Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MIRO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed, PubMed, PubMed). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed, PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MIRO1_HUMAN
GO:0046872 metal ion binding 37.5000 4 yes
GO:0017076 purine nucleotide binding 29.1667 4 yes
GO:0032555 purine ribonucleotide binding 29.1667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.1667 4 yes
GO:0016462 pyrophosphatase activity 20.8333 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.8333 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.8333 6 yes
GO:0003924 GTPase activity 16.6667 7 yes
GO:0005525 GTP binding 16.6667 5 yes
GO:0019001 guanyl nucleotide binding 16.6667 5 yes
GO:0032561 guanyl ribonucleotide binding 16.6667 5 yes
GO:0005509 calcium ion binding 12.5000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MIRO1_HUMAN
GO:0051128 regulation of cellular component organization 54.1667 4 yes
GO:0048522 positive regulation of cellular process 54.1667 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0008104 protein localization 41.6667 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0033043 regulation of organelle organization 37.5000 5 yes
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0042981 regulation of apoptotic process 37.5000 6 no
GO:0043067 regulation of programmed cell death 37.5000 5 no
GO:0007005 mitochondrion organization 33.3333 5 yes
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0061024 membrane organization 29.1667 4 yes
GO:0001932 regulation of protein phosphorylation 29.1667 7 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0042325 regulation of phosphorylation 29.1667 7 no
GO:0051049 regulation of transport 29.1667 4 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0071702 organic substance transport 29.1667 4 no
GO:0071705 nitrogen compound transport 29.1667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0007006 mitochondrial membrane organization 25.0000 5 yes
GO:0010821 regulation of mitochondrion organization 25.0000 6 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0010243 response to organonitrogen compound 20.8333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.8333 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.8333 5 no
GO:0051248 negative regulation of protein metabolic process 20.8333 6 no
GO:0060341 regulation of cellular localization 20.8333 4 no
GO:0008284 positive regulation of cell population proliferation 20.8333 5 no
GO:0009889 regulation of biosynthetic process 20.8333 4 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:0009967 positive regulation of signal transduction 20.8333 5 no
GO:0010628 positive regulation of gene expression 20.8333 6 no
GO:0010647 positive regulation of cell communication 20.8333 5 no
GO:0023056 positive regulation of signaling 20.8333 4 no
GO:0031326 regulation of cellular biosynthetic process 20.8333 5 no
GO:0031401 positive regulation of protein modification process 20.8333 7 no
GO:0036211 protein modification process 20.8333 4 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0043412 macromolecule modification 20.8333 4 no
GO:0048584 positive regulation of response to stimulus 20.8333 4 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0008637 apoptotic mitochondrial changes 16.6667 6 yes
GO:0010970 transport along microtubule 16.6667 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 16.6667 4 yes
GO:0035794 positive regulation of mitochondrial membrane permeability 16.6667 5 yes
GO:0046902 regulation of mitochondrial membrane permeability 16.6667 4 yes
GO:0097345 mitochondrial outer membrane permeabilization 16.6667 7 yes
GO:0099111 microtubule-based transport 16.6667 4 yes
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 16.6667 5 yes
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 16.6667 6 yes
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death 16.6667 6 yes
GO:1905710 positive regulation of membrane permeability 16.6667 4 yes
GO:0007264 small GTPase mediated signal transduction 12.5000 4 yes
GO:0034643 establishment of mitochondrion localization, microtubule-mediated 12.5000 4 yes
GO:0047497 mitochondrion transport along microtubule 12.5000 5 yes
GO:0051654 establishment of mitochondrion localization 12.5000 4 yes
GO:0072384 organelle transport along microtubule 12.5000 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in MIRO1_HUMAN
DOID:331 central nervous system disease 8.3333 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRAK2_HUMAN [view interactions] Low throughput no yes
TRAK1_HUMAN [view interactions] Low throughput no yes
KIF5C_HUMAN [view entry] [view interactions] Low throughput yes yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
PINK1_HUMAN [view interactions] Low throughput no yes
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDK20_HUMAN [view interactions] Low throughput no yes
HUMMR_HUMAN [view interactions] Low throughput no yes
MIRO1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF1_HUMAN [view interactions] High throughput no no
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
COQ9_HUMAN [view interactions] High throughput no yes
HDHD5_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
E2F3_HUMAN [view interactions] High throughput no no
IRAK1_HUMAN [view interactions] High throughput no yes
SP7_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
AMFR_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
PCSK9_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PTN18_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
TRI66_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FRIL_HUMAN [view interactions] High throughput no yes
GRAH_HUMAN [view interactions] High throughput no no
ISLR_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
PPTC7_HUMAN [view interactions] High throughput no yes
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
ASB14_HUMAN [view interactions] High throughput no no
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
KLK5_HUMAN [view interactions] High throughput no no
TRDN_HUMAN [view interactions] High throughput no no
AT2A3_HUMAN [view interactions] High throughput no yes
NUBP2_HUMAN [view interactions] High throughput no yes
FFAR1_HUMAN [view interactions] High throughput no no
SPRTN_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
FURIN_HUMAN [view interactions] High throughput no yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
TM11B_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
AT8A1_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MFN1_HUMAN [view interactions] Computational no yes
MAT2B_HUMAN [view interactions] Computational no yes
MUL1_HUMAN [view interactions] Computational no no
MFN2_HUMAN [view entry] [view interactions] Computational yes yes
FKBP8_HUMAN [view entry] [view interactions] Computational yes yes
TOM70_HUMAN [view interactions] Computational no yes
VDAC1_HUMAN [view entry] [view interactions] Computational yes yes
VDAC3_HUMAN [view entry] [view interactions] Computational yes yes
PTH2_HUMAN [view interactions] Computational no yes
IDE_HUMAN [view interactions] Computational no yes
VDAC2_HUMAN [view entry] [view interactions] Computational yes yes
TOM20_HUMAN [view entry] [view interactions] Computational yes yes
MCU_HUMAN [view interactions] Computational no yes