Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PSA4_HUMAN

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PSA4_HUMAN
GO:0017076 purine nucleotide binding 24.2424 4 no
GO:0032555 purine ribonucleotide binding 24.2424 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.2424 4 no
GO:0004175 endopeptidase activity 9.0909 4 yes
GO:0004298 threonine-type endopeptidase activity 4.5455 5 yes
GO:0070003 threonine-type peptidase activity 4.5455 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PSA4_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 59.0909 4 no
GO:0060255 regulation of macromolecule metabolic process 59.0909 4 no
GO:0080090 regulation of primary metabolic process 59.0909 4 no
GO:0031323 regulation of cellular metabolic process 53.0303 4 no
GO:0009893 positive regulation of metabolic process 46.9697 4 no
GO:0010646 regulation of cell communication 45.4545 4 no
GO:0048523 negative regulation of cellular process 45.4545 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.9394 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 43.9394 5 no
GO:0051246 regulation of protein metabolic process 43.9394 5 no
GO:0036211 protein modification process 42.4242 4 no
GO:0043412 macromolecule modification 42.4242 4 no
GO:0031325 positive regulation of cellular metabolic process 42.4242 5 no
GO:0051128 regulation of cellular component organization 42.4242 4 no
GO:0006508 proteolysis 36.3636 4 yes
GO:0006996 organelle organization 36.3636 4 no
GO:0009966 regulation of signal transduction 36.3636 4 no
GO:0010647 positive regulation of cell communication 34.8485 5 no
GO:0023056 positive regulation of signaling 34.8485 4 no
GO:0009889 regulation of biosynthetic process 34.8485 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.8485 5 no
GO:0031326 regulation of cellular biosynthetic process 34.8485 5 no
GO:0009057 macromolecule catabolic process 33.3333 4 yes
GO:0051603 proteolysis involved in protein catabolic process 33.3333 5 yes
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0044265 cellular macromolecule catabolic process 31.8182 4 yes
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0042981 regulation of apoptotic process 31.8182 6 no
GO:0043067 regulation of programmed cell death 31.8182 5 no
GO:0048584 positive regulation of response to stimulus 31.8182 4 no
GO:0051247 positive regulation of protein metabolic process 31.8182 6 no
GO:0019941 modification-dependent protein catabolic process 30.3030 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 30.3030 5 yes
GO:0009967 positive regulation of signal transduction 30.3030 5 no
GO:0010605 negative regulation of macromolecule metabolic process 30.3030 5 no
GO:0031324 negative regulation of cellular metabolic process 30.3030 5 no
GO:0048585 negative regulation of response to stimulus 28.7879 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.7879 5 no
GO:0022607 cellular component assembly 28.7879 4 no
GO:0008104 protein localization 27.2727 4 no
GO:0010648 negative regulation of cell communication 27.2727 5 no
GO:0023057 negative regulation of signaling 27.2727 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.2727 6 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:0051049 regulation of transport 25.7576 4 no
GO:0006355 regulation of DNA-templated transcription 25.7576 6 no
GO:0009891 positive regulation of biosynthetic process 25.7576 5 no
GO:0009968 negative regulation of signal transduction 25.7576 5 no
GO:0019220 regulation of phosphate metabolic process 25.7576 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.7576 6 no
GO:0031401 positive regulation of protein modification process 25.7576 7 no
GO:0051174 regulation of phosphorus metabolic process 25.7576 5 no
GO:0051252 regulation of RNA metabolic process 25.7576 5 no
GO:0051338 regulation of transferase activity 25.7576 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.7576 7 no
GO:2001141 regulation of RNA biosynthetic process 25.7576 6 no
GO:0051130 positive regulation of cellular component organization 25.7576 5 no
GO:0006511 ubiquitin-dependent protein catabolic process 24.2424 7 yes
GO:0032880 regulation of protein localization 24.2424 5 no
GO:0060341 regulation of cellular localization 24.2424 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.2424 6 no
GO:0033043 regulation of organelle organization 24.2424 5 no
GO:0071310 cellular response to organic substance 22.7273 4 no
GO:0001932 regulation of protein phosphorylation 22.7273 7 no
GO:0042176 regulation of protein catabolic process 22.7273 5 no
GO:0042325 regulation of phosphorylation 22.7273 7 no
GO:0043085 positive regulation of catalytic activity 22.7273 4 no
GO:0051248 negative regulation of protein metabolic process 22.7273 6 no
GO:0070647 protein modification by small protein conjugation or removal 22.7273 5 no
GO:0031329 regulation of cellular catabolic process 22.7273 5 no
GO:0010498 proteasomal protein catabolic process 21.2121 5 yes
GO:0030163 protein catabolic process 21.2121 4 yes
GO:1901565 organonitrogen compound catabolic process 21.2121 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.2121 7 no
GO:0060548 negative regulation of cell death 21.2121 5 no
GO:2001233 regulation of apoptotic signaling pathway 21.2121 5 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FOS_HUMAN [view interactions] Low throughput no yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
PSA2_HUMAN [view interactions] Low throughput no yes
PSA3_HUMAN [view interactions] Low throughput no no
PSA7_HUMAN [view interactions] Low throughput no yes
POMP_HUMAN [view interactions] Low throughput no yes
PSMG2_HUMAN [view interactions] Low throughput no yes
AKIR2_HUMAN [view interactions] Low throughput no no
PSB5_HUMAN [view interactions] Low throughput no yes
PSB4_HUMAN [view interactions] Low throughput no yes
PSB1_HUMAN [view interactions] Low throughput no yes
PSB3_HUMAN [view interactions] Low throughput no yes
PSB2_HUMAN [view interactions] Low throughput no yes
PSB7_HUMAN [view interactions] Low throughput no yes
BHE41_HUMAN [view interactions] Low throughput no no
HIF1A_HUMAN [view interactions] Low throughput no no
PSA6_HUMAN [view interactions] Low throughput no yes
PSA5_HUMAN [view interactions] Low throughput no yes
PSA1_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK1_HUMAN [view interactions] Low throughput no yes
PSB6_HUMAN [view entry] [view interactions] Low throughput yes yes
PSB8_HUMAN [view interactions] Low throughput no yes
NFKB1_HUMAN [view interactions] Low throughput no yes
ABL1_HUMAN [view entry] [view interactions] Low throughput yes yes
ASB10_HUMAN [view interactions] Low throughput no no
UBP14_HUMAN [view entry] [view interactions] Low throughput yes yes
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
COG2_HUMAN [view interactions] High throughput no no
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PRS6A_HUMAN [view entry] [view interactions] High throughput yes yes
PSD13_HUMAN [view interactions] High throughput no yes
PSMD6_HUMAN [view interactions] High throughput no yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
PRS7_HUMAN [view interactions] High throughput no yes
PSD12_HUMAN [view interactions] High throughput no yes
PSMD7_HUMAN [view interactions] High throughput no yes
PSMG4_HUMAN [view interactions] High throughput no yes
SEML_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
RHOU_HUMAN [view interactions] High throughput no no
NQO1_HUMAN [view interactions] High throughput no no
OTUD4_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
PSMD5_HUMAN [view interactions] High throughput no yes
PSMA8_HUMAN [view interactions] High throughput no no
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
AP3M1_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
RPP38_HUMAN [view interactions] High throughput no yes
P5CR3_HUMAN [view interactions] High throughput no no
CCAR2_HUMAN [view interactions] High throughput no yes
ELP6_HUMAN [view interactions] High throughput no no
EXOS4_HUMAN [view interactions] High throughput no yes
EXOS5_HUMAN [view interactions] High throughput no yes
GET3_HUMAN [view interactions] High throughput no yes
CHMP5_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
ERO1B_HUMAN [view interactions] High throughput no yes
RT09_HUMAN [view interactions] High throughput no yes
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
SAE2_HUMAN [view interactions] High throughput no yes
XPOT_HUMAN [view interactions] High throughput no no
RAN_HUMAN [view entry] [view interactions] High throughput yes no
WDR11_HUMAN [view interactions] High throughput no yes
PSB10_HUMAN [view interactions] High throughput no no
PSMD9_HUMAN [view interactions] High throughput no yes
TXND5_HUMAN [view interactions] High throughput no yes
TXNL1_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
UCHL5_HUMAN [view interactions] High throughput no yes
SLX1_HUMAN [view interactions] High throughput no yes
BABA1_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
BUB1B_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
PSB9_HUMAN [view interactions] High throughput no no
SHLD3_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
VCAM1_HUMAN [view interactions] High throughput no no
COX15_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
PSA4_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
AMFR_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
KLF15_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
KLF8_HUMAN [view interactions] High throughput no no
TLX2_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC3_HUMAN [view interactions] High throughput no no
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
IKZF1_HUMAN [view interactions] High throughput no no
TRI38_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
CI072_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
ADRM1_HUMAN [view interactions] High throughput no yes
PRS10_HUMAN [view interactions] High throughput no yes
PSMD4_HUMAN [view interactions] High throughput no yes
GATA1_HUMAN [view interactions] High throughput no no
REL_HUMAN [view interactions] High throughput no yes
CARD9_HUMAN [view interactions] High throughput no no
RN185_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view interactions] High throughput no yes
RD23A_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD8_HUMAN [view interactions] High throughput no yes
PSME2_HUMAN [view interactions] High throughput no no
PSME1_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
HUWE1_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
HERC3_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ZN598_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
PPP6_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RELB_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
SHRPN_HUMAN [view entry] [view interactions] High throughput yes yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
PRS4_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL4_HUMAN [view interactions] High throughput no yes
DESI1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PSME3_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
ATX3_HUMAN [view interactions] High throughput no yes
VRK3_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
INSI2_HUMAN [view interactions] High throughput no yes
UNKL_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
MAF_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
PAGE4_HUMAN [view interactions] High throughput no no
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
PSMG3_HUMAN [view interactions] High throughput no yes
PSME4_HUMAN [view interactions] High throughput no yes
SELO_HUMAN [view interactions] High throughput no yes
PSMF1_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
PSMD2_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
ECM29_HUMAN [view interactions] High throughput no no
PSMG1_HUMAN [view interactions] High throughput no yes
PSMD3_HUMAN [view interactions] High throughput no yes
PRS6B_HUMAN [view interactions] High throughput no yes
P73_HUMAN [view interactions] Computational no no
OAZ1_HUMAN [view interactions] Computational no yes
RUNX3_HUMAN [view interactions] Computational no no
CDC6_HUMAN [view interactions] Computational no yes
NUMB_HUMAN [view entry] [view interactions] Computational yes yes
PSD10_HUMAN [view entry] [view interactions] Computational yes yes
ACHA3_HUMAN [view entry] [view interactions] Computational yes no
RPN1_HUMAN [view entry] [view interactions] Computational yes yes
TF65_HUMAN [view entry] [view interactions] Computational yes yes
ORC1_HUMAN [view interactions] Computational no yes
FBXL7_HUMAN [view interactions] Computational no no
ACHA5_HUMAN [view entry] [view interactions] Computational yes yes
SUFU_HUMAN [view interactions] Computational no yes
MK06_HUMAN [view interactions] Computational no yes
GLI1_HUMAN [view interactions] Computational no no
PSB11_HUMAN [view interactions] Computational no no
GEMI_HUMAN [view interactions] Computational no no
OAZ2_HUMAN [view interactions] Computational no no
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
UBFD1_HUMAN [view interactions] Computational no no
COP1_HUMAN [view interactions] Computational no no
CCND1_HUMAN [view interactions] Computational no yes
TCPB_HUMAN [view entry] [view interactions] Computational yes yes
HNRPD_HUMAN [view entry] [view interactions] Computational yes yes
GLI3_HUMAN [view interactions] Computational no yes
TCPD_HUMAN [view entry] [view interactions] Computational yes yes
RPN2_HUMAN [view entry] [view interactions] Computational yes yes
SHH_HUMAN [view interactions] Computational no no
TCPQ_HUMAN [view entry] [view interactions] Computational yes yes
SPRE3_HUMAN [view interactions] Computational no no
PAK2_HUMAN [view entry] [view interactions] Computational yes no
GLI2_HUMAN [view interactions] Computational no yes
DCOR_HUMAN [view interactions] Computational no yes
NF1_HUMAN [view entry] [view interactions] Computational yes no
NOTC4_HUMAN [view interactions] Computational no no
PRIC1_HUMAN [view interactions] Computational no yes
TCPE_HUMAN [view entry] [view interactions] Computational yes yes
ACHB4_HUMAN [view entry] [view interactions] Computational yes no
MPIP1_HUMAN [view interactions] Computational no no
SPRE2_HUMAN [view interactions] Computational no yes
M3K14_HUMAN [view interactions] Computational no yes
UBCP1_HUMAN [view interactions] Computational no yes
RUNX2_HUMAN [view interactions] Computational no no
SPRE1_HUMAN [view interactions] Computational no yes