Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FIBP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FIBP_HUMAN
GO:0017076 purine nucleotide binding 43.7500 4 no
GO:0032555 purine ribonucleotide binding 43.7500 4 no
GO:0035639 purine ribonucleoside triphosphate binding 43.7500 4 no
GO:0005525 GTP binding 31.2500 5 no
GO:0019001 guanyl nucleotide binding 31.2500 5 no
GO:0019900 kinase binding 31.2500 4 no
GO:0019901 protein kinase binding 31.2500 5 no
GO:0032561 guanyl ribonucleotide binding 31.2500 5 no
GO:0004674 protein serine/threonine kinase activity 25.0000 4 no
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0046872 metal ion binding 25.0000 4 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in FIBP_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 68.7500 4 no
GO:0060255 regulation of macromolecule metabolic process 68.7500 4 no
GO:0080090 regulation of primary metabolic process 68.7500 4 no
GO:0051049 regulation of transport 68.7500 4 no
GO:0010646 regulation of cell communication 68.7500 4 no
GO:0031323 regulation of cellular metabolic process 68.7500 4 no
GO:0048523 negative regulation of cellular process 68.7500 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 62.5000 5 no
GO:0010468 regulation of gene expression 62.5000 5 no
GO:0009893 positive regulation of metabolic process 62.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 no
GO:0031325 positive regulation of cellular metabolic process 62.5000 5 no
GO:0051174 regulation of phosphorus metabolic process 56.2500 5 no
GO:0051246 regulation of protein metabolic process 56.2500 5 no
GO:0051247 positive regulation of protein metabolic process 56.2500 6 no
GO:0051128 regulation of cellular component organization 56.2500 4 no
GO:0009966 regulation of signal transduction 56.2500 4 no
GO:0019220 regulation of phosphate metabolic process 56.2500 6 no
GO:0022607 cellular component assembly 56.2500 4 no
GO:2000145 regulation of cell motility 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0010941 regulation of cell death 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0043067 regulation of programmed cell death 50.0000 5 no
GO:0033043 regulation of organelle organization 50.0000 5 no
GO:0030334 regulation of cell migration 50.0000 5 no
GO:0031399 regulation of protein modification process 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.7500 5 no
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 no
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:0030030 cell projection organization 43.7500 4 no
GO:0042981 regulation of apoptotic process 43.7500 6 no
GO:0051050 positive regulation of transport 43.7500 4 no
GO:0051094 positive regulation of developmental process 43.7500 4 no
GO:0051130 positive regulation of cellular component organization 43.7500 5 no
GO:0060627 regulation of vesicle-mediated transport 43.7500 4 no
GO:0006996 organelle organization 43.7500 4 no
GO:0022603 regulation of anatomical structure morphogenesis 43.7500 4 no
GO:0010647 positive regulation of cell communication 43.7500 5 no
GO:0023056 positive regulation of signaling 43.7500 4 no
GO:0031401 positive regulation of protein modification process 43.7500 7 no
GO:0042325 regulation of phosphorylation 43.7500 7 no
GO:0043933 protein-containing complex organization 43.7500 4 no
GO:0048584 positive regulation of response to stimulus 37.5000 4 no
GO:0051241 negative regulation of multicellular organismal process 37.5000 4 no
GO:0065003 protein-containing complex assembly 37.5000 5 no
GO:0009894 regulation of catabolic process 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0030162 regulation of proteolysis 37.5000 6 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0031329 regulation of cellular catabolic process 37.5000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0002685 regulation of leukocyte migration 37.5000 4 no
GO:0010942 positive regulation of cell death 37.5000 5 no
GO:0031175 neuron projection development 37.5000 6 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0032880 regulation of protein localization 37.5000 5 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0043269 regulation of ion transport 37.5000 5 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0051338 regulation of transferase activity 37.5000 4 no
GO:0060341 regulation of cellular localization 37.5000 4 no
GO:0060548 negative regulation of cell death 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0120036 plasma membrane bounded cell projection organization 37.5000 5 no
GO:0010638 positive regulation of organelle organization 37.5000 6 no
GO:0051493 regulation of cytoskeleton organization 37.5000 6 no
GO:0051046 regulation of secretion 37.5000 5 no
GO:1903530 regulation of secretion by cell 37.5000 4 no
GO:0001932 regulation of protein phosphorylation 37.5000 7 no
GO:0001934 positive regulation of protein phosphorylation 37.5000 8 no
GO:0006796 phosphate-containing compound metabolic process 37.5000 4 no
GO:0009967 positive regulation of signal transduction 37.5000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0042327 positive regulation of phosphorylation 37.5000 8 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0045937 positive regulation of phosphate metabolic process 37.5000 7 no
GO:0051336 regulation of hydrolase activity 31.2500 4 no
GO:2000146 negative regulation of cell motility 31.2500 5 no
GO:0006355 regulation of DNA-templated transcription 31.2500 6 no
GO:0010243 response to organonitrogen compound 31.2500 4 no
GO:0045862 positive regulation of proteolysis 31.2500 7 no
GO:0051248 negative regulation of protein metabolic process 31.2500 6 no
GO:0051252 regulation of RNA metabolic process 31.2500 5 no
GO:1903506 regulation of nucleic acid-templated transcription 31.2500 7 no
GO:2001141 regulation of RNA biosynthetic process 31.2500 6 no
GO:0002684 positive regulation of immune system process 31.2500 4 no
GO:0009890 negative regulation of biosynthetic process 31.2500 5 no
GO:0010629 negative regulation of gene expression 31.2500 6 no
GO:0010648 negative regulation of cell communication 31.2500 5 no
GO:0023057 negative regulation of signaling 31.2500 4 no
GO:0032990 cell part morphogenesis 31.2500 4 no
GO:0034097 response to cytokine 31.2500 4 no
GO:0043065 positive regulation of apoptotic process 31.2500 7 no
GO:0043068 positive regulation of programmed cell death 31.2500 6 no
GO:0044087 regulation of cellular component biogenesis 31.2500 4 no
GO:0045597 positive regulation of cell differentiation 31.2500 5 no
GO:0051222 positive regulation of protein transport 31.2500 5 no
GO:0051223 regulation of protein transport 31.2500 5 no
GO:0070201 regulation of establishment of protein localization 31.2500 6 no
GO:0097435 supramolecular fiber organization 31.2500 4 no
GO:1901701 cellular response to oxygen-containing compound 31.2500 4 no
GO:1902533 positive regulation of intracellular signal transduction 31.2500 6 no
GO:1903829 positive regulation of protein localization 31.2500 5 no
GO:1904951 positive regulation of establishment of protein localization 31.2500 6 no
GO:0032956 regulation of actin cytoskeleton organization 31.2500 5 no
GO:0032970 regulation of actin filament-based process 31.2500 4 no
GO:0061024 membrane organization 31.2500 4 no
GO:0006468 protein phosphorylation 31.2500 5 no
GO:0016310 phosphorylation 31.2500 5 no
GO:0030336 negative regulation of cell migration 31.2500 6 no
GO:0040013 negative regulation of locomotion 31.2500 4 no
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 25.0000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0006915 apoptotic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:1901652 response to peptide 25.0000 4 no
GO:0002687 positive regulation of leukocyte migration 25.0000 5 no
GO:0002688 regulation of leukocyte chemotaxis 25.0000 5 no
GO:0006897 endocytosis 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0032103 positive regulation of response to external stimulus 25.0000 5 no
GO:0033674 positive regulation of kinase activity 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0043549 regulation of kinase activity 25.0000 5 no
GO:0045596 negative regulation of cell differentiation 25.0000 5 no
GO:0045664 regulation of neuron differentiation 25.0000 5 no
GO:0045859 regulation of protein kinase activity 25.0000 6 no
GO:0045860 positive regulation of protein kinase activity 25.0000 7 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0048638 regulation of developmental growth 25.0000 4 no
GO:0048812 neuron projection morphogenesis 25.0000 7 no
GO:0048858 cell projection morphogenesis 25.0000 5 no
GO:0050920 regulation of chemotaxis 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0051347 positive regulation of transferase activity 25.0000 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 25.0000 6 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1901215 negative regulation of neuron death 25.0000 6 no
GO:1901216 positive regulation of neuron death 25.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902905 positive regulation of supramolecular fiber organization 25.0000 6 no
GO:1903828 negative regulation of protein localization 25.0000 5 no
GO:2000112 regulation of cellular macromolecule biosynthetic process 25.0000 6 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0007015 actin filament organization 25.0000 5 no
GO:0010810 regulation of cell-substrate adhesion 25.0000 5 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0030865 cortical cytoskeleton organization 25.0000 6 no
GO:0044089 positive regulation of cellular component biogenesis 25.0000 5 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0051495 positive regulation of cytoskeleton organization 25.0000 7 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0010506 regulation of autophagy 25.0000 6 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0071345 cellular response to cytokine stimulus 25.0000 5 no
GO:0001558 regulation of cell growth 25.0000 4 no
GO:0017157 regulation of exocytosis 25.0000 5 no
GO:0051047 positive regulation of secretion 25.0000 5 no
GO:1903532 positive regulation of secretion by cell 25.0000 5 no
GO:0016055 Wnt signaling pathway 25.0000 5 no
GO:0018193 peptidyl-amino acid modification 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 18.7500 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 18.7500 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in FIBP_HUMAN
DOID:574 peripheral nervous system disease 12.5000 3 no
DOID:870 neuropathy 12.5000 4 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FGF1_HUMAN [view interactions] Low throughput no no
WASL_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
AP4B1_HUMAN [view interactions] High throughput no yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI4_HUMAN [view interactions] High throughput no yes
C2CD5_HUMAN [view interactions] High throughput no yes
RNF32_HUMAN [view interactions] High throughput no no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
TEN1_HUMAN [view interactions] High throughput no no
CLC2L_HUMAN [view interactions] High throughput no yes
TMM94_HUMAN [view interactions] High throughput no yes
CABL2_HUMAN [view interactions] High throughput no no
CABL1_HUMAN [view interactions] High throughput no no
ASTRC_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
WDFY2_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
RPTOR_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
SNIP1_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
EFNB1_HUMAN [view interactions] High throughput no yes
SC5A6_HUMAN [view interactions] High throughput no no
CD6_HUMAN [view interactions] High throughput no no
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
IL13_HUMAN [view interactions] High throughput no no
DLL1_HUMAN [view interactions] High throughput no no
V1BR_HUMAN [view interactions] High throughput no no
ZCH10_HUMAN [view interactions] High throughput no yes
VISL1_HUMAN [view entry] [view interactions] High throughput yes no
GOGA4_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
PUR8_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
LDLR_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
CDN1B_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no