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SFPQ_HUMAN

DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3 side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5-CTGAGTC-3 in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation . Required for the assembly of nuclear speckles (PubMed). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SFPQ_HUMAN
GO:0003723 RNA binding 41.8033 4 yes
GO:0043168 anion binding 26.2295 4 no
GO:0000166 nucleotide binding 24.5902 4 no
GO:0017076 purine nucleotide binding 23.7705 5 no
GO:0043169 cation binding 22.9508 4 no
GO:0046872 metal ion binding 22.9508 5 no
GO:0032555 purine ribonucleotide binding 22.1311 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.3115 4 no
GO:0030554 adenyl nucleotide binding 20.4918 6 no
GO:0003677 DNA binding 18.8525 4 yes
GO:0043565 sequence-specific DNA binding 10.6557 5 yes
GO:0042803 protein homodimerization activity 9.8361 4 yes
GO:0003690 double-stranded DNA binding 7.3770 5 yes
GO:0000976 transcription cis-regulatory region binding 5.7377 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 5.7377 4 yes
GO:0042826 histone deacetylase binding 5.7377 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 5.7377 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SFPQ_HUMAN
GO:0060255 regulation of macromolecule metabolic process 66.3934 4 yes
GO:0080090 regulation of primary metabolic process 65.5738 4 yes
GO:0031323 regulation of cellular metabolic process 63.1148 4 yes
GO:0048522 positive regulation of cellular process 63.1148 4 yes
GO:0048523 negative regulation of cellular process 59.8361 4 yes
GO:0009889 regulation of biosynthetic process 56.5574 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.7377 5 yes
GO:0031326 regulation of cellular biosynthetic process 55.7377 5 yes
GO:0010468 regulation of gene expression 54.9180 6 yes
GO:0009892 negative regulation of metabolic process 49.1803 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 49.1803 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 48.3607 5 yes
GO:0009893 positive regulation of metabolic process 46.7213 4 yes
GO:0051252 regulation of RNA metabolic process 45.9016 5 yes
GO:0010646 regulation of cell communication 45.0820 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.2623 5 yes
GO:0031324 negative regulation of cellular metabolic process 42.6230 5 yes
GO:0051128 regulation of cellular component organization 41.8033 4 no
GO:0051246 regulation of protein metabolic process 40.1639 5 no
GO:0006996 organelle organization 39.3443 4 no
GO:0031325 positive regulation of cellular metabolic process 38.5246 5 yes
GO:0006355 regulation of DNA-templated transcription 37.7049 7 yes
GO:0009890 negative regulation of biosynthetic process 37.7049 5 yes
GO:0009966 regulation of signal transduction 37.7049 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 37.7049 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 37.7049 6 yes
GO:2001141 regulation of RNA biosynthetic process 37.7049 6 yes
GO:0009891 positive regulation of biosynthetic process 36.0656 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 35.2459 6 yes
GO:0022607 cellular component assembly 35.2459 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 34.4262 6 yes
GO:0043933 protein-containing complex organization 31.9672 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 31.1475 8 yes
GO:0043067 regulation of programmed cell death 31.1475 4 yes
GO:0042981 regulation of apoptotic process 30.3279 5 yes
GO:0090304 nucleic acid metabolic process 30.3279 4 yes
GO:0043412 macromolecule modification 30.3279 4 no
GO:0048585 negative regulation of response to stimulus 29.5082 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 28.6885 5 yes
GO:0009894 regulation of catabolic process 28.6885 4 no
GO:0031399 regulation of protein modification process 27.8689 6 no
GO:0036211 protein modification process 27.8689 4 no
GO:0051247 positive regulation of protein metabolic process 27.8689 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.0492 5 yes
GO:0048584 positive regulation of response to stimulus 27.0492 4 yes
GO:0051253 negative regulation of RNA metabolic process 27.0492 6 yes
GO:0010648 negative regulation of cell communication 27.0492 5 no
GO:0023057 negative regulation of signaling 27.0492 4 no
GO:0008104 protein localization 27.0492 4 no
GO:1902531 regulation of intracellular signal transduction 26.2295 5 yes
GO:0009968 negative regulation of signal transduction 26.2295 5 no
GO:0010647 positive regulation of cell communication 24.5902 5 yes
GO:0016070 RNA metabolic process 24.5902 5 yes
GO:0023056 positive regulation of signaling 24.5902 4 yes
GO:0019220 regulation of phosphate metabolic process 24.5902 6 no
GO:0033043 regulation of organelle organization 24.5902 5 no
GO:0051049 regulation of transport 24.5902 4 no
GO:0051174 regulation of phosphorus metabolic process 24.5902 5 no
GO:0080134 regulation of response to stress 23.7705 4 yes
GO:0010629 negative regulation of gene expression 23.7705 7 no
GO:0051130 positive regulation of cellular component organization 23.7705 5 no
GO:0060341 regulation of cellular localization 23.7705 4 no
GO:0010628 positive regulation of gene expression 22.9508 7 no
GO:0051248 negative regulation of protein metabolic process 22.9508 6 no
GO:0051254 positive regulation of RNA metabolic process 22.1311 6 yes
GO:0032880 regulation of protein localization 22.1311 5 no
GO:0044087 regulation of cellular component biogenesis 22.1311 4 no
GO:0009967 positive regulation of signal transduction 20.4918 5 yes
GO:0045892 negative regulation of DNA-templated transcription 20.4918 8 yes
GO:1902679 negative regulation of RNA biosynthetic process 20.4918 7 yes
GO:0043066 negative regulation of apoptotic process 20.4918 6 no
GO:0043069 negative regulation of programmed cell death 20.4918 5 no
GO:0071310 cellular response to organic substance 20.4918 4 no
GO:0065003 protein-containing complex assembly 20.4918 5 no
GO:0045893 positive regulation of DNA-templated transcription 19.6721 8 yes
GO:1902680 positive regulation of RNA biosynthetic process 19.6721 7 yes
GO:0006396 RNA processing 18.8525 6 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 18.8525 9 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 17.2131 9 yes
GO:0032101 regulation of response to external stimulus 16.3934 4 yes
GO:0016071 mRNA metabolic process 15.5738 6 yes
GO:0043068 positive regulation of programmed cell death 13.9344 5 yes
GO:1902533 positive regulation of intracellular signal transduction 13.9344 6 yes
GO:2001233 regulation of apoptotic signaling pathway 13.9344 5 yes
GO:0006397 mRNA processing 13.1148 7 yes
GO:0008380 RNA splicing 13.1148 7 yes
GO:0031347 regulation of defense response 13.1148 5 yes
GO:0043065 positive regulation of apoptotic process 13.1148 6 yes
GO:0050776 regulation of immune response 12.2951 4 yes
GO:0002684 positive regulation of immune system process 11.4754 4 yes
GO:0006974 DNA damage response 11.4754 4 yes
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 10.6557 9 yes
GO:0000398 mRNA splicing, via spliceosome 10.6557 8 yes
GO:0006259 DNA metabolic process 10.6557 5 yes
GO:0000375 RNA splicing, via transesterification reactions 10.6557 8 yes
GO:0002831 regulation of response to biotic stimulus 9.8361 4 yes
GO:0032103 positive regulation of response to external stimulus 9.8361 5 yes
GO:2001242 regulation of intrinsic apoptotic signaling pathway 9.8361 6 yes
GO:0045088 regulation of innate immune response 9.0164 5 yes
GO:0050778 positive regulation of immune response 9.0164 5 yes
GO:0140546 defense response to symbiont 9.0164 4 yes
GO:0006281 DNA repair 8.1967 5 yes
GO:0031349 positive regulation of defense response 8.1967 5 yes
GO:0071824 protein-DNA complex organization 8.1967 5 yes
GO:0006325 chromatin organization 7.3770 6 yes
GO:0002833 positive regulation of response to biotic stimulus 5.7377 5 yes
GO:0006302 double-strand break repair 5.7377 6 yes
GO:0045089 positive regulation of innate immune response 5.7377 6 yes
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 5.7377 7 yes
GO:0006338 chromatin remodeling 4.9180 7 yes
GO:2001235 positive regulation of apoptotic signaling pathway 4.9180 6 yes
GO:0000380 alternative mRNA splicing, via spliceosome 4.0984 9 yes
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 3.2787 7 yes
GO:0006310 DNA recombination 2.4590 6 yes
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 2.4590 8 yes
GO:0000724 double-strand break repair via homologous recombination 1.6393 7 yes
GO:0000725 recombinational repair 1.6393 6 yes
GO:0042754 negative regulation of circadian rhythm 1.6393 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LMX1B_HUMAN [view interactions] Low throughput no no
DIDO1_HUMAN [view interactions] Low throughput no yes
NFKB1_HUMAN [view interactions] Low throughput no yes
IBP3_HUMAN [view interactions] Low throughput no no
TADBP_HUMAN [view interactions] Low throughput no yes
PTBP1_HUMAN [view interactions] Low throughput no no
RXRA_HUMAN [view interactions] Low throughput no yes
SIN3A_HUMAN [view interactions] Low throughput no yes
SNRPA_HUMAN [view interactions] Low throughput no yes
GAS7_HUMAN [view entry] [view interactions] Low throughput yes yes
TOP1_HUMAN [view interactions] Low throughput no yes
FUS_HUMAN [view entry] [view interactions] Low throughput yes yes
RU17_HUMAN [view interactions] Low throughput no yes
HNF4A_HUMAN [view interactions] Low throughput no no
PSPC1_HUMAN [view interactions] Low throughput no yes
NR4A2_HUMAN [view interactions] Low throughput no yes
CCNF_HUMAN [view interactions] Low throughput no no
DUX4_HUMAN [view interactions] Low throughput no no
DUX4C_HUMAN [view interactions] Low throughput no no
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] Low throughput yes yes
FHL2_HUMAN [view interactions] Low throughput no yes
PPARG_HUMAN [view interactions] Low throughput no yes
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
RA51D_HUMAN [view interactions] Low throughput no no
SP1_HUMAN [view interactions] Low throughput no yes
SP3_HUMAN [view interactions] Low throughput no no
HDAC1_HUMAN [view interactions] Low throughput no no
HDAC2_HUMAN [view interactions] Low throughput no yes
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
PITX3_HUMAN [view interactions] Low throughput no no
THA_HUMAN [view interactions] Low throughput no yes
ELAV4_HUMAN [view entry] [view interactions] Low throughput yes yes
ANDR_HUMAN [view interactions] Low throughput no no
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCI_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT6_HUMAN [view interactions] Low throughput no yes
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
HAKAI_HUMAN [view interactions] Low throughput no yes
PARK7_HUMAN [view entry] [view interactions] Low throughput yes yes
PRGC1_HUMAN [view interactions] Low throughput no no
PAWR_HUMAN [view interactions] Low throughput no yes
NONO_HUMAN [view interactions] Low throughput no yes
ZMYM2_HUMAN [view interactions] Low throughput no yes
RNF43_HUMAN [view interactions] Low throughput no yes
PTK6_HUMAN [view interactions] Low throughput no yes
TR150_HUMAN [view interactions] Low throughput no yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
CXXC1_HUMAN [view interactions] High throughput no yes
VRK1_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
DDX41_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RBP56_HUMAN [view interactions] High throughput no yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC3_HUMAN [view interactions] High throughput no no
DHYS_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
EWS_HUMAN [view interactions] High throughput no yes
ERCC6_HUMAN [view interactions] High throughput no no
THOC4_HUMAN [view interactions] High throughput no no
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
SMRC1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RMXL1_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
MMAD_HUMAN [view interactions] High throughput no no
NCOA5_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
RBM27_HUMAN [view interactions] High throughput no yes
WAPL_HUMAN [view interactions] High throughput no yes
FA98A_HUMAN [view interactions] High throughput no no
SCC4_HUMAN [view interactions] High throughput no no
OCRL_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
RRP1B_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ZCH18_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
MTA70_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
MET14_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
NEK4_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
PAK4_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ZN263_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CRY1_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
NCBP2_HUMAN [view interactions] High throughput no yes
FNDC5_HUMAN [view interactions] High throughput no no
ZN213_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
F16P1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
MT21E_HUMAN [view interactions] High throughput no no
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
IF16_HUMAN [view interactions] High throughput no no
AT11C_HUMAN [view interactions] High throughput no no
WDR76_HUMAN [view interactions] High throughput no no
WDR7_HUMAN [view entry] [view interactions] High throughput yes no
EIF3F_HUMAN [view interactions] High throughput no yes
UTP20_HUMAN [view interactions] High throughput no no
IF5A1_HUMAN [view interactions] High throughput no yes
MTHFS_HUMAN [view interactions] High throughput no yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
CPSF5_HUMAN [view interactions] High throughput no yes
RBM45_HUMAN [view interactions] High throughput no yes
NUFP2_HUMAN [view interactions] High throughput no no
SNUT1_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
PPIL4_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
DDX42_HUMAN [view interactions] High throughput no yes
MET17_HUMAN [view interactions] High throughput no yes
WBP4_HUMAN [view interactions] High throughput no yes
PP1RA_HUMAN [view interactions] High throughput no yes
FA76B_HUMAN [view interactions] High throughput no no
BTK_HUMAN [view interactions] High throughput no no
KDF1_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
MKRN1_HUMAN [view interactions] High throughput no no
KDM1A_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
MB212_HUMAN [view interactions] High throughput no no
PD1L1_HUMAN [view interactions] High throughput no no
SCRB2_HUMAN [view interactions] High throughput no yes
SPOP_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
ANR50_HUMAN [view interactions] High throughput no no
TM14B_HUMAN [view interactions] High throughput no no
TRI68_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
ANGI_HUMAN [view interactions] High throughput no no
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
BTF3_HUMAN [view interactions] High throughput no yes
RYR2_HUMAN [view entry] [view interactions] High throughput yes yes
SLN11_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
AUTS2_HUMAN [view interactions] High throughput no yes
HECD1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CUL4B_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
PEG10_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
PPHLN_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
BFAR_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
CZIB_HUMAN [view interactions] High throughput no no
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
RBM7_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
ZN768_HUMAN [view interactions] High throughput no yes
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
MBB1A_HUMAN [view interactions] High throughput no yes
ZCHC3_HUMAN [view interactions] High throughput no no
JUPI1_HUMAN [view interactions] High throughput no yes
CFA97_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
EXOSX_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS2_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
DJC21_HUMAN [view interactions] High throughput no yes
IKBB_HUMAN [view interactions] High throughput no no
DHX57_HUMAN [view interactions] High throughput no no
IKBE_HUMAN [view entry] [view interactions] High throughput yes yes
TRI31_HUMAN [view interactions] High throughput no no
NFKB2_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
M3K14_HUMAN [view interactions] High throughput no yes
FOXC1_HUMAN [view interactions] High throughput no no
RELB_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
TBK1_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF1_HUMAN [view interactions] High throughput no no
IKZF1_HUMAN [view interactions] High throughput no no
CSN5_HUMAN [view interactions] High throughput no yes
IKZF3_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
5HT7R_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
RNF8_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
NDC80_HUMAN [view interactions] High throughput no no
DOT1L_HUMAN [view interactions] High throughput no yes
SP100_HUMAN [view interactions] High throughput no no
MEN1_HUMAN [view interactions] High throughput no yes
TSYL5_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
KATIP_HUMAN [view interactions] High throughput no yes
GATA4_HUMAN [view interactions] High throughput no no
LTOR5_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
4ET_HUMAN [view interactions] High throughput no yes
CDK7_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
MDC1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1A_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2O_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
GCSP_HUMAN [view interactions] High throughput no yes
CPSF7_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
DMRTB_HUMAN [view interactions] High throughput no no
FND3A_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS8_HUMAN [view interactions] High throughput no yes
HSF1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
SF01_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
CEP55_HUMAN [view interactions] High throughput no yes
SMC5_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CPSF6_HUMAN [view interactions] High throughput no yes
MUS81_HUMAN [view interactions] High throughput no no
CSTFT_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
TCRG1_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no no
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
SMCA2_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
SRRM1_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
SRRM2_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
SMRD1_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC9_HUMAN [view entry] [view interactions] High throughput yes yes
TOPRS_HUMAN [view interactions] High throughput no yes
H31T_HUMAN [view interactions] High throughput no yes
U2AF1_HUMAN [view interactions] High throughput no yes
SF3B1_HUMAN [view interactions] High throughput no yes
TAD2A_HUMAN [view interactions] High throughput no no
HNRPR_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
HNRPC_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
RU2A_HUMAN [view interactions] High throughput no yes
SRSF5_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
CK068_HUMAN [view interactions] High throughput no yes
SRSF7_HUMAN [view interactions] High throughput no yes
SF3B3_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
SRSF3_HUMAN [view interactions] High throughput no yes
RAD21_HUMAN [view interactions] High throughput no yes
SRSF4_HUMAN [view interactions] High throughput no yes
CEBPA_HUMAN [view interactions] High throughput no yes
SMD2_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A1_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
PHF5A_HUMAN [view interactions] High throughput no yes
PER2_HUMAN [view interactions] High throughput no yes
HTSF1_HUMAN [view interactions] High throughput no yes
PER1_HUMAN [view interactions] High throughput no no
ILF3_HUMAN [view interactions] High throughput no yes
NR2C1_HUMAN [view interactions] High throughput no yes
TOP2B_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
SLTM_HUMAN [view interactions] High throughput no yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
SSRD_HUMAN [view interactions] High throughput no yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
TIM10_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
TPR_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
STAG2_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
SON_HUMAN [view interactions] High throughput no yes
RARA_HUMAN [view interactions] High throughput no no
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
UT14A_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
SMCA5_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
VTNC_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
ASB3_HUMAN [view interactions] High throughput no yes
TIM9_HUMAN [view interactions] High throughput no yes
ASB12_HUMAN [view interactions] High throughput no no
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
ASB18_HUMAN [view interactions] High throughput no no
SYCC_HUMAN [view interactions] High throughput no yes
ERG_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
DPH5_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
NXF1_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
CCDC8_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
PO210_HUMAN [view interactions] High throughput no yes
ORC6_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
KS6B2_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
PGK1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
SYTC_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
WBP11_HUMAN [view interactions] High throughput no yes
KAT5_HUMAN [view interactions] High throughput no yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD2_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
MCM5_HUMAN [view interactions] High throughput no no
5MP2_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
MYEF2_HUMAN [view interactions] High throughput no no
NKX21_HUMAN [view interactions] High throughput no no
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN746_HUMAN [view interactions] High throughput no no
ROAA_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2A_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
PLRG1_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
PRP19_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
PRC2C_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
FACD2_HUMAN [view interactions] High throughput no no
HNRPU_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2A_HUMAN [view interactions] High throughput no no
PFKAL_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
U520_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
SMD3_HUMAN [view interactions] High throughput no yes
CBAR1_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
TTC23_HUMAN [view interactions] High throughput no yes
SMD1_HUMAN [view interactions] High throughput no yes
TEDC2_HUMAN [view interactions] High throughput no no
SRSF1_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
IDHC_HUMAN [view interactions] High throughput no no
PCF11_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
SCP2_HUMAN [view interactions] High throughput no no
PRP8_HUMAN [view interactions] High throughput no yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
AAR2_HUMAN [view interactions] High throughput no no
MSH2_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
ZO1_HUMAN [view entry] [view interactions] High throughput yes no
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
SF3B2_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
GCN1_HUMAN [view interactions] High throughput no yes
YLPM1_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
DDX23_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CWC15_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
R113A_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
ACTC_HUMAN [view interactions] High throughput no no
RIOK1_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
FGF11_HUMAN [view interactions] High throughput no no
DPPA3_HUMAN [view interactions] High throughput no no
MEPCE_HUMAN [view interactions] High throughput no yes
CELF1_HUMAN [view interactions] High throughput no yes
CD2B2_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
CH082_HUMAN [view interactions] High throughput no yes
EXOS5_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
SMAD5_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
AGR2_HUMAN [view interactions] High throughput no no
PML_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
NUP35_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
DTX2_HUMAN [view interactions] High throughput no yes
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
CEBPB_HUMAN [view interactions] High throughput no no
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
MK13_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
R144A_HUMAN [view interactions] High throughput no yes
PCDH7_HUMAN [view entry] [view interactions] High throughput yes no
REST_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
DSRAD_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
RED1_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
EYA4_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
PSA3_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CTR9_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARM12_HUMAN [view interactions] High throughput no no
BCLF1_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
SNIP1_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
ZFY21_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
SREK1_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes