PFKAL_HUMAN
Evidence for PS localization
Functions
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PFKAL_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 32.7273 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.9091 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 30.9091 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.9091 | 4 | yes |
| GO:0005524 | ATP binding | 27.2727 | 5 | yes |
| GO:0016301 | kinase activity | 27.2727 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.2727 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.2727 | 5 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.4545 | 4 | yes |
| GO:0019900 | kinase binding | 21.8182 | 4 | yes |
| GO:0019200 | carbohydrate kinase activity | 9.0909 | 5 | yes |
| GO:0003872 | 6-phosphofructokinase activity | 7.2727 | 6 | yes |
| GO:0008443 | phosphofructokinase activity | 7.2727 | 5 | yes |
| GO:0016208 | AMP binding | 7.2727 | 4 | yes |
| GO:0070061 | fructose binding | 5.4545 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PFKAL_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 52.7273 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 52.7273 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.7273 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.2727 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.2727 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.6364 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.6364 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.8182 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0016310 | phosphorylation | 34.5455 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.5455 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.7273 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.9091 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.9091 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.9091 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.9091 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9091 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.0909 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 29.0909 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.0909 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.0909 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 29.0909 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.0909 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.0909 | 5 | no |
| GO:0048878 | chemical homeostasis | 27.2727 | 4 | no |
| GO:0051049 | regulation of transport | 25.4545 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 25.4545 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.4545 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.4545 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 25.4545 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4545 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.4545 | 6 | no |
| GO:0010941 | regulation of cell death | 25.4545 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.4545 | 5 | no |
| GO:0071310 | cellular response to organic substance | 25.4545 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 25.4545 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 25.4545 | 5 | yes |
| GO:0016052 | carbohydrate catabolic process | 23.6364 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 23.6364 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 23.6364 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 23.6364 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 23.6364 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 23.6364 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.6364 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.6364 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.6364 | 5 | no |
| GO:0006163 | purine nucleotide metabolic process | 23.6364 | 5 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 21.8182 | 7 | yes |
| GO:0009259 | ribonucleotide metabolic process | 21.8182 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 21.8182 | 6 | yes |
| GO:0032880 | regulation of protein localization | 21.8182 | 5 | yes |
| GO:0046031 | ADP metabolic process | 21.8182 | 7 | yes |
| GO:0046034 | ATP metabolic process | 21.8182 | 7 | yes |
| GO:0046939 | nucleotide phosphorylation | 21.8182 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.8182 | 7 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.8182 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.8182 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.8182 | 5 | no |
| GO:0008104 | protein localization | 21.8182 | 4 | no |
| GO:0036211 | protein modification process | 21.8182 | 4 | no |
| GO:0043412 | macromolecule modification | 21.8182 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.8182 | 4 | no |
| GO:0006090 | pyruvate metabolic process | 21.8182 | 7 | yes |
| GO:0006096 | glycolytic process | 21.8182 | 5 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 21.8182 | 6 | yes |
| GO:0006757 | ATP generation from ADP | 21.8182 | 4 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 21.8182 | 5 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 21.8182 | 6 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 21.8182 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 21.8182 | 6 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 21.8182 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 21.8182 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 21.8182 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 21.8182 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 20.0000 | 5 | yes |
| GO:0019318 | hexose metabolic process | 20.0000 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 20.0000 | 4 | yes |
| GO:0006006 | glucose metabolic process | 18.1818 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 12.7273 | 6 | yes |
| GO:0019320 | hexose catabolic process | 10.9091 | 5 | yes |
| GO:0046365 | monosaccharide catabolic process | 10.9091 | 4 | yes |
| GO:0051046 | regulation of secretion | 10.9091 | 5 | yes |
| GO:0051223 | regulation of protein transport | 10.9091 | 5 | yes |
| GO:0061615 | glycolytic process through fructose-6-phosphate | 10.9091 | 6 | yes |
| GO:0061620 | glycolytic process through glucose-6-phosphate | 10.9091 | 7 | yes |
| GO:0061621 | canonical glycolysis | 10.9091 | 4 | yes |
| GO:0061718 | glucose catabolic process to pyruvate | 10.9091 | 7 | yes |
| GO:1903530 | regulation of secretion by cell | 10.9091 | 4 | yes |
| GO:0006002 | fructose 6-phosphate metabolic process | 10.9091 | 4 | yes |
| GO:0006007 | glucose catabolic process | 10.9091 | 6 | yes |
| GO:0030388 | fructose 1,6-bisphosphate metabolic process | 9.0909 | 4 | yes |
| GO:0009743 | response to carbohydrate | 7.2727 | 4 | yes |
| GO:0046883 | regulation of hormone secretion | 7.2727 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 7.2727 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 7.2727 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 7.2727 | 5 | yes |
| GO:1903828 | negative regulation of protein localization | 7.2727 | 5 | yes |
| GO:0002791 | regulation of peptide secretion | 7.2727 | 6 | yes |
| GO:0009746 | response to hexose | 5.4545 | 6 | yes |
| GO:0009749 | response to glucose | 5.4545 | 7 | yes |
| GO:0034284 | response to monosaccharide | 5.4545 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 5.4545 | 6 | yes |
| GO:0051051 | negative regulation of transport | 5.4545 | 4 | yes |
| GO:1904950 | negative regulation of establishment of protein localization | 5.4545 | 6 | yes |
| GO:0046676 | negative regulation of insulin secretion | 3.6364 | 7 | yes |
| GO:0046888 | negative regulation of hormone secretion | 3.6364 | 5 | yes |
| GO:0050709 | negative regulation of protein secretion | 3.6364 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 3.6364 | 5 | yes |
| GO:0051224 | negative regulation of protein transport | 3.6364 | 5 | yes |
| GO:0090278 | negative regulation of peptide hormone secretion | 3.6364 | 6 | yes |
| GO:1903531 | negative regulation of secretion by cell | 3.6364 | 5 | yes |
| GO:0002792 | negative regulation of peptide secretion | 3.6364 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PFKAL_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 5.4545 | 3 | no |
| DOID:331 | central nervous system disease | 3.6364 | 3 | no |
| DOID:936 | brain disease | 3.6364 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 3.6364 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PFKAL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRK6_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMXL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ANGI_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| MYD88_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TESK1_HUMAN | [view interactions] | High throughput | no | no |
| KRA59_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| GTPB3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| M3K8_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| RELB_HUMAN | [view interactions] | High throughput | no | yes |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TAF10_HUMAN | [view interactions] | High throughput | no | yes |
| TAF13_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN746_HUMAN | [view interactions] | High throughput | no | no |
| TFR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| HIF1A_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| LRRF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| EF1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| TSNAX_HUMAN | [view interactions] | High throughput | no | yes |
| SCAI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| TKTL1_HUMAN | [view interactions] | Computational | no | no |
| HKDC1_HUMAN | [view interactions] | Computational | no | no |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| F262_HUMAN | [view interactions] | Computational | no | no |
| F263_HUMAN | [view interactions] | Computational | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| F16P1_HUMAN | [view interactions] | Computational | no | no |
| TIGAR_HUMAN | [view interactions] | Computational | no | yes |
| ENOB_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HXK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HXK2_HUMAN | [view interactions] | Computational | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| F16P2_HUMAN | [view interactions] | Computational | no | no |
| ACOT4_HUMAN | [view interactions] | Computational | no | yes |
| A0A2U3TZM8_HUMAN | [view interactions] | Computational | no | no |
| ACOT2_HUMAN | [view interactions] | Computational | no | yes |
| TKTL2_HUMAN | [view interactions] | Computational | no | no |
| ACOT1_HUMAN | [view interactions] | Computational | no | yes |
| F261_HUMAN | [view interactions] | Computational | no | no |
| MPI_HUMAN | [view interactions] | Computational | no | yes |
| TKT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HXK3_HUMAN | [view interactions] | Computational | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| F264_HUMAN | [view interactions] | Computational | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |