Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SH3L2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SH3L2_HUMAN
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0005524 ATP binding 22.2222 5 no
GO:0017076 purine nucleotide binding 22.2222 4 no
GO:0030554 adenyl nucleotide binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0032559 adenyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0008017 microtubule binding 22.2222 5 no
GO:0015631 tubulin binding 22.2222 4 no
GO:0045296 cadherin binding 22.2222 4 no
GO:0004866 endopeptidase inhibitor activity 22.2222 5 no
GO:0030414 peptidase inhibitor activity 22.2222 4 no
GO:0061135 endopeptidase regulator activity 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SH3L2_HUMAN
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 no
GO:0051246 regulation of protein metabolic process 66.6667 5 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0048523 negative regulation of cellular process 66.6667 4 no
GO:0048522 positive regulation of cellular process 55.5556 4 no
GO:0009892 negative regulation of metabolic process 55.5556 4 no
GO:0010605 negative regulation of macromolecule metabolic process 55.5556 5 no
GO:0031324 negative regulation of cellular metabolic process 55.5556 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 55.5556 5 no
GO:0051248 negative regulation of protein metabolic process 55.5556 6 no
GO:0001932 regulation of protein phosphorylation 44.4444 7 no
GO:0009893 positive regulation of metabolic process 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0019220 regulation of phosphate metabolic process 44.4444 6 no
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 no
GO:0031399 regulation of protein modification process 44.4444 6 no
GO:0042325 regulation of phosphorylation 44.4444 7 no
GO:0043549 regulation of kinase activity 44.4444 5 no
GO:0045859 regulation of protein kinase activity 44.4444 6 no
GO:0051049 regulation of transport 44.4444 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 44.4444 5 no
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 no
GO:0051338 regulation of transferase activity 44.4444 4 no
GO:0043085 positive regulation of catalytic activity 44.4444 4 no
GO:0009966 regulation of signal transduction 44.4444 4 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043269 regulation of ion transport 33.3333 5 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0080135 regulation of cellular response to stress 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0001933 negative regulation of protein phosphorylation 33.3333 8 no
GO:0010563 negative regulation of phosphorus metabolic process 33.3333 6 no
GO:0031344 regulation of cell projection organization 33.3333 5 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0042326 negative regulation of phosphorylation 33.3333 8 no
GO:0045936 negative regulation of phosphate metabolic process 33.3333 7 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0001894 tissue homeostasis 22.2222 5 no
GO:0001895 retina homeostasis 22.2222 6 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0016192 vesicle-mediated transport 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0060249 anatomical structure homeostasis 22.2222 4 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 22.2222 7 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1903076 regulation of protein localization to plasma membrane 22.2222 7 no
GO:1904375 regulation of protein localization to cell periphery 22.2222 6 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0006469 negative regulation of protein kinase activity 22.2222 7 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0031401 positive regulation of protein modification process 22.2222 7 no
GO:0033673 negative regulation of kinase activity 22.2222 6 no
GO:0033674 positive regulation of kinase activity 22.2222 6 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0043086 negative regulation of catalytic activity 22.2222 4 no
GO:0045860 positive regulation of protein kinase activity 22.2222 7 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 22.2222 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 22.2222 9 no
GO:0050807 regulation of synapse organization 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051347 positive regulation of transferase activity 22.2222 5 no
GO:0051348 negative regulation of transferase activity 22.2222 5 no
GO:0061097 regulation of protein tyrosine kinase activity 22.2222 7 no
GO:0061098 positive regulation of protein tyrosine kinase activity 22.2222 8 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0099175 regulation of postsynapse organization 22.2222 6 no
GO:0006355 regulation of DNA-templated transcription 22.2222 6 no
GO:0007613 memory 22.2222 4 no
GO:0007616 long-term memory 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1902532 negative regulation of intracellular signal transduction 22.2222 6 no
GO:1903506 regulation of nucleic acid-templated transcription 22.2222 7 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0031345 negative regulation of cell projection organization 22.2222 6 no
GO:0051129 negative regulation of cellular component organization 22.2222 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0031329 regulation of cellular catabolic process 22.2222 5 no
GO:0045861 negative regulation of proteolysis 22.2222 7 no
GO:0010629 negative regulation of gene expression 22.2222 6 no
GO:0010941 regulation of cell death 22.2222 4 no
GO:0010942 positive regulation of cell death 22.2222 5 no
GO:0032412 regulation of ion transmembrane transporter activity 22.2222 5 no
GO:0034248 regulation of cellular amide metabolic process 22.2222 5 no
GO:0034249 negative regulation of cellular amide metabolic process 22.2222 6 no
GO:0034765 regulation of ion transmembrane transport 22.2222 5 no
GO:0042981 regulation of apoptotic process 22.2222 6 no
GO:0043065 positive regulation of apoptotic process 22.2222 7 no
GO:0043066 negative regulation of apoptotic process 22.2222 7 no
GO:0043067 regulation of programmed cell death 22.2222 5 no
GO:0043068 positive regulation of programmed cell death 22.2222 6 no
GO:0043069 negative regulation of programmed cell death 22.2222 6 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:1904062 regulation of cation transmembrane transport 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IQCB1_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MB212_HUMAN [view interactions] High throughput no no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
PAN2_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
BCAR1_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
PLK4_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
UB2D1_HUMAN [view interactions] High throughput no yes