MIRO1_HUMAN
Evidence for PS localization
Functions
Mitochondrial GTPase involved in mitochondrial trafficking (PubMed, PubMed, PubMed). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed, PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MIRO1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.0000 | 4 | yes |
| GO:0043169 | cation binding | 40.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 40.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 35.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | yes |
| GO:0003924 | GTPase activity | 15.0000 | 7 | yes |
| GO:0005509 | calcium ion binding | 15.0000 | 6 | yes |
| GO:0005525 | GTP binding | 15.0000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 15.0000 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 15.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MIRO1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 55.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 45.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.0000 | 4 | no |
| GO:0007005 | mitochondrion organization | 40.0000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 35.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 35.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 35.0000 | 7 | no |
| GO:0048523 | negative regulation of cellular process | 35.0000 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 35.0000 | 6 | no |
| GO:0061024 | membrane organization | 30.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0033365 | protein localization to organelle | 30.0000 | 5 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 25.0000 | 5 | no |
| GO:0001558 | regulation of cell growth | 25.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0007006 | mitochondrial membrane organization | 25.0000 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 25.0000 | 6 | yes |
| GO:0010970 | transport along microtubule | 25.0000 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 25.0000 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 25.0000 | 4 | yes |
| GO:0099111 | microtubule-based transport | 25.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0040017 | positive regulation of locomotion | 25.0000 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 25.0000 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0034643 | establishment of mitochondrion localization, microtubule-mediated | 20.0000 | 4 | yes |
| GO:0047497 | mitochondrion transport along microtubule | 20.0000 | 5 | yes |
| GO:0051654 | establishment of mitochondrion localization | 20.0000 | 4 | yes |
| GO:0072384 | organelle transport along microtubule | 20.0000 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 20.0000 | 4 | yes |
| GO:0007015 | actin filament organization | 15.0000 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 15.0000 | 5 | yes |
| GO:0008637 | apoptotic mitochondrial changes | 15.0000 | 6 | yes |
| GO:0035794 | positive regulation of mitochondrial membrane permeability | 15.0000 | 5 | yes |
| GO:0046902 | regulation of mitochondrial membrane permeability | 15.0000 | 4 | yes |
| GO:0097345 | mitochondrial outer membrane permeabilization | 15.0000 | 7 | yes |
| GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | 15.0000 | 5 | yes |
| GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 15.0000 | 6 | yes |
| GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | 15.0000 | 6 | yes |
| GO:1905710 | positive regulation of membrane permeability | 15.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRAK2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDK20_HUMAN | [view interactions] | Low throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | Low throughput | no | yes |
| MIRO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| HDHD5_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SP7_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PCSK9_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN18_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| PPTC7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| TRDN_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| AT8A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |