Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CYBP_HUMAN

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI001105 DEG_SIAH_1 DEG 59 67 -

Molecular function

Term Name % Distance from the top of the tree Annotated in CYBP_HUMAN
GO:0017076 purine nucleotide binding 41.0959 4 no
GO:0032555 purine ribonucleotide binding 39.7260 4 no
GO:0035639 purine ribonucleoside triphosphate binding 39.7260 4 no
GO:0030554 adenyl nucleotide binding 26.0274 5 no
GO:0005524 ATP binding 24.6575 5 no
GO:0032559 adenyl ribonucleotide binding 24.6575 5 no
GO:0019900 kinase binding 21.9178 4 no
GO:0046872 metal ion binding 21.9178 4 no
GO:0019901 protein kinase binding 20.5479 5 no
GO:0044389 ubiquitin-like protein ligase binding 16.4384 4 yes
GO:0031625 ubiquitin protein ligase binding 15.0685 5 yes
GO:0042803 protein homodimerization activity 9.5890 4 yes
GO:0015631 tubulin binding 6.8493 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CYBP_HUMAN
GO:0048522 positive regulation of cellular process 60.2740 4 no
GO:0010646 regulation of cell communication 50.6849 4 no
GO:0080090 regulation of primary metabolic process 49.3151 4 no
GO:0031323 regulation of cellular metabolic process 47.9452 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.5753 4 no
GO:0060255 regulation of macromolecule metabolic process 46.5753 4 no
GO:0009966 regulation of signal transduction 45.2055 4 no
GO:0048523 negative regulation of cellular process 45.2055 4 no
GO:0009893 positive regulation of metabolic process 43.8356 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.3562 5 no
GO:0010604 positive regulation of macromolecule metabolic process 36.9863 5 no
GO:0051128 regulation of cellular component organization 35.6164 4 no
GO:0031325 positive regulation of cellular metabolic process 35.6164 5 no
GO:0006996 organelle organization 34.2466 4 no
GO:0022607 cellular component assembly 34.2466 4 no
GO:1902531 regulation of intracellular signal transduction 34.2466 5 no
GO:0010468 regulation of gene expression 34.2466 5 no
GO:0010941 regulation of cell death 32.8767 4 no
GO:0042981 regulation of apoptotic process 32.8767 6 no
GO:0043067 regulation of programmed cell death 32.8767 5 no
GO:0048584 positive regulation of response to stimulus 32.8767 4 no
GO:0051246 regulation of protein metabolic process 31.5068 5 no
GO:0023056 positive regulation of signaling 31.5068 4 no
GO:0009889 regulation of biosynthetic process 30.1370 4 no
GO:0010647 positive regulation of cell communication 30.1370 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.1370 5 no
GO:0031326 regulation of cellular biosynthetic process 30.1370 5 no
GO:0051247 positive regulation of protein metabolic process 28.7671 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.7671 5 no
GO:0043412 macromolecule modification 27.3973 4 no
GO:0031399 regulation of protein modification process 27.3973 6 no
GO:0036211 protein modification process 26.0274 4 no
GO:0009967 positive regulation of signal transduction 26.0274 5 no
GO:0044087 regulation of cellular component biogenesis 24.6575 4 no
GO:0008104 protein localization 24.6575 4 no
GO:0080134 regulation of response to stress 24.6575 4 no
GO:0009891 positive regulation of biosynthetic process 24.6575 5 no
GO:0009894 regulation of catabolic process 24.6575 4 no
GO:0031328 positive regulation of cellular biosynthetic process 24.6575 6 no
GO:0051252 regulation of RNA metabolic process 24.6575 5 no
GO:0071310 cellular response to organic substance 23.2877 4 yes
GO:0043085 positive regulation of catalytic activity 23.2877 4 no
GO:0033043 regulation of organelle organization 23.2877 5 no
GO:0071702 organic substance transport 23.2877 4 no
GO:0019220 regulation of phosphate metabolic process 23.2877 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.2877 6 no
GO:0051174 regulation of phosphorus metabolic process 23.2877 5 no
GO:0051049 regulation of transport 23.2877 4 no
GO:0006355 regulation of DNA-templated transcription 23.2877 6 no
GO:1903506 regulation of nucleic acid-templated transcription 23.2877 7 no
GO:2001141 regulation of RNA biosynthetic process 23.2877 6 no
GO:0042127 regulation of cell population proliferation 21.9178 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.9178 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.9178 6 no
GO:0043066 negative regulation of apoptotic process 21.9178 7 no
GO:0043069 negative regulation of programmed cell death 21.9178 6 no
GO:0060548 negative regulation of cell death 21.9178 5 no
GO:0071705 nitrogen compound transport 20.5479 4 no
GO:0030030 cell projection organization 20.5479 4 no
GO:0060341 regulation of cellular localization 20.5479 4 no
GO:0009892 negative regulation of metabolic process 20.5479 4 no
GO:0045595 regulation of cell differentiation 20.5479 4 no
GO:0034097 response to cytokine 13.6986 4 yes
GO:0071345 cellular response to cytokine stimulus 9.5890 5 yes
GO:0007507 heart development 4.1096 4 yes
GO:1990823 response to leukemia inhibitory factor 2.7397 5 yes
GO:1990830 cellular response to leukemia inhibitory factor 2.7397 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in CYBP_HUMAN
DOID:0050686 organ system cancer 2.7397 3 no
DOID:10534 stomach cancer 2.7397 5 no
DOID:3119 gastrointestinal system cancer 2.7397 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S10A1_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
ENPL_HUMAN [view entry] [view interactions] Low throughput yes yes
RSMB_HUMAN [view interactions] Low throughput no yes
ROAA_HUMAN [view interactions] Low throughput no yes
PRP31_HUMAN [view interactions] Low throughput no yes
NPM_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
MIPT3_HUMAN [view interactions] Low throughput no yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
BIRC6_HUMAN [view entry] [view interactions] Low throughput yes yes
SIAH2_HUMAN [view interactions] Low throughput no no
SIAH1_HUMAN [view interactions] Low throughput no yes
MLF1_HUMAN [view entry] [view interactions] Low throughput yes yes
S10A6_HUMAN [view interactions] Low throughput no yes
RNF41_HUMAN [view interactions] Low throughput no yes
S100P_HUMAN [view interactions] Low throughput no no
S100B_HUMAN [view entry] [view interactions] Low throughput yes yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
CYBP_HUMAN [view entry] [view interactions] Low throughput yes yes
S10A5_HUMAN [view interactions] Low throughput no no
TBL1X_HUMAN [view interactions] Low throughput no yes
SKP1_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
CE104_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
NECD_HUMAN [view interactions] High throughput no no
PPE2_HUMAN [view interactions] High throughput no no
NFYC_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
FGFR3_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
FHI2B_HUMAN [view interactions] High throughput no yes
PEA15_HUMAN [view entry] [view interactions] High throughput yes no
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
ITA4_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
RPTOR_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
EYA3_HUMAN [view interactions] High throughput no no
PTN3_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
GLP1R_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
IF16_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
DNJB5_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FZR1_HUMAN [view interactions] High throughput no no
M4K4_HUMAN [view interactions] High throughput no yes
M4K5_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
SIR6_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHBT1_HUMAN [view interactions] High throughput no yes
RHBT2_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
RPAC2_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
ROA0_HUMAN [view interactions] High throughput no yes
SYAC_HUMAN [view interactions] High throughput no yes
IPO11_HUMAN [view interactions] High throughput no yes
TRMB_HUMAN [view interactions] High throughput no yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
TPD52_HUMAN [view interactions] High throughput no yes
ANXA2_HUMAN [view entry] [view interactions] High throughput yes no
FERM1_HUMAN [view interactions] High throughput no yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
DAA11_HUMAN [view interactions] High throughput no no
NAA20_HUMAN [view interactions] High throughput no no
NAA25_HUMAN [view interactions] High throughput no yes
TAGL2_HUMAN [view entry] [view interactions] High throughput yes no
UBP19_HUMAN [view interactions] High throughput no no
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
CHRD1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
F120C_HUMAN [view interactions] High throughput no yes
GLE1_HUMAN [view interactions] High throughput no yes
SYMPK_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
PATL1_HUMAN [view interactions] High throughput no yes
MFN2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
CMC1_HUMAN [view entry] [view interactions] High throughput yes yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DJC21_HUMAN [view interactions] High throughput no yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
DYR2_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
BEX3_HUMAN [view interactions] High throughput no yes
LMAN1_HUMAN [view interactions] High throughput no yes
MK13_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
OTUD5_HUMAN [view interactions] High throughput no yes
FAK1_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
PXMP2_HUMAN [view interactions] High throughput no no
UBP13_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
STK3_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
FRMD5_HUMAN [view interactions] High throughput no no
NBR1_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
CARM1_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
IRS4_HUMAN [view interactions] High throughput no no
RPAP3_HUMAN [view interactions] High throughput no yes
SGT1_HUMAN [view interactions] High throughput no no
AIM2_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
SNX4_HUMAN [view entry] [view interactions] High throughput yes yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG29_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
KDM4A_HUMAN [view interactions] High throughput no yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
KAPCG_HUMAN [view interactions] High throughput no no
MK04_HUMAN [view interactions] High throughput no no
GRK6_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
KC1G2_HUMAN [view interactions] High throughput no yes
RIPK1_HUMAN [view interactions] High throughput no yes
ILK_HUMAN [view interactions] High throughput no no
CDK10_HUMAN [view interactions] High throughput no no
LRRK1_HUMAN [view interactions] High throughput no yes
ADCK1_HUMAN [view interactions] High throughput no no
NEK8_HUMAN [view interactions] High throughput no yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
MK15_HUMAN [view interactions] High throughput no no
SGK3_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
KPSH2_HUMAN [view interactions] High throughput no no
TSSK2_HUMAN [view interactions] High throughput no no
TESK2_HUMAN [view interactions] High throughput no yes
E2AK1_HUMAN [view interactions] High throughput no yes
TSSK1_HUMAN [view interactions] High throughput no no
DYRK4_HUMAN [view interactions] High throughput no no
AAKG3_HUMAN [view interactions] High throughput no no
SIK3_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view interactions] High throughput no yes
IF6_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
TRM7_HUMAN [view interactions] High throughput no yes
EIF1B_HUMAN [view interactions] High throughput no no
CNOT8_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
3MG_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
IKKE_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
CD8A_HUMAN [view interactions] High throughput no no
PINX1_HUMAN [view interactions] High throughput no yes
CCR2_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
S10A2_HUMAN [view interactions] High throughput no no
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
AP3D1_HUMAN [view entry] [view interactions] High throughput yes no
CFLAR_HUMAN [view interactions] High throughput no yes
TET3_HUMAN [view interactions] High throughput no yes
FBX24_HUMAN [view interactions] High throughput no no
RMP_HUMAN [view interactions] High throughput no yes
REC8_HUMAN [view interactions] High throughput no yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
MOS_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RAG1_HUMAN [view interactions] High throughput no no
ERCC2_HUMAN [view interactions] High throughput no yes
GNAZ_HUMAN [view entry] [view interactions] High throughput yes yes
GNA15_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
MCM7_HUMAN [view interactions] High throughput no no
CACP_HUMAN [view entry] [view interactions] High throughput yes yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
NAL12_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
KEAP1_HUMAN [view interactions] High throughput no yes
SIM2_HUMAN [view interactions] High throughput no yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
KLH38_HUMAN [view interactions] High throughput no no
TFDP3_HUMAN [view interactions] High throughput no no
UBP49_HUMAN [view interactions] High throughput no yes
DET1_HUMAN [view interactions] High throughput no no
PIWL4_HUMAN [view interactions] High throughput no yes
IPRI_HUMAN [view interactions] High throughput no no
SMRD2_HUMAN [view interactions] High throughput no no
TRI43_HUMAN [view interactions] High throughput no no
PIWL1_HUMAN [view interactions] High throughput no no
NAT10_HUMAN [view interactions] High throughput no yes
KLHL1_HUMAN [view interactions] High throughput no no
WSB2_HUMAN [view interactions] High throughput no yes
E2AK4_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
FBXW2_HUMAN [view interactions] High throughput no yes
UBP18_HUMAN [view interactions] High throughput no yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
NOD1_HUMAN [view interactions] High throughput no no
TRI17_HUMAN [view interactions] High throughput no yes
COPG1_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
PP6R2_HUMAN [view interactions] High throughput no no
NPHP1_HUMAN [view interactions] High throughput no yes
NPHP4_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] Computational yes yes
GSK3A_HUMAN [view interactions] Computational no yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
NUDC_HUMAN [view interactions] Computational no yes
AXIN1_HUMAN [view interactions] Computational no yes
APC_HUMAN [view entry] [view interactions] Computational yes no