Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DAPK1_HUMAN

Isoform 2 cannot induce apoptosis but can induce membrane blebbing. [View more on UniProt]

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Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DAPK1_HUMAN
GO:0003779 actin binding 47.7778 4 no
GO:0043168 anion binding 30.0000 4 yes
GO:0000166 nucleotide binding 25.5556 4 yes
GO:0017076 purine nucleotide binding 25.5556 5 yes
GO:0043169 cation binding 25.5556 4 no
GO:0046872 metal ion binding 25.5556 5 no
GO:0032555 purine ribonucleotide binding 24.4444 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 24.4444 4 yes
GO:0030554 adenyl nucleotide binding 22.2222 6 yes
GO:0005524 ATP binding 21.1111 5 yes
GO:0032559 adenyl ribonucleotide binding 21.1111 5 yes
GO:0016301 kinase activity 8.8889 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 8.8889 4 yes
GO:0004674 protein serine/threonine kinase activity 7.7778 4 yes
GO:0106310 protein serine kinase activity 7.7778 4 yes
GO:0005525 GTP binding 6.6667 5 yes
GO:0019001 guanyl nucleotide binding 6.6667 6 yes
GO:0032561 guanyl ribonucleotide binding 6.6667 5 yes
GO:0019905 syntaxin binding 4.4444 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 2.2222 5 yes
GO:0017075 syntaxin-1 binding 2.2222 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DAPK1_HUMAN
GO:0048522 positive regulation of cellular process 64.4444 4 yes
GO:0051128 regulation of cellular component organization 63.3333 4 no
GO:0048523 negative regulation of cellular process 53.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.2222 4 yes
GO:0031323 regulation of cellular metabolic process 48.8889 4 yes
GO:0080090 regulation of primary metabolic process 48.8889 4 yes
GO:0033043 regulation of organelle organization 44.4444 5 no
GO:0009893 positive regulation of metabolic process 43.3333 4 yes
GO:0006996 organelle organization 43.3333 4 no
GO:0022607 cellular component assembly 42.2222 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.1111 5 yes
GO:0044087 regulation of cellular component biogenesis 41.1111 4 no
GO:0097435 supramolecular fiber organization 40.0000 4 no
GO:0010646 regulation of cell communication 38.8889 4 yes
GO:0051493 regulation of cytoskeleton organization 38.8889 6 no
GO:0007015 actin filament organization 37.7778 5 no
GO:0051246 regulation of protein metabolic process 36.6667 5 yes
GO:0009889 regulation of biosynthetic process 35.5556 4 yes
GO:0009966 regulation of signal transduction 35.5556 4 yes
GO:0031325 positive regulation of cellular metabolic process 35.5556 5 yes
GO:0032970 regulation of actin filament-based process 35.5556 4 no
GO:0010556 regulation of macromolecule biosynthetic process 34.4444 5 yes
GO:0031326 regulation of cellular biosynthetic process 34.4444 5 yes
GO:0032956 regulation of actin cytoskeleton organization 34.4444 5 no
GO:0051130 positive regulation of cellular component organization 34.4444 5 no
GO:0010468 regulation of gene expression 33.3333 6 yes
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0110053 regulation of actin filament organization 32.2222 6 no
GO:1902903 regulation of supramolecular fiber organization 32.2222 5 no
GO:0032535 regulation of cellular component size 32.2222 4 no
GO:0051247 positive regulation of protein metabolic process 28.8889 6 yes
GO:0043254 regulation of protein-containing complex assembly 28.8889 5 no
GO:0008064 regulation of actin polymerization or depolymerization 28.8889 6 no
GO:0030832 regulation of actin filament length 28.8889 5 no
GO:0031399 regulation of protein modification process 27.7778 6 no
GO:0051129 negative regulation of cellular component organization 27.7778 5 no
GO:0009892 negative regulation of metabolic process 26.6667 4 yes
GO:0032271 regulation of protein polymerization 26.6667 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.5556 5 yes
GO:0051049 regulation of transport 25.5556 4 yes
GO:0008104 protein localization 25.5556 4 no
GO:0043933 protein-containing complex organization 24.4444 4 no
GO:0048584 positive regulation of response to stimulus 24.4444 4 no
GO:0030833 regulation of actin filament polymerization 24.4444 7 no
GO:0009891 positive regulation of biosynthetic process 23.3333 5 no
GO:0031344 regulation of cell projection organization 23.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:0010647 positive regulation of cell communication 21.1111 5 no
GO:0023056 positive regulation of signaling 21.1111 4 no
GO:0031401 positive regulation of protein modification process 21.1111 7 no
GO:1902531 regulation of intracellular signal transduction 21.1111 5 no
GO:0010639 negative regulation of organelle organization 21.1111 6 no
GO:0030834 regulation of actin filament depolymerization 21.1111 7 no
GO:0043244 regulation of protein-containing complex disassembly 21.1111 5 no
GO:1901879 regulation of protein depolymerization 21.1111 6 no
GO:0009894 regulation of catabolic process 20.0000 4 yes
GO:0036211 protein modification process 20.0000 4 yes
GO:0043412 macromolecule modification 20.0000 4 yes
GO:0071310 cellular response to organic substance 18.8889 4 yes
GO:0006915 apoptotic process 17.7778 4 yes
GO:0051248 negative regulation of protein metabolic process 17.7778 6 yes
GO:0042981 regulation of apoptotic process 16.6667 5 yes
GO:0043067 regulation of programmed cell death 16.6667 4 yes
GO:0051336 regulation of hydrolase activity 14.4444 4 yes
GO:0009890 negative regulation of biosynthetic process 13.3333 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 13.3333 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 13.3333 6 yes
GO:0034762 regulation of transmembrane transport 13.3333 4 yes
GO:0051345 positive regulation of hydrolase activity 13.3333 5 yes
GO:0006796 phosphate-containing compound metabolic process 12.2222 4 yes
GO:0009896 positive regulation of catabolic process 11.1111 5 yes
GO:0034097 response to cytokine 11.1111 4 yes
GO:0071345 cellular response to cytokine stimulus 11.1111 5 yes
GO:0010629 negative regulation of gene expression 10.0000 7 yes
GO:0030162 regulation of proteolysis 10.0000 6 yes
GO:0043068 positive regulation of programmed cell death 10.0000 5 yes
GO:1901701 cellular response to oxygen-containing compound 10.0000 4 yes
GO:0016310 phosphorylation 8.8889 5 yes
GO:0022898 regulation of transmembrane transporter activity 8.8889 4 yes
GO:0031329 regulation of cellular catabolic process 8.8889 5 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 8.8889 5 yes
GO:0043065 positive regulation of apoptotic process 8.8889 6 yes
GO:0045862 positive regulation of proteolysis 8.8889 7 yes
GO:0006468 protein phosphorylation 7.7778 5 yes
GO:0010506 regulation of autophagy 7.7778 6 yes
GO:0034341 response to type II interferon 7.7778 5 yes
GO:0034599 cellular response to oxidative stress 7.7778 4 yes
GO:0062197 cellular response to chemical stress 7.7778 4 yes
GO:0071346 cellular response to type II interferon 7.7778 6 yes
GO:0043066 negative regulation of apoptotic process 6.6667 6 yes
GO:0043069 negative regulation of programmed cell death 6.6667 5 yes
GO:0002831 regulation of response to biotic stimulus 5.5556 4 yes
GO:0006417 regulation of translation 5.5556 6 yes
GO:0010608 post-transcriptional regulation of gene expression 5.5556 7 yes
GO:0031331 positive regulation of cellular catabolic process 5.5556 6 yes
GO:0046777 protein autophosphorylation 5.5556 6 yes
GO:0010508 positive regulation of autophagy 4.4444 7 yes
GO:0010950 positive regulation of endopeptidase activity 4.4444 7 yes
GO:0010952 positive regulation of peptidase activity 4.4444 6 yes
GO:0017148 negative regulation of translation 4.4444 7 yes
GO:0052547 regulation of peptidase activity 4.4444 5 yes
GO:0052548 regulation of endopeptidase activity 4.4444 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 4.4444 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 4.4444 8 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.3333 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.3333 8 yes
GO:0097191 extrinsic apoptotic signaling pathway 3.3333 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 3.3333 4 yes
GO:2000310 regulation of NMDA receptor activity 3.3333 5 yes
GO:0002357 defense response to tumor cell 2.2222 4 yes
GO:0002834 regulation of response to tumor cell 2.2222 5 yes
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 2.2222 5 yes
GO:0033194 response to hydroperoxide 2.2222 4 yes
GO:0071447 cellular response to hydroperoxide 2.2222 5 yes
GO:1904092 regulation of autophagic cell death 2.2222 5 yes
GO:1904094 positive regulation of autophagic cell death 2.2222 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
PDCD6_HUMAN [view interactions] Low throughput no no
KLH20_HUMAN [view interactions] Low throughput no yes
KPYM_HUMAN [view interactions] Low throughput no yes
BECN1_HUMAN [view interactions] Low throughput no yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
2ABD_HUMAN [view interactions] Low throughput no yes
2ABA_HUMAN [view interactions] Low throughput no yes
DAPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
LRRK1_HUMAN [view interactions] Low throughput no yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
LRRF1_HUMAN [view interactions] Low throughput no yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
MCM3_HUMAN [view interactions] Low throughput no no
2AAB_HUMAN [view interactions] Low throughput no yes
FADD_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
UNC5B_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
KRIT1_HUMAN [view interactions] Low throughput no no
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
F10A1_HUMAN [view interactions] Low throughput no yes
CCDB1_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
MIB1_HUMAN [view entry] [view interactions] Low throughput yes yes
2A5A_HUMAN [view interactions] Low throughput no yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
UNC5A_HUMAN [view interactions] Low throughput no no
UNC5C_HUMAN [view interactions] Low throughput no no
NS1BP_HUMAN [view interactions] Low throughput no yes
ML12B_HUMAN [view interactions] Low throughput no no
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
SVIL_HUMAN [view interactions] High throughput no yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TWF1_HUMAN [view entry] [view interactions] High throughput yes no
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
GILT_HUMAN [view interactions] High throughput no no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD3_HUMAN [view interactions] High throughput no yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
ERP44_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1B_HUMAN [view interactions] High throughput no no
ARPC2_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC3_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC5_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
TOM1_HUMAN [view interactions] High throughput no yes
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MARK3_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
NEXN_HUMAN [view interactions] High throughput no yes
FLII_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
LRCH2_HUMAN [view interactions] High throughput no no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
ARC1A_HUMAN [view entry] [view interactions] High throughput yes yes
COR2A_HUMAN [view entry] [view interactions] High throughput yes no
DOCK7_HUMAN [view entry] [view interactions] High throughput yes no
ARP5L_HUMAN [view entry] [view interactions] High throughput yes yes
CP250_HUMAN [view interactions] High throughput no no
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
MARK1_HUMAN [view entry] [view interactions] High throughput yes no
ADDG_HUMAN [view entry] [view interactions] High throughput yes yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
SH3L2_HUMAN [view entry] [view interactions] High throughput yes yes
TF3C4_HUMAN [view interactions] High throughput no no
MYO5B_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
COR2B_HUMAN [view entry] [view interactions] High throughput yes yes
COF2_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
SCIN_HUMAN [view entry] [view interactions] High throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK3_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
FXL14_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
T2R60_HUMAN [view interactions] High throughput no no
VN1R1_HUMAN [view interactions] High throughput no no
PIM2_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
AHDC1_HUMAN [view interactions] High throughput no yes
TTC27_HUMAN [view interactions] High throughput no yes
SPAS2_HUMAN [view interactions] High throughput no yes
CKLF4_HUMAN [view interactions] High throughput no yes
PWP1_HUMAN [view interactions] High throughput no no
SH22A_HUMAN [view interactions] High throughput no no
SCEL_HUMAN [view interactions] High throughput no no
C42S1_HUMAN [view interactions] High throughput no no
SGK2_HUMAN [view interactions] High throughput no yes
FIBP_HUMAN [view entry] [view interactions] High throughput yes yes
SCYL1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
VGLL4_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
LARGN_HUMAN [view interactions] High throughput no yes
CQ082_HUMAN [view interactions] High throughput no no
PCP4_HUMAN [view interactions] High throughput no yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
MTDC_HUMAN [view interactions] High throughput no yes
RFC5_HUMAN [view interactions] High throughput no yes
SCRN3_HUMAN [view interactions] High throughput no yes
JHY_HUMAN [view interactions] High throughput no no
CI037_HUMAN [view interactions] High throughput no no
SLAI2_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
AAKG2_HUMAN [view interactions] High throughput no yes
RPAP3_HUMAN [view interactions] High throughput no yes
MCM10_HUMAN [view interactions] High throughput no no
STAR3_HUMAN [view interactions] High throughput no yes
ATF6A_HUMAN [view interactions] High throughput no yes
SNURF_HUMAN [view interactions] High throughput no no
PHKG2_HUMAN [view interactions] High throughput no no
CBLB_HUMAN [view entry] [view interactions] High throughput yes yes
NECP1_HUMAN [view interactions] High throughput no no
BORG2_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
DUS1L_HUMAN [view interactions] High throughput no yes
GRL1A_HUMAN [view interactions] High throughput no no
MFI_HUMAN [view interactions] High throughput no no
TB22B_HUMAN [view interactions] High throughput no no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
LMF2_HUMAN [view interactions] High throughput no yes
SRS10_HUMAN [view interactions] High throughput no yes
ZMAT4_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
LIMS1_HUMAN [view interactions] High throughput no yes
DUX3_HUMAN [view interactions] High throughput no no
NECA1_HUMAN [view interactions] High throughput no yes
PAK6_HUMAN [view entry] [view interactions] High throughput yes yes
ORML2_HUMAN [view interactions] High throughput no no
SARNP_HUMAN [view interactions] High throughput no yes
HYCC2_HUMAN [view interactions] High throughput no yes
T2FA_HUMAN [view interactions] High throughput no yes
PIM1_HUMAN [view interactions] High throughput no yes
SNX9_HUMAN [view entry] [view interactions] High throughput yes yes
CC149_HUMAN [view interactions] High throughput no yes
PAPS2_HUMAN [view interactions] High throughput no yes
MRGBP_HUMAN [view interactions] High throughput no no
F107A_HUMAN [view entry] [view interactions] High throughput yes no
TPC2A_HUMAN [view interactions] High throughput no yes
ARRD1_HUMAN [view interactions] High throughput no yes
DEN1C_HUMAN [view interactions] High throughput no no
PP14A_HUMAN [view interactions] High throughput no yes
RPGF3_HUMAN [view interactions] High throughput no yes
GAK1B_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
APEX2_HUMAN [view interactions] High throughput no no
SPR2G_HUMAN [view interactions] High throughput no no
NCBP3_HUMAN [view interactions] High throughput no yes
TBB4B_HUMAN [view interactions] High throughput no yes
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
ZMYM5_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
RS32_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
PRC2B_HUMAN [view interactions] High throughput no no
CR3L4_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
TTLL3_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
PELI1_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
DTWD1_HUMAN [view interactions] High throughput no yes
ABLM1_HUMAN [view entry] [view interactions] High throughput yes yes
GRP2_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes