Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WASL_HUMAN

Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed, PubMed, PubMed, PubMed, PubMed). Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed). In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed). Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression . Plays a role in dendrite spine morphogenesis . Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed). [View more on UniProt]

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No data found.

No data found.

ELM instance Name Type Start End Partner
ELMI003346 LIG_GBD_Chelix_1 LIG 467 475 -
ELMI003346 LIG_GBD_Chelix_1 LIG 467 475 -

Molecular function

Term Name % Distance from the top of the tree Annotated in WASL_HUMAN
GO:0043168 anion binding 34.8485 4 no
GO:0003779 actin binding 31.8182 4 yes
GO:0019900 kinase binding 27.2727 4 no
GO:0000166 nucleotide binding 25.7576 4 no
GO:0017076 purine nucleotide binding 25.7576 5 no
GO:0032555 purine ribonucleotide binding 25.7576 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.7576 4 no
GO:0019901 protein kinase binding 24.2424 5 no
GO:0045296 cadherin binding 22.7273 4 no
GO:0005524 ATP binding 21.2121 5 no
GO:0030554 adenyl nucleotide binding 21.2121 6 no
GO:0032559 adenyl ribonucleotide binding 21.2121 5 no
GO:0030695 GTPase regulator activity 13.6364 4 yes
GO:0015631 tubulin binding 7.5758 4 yes
GO:0008017 microtubule binding 6.0606 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in WASL_HUMAN
GO:0048522 positive regulation of cellular process 81.8182 4 yes
GO:0051128 regulation of cellular component organization 69.6970 4 yes
GO:0031323 regulation of cellular metabolic process 59.0909 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.0909 4 yes
GO:0048523 negative regulation of cellular process 57.5758 4 yes
GO:0080090 regulation of primary metabolic process 56.0606 4 yes
GO:0010646 regulation of cell communication 51.5152 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0051130 positive regulation of cellular component organization 50.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.9697 5 yes
GO:0022607 cellular component assembly 46.9697 4 yes
GO:0031325 positive regulation of cellular metabolic process 46.9697 5 yes
GO:0048584 positive regulation of response to stimulus 45.4545 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0009889 regulation of biosynthetic process 45.4545 4 yes
GO:0031326 regulation of cellular biosynthetic process 45.4545 5 yes
GO:0044087 regulation of cellular component biogenesis 45.4545 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 43.9394 5 yes
GO:0033043 regulation of organelle organization 42.4242 5 no
GO:0010468 regulation of gene expression 42.4242 6 yes
GO:0030030 cell projection organization 39.3939 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.8788 6 yes
GO:0010647 positive regulation of cell communication 37.8788 5 no
GO:0023056 positive regulation of signaling 37.8788 4 no
GO:0007010 cytoskeleton organization 37.8788 5 no
GO:0031344 regulation of cell projection organization 37.8788 5 yes
GO:0051049 regulation of transport 37.8788 4 yes
GO:0097435 supramolecular fiber organization 36.3636 4 yes
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0051246 regulation of protein metabolic process 36.3636 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 yes
GO:0051240 positive regulation of multicellular organismal process 34.8485 4 no
GO:1902531 regulation of intracellular signal transduction 34.8485 5 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 yes
GO:0120036 plasma membrane bounded cell projection organization 31.8182 5 yes
GO:0051493 regulation of cytoskeleton organization 31.8182 6 no
GO:0008104 protein localization 31.8182 4 no
GO:0007015 actin filament organization 31.8182 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 31.8182 6 yes
GO:0031346 positive regulation of cell projection organization 31.8182 6 yes
GO:0044089 positive regulation of cellular component biogenesis 31.8182 5 yes
GO:0019220 regulation of phosphate metabolic process 30.3030 6 no
GO:0031399 regulation of protein modification process 30.3030 6 no
GO:0032956 regulation of actin cytoskeleton organization 30.3030 5 no
GO:0032970 regulation of actin filament-based process 30.3030 4 no
GO:0042325 regulation of phosphorylation 30.3030 7 no
GO:0051174 regulation of phosphorus metabolic process 30.3030 5 no
GO:0080134 regulation of response to stress 28.7879 4 no
GO:0001932 regulation of protein phosphorylation 28.7879 7 no
GO:0042981 regulation of apoptotic process 28.7879 5 no
GO:0043067 regulation of programmed cell death 28.7879 4 no
GO:0051247 positive regulation of protein metabolic process 28.7879 6 no
GO:1902903 regulation of supramolecular fiber organization 28.7879 5 no
GO:0051252 regulation of RNA metabolic process 28.7879 5 yes
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 yes
GO:0110053 regulation of actin filament organization 27.2727 6 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:0098657 import into cell 27.2727 4 no
GO:0006355 regulation of DNA-templated transcription 27.2727 7 yes
GO:0043933 protein-containing complex organization 27.2727 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.2727 5 yes
GO:0060341 regulation of cellular localization 27.2727 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.7576 4 yes
GO:2000145 regulation of cell motility 25.7576 4 yes
GO:0009892 negative regulation of metabolic process 25.7576 4 no
GO:0010638 positive regulation of organelle organization 25.7576 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 24.2424 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 24.2424 5 no
GO:0010605 negative regulation of macromolecule metabolic process 24.2424 5 no
GO:0043254 regulation of protein-containing complex assembly 24.2424 5 no
GO:1902905 positive regulation of supramolecular fiber organization 24.2424 6 no
GO:0010562 positive regulation of phosphorus metabolic process 24.2424 6 no
GO:0042327 positive regulation of phosphorylation 24.2424 8 no
GO:0045937 positive regulation of phosphate metabolic process 24.2424 7 no
GO:0030334 regulation of cell migration 24.2424 5 yes
GO:0032880 regulation of protein localization 24.2424 5 yes
GO:0060627 regulation of vesicle-mediated transport 24.2424 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.7273 5 no
GO:0051495 positive regulation of cytoskeleton organization 22.7273 7 no
GO:0051094 positive regulation of developmental process 22.7273 4 no
GO:0001934 positive regulation of protein phosphorylation 22.7273 8 no
GO:0031401 positive regulation of protein modification process 22.7273 7 no
GO:0006357 regulation of transcription by RNA polymerase II 22.7273 8 yes
GO:0048812 neuron projection morphogenesis 22.7273 5 yes
GO:0051050 positive regulation of transport 22.7273 4 yes
GO:0065003 protein-containing complex assembly 22.7273 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 21.2121 7 yes
GO:0071310 cellular response to organic substance 21.2121 4 no
GO:0030155 regulation of cell adhesion 21.2121 4 no
GO:0042127 regulation of cell population proliferation 21.2121 4 no
GO:0043549 regulation of kinase activity 21.2121 5 no
GO:0045859 regulation of protein kinase activity 21.2121 6 no
GO:0051338 regulation of transferase activity 21.2121 4 no
GO:0051726 regulation of cell cycle 21.2121 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.2121 4 no
GO:0043085 positive regulation of catalytic activity 21.2121 4 no
GO:0045595 regulation of cell differentiation 21.2121 4 no
GO:0045893 positive regulation of DNA-templated transcription 21.2121 8 yes
GO:0051254 positive regulation of RNA metabolic process 21.2121 6 yes
GO:0060491 regulation of cell projection assembly 21.2121 5 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 19.6970 6 yes
GO:0051129 negative regulation of cellular component organization 19.6970 5 yes
GO:0030100 regulation of endocytosis 18.1818 5 yes
GO:0061024 membrane organization 18.1818 4 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 16.6667 6 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 15.1515 9 yes
GO:0008154 actin polymerization or depolymerization 13.6364 6 yes
GO:0050807 regulation of synapse organization 13.6364 5 yes
GO:0031175 neuron projection development 12.1212 6 yes
GO:0106027 neuron projection organization 10.6061 6 yes
GO:0030041 actin filament polymerization 10.6061 7 yes
GO:0030705 cytoskeleton-dependent intracellular transport 10.6061 4 yes
GO:0051258 protein polymerization 10.6061 6 yes
GO:0097061 dendritic spine organization 9.0909 5 yes
GO:0099173 postsynapse organization 9.0909 4 yes
GO:0099175 regulation of postsynapse organization 9.0909 6 yes
GO:0002683 negative regulation of immune system process 9.0909 4 yes
GO:0071675 regulation of mononuclear cell migration 7.5758 5 yes
GO:0002685 regulation of leukocyte migration 7.5758 4 yes
GO:2000146 negative regulation of cell motility 6.0606 5 yes
GO:2000401 regulation of lymphocyte migration 6.0606 6 yes
GO:0040013 negative regulation of locomotion 6.0606 4 yes
GO:0045807 positive regulation of endocytosis 6.0606 5 yes
GO:0099515 actin filament-based transport 4.5455 5 yes
GO:0099518 vesicle cytoskeletal trafficking 4.5455 5 yes
GO:1903729 regulation of plasma membrane organization 4.5455 5 yes
GO:0016050 vesicle organization 4.5455 5 yes
GO:0030050 vesicle transport along actin filament 4.5455 4 yes
GO:0030336 negative regulation of cell migration 4.5455 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 4.5455 6 yes
GO:0051489 regulation of filopodium assembly 4.5455 7 yes
GO:0051491 positive regulation of filopodium assembly 4.5455 7 yes
GO:0051650 establishment of vesicle localization 4.5455 4 yes
GO:0060997 dendritic spine morphogenesis 4.5455 6 yes
GO:0071676 negative regulation of mononuclear cell migration 3.0303 6 yes
GO:1903525 regulation of membrane tubulation 3.0303 6 yes
GO:1903526 negative regulation of membrane tubulation 3.0303 6 yes
GO:2000369 regulation of clathrin-dependent endocytosis 3.0303 7 yes
GO:2000370 positive regulation of clathrin-dependent endocytosis 3.0303 7 yes
GO:2000402 negative regulation of lymphocyte migration 3.0303 7 yes
GO:0002686 negative regulation of leukocyte migration 3.0303 5 yes
GO:0006900 vesicle budding from membrane 3.0303 5 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 3.0303 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
PROF1_HUMAN [view entry] [view interactions] Low throughput yes yes
PROF2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARP3_HUMAN [view entry] [view interactions] Low throughput yes yes
ARPC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CIP4_HUMAN [view interactions] Low throughput no no
ITA2_HUMAN [view interactions] Low throughput no yes
CD44_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
PGFRB_HUMAN [view interactions] Low throughput no yes
COBL_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] Low throughput yes no
DNMBP_HUMAN [view interactions] Low throughput no no
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
ARPC3_HUMAN [view entry] [view interactions] Low throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] Low throughput yes no
BI2L1_HUMAN [view interactions] Low throughput no yes
PTN2_HUMAN [view interactions] Low throughput no yes
RHOQ_HUMAN [view interactions] Low throughput no no
VINEX_HUMAN [view interactions] Low throughput no no
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CORO7_HUMAN [view interactions] Low throughput no no
ACTG_HUMAN [view entry] [view interactions] Low throughput yes yes
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40A_HUMAN [view interactions] Low throughput no no
VIPR1_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90B_HUMAN [view entry] [view interactions] Low throughput yes yes
FBP1L_HUMAN [view interactions] Low throughput no yes
PPIP1_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
GELS_HUMAN [view entry] [view interactions] Low throughput yes no
ARPC5_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK1_HUMAN [view interactions] Low throughput no yes
CIB1_HUMAN [view interactions] Low throughput no no
WIPF1_HUMAN [view interactions] Low throughput no no
ROBO4_HUMAN [view interactions] Low throughput no no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
FNBP1_HUMAN [view interactions] Low throughput no yes
NOSTN_HUMAN [view interactions] Low throughput no yes
SNX9_HUMAN [view entry] [view interactions] Low throughput yes yes
PAK4_HUMAN [view interactions] Low throughput no yes
SPN90_HUMAN [view entry] [view interactions] Low throughput yes no
CRK_HUMAN [view entry] [view interactions] Low throughput yes no
ARP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC1B_HUMAN [view interactions] Low throughput no no
WASL_HUMAN [view entry] [view interactions] Low throughput yes yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
MERTK_HUMAN [view interactions] High throughput no yes
CE192_HUMAN [view interactions] High throughput no yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
PTK6_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
UBS3B_HUMAN [view interactions] High throughput no yes
PACN3_HUMAN [view interactions] High throughput no yes
PACN2_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
ITBP2_HUMAN [view interactions] High throughput no no
ITCH_HUMAN [view interactions] High throughput no yes
TNNT3_HUMAN [view interactions] High throughput no no
WWP1_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ITSN2_HUMAN [view entry] [view interactions] High throughput yes yes
ANM2_HUMAN [view interactions] High throughput no yes
OSTF1_HUMAN [view interactions] High throughput no yes
ABI2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3R1_HUMAN [view interactions] High throughput no yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
UBS3A_HUMAN [view interactions] High throughput no no
RHG12_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
ARGAL_HUMAN [view interactions] High throughput no yes
RHOV_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
PDIA1_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
LSM1_HUMAN [view interactions] High throughput no no
ZN638_HUMAN [view interactions] High throughput no yes
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
WASF3_HUMAN [view entry] [view interactions] High throughput yes yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
DVL2_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP1_HUMAN [view interactions] High throughput no yes
TGM2_HUMAN [view interactions] High throughput no no
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
PAXI_HUMAN [view interactions] High throughput no yes
F10A1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K1_HUMAN [view entry] [view interactions] High throughput yes yes
LARP1_HUMAN [view interactions] High throughput no yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
MACF1_HUMAN [view entry] [view interactions] High throughput yes yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA2_HUMAN [view interactions] High throughput no yes
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
FIBP_HUMAN [view entry] [view interactions] High throughput yes yes
GIT2_HUMAN [view interactions] High throughput no yes
RNF8_HUMAN [view interactions] High throughput no yes
HPT_HUMAN [view interactions] High throughput no no
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
FCSD2_HUMAN [view interactions] High throughput no no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN395_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
SKA1_HUMAN [view interactions] High throughput no yes
KI18A_HUMAN [view interactions] High throughput no yes
CHMP6_HUMAN [view interactions] High throughput no yes
ERR2_HUMAN [view interactions] High throughput no no
CHLE_HUMAN [view interactions] High throughput no no
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF3_HUMAN [view interactions] High throughput no yes
ACY2_HUMAN [view interactions] High throughput no no
ACTBL_HUMAN [view interactions] High throughput no no
WIPF2_HUMAN [view entry] [view interactions] High throughput yes yes
ATG4C_HUMAN [view interactions] High throughput no yes