PFKAL_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PFKAL_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 36.6667 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 36.6667 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.6667 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | yes |
| GO:0043169 | cation binding | 30.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 30.0000 | 5 | yes |
| GO:0003723 | RNA binding | 30.0000 | 4 | no |
| GO:0005524 | ATP binding | 28.3333 | 5 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.3333 | 4 | no |
| GO:0016301 | kinase activity | 18.3333 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 18.3333 | 4 | yes |
| GO:0003872 | 6-phosphofructokinase activity | 6.6667 | 6 | yes |
| GO:0008443 | phosphofructokinase activity | 6.6667 | 5 | yes |
| GO:0016208 | AMP binding | 6.6667 | 5 | yes |
| GO:0019200 | carbohydrate kinase activity | 6.6667 | 5 | yes |
| GO:0070061 | fructose binding | 5.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PFKAL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 46.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.6667 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 45.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 45.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 43.3333 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.3333 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.6667 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.6667 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.6667 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.6667 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 30.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 28.3333 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.3333 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.3333 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.3333 | 7 | no |
| GO:0008104 | protein localization | 28.3333 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.3333 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 28.3333 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.3333 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0080134 | regulation of response to stress | 26.6667 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.3333 | 4 | no |
| GO:0036211 | protein modification process | 23.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 23.3333 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 21.6667 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 21.6667 | 4 | yes |
| GO:0032880 | regulation of protein localization | 21.6667 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 21.6667 | 4 | no |
| GO:0050890 | cognition | 21.6667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.6667 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 21.6667 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.6667 | 6 | no |
| GO:0031399 | regulation of protein modification process | 21.6667 | 6 | no |
| GO:0006163 | purine nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 16.6667 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 16.6667 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 16.6667 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 15.0000 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 15.0000 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 15.0000 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 15.0000 | 7 | yes |
| GO:0034655 | nucleobase-containing compound catabolic process | 15.0000 | 4 | yes |
| GO:0046034 | ATP metabolic process | 15.0000 | 7 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 15.0000 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 15.0000 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 13.3333 | 6 | yes |
| GO:0016052 | carbohydrate catabolic process | 11.6667 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 11.6667 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 11.6667 | 4 | yes |
| GO:0006006 | glucose metabolic process | 10.0000 | 5 | yes |
| GO:0006090 | pyruvate metabolic process | 10.0000 | 7 | yes |
| GO:0006096 | glycolytic process | 10.0000 | 4 | yes |
| GO:0006195 | purine nucleotide catabolic process | 10.0000 | 6 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 10.0000 | 5 | yes |
| GO:0009134 | nucleoside diphosphate catabolic process | 10.0000 | 6 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 10.0000 | 6 | yes |
| GO:0009137 | purine nucleoside diphosphate catabolic process | 10.0000 | 7 | yes |
| GO:0009154 | purine ribonucleotide catabolic process | 10.0000 | 6 | yes |
| GO:0009166 | nucleotide catabolic process | 10.0000 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 10.0000 | 7 | yes |
| GO:0009181 | purine ribonucleoside diphosphate catabolic process | 10.0000 | 8 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 10.0000 | 6 | yes |
| GO:0009191 | ribonucleoside diphosphate catabolic process | 10.0000 | 7 | yes |
| GO:0009261 | ribonucleotide catabolic process | 10.0000 | 5 | yes |
| GO:0019318 | hexose metabolic process | 10.0000 | 4 | yes |
| GO:0019362 | pyridine nucleotide metabolic process | 10.0000 | 5 | yes |
| GO:0019364 | pyridine nucleotide catabolic process | 10.0000 | 6 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 10.0000 | 6 | yes |
| GO:0046031 | ADP metabolic process | 10.0000 | 7 | yes |
| GO:0046032 | ADP catabolic process | 10.0000 | 7 | yes |
| GO:0046434 | organophosphate catabolic process | 10.0000 | 4 | yes |
| GO:0046496 | nicotinamide nucleotide metabolic process | 10.0000 | 6 | yes |
| GO:0051046 | regulation of secretion | 10.0000 | 5 | yes |
| GO:0051223 | regulation of protein transport | 10.0000 | 5 | yes |
| GO:0072523 | purine-containing compound catabolic process | 10.0000 | 5 | yes |
| GO:0072524 | pyridine-containing compound metabolic process | 10.0000 | 4 | yes |
| GO:0072526 | pyridine-containing compound catabolic process | 10.0000 | 5 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 10.0000 | 4 | yes |
| GO:1901292 | nucleoside phosphate catabolic process | 10.0000 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 10.0000 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 8.3333 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 8.3333 | 5 | yes |
| GO:0002791 | regulation of peptide secretion | 6.6667 | 6 | yes |
| GO:0006002 | fructose 6-phosphate metabolic process | 6.6667 | 4 | yes |
| GO:0006007 | glucose catabolic process | 6.6667 | 6 | yes |
| GO:0006734 | NADH metabolic process | 6.6667 | 7 | yes |
| GO:0006735 | NADH regeneration | 6.6667 | 8 | yes |
| GO:0019320 | hexose catabolic process | 6.6667 | 5 | yes |
| GO:0019674 | NAD metabolic process | 6.6667 | 6 | yes |
| GO:0019677 | NAD catabolic process | 6.6667 | 7 | yes |
| GO:0030388 | fructose 1,6-bisphosphate metabolic process | 6.6667 | 4 | yes |
| GO:0046365 | monosaccharide catabolic process | 6.6667 | 4 | yes |
| GO:0046883 | regulation of hormone secretion | 6.6667 | 4 | yes |
| GO:0050796 | regulation of insulin secretion | 6.6667 | 6 | yes |
| GO:0051051 | negative regulation of transport | 6.6667 | 4 | yes |
| GO:0061615 | glycolytic process through fructose-6-phosphate | 6.6667 | 5 | yes |
| GO:0061620 | glycolytic process through glucose-6-phosphate | 6.6667 | 6 | yes |
| GO:0061621 | canonical glycolysis | 6.6667 | 7 | yes |
| GO:0061718 | glucose catabolic process to pyruvate | 6.6667 | 7 | yes |
| GO:0090087 | regulation of peptide transport | 6.6667 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 6.6667 | 5 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 6.6667 | 6 | yes |
| GO:0002792 | negative regulation of peptide secretion | 5.0000 | 6 | yes |
| GO:0046676 | negative regulation of insulin secretion | 5.0000 | 7 | yes |
| GO:0046888 | negative regulation of hormone secretion | 5.0000 | 5 | yes |
| GO:0050709 | negative regulation of protein secretion | 5.0000 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 5.0000 | 5 | yes |
| GO:0051224 | negative regulation of protein transport | 5.0000 | 5 | yes |
| GO:0090278 | negative regulation of peptide hormone secretion | 5.0000 | 6 | yes |
| GO:1903531 | negative regulation of secretion by cell | 5.0000 | 5 | yes |
| GO:0009743 | response to carbohydrate | 3.3333 | 4 | yes |
| GO:0009746 | response to hexose | 3.3333 | 6 | yes |
| GO:0009749 | response to glucose | 3.3333 | 7 | yes |
| GO:0034284 | response to monosaccharide | 3.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DAAF5_HUMAN | [view interactions] | Low throughput | no | no |
| UBP39_HUMAN | [view interactions] | Low throughput | no | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| DPF3_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3C1_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| MSH2_HUMAN | [view interactions] | High throughput | no | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRK6_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MYD88_HUMAN | [view interactions] | High throughput | no | yes |
| TESK1_HUMAN | [view interactions] | High throughput | no | no |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| GTPB3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| M3K8_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAF10_HUMAN | [view interactions] | High throughput | no | yes |
| TAF13_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TFR2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |