ELAV4_HUMAN
Evidence for PS localization
Functions
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Binds to AU-rich element (ARE) sequences in the 3 untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed, PubMed, PubMed, PubMed). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function . By binding to the mRNA 3UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed). Also binds to the polyadenylated (poly(A)) tail in the 3UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed, PubMed, PubMed, PubMed). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells . Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA . Binds and stabilizes MSI1 mRNA in neural stem cells . Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed, PubMed). Protects CDKN1A mRNA from decay by binding to its 3-UTR . May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function . Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth . Binds to BDNF long 3UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC . By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration . Acts as a stabilizing factor by binding to the 3UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex . May also negatively regulate translation by binding to the 5UTR of Ins2 mRNA, thereby repressing its translation . Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished . Also plays a role in the regulation of alternative splicing (PubMed). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ELAV4_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 58.3333 | 4 | yes |
| GO:0043168 | anion binding | 29.1667 | 4 | no |
| GO:0003729 | mRNA binding | 25.0000 | 5 | yes |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0043169 | cation binding | 20.8333 | 4 | no |
| GO:0046872 | metal ion binding | 20.8333 | 5 | no |
| GO:0003727 | single-stranded RNA binding | 16.6667 | 5 | yes |
| GO:0003730 | mRNA 3-UTR binding | 16.6667 | 6 | yes |
| GO:0008143 | poly(A) binding | 8.3333 | 7 | yes |
| GO:0035925 | mRNA 3-UTR AU-rich region binding | 8.3333 | 7 | yes |
| GO:0070717 | poly-purine tract binding | 8.3333 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ELAV4_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 70.8333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 70.8333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 62.5000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 58.3333 | 4 | yes |
| GO:0010468 | regulation of gene expression | 58.3333 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 58.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 58.3333 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 58.3333 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 58.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 54.1667 | 5 | yes |
| GO:0010646 | regulation of cell communication | 54.1667 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 50.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 45.8333 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 45.8333 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.8333 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 45.8333 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 45.8333 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 41.6667 | 7 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.5000 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 37.5000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 37.5000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 37.5000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 33.3333 | 7 | yes |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 33.3333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.1667 | 6 | no |
| GO:0031399 | regulation of protein modification process | 29.1667 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.1667 | 5 | no |
| GO:0006396 | RNA processing | 29.1667 | 6 | yes |
| GO:0016070 | RNA metabolic process | 29.1667 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 29.1667 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.1667 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 29.1667 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 29.1667 | 6 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.1667 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0006397 | mRNA processing | 25.0000 | 7 | yes |
| GO:0006417 | regulation of translation | 25.0000 | 6 | yes |
| GO:0008380 | RNA splicing | 25.0000 | 7 | yes |
| GO:0016071 | mRNA metabolic process | 25.0000 | 6 | yes |
| GO:0043488 | regulation of mRNA stability | 25.0000 | 4 | yes |
| GO:0050890 | cognition | 25.0000 | 4 | yes |
| GO:0061013 | regulation of mRNA catabolic process | 25.0000 | 5 | yes |
| GO:1903311 | regulation of mRNA metabolic process | 25.0000 | 6 | yes |
| GO:0006915 | apoptotic process | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 20.8333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 20.8333 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8333 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8333 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8333 | 7 | no |
| GO:0009895 | negative regulation of catabolic process | 20.8333 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 20.8333 | 4 | yes |
| GO:0030030 | cell projection organization | 20.8333 | 4 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 20.8333 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.8333 | 4 | no |
| GO:0006974 | DNA damage response | 20.8333 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 20.8333 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.8333 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.8333 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 16.6667 | 7 | yes |
| GO:0051094 | positive regulation of developmental process | 16.6667 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 16.6667 | 5 | yes |
| GO:1902369 | negative regulation of RNA catabolic process | 16.6667 | 6 | yes |
| GO:1902373 | negative regulation of mRNA catabolic process | 16.6667 | 6 | yes |
| GO:1903312 | negative regulation of mRNA metabolic process | 16.6667 | 7 | yes |
| GO:0007612 | learning | 12.5000 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 12.5000 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.5000 | 6 | yes |
| GO:0043489 | RNA stabilization | 12.5000 | 4 | yes |
| GO:0048255 | mRNA stabilization | 12.5000 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 12.5000 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.5000 | 4 | yes |
| GO:0008306 | associative learning | 8.3333 | 5 | yes |
| GO:0010976 | positive regulation of neuron projection development | 8.3333 | 7 | yes |
| GO:0030182 | neuron differentiation | 8.3333 | 4 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 8.3333 | 4 | yes |
| GO:0048813 | dendrite morphogenesis | 8.3333 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 8.3333 | 4 | yes |
| GO:1990089 | response to nerve growth factor | 8.3333 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 8.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NXF1_HUMAN | [view interactions] | Low throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | Low throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMN_HUMAN | [view interactions] | Low throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| P20L1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| EYA3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT8B4_HUMAN | [view interactions] | High throughput | no | yes |
| ATS18_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TUB_HUMAN | [view interactions] | High throughput | no | yes |
| RNF41_HUMAN | [view interactions] | High throughput | no | yes |
| CC140_HUMAN | [view interactions] | High throughput | no | no |
| RS30_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| ZC11A_HUMAN | [view interactions] | High throughput | no | yes |
| E4F1_HUMAN | [view interactions] | High throughput | no | yes |
| PNRC2_HUMAN | [view interactions] | High throughput | no | yes |
| GOG8A_HUMAN | [view interactions] | High throughput | no | no |
| H2AB2_HUMAN | [view interactions] | High throughput | no | no |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV2_HUMAN | [view interactions] | High throughput | no | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |