MP2K2_HUMAN
Evidence for PS localization
Functions
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases . Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003388 | DOC_MAPK_MEF2A_6 | DOC | 6 | 14 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MP2K2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 45.0000 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 41.6667 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 41.6667 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 34.1667 | 5 | yes |
| GO:0003723 | RNA binding | 33.3333 | 4 | no |
| GO:0005524 | ATP binding | 30.8333 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.8333 | 5 | yes |
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
| GO:0019901 | protein kinase binding | 25.8333 | 5 | no |
| GO:0046872 | metal ion binding | 24.1667 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 20.8333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.8333 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.8333 | 6 | no |
| GO:0016301 | kinase activity | 15.8333 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 13.3333 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 12.5000 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 11.6667 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 11.6667 | 4 | yes |
| GO:0019887 | protein kinase regulator activity | 8.3333 | 4 | yes |
| GO:0004708 | MAP kinase kinase activity | 5.0000 | 5 | yes |
| GO:0004713 | protein tyrosine kinase activity | 5.0000 | 4 | yes |
| GO:0019209 | kinase activator activity | 5.0000 | 4 | yes |
| GO:0030295 | protein kinase activator activity | 5.0000 | 5 | yes |
| GO:0005078 | MAP-kinase scaffold activity | 3.3333 | 4 | yes |
| GO:0043539 | protein serine/threonine kinase activator activity | 3.3333 | 6 | yes |
| GO:0030165 | PDZ domain binding | 1.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K2_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.6667 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 48.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 47.5000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 45.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.1667 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 39.1667 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.1667 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 39.1667 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.3333 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.3333 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 38.3333 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 38.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.5000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 36.6667 | 6 | yes |
| GO:0006996 | organelle organization | 35.8333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 34.1667 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 34.1667 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.5000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.6667 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 31.6667 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 31.6667 | 5 | no |
| GO:0010941 | regulation of cell death | 31.6667 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.8333 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 30.8333 | 7 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 30.0000 | 6 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 30.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.0000 | 6 | yes |
| GO:0042981 | regulation of apoptotic process | 30.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.0000 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.1667 | 7 | yes |
| GO:0051049 | regulation of transport | 27.5000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 27.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.5000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.5000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 26.6667 | 4 | yes |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.8333 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.8333 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.8333 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0060548 | negative regulation of cell death | 25.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 24.1667 | 7 | yes |
| GO:0071310 | cellular response to organic substance | 24.1667 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.1667 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.1667 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.3333 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | yes |
| GO:0042327 | positive regulation of phosphorylation | 23.3333 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.3333 | 7 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 22.5000 | 8 | yes |
| GO:0043408 | regulation of MAPK cascade | 22.5000 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.5000 | 6 | yes |
| GO:0080134 | regulation of response to stress | 22.5000 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 22.5000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.5000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.6667 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.6667 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 21.6667 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.6667 | 6 | no |
| GO:0071702 | organic substance transport | 21.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 21.6667 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.6667 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.6667 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.8333 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 20.8333 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0007010 | cytoskeleton organization | 20.8333 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.0000 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 19.1667 | 6 | yes |
| GO:0016310 | phosphorylation | 18.3333 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 18.3333 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 17.5000 | 6 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 17.5000 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 16.6667 | 5 | yes |
| GO:0032386 | regulation of intracellular transport | 15.8333 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 15.8333 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 15.8333 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 15.8333 | 8 | yes |
| GO:0006468 | protein phosphorylation | 14.1667 | 5 | yes |
| GO:0033674 | positive regulation of kinase activity | 14.1667 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 13.3333 | 7 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 11.6667 | 7 | yes |
| GO:0000165 | MAPK cascade | 10.0000 | 4 | yes |
| GO:0018193 | peptidyl-amino acid modification | 9.1667 | 5 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 9.1667 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 9.1667 | 4 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 9.1667 | 5 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 7.5000 | 8 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 5.8333 | 6 | yes |
| GO:0018209 | peptidyl-serine modification | 5.8333 | 6 | yes |
| GO:0046777 | protein autophosphorylation | 5.8333 | 6 | yes |
| GO:0070371 | ERK1 and ERK2 cascade | 5.0000 | 5 | yes |
| GO:0090170 | regulation of Golgi inheritance | 4.1667 | 7 | yes |
| GO:1903358 | regulation of Golgi organization | 4.1667 | 6 | yes |
| GO:1903649 | regulation of cytoplasmic transport | 4.1667 | 6 | yes |
| GO:2000641 | regulation of early endosome to late endosome transport | 4.1667 | 5 | yes |
| GO:0060147 | regulation of post-transcriptional gene silencing | 3.3333 | 6 | yes |
| GO:0060148 | positive regulation of post-transcriptional gene silencing | 3.3333 | 4 | yes |
| GO:0060964 | regulation of miRNA-mediated gene silencing | 3.3333 | 8 | yes |
| GO:0060966 | regulation of gene silencing by RNA | 3.3333 | 6 | yes |
| GO:0070920 | regulation of production of small RNA involved in gene silencing by RNA | 3.3333 | 6 | yes |
| GO:1900368 | regulation of post-transcriptional gene silencing by RNA | 3.3333 | 7 | yes |
| GO:1900370 | positive regulation of post-transcriptional gene silencing by RNA | 3.3333 | 5 | yes |
| GO:1903798 | regulation of miRNA maturation | 3.3333 | 7 | yes |
| GO:2000637 | positive regulation of miRNA-mediated gene silencing | 3.3333 | 6 | yes |
| GO:1903800 | positive regulation of miRNA maturation | 2.5000 | 7 | yes |
| GO:0036289 | peptidyl-serine autophosphorylation | 1.6667 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MP2K2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.5000 | 3 | no |
| DOID:114 | heart disease | 2.5000 | 3 | no |
| DOID:612 | primary immunodeficiency disease | 1.6667 | 3 | no |
| DOID:1289 | neurodegenerative disease | 1.6667 | 4 | no |
| DOID:0050700 | cardiomyopathy | 1.6667 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.6667 | 5 | no |
| DOID:12930 | dilated cardiomyopathy | 1.6667 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BRAF_HUMAN | [view interactions] | Low throughput | no | yes |
| KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARAF_HUMAN | [view interactions] | Low throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MP2K2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS12_HUMAN | [view interactions] | Low throughput | no | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR83_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
| NF2L2_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| RIPR2_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS905_HUMAN | [view interactions] | High throughput | no | no |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| HS904_HUMAN | [view interactions] | High throughput | no | no |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| H90B4_HUMAN | [view interactions] | High throughput | no | no |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M2OM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEMO_HUMAN | [view interactions] | High throughput | no | no |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| BABA1_HUMAN | [view interactions] | High throughput | no | yes |
| SAS10_HUMAN | [view interactions] | High throughput | no | yes |
| LUC7L_HUMAN | [view interactions] | High throughput | no | yes |
| INO1_HUMAN | [view interactions] | High throughput | no | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UIMC1_HUMAN | [view interactions] | High throughput | no | no |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| VASH2_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA2_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRMS_HUMAN | [view interactions] | High throughput | no | no |
| KS6A6_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| NAR3_HUMAN | [view interactions] | High throughput | no | no |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDG2_HUMAN | [view interactions] | High throughput | no | yes |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| PALD_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FANCA_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATR_HUMAN | [view interactions] | High throughput | no | no |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| P4K2B_HUMAN | [view interactions] | High throughput | no | yes |
| PI3R4_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| ARMX5_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| BBS2_HUMAN | [view interactions] | High throughput | no | no |
| PANK4_HUMAN | [view interactions] | High throughput | no | no |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| SHKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PISD_HUMAN | [view interactions] | High throughput | no | yes |
| APC1_HUMAN | [view interactions] | High throughput | no | no |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| HPS3_HUMAN | [view interactions] | High throughput | no | yes |
| GANP_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDRF1_HUMAN | [view interactions] | High throughput | no | no |
| HEAT6_HUMAN | [view interactions] | High throughput | no | no |
| PASK_HUMAN | [view interactions] | High throughput | no | yes |
| WDR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| K0100_HUMAN | [view interactions] | High throughput | no | yes |
| CLN6_HUMAN | [view interactions] | High throughput | no | no |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| FA83D_HUMAN | [view interactions] | High throughput | no | no |
| MIRO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNFX1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| ERF_HUMAN | [view interactions] | High throughput | no | yes |
| VIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| TTF2_HUMAN | [view interactions] | High throughput | no | yes |
| VP13C_HUMAN | [view interactions] | High throughput | no | yes |
| DPOLA_HUMAN | [view interactions] | High throughput | no | yes |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| DJB14_HUMAN | [view interactions] | High throughput | no | yes |
| OSGEP_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BBS7_HUMAN | [view interactions] | High throughput | no | no |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR59_HUMAN | [view interactions] | High throughput | no | yes |
| F91A1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF2A_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| PNMT_HUMAN | [view interactions] | High throughput | no | no |
| DCK_HUMAN | [view interactions] | High throughput | no | no |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| MK13_HUMAN | [view interactions] | Computational | no | yes |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| PA24A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IL6_HUMAN | [view interactions] | Computational | no | no |
| KAPCG_HUMAN | [view interactions] | Computational | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IL2RG_HUMAN | [view interactions] | Computational | no | no |
| MK09_HUMAN | [view interactions] | Computational | no | yes |
| CCL4_HUMAN | [view interactions] | Computational | no | no |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| MK12_HUMAN | [view interactions] | Computational | no | no |
| LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| M3K1_HUMAN | [view interactions] | Computational | no | yes |
| IL6RB_HUMAN | [view interactions] | Computational | no | no |
| JAK1_HUMAN | [view interactions] | Computational | no | yes |
| NET1_HUMAN | [view interactions] | Computational | no | no |
| ANGT_HUMAN | [view interactions] | Computational | no | no |
| 2ABB_HUMAN | [view interactions] | Computational | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK11_HUMAN | [view interactions] | Computational | no | yes |
| IL2_HUMAN | [view interactions] | Computational | no | no |
| RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DCC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IL2RB_HUMAN | [view interactions] | Computational | no | no |
| IL6RA_HUMAN | [view interactions] | Computational | no | no |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| M3K7_HUMAN | [view interactions] | Computational | no | yes |
| IL2RA_HUMAN | [view interactions] | Computational | no | no |
| GAB2_HUMAN | [view interactions] | Computational | no | yes |
| M3K8_HUMAN | [view interactions] | Computational | no | yes |
| PP2AB_HUMAN | [view interactions] | Computational | no | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| 2AAB_HUMAN | [view interactions] | Computational | no | yes |
| TYK2_HUMAN | [view interactions] | Computational | no | no |
| JAK3_HUMAN | [view interactions] | Computational | no | no |
| KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| THRB_HUMAN | [view interactions] | Computational | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LTOR3_HUMAN | [view interactions] | Computational | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCL11_HUMAN | [view interactions] | Computational | no | no |
| DYN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PTN11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |