PRS6A_HUMAN
Evidence for PS localization
Functions
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PRS6A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.8182 | 4 | yes |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 29.0909 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.0909 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.1818 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 26.3636 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 26.3636 | 5 | yes |
| GO:0005524 | ATP binding | 25.4545 | 5 | yes |
| GO:0003723 | RNA binding | 25.4545 | 4 | no |
| GO:0043169 | cation binding | 20.9091 | 4 | no |
| GO:0046872 | metal ion binding | 20.9091 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 14.5455 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 14.5455 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 14.5455 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 11.8182 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PRS6A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.1818 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 56.3636 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 55.4545 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.6364 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.7273 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.3636 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 46.3636 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 45.4545 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 45.4545 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.5455 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.6364 | 4 | yes |
| GO:0010468 | regulation of gene expression | 42.7273 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 39.0909 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.1818 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 37.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.4545 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.4545 | 5 | yes |
| GO:0022607 | cellular component assembly | 34.5455 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 34.5455 | 5 | no |
| GO:0009894 | regulation of catabolic process | 33.6364 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 32.7273 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 32.7273 | 5 | yes |
| GO:0036211 | protein modification process | 30.9091 | 4 | no |
| GO:0043412 | macromolecule modification | 30.9091 | 4 | no |
| GO:0006996 | organelle organization | 30.9091 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.0000 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 30.0000 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.0000 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 29.0909 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.0909 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.0909 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.0909 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.0909 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 28.1818 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.1818 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.1818 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.1818 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.1818 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.1818 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 25.4545 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 25.4545 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.5455 | 5 | no |
| GO:0006508 | proteolysis | 24.5455 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 24.5455 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.5455 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.6364 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.6364 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.6364 | 4 | no |
| GO:0008104 | protein localization | 23.6364 | 4 | no |
| GO:0030162 | regulation of proteolysis | 22.7273 | 6 | yes |
| GO:0032880 | regulation of protein localization | 22.7273 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.8182 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.8182 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.8182 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.8182 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.9091 | 7 | no |
| GO:0051726 | regulation of cell cycle | 20.9091 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.0000 | 8 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 20.0000 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 20.0000 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 20.0000 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 20.0000 | 4 | yes |
| GO:0009896 | positive regulation of catabolic process | 19.0909 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 18.1818 | 7 | yes |
| GO:0042176 | regulation of protein catabolic process | 18.1818 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 18.1818 | 6 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 18.1818 | 7 | yes |
| GO:0030163 | protein catabolic process | 17.2727 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 16.3636 | 8 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 16.3636 | 7 | yes |
| GO:0010498 | proteasomal protein catabolic process | 15.4545 | 5 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 15.4545 | 6 | yes |
| GO:0045862 | positive regulation of proteolysis | 15.4545 | 7 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 14.5455 | 6 | yes |
| GO:0045732 | positive regulation of protein catabolic process | 11.8182 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 11.8182 | 9 | yes |
| GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 11.8182 | 8 | yes |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | 10.9091 | 7 | yes |
| GO:0044788 | modulation by host of viral process | 4.5455 | 5 | yes |
| GO:0051851 | modulation by host of symbiont process | 4.5455 | 4 | yes |
| GO:0044793 | negative regulation by host of viral process | 2.7273 | 6 | yes |
| GO:0043921 | modulation by host of viral transcription | 1.8182 | 6 | yes |
| GO:0043922 | negative regulation by host of viral transcription | 1.8182 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRS6B_HUMAN | [view interactions] | Low throughput | no | yes |
| INSI2_HUMAN | [view interactions] | Low throughput | no | yes |
| INSI1_HUMAN | [view interactions] | Low throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRXR2_HUMAN | [view interactions] | Low throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| EPAS1_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JKAMP_HUMAN | [view interactions] | Low throughput | no | yes |
| UBD_HUMAN | [view interactions] | Low throughput | no | no |
| C2TA_HUMAN | [view interactions] | Low throughput | no | no |
| PSA3_HUMAN | [view interactions] | Low throughput | no | no |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FOSL1_HUMAN | [view interactions] | Low throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RN19A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOP2_HUMAN | [view interactions] | Low throughput | no | no |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAX_HUMAN | [view interactions] | Low throughput | no | yes |
| TXNL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PSD10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSMD9_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS10_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | Low throughput | no | yes |
| PSB5_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| TRMO_HUMAN | [view interactions] | High throughput | no | no |
| PSME4_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| YETS2_HUMAN | [view interactions] | High throughput | no | no |
| PSME2_HUMAN | [view interactions] | High throughput | no | no |
| SCML1_HUMAN | [view interactions] | High throughput | no | no |
| PSMF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBD2B_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB9_HUMAN | [view interactions] | High throughput | no | no |
| PSMG3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| SEML_HUMAN | [view interactions] | High throughput | no | yes |
| CCD92_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| MTSS1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| AKIR2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RITA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| IRF2_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| DDI1_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| DDI2_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| GLI2_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| KLF15_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| 5HT1E_HUMAN | [view interactions] | High throughput | no | yes |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAAF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| SOMA_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| PSB8_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PSMA8_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| ECD_HUMAN | [view interactions] | High throughput | no | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMG2_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| RFC2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABRX2_HUMAN | [view interactions] | High throughput | no | yes |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| LS14A_HUMAN | [view interactions] | High throughput | no | yes |
| CAN3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPF1_HUMAN | [view interactions] | High throughput | no | no |
| MKS3_HUMAN | [view interactions] | High throughput | no | no |
| IN80D_HUMAN | [view interactions] | High throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| MXI1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| PMS2_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PRI1_HUMAN | [view interactions] | High throughput | no | no |
| SMAD5_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD9_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2Q1_HUMAN | [view interactions] | High throughput | no | no |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| GCP60_HUMAN | [view interactions] | High throughput | no | yes |
| NOS2_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ASB11_HUMAN | [view interactions] | High throughput | no | no |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFN2B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| CC74B_HUMAN | [view interactions] | High throughput | no | no |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASF7_HUMAN | [view interactions] | High throughput | no | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CSR2B_HUMAN | [view interactions] | High throughput | no | no |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZZZ3_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| TPD53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| ITPR2_HUMAN | [view interactions] | High throughput | no | yes |
| LMBL2_HUMAN | [view interactions] | High throughput | no | no |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| STKL1_HUMAN | [view interactions] | High throughput | no | no |
| FA83D_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| NKX21_HUMAN | [view interactions] | High throughput | no | no |
| CCD40_HUMAN | [view interactions] | High throughput | no | no |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| CLC14_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| DUS15_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| FGF11_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| AL1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT38_HUMAN | [view interactions] | High throughput | no | no |
| KDM6B_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| DESI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK2_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BMAL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| CDKN3_HUMAN | [view interactions] | High throughput | no | no |
| EYA3_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GA45A_HUMAN | [view interactions] | High throughput | no | no |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| UCHL5_HUMAN | [view interactions] | High throughput | no | yes |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| MAF_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| TADA3_HUMAN | [view interactions] | High throughput | no | yes |
| PSD12_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| E2F6_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| T2FA_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| EIF2D_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| CC74A_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| ZFN2A_HUMAN | [view interactions] | High throughput | no | yes |
| ELF2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| TAB1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| PHF19_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| LIN54_HUMAN | [view interactions] | High throughput | no | yes |
| ANKZ1_HUMAN | [view interactions] | High throughput | no | yes |
| F117B_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| MEX3D_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAS2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| MGAP_HUMAN | [view interactions] | High throughput | no | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2C_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| SEN15_HUMAN | [view interactions] | High throughput | no | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FWCH2_HUMAN | [view interactions] | High throughput | no | no |
| PSA7_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| CBPE_HUMAN | [view interactions] | High throughput | no | yes |