regulation of cellular biosynthetic process 35.8974 5 yes
GO:0009966 regulation of signal transduction 34.6154 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.0513 5 no
GO:0010468 regulation of gene expression 30.7692 6 no
GO:0071705 nitrogen compound transport 30.7692 4 no
GO:1902531 regulation of intracellular signal transduction 29.4872 5 no
GO:0048584 positive regulation of response to stimulus 28.2051 4 no
GO:0031325 positive regulation of cellular metabolic process 28.2051 5 no
GO:0009892 negative regulation of metabolic process 26.9231 4 yes
GO:0042981 regulation of apoptotic process 26.9231 5 no
GO:0043067 regulation of programmed cell death 26.9231 4 no
GO:0009894 regulation of catabolic process 25.6410 4 no
GO:0023056 positive regulation of signaling 25.6410 4 no
GO:0032880 regulation of protein localization 25.6410 5 no
GO:0060341 regulation of cellular localization 25.6410 4 no
GO:0015031 protein transport 25.6410 4 no
GO:0031324 negative regulation of cellular metabolic process 24.3590 5 yes
GO:0010647 positive regulation of cell communication 24.3590 5 no
GO:0051049 regulation of transport 24.3590 4 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0051247 positive regulation of protein metabolic process 23.0769 6 no
GO:0009967 positive regulation of signal transduction 21.7949 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.7949 5 no
GO:0071310 cellular response to organic substance 21.7949 4 no
GO:0033365 protein localization to organelle 21.7949 5 no
GO:0009891 positive regulation of biosynthetic process 21.7949 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.7949 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.7949 6 no
GO:0009890 negative regulation of biosynthetic process 20.5128 5 yes
GO:0019220 regulation of phosphate metabolic process 20.5128 6 no
GO:0031399 regulation of protein modification process 20.5128 6 no
GO:0051174 regulation of phosphorus metabolic process 20.5128 5 no
GO:0051240 positive regulation of multicellular organismal process 20.5128 4 no
GO:1902533 positive regulation of intracellular signal transduction 20.5128 6 no
GO:1903829 positive regulation of protein localization 20.5128 5 no
GO:0010648 negative regulation of cell communication 20.5128 5 no
GO:0023057 negative regulation of signaling 20.5128 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.5128 5 no
GO:0031327 negative regulation of cellular biosynthetic process 19.2308 6 yes
GO:0062012 regulation of small molecule metabolic process 5.1282 4 yes
GO:0008202 steroid metabolic process 3.8462 4 yes
GO:0019216 regulation of lipid metabolic process 3.8462 5 yes
GO:0008203 cholesterol metabolic process 2.5641 5 yes
GO:0010565 regulation of cellular ketone metabolic process 2.5641 5 yes
GO:0010894 negative regulation of steroid biosynthetic process 2.5641 7 yes
GO:0016125 sterol metabolic process 2.5641 4 yes
GO:0019217 regulation of fatty acid metabolic process 2.5641 6 yes
GO:0019218 regulation of steroid metabolic process 2.5641 6 yes
GO:0032933 SREBP signaling pathway 2.5641 4 yes
GO:0042304 regulation of fatty acid biosynthetic process 2.5641 6 yes
GO:0045540 regulation of cholesterol biosynthetic process 2.5641 6 yes
GO:0045541 negative regulation of cholesterol biosynthetic process 2.5641 7 yes
GO:0045717 negative regulation of fatty acid biosynthetic process 2.5641 7 yes
GO:0045833 negative regulation of lipid metabolic process 2.5641 5 yes
GO:0045922 negative regulation of fatty acid metabolic process 2.5641 6 yes
GO:0045939 negative regulation of steroid metabolic process 2.5641 6 yes
GO:0046890 regulation of lipid biosynthetic process 2.5641 5 yes
GO:0050810 regulation of steroid biosynthetic process 2.5641 6 yes
GO:0051055 negative regulation of lipid biosynthetic process 2.5641 6 yes
GO:0062014 negative regulation of small molecule metabolic process 2.5641 5 yes
GO:0071501 cellular response to sterol depletion 2.5641 4 yes
GO:0090181 regulation of cholesterol metabolic process 2.5641 5 yes
GO:0090206 negative regulation of cholesterol metabolic process 2.5641 6 yes
GO:0106118 regulation of sterol biosynthetic process 2.5641 7 yes
GO:0106119 negative regulation of sterol biosynthetic process 2.5641 8 yes
GO:1902652 secondary alcohol metabolic process 2.5641 4 yes
GO:1902930 regulation of alcohol biosynthetic process 2.5641 5 yes
GO:1902931 negative regulation of alcohol biosynthetic process 2.5641 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NICA_HUMAN [view interactions] Low throughput no yes
AMFR_HUMAN [view interactions] Low throughput no yes
INSI1_HUMAN [view interactions] Low throughput no no
RN170_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ERLN1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAF2_HUMAN [view interactions] Low throughput no yes
RN185_HUMAN [view interactions] Low throughput no no
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
SCAP_HUMAN [view interactions] Low throughput no yes
SRBP1_HUMAN [view interactions] Low throughput no yes
SRBP2_HUMAN [view interactions] Low throughput no yes
RNF5_HUMAN [view interactions] Low throughput no yes
TBA1B_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
CCNB1_HUMAN [view interactions] Low throughput no no
WLS_HUMAN [view entry] [view interactions] Low throughput yes no
GORS2_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SHCAF_HUMAN [view interactions] High throughput no yes
TAP2_HUMAN [view interactions] High throughput no no
DOT1L_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
PAQR2_HUMAN [view interactions] High throughput no yes
GBRA1_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
FND3A_HUMAN [view interactions] High throughput no yes
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
GRM2_HUMAN [view entry] [view interactions] High throughput yes yes
B3GN2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
K2C7_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
HNRL2_HUMAN [view interactions] High throughput no yes
PDCD6_HUMAN [view interactions] High throughput no no
MCU_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no no
FAKD5_HUMAN [view interactions] High throughput no yes
RT12_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
VWA8_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA4_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CATL1_HUMAN [view interactions] High throughput no yes
AMPN_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
T106B_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
ICT1_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
HDA11_HUMAN [view interactions] High throughput no no
ARL10_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
KCNQ2_HUMAN [view entry] [view interactions] High throughput yes yes
S38A1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RBP2_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
BMR1A_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
KLH21_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
UFL1_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
CSCL2_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
SYVN1_HUMAN [view interactions] High throughput no yes
RN139_HUMAN [view interactions] High throughput no yes
TMUB1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
GALNS_HUMAN [view interactions] High throughput no yes
GSTM5_HUMAN [view interactions] High throughput no yes
AMGO1_HUMAN [view interactions] High throughput no yes
FKB14_HUMAN [view interactions] High throughput no yes
ECH1_HUMAN [view interactions] High throughput no yes
CLN6_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
NPC1_HUMAN [view interactions] High throughput no yes
SIM26_HUMAN [view interactions] High throughput no no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
FINC_HUMAN [view interactions] High throughput no yes
COX15_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2B_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TBA8_HUMAN [view interactions] High throughput no yes
UBAC2_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
MBRL_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
PPT1_HUMAN [view interactions] High throughput no yes
RIPK2_HUMAN [view interactions] High throughput no yes
SP1_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR4_HUMAN [view interactions] High throughput no no
STYK1_HUMAN [view interactions] High throughput no yes
TYRO3_HUMAN [view interactions] High throughput no yes
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
ICOS_HUMAN [view interactions] High throughput no no
CD177_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
LN28A_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TFDP1_HUMAN [view interactions] High throughput no yes
TCPA_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
CCD47_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
TIF1B_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
MIRO1_HUMAN [view entry] [view interactions] High throughput yes yes
TIM50_HUMAN [view entry] [view interactions] High throughput yes yes
MLF2_HUMAN [view entry] [view interactions] High throughput yes yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
ADA1D_HUMAN [view interactions] High throughput no no
PP6R3_HUMAN [view interactions] High throughput no yes
STK3_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TECT1_HUMAN [view interactions] High throughput no yes
MKS3_HUMAN [view interactions] High throughput no no
FTM_HUMAN [view interactions] High throughput no yes
CE128_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
SCLT1_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
EPHAA_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CASP8_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
UFD1_HUMAN [view interactions] High throughput no no
DERL1_HUMAN [view interactions] High throughput no yes
CD3D_HUMAN [view interactions] High throughput no no
TFE2_HUMAN [view interactions] High throughput no no
TBB5_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
MMS19_HUMAN [view interactions] High throughput no yes
CLN3_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
APH1A_HUMAN [view interactions] High throughput no yes
PEN2_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
RIC3_HUMAN [view interactions] High throughput no yes
ARSK_HUMAN [view interactions] High throughput no no
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
CD109_HUMAN [view interactions] High throughput no no
CA2D1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
SEPR_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PODO_HUMAN [view interactions] High throughput no no
MERL_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
TMUB2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
EDEM3_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TXTP_HUMAN [view entry] [view interactions] High throughput yes no
LAP2A_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
S15A3_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
PPAP_HUMAN [view interactions] High throughput no no
DUS7_HUMAN [view interactions] High throughput no yes
TPTE_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
MD2L2_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
FA20C_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
EDEM1_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
CHSTA_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
CATB_HUMAN [view interactions] High throughput no yes
FURIN_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
CATS_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
GET4_HUMAN [view interactions] High throughput no yes