Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TPD53_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

[View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TPD53_HUMAN
GO:0005524 ATP binding 29.4118 5 no
GO:0017076 purine nucleotide binding 29.4118 4 no
GO:0030554 adenyl nucleotide binding 29.4118 5 no
GO:0032555 purine ribonucleotide binding 29.4118 4 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0045296 cadherin binding 29.4118 4 no
GO:0042803 protein homodimerization activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TPD53_HUMAN
GO:0031323 regulation of cellular metabolic process 70.5882 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.7059 4 yes
GO:0080090 regulation of primary metabolic process 64.7059 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 58.8235 4 yes
GO:0048522 positive regulation of cellular process 52.9412 4 yes
GO:0051049 regulation of transport 52.9412 4 no
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0010646 regulation of cell communication 52.9412 4 yes
GO:0008104 protein localization 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 yes
GO:0051246 regulation of protein metabolic process 35.2941 5 yes
GO:1902531 regulation of intracellular signal transduction 35.2941 5 yes
GO:0009889 regulation of biosynthetic process 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 5 no
GO:0010556 regulation of macromolecule biosynthetic process 35.2941 5 no
GO:0031326 regulation of cellular biosynthetic process 35.2941 5 no
GO:0051128 regulation of cellular component organization 35.2941 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0031324 negative regulation of cellular metabolic process 35.2941 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0042981 regulation of apoptotic process 29.4118 6 yes
GO:0043067 regulation of programmed cell death 29.4118 5 yes
GO:0043085 positive regulation of catalytic activity 29.4118 4 yes
GO:0043408 regulation of MAPK cascade 29.4118 6 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 yes
GO:0006355 regulation of DNA-templated transcription 29.4118 6 no
GO:0006796 phosphate-containing compound metabolic process 29.4118 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0051252 regulation of RNA metabolic process 29.4118 5 no
GO:1903506 regulation of nucleic acid-templated transcription 29.4118 7 no
GO:2001141 regulation of RNA biosynthetic process 29.4118 6 no
GO:0015031 protein transport 29.4118 4 no
GO:0071702 organic substance transport 29.4118 4 no
GO:0071705 nitrogen compound transport 29.4118 4 no
GO:0009893 positive regulation of metabolic process 29.4118 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.4118 5 yes
GO:0010941 regulation of cell death 29.4118 4 yes
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 yes
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 yes
GO:0051247 positive regulation of protein metabolic process 23.5294 6 yes
GO:0006468 protein phosphorylation 23.5294 5 no
GO:0006996 organelle organization 23.5294 4 no
GO:0016310 phosphorylation 23.5294 5 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0016192 vesicle-mediated transport 23.5294 4 no
GO:0071310 cellular response to organic substance 23.5294 4 no
GO:0043269 regulation of ion transport 23.5294 5 no
GO:0006605 protein targeting 23.5294 5 no
GO:0006886 intracellular protein transport 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0010647 positive regulation of cell communication 23.5294 5 yes
GO:0019220 regulation of phosphate metabolic process 23.5294 6 yes
GO:0023056 positive regulation of signaling 23.5294 4 yes
GO:0031399 regulation of protein modification process 23.5294 6 yes
GO:0042325 regulation of phosphorylation 17.6471 7 yes
GO:0043065 positive regulation of apoptotic process 17.6471 7 yes
GO:0043068 positive regulation of programmed cell death 17.6471 6 yes
GO:0043410 positive regulation of MAPK cascade 17.6471 7 yes
GO:0043549 regulation of kinase activity 17.6471 5 yes
GO:0045859 regulation of protein kinase activity 17.6471 6 yes
GO:0048584 positive regulation of response to stimulus 17.6471 4 yes
GO:0051338 regulation of transferase activity 17.6471 4 yes
GO:0071900 regulation of protein serine/threonine kinase activity 17.6471 7 yes
GO:1902533 positive regulation of intracellular signal transduction 17.6471 6 yes
GO:0001932 regulation of protein phosphorylation 17.6471 7 yes
GO:0009967 positive regulation of signal transduction 17.6471 5 yes
GO:0010942 positive regulation of cell death 17.6471 5 yes
GO:0032872 regulation of stress-activated MAPK cascade 11.7647 6 yes
GO:0032874 positive regulation of stress-activated MAPK cascade 11.7647 7 yes
GO:0033674 positive regulation of kinase activity 11.7647 6 yes
GO:0042327 positive regulation of phosphorylation 11.7647 8 yes
GO:0043405 regulation of MAP kinase activity 11.7647 8 yes
GO:0043406 positive regulation of MAP kinase activity 11.7647 8 yes
GO:0044772 mitotic cell cycle phase transition 11.7647 4 yes
GO:0044839 cell cycle G2/M phase transition 11.7647 4 yes
GO:0045860 positive regulation of protein kinase activity 11.7647 7 yes
GO:0045937 positive regulation of phosphate metabolic process 11.7647 7 yes
GO:0046328 regulation of JNK cascade 11.7647 7 yes
GO:0046330 positive regulation of JNK cascade 11.7647 8 yes
GO:0051347 positive regulation of transferase activity 11.7647 5 yes
GO:0070302 regulation of stress-activated protein kinase signaling cascade 11.7647 5 yes
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 11.7647 6 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 11.7647 8 yes
GO:0080134 regulation of response to stress 11.7647 4 yes
GO:0080135 regulation of cellular response to stress 11.7647 4 yes
GO:2001233 regulation of apoptotic signaling pathway 11.7647 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 11.7647 6 yes
GO:0000086 G2/M transition of mitotic cell cycle 11.7647 5 yes
GO:0001934 positive regulation of protein phosphorylation 11.7647 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 11.7647 6 yes
GO:0031401 positive regulation of protein modification process 11.7647 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
TPD55_HUMAN [view interactions] Low throughput no no
1433S_HUMAN [view entry] [view interactions] Low throughput yes yes
MAL2_HUMAN [view interactions] Low throughput no no
TPD52_HUMAN [view interactions] High throughput no yes
TPD53_HUMAN [view entry] [view interactions] High throughput yes yes
TPD54_HUMAN [view interactions] High throughput no yes
ABL2_HUMAN [view entry] [view interactions] High throughput yes yes
PAK6_HUMAN [view entry] [view interactions] High throughput yes yes
YAE1_HUMAN [view interactions] High throughput no yes
EIF3J_HUMAN [view interactions] High throughput no yes
GP135_HUMAN [view interactions] High throughput no no
HDAC1_HUMAN [view interactions] High throughput no no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2A_HUMAN [view interactions] High throughput no yes
PBX3_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
AZIN2_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
GOPC_HUMAN [view entry] [view interactions] High throughput yes yes
TNR1B_HUMAN [view interactions] High throughput no no
NMD3B_HUMAN [view entry] [view interactions] High throughput yes no
TXN4A_HUMAN [view interactions] High throughput no no
KCD12_HUMAN [view entry] [view interactions] High throughput yes no
GABR1_HUMAN [view entry] [view interactions] High throughput yes yes
GSKIP_HUMAN [view interactions] High throughput no yes
EPN3_HUMAN [view interactions] High throughput no no
SPEB_HUMAN [view interactions] High throughput no no
INO1_HUMAN [view interactions] High throughput no no
NPM3_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
UCHL3_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
AUXI_HUMAN [view entry] [view interactions] Computational yes yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
TBC8B_HUMAN [view interactions] Computational no yes